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Items: 30


Bistable switches as integrators and actuators during cell cycle progression.

Stallaert W, Kedziora KM, Chao HX, Purvis JE.

FEBS Lett. 2019 Oct;593(20):2805-2816. doi: 10.1002/1873-3468.13628. Epub 2019 Oct 16. Review.


Genetic determinants of cellular addiction to DNA polymerase theta.

Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP.

Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1.


Chemical screen for epigenetic barriers to single allele activation of Oct4.

Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA.

Stem Cell Res. 2019 Jul;38:101470. doi: 10.1016/j.scr.2019.101470. Epub 2019 May 24.


Correction: Rapid DNA replication origin licensing protects stem cell pluripotency.

Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG.

Elife. 2019 Jun 5;8. pii: e49040. doi: 10.7554/eLife.49040.


Reprogramming favors the elite.

Wolff SC, Purvis JE.

Science. 2019 Apr 26;364(6438):330-331. doi: 10.1126/science.aax1681. No abstract available.


Evidence that the human cell cycle is a series of uncoupled, memoryless phases.

Chao HX, Fakhreddin RI, Shimerov HK, Kedziora KM, Kumar RJ, Perez J, Limas JC, Grant GD, Cook JG, Gupta GP, Purvis JE.

Mol Syst Biol. 2019 Mar 18;15(3):e8604. doi: 10.15252/msb.20188604.


Accurate delineation of cell cycle phase transitions in living cells with PIP-FUCCI.

Grant GD, Kedziora KM, Limas JC, Cook JG, Purvis JE.

Cell Cycle. 2018;17(21-22):2496-2516. doi: 10.1080/15384101.2018.1547001.


Inheritance of OCT4 predetermines fate choice in human embryonic stem cells.

Wolff SC, Kedziora KM, Dumitru R, Dungee CD, Zikry TM, Beltran AS, Haggerty RA, Cheng J, Redick MA, Purvis JE.

Mol Syst Biol. 2018 Sep 3;14(9):e8140. doi: 10.15252/msb.20178140.


The Cell Cycle Browser: An Interactive Tool for Visualizing, Simulating, and Perturbing Cell-Cycle Progression.

Borland D, Yi H, Grant GD, Kedziora KM, Chao HX, Haggerty RA, Kumar J, Wolff SC, Cook JG, Purvis JE.

Cell Syst. 2018 Aug 22;7(2):180-184.e4. doi: 10.1016/j.cels.2018.06.004. Epub 2018 Aug 1.


Natural language processing: put your model where your mouth is.

Haggerty RA, Purvis JE.

Mol Syst Biol. 2017 Dec 18;13(12):958. doi: 10.15252/msb.20178077. No abstract available.


Rapid DNA replication origin licensing protects stem cell pluripotency.

Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG.

Elife. 2017 Nov 17;6. pii: e30473. doi: 10.7554/eLife.30473. Erratum in: Elife. 2019 Jun 05;8:.


Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle.

Chao HX, Poovey CE, Privette AA, Grant GD, Chao HY, Cook JG, Purvis JE.

Cell Syst. 2017 Nov 22;5(5):445-459.e5. doi: 10.1016/j.cels.2017.09.015. Epub 2017 Oct 25.


Cell biology: The persistence of memory.

Kedziora KM, Purvis JE.

Nature. 2017 Sep 21;549(7672):343-344. doi: 10.1038/nature23549. Epub 2017 Sep 6. No abstract available.


p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics.

Hafner A, Stewart-Ornstein J, Purvis JE, Forrester WC, Bulyk ML, Lahav G.

Nat Struct Mol Biol. 2017 Oct;24(10):840-847. doi: 10.1038/nsmb.3452. Epub 2017 Aug 21.


An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells.

Baran-Gale J, Purvis JE, Sethupathy P.

RNA. 2016 Oct;22(10):1592-603. doi: 10.1261/rna.056895.116. Epub 2016 Aug 18.


Sequential replication-coupled destruction at G1/S ensures genome stability.

Coleman KE, Grant GD, Haggerty RA, Brantley K, Shibata E, Workman BD, Dutta A, Varma D, Purvis JE, Cook JG.

Genes Dev. 2015 Aug 15;29(16):1734-46. doi: 10.1101/gad.263731.115. Epub 2015 Aug 13.


Multi-scale imaging and informatics pipeline for in situ pluripotent stem cell analysis.

Gorman BR, Lu J, Baccei A, Lowry NC, Purvis JE, Mangoubi RS, Lerou PH.

PLoS One. 2014 Dec 31;9(12):e116037. doi: 10.1371/journal.pone.0116037. eCollection 2014.


Computational analysis of signaling patterns in single cells.

Davis DM, Purvis JE.

Semin Cell Dev Biol. 2015 Jan;37:35-43. doi: 10.1016/j.semcdb.2014.09.015. Epub 2014 Sep 26. Review.


Encoding and decoding cellular information through signaling dynamics.

Purvis JE, Lahav G.

Cell. 2013 Feb 28;152(5):945-56. doi: 10.1016/j.cell.2013.02.005. Review.


Decoding the insulin signal.

Purvis JE, Lahav G.

Mol Cell. 2012 Jun 29;46(6):715-6. doi: 10.1016/j.molcel.2012.06.005.


p53 dynamics control cell fate.

Purvis JE, Karhohs KW, Mock C, Batchelor E, Loewer A, Lahav G.

Science. 2012 Jun 15;336(6087):1440-4. doi: 10.1126/science.1218351.


Cancer Cell: Linking Oncogenic Signaling to Molecular Structure.

Purvis JE, Shih AJ, Liu Y, Radhakrishnan R.

Chapman Hall CRC Math Comput Biol Ser. 2011;2011:31-44.


Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli.

Chatterjee MS, Purvis JE, Brass LF, Diamond SL.

Nat Biotechnol. 2010 Jul;28(7):727-32. doi: 10.1038/nbt.1642. Epub 2010 Jun 20.


A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.

Shah PP, Wang T, Kaletsky RL, Myers MC, Purvis JE, Jing H, Huryn DM, Greenbaum DC, Smith AB 3rd, Bates P, Diamond SL.

Mol Pharmacol. 2010 Aug;78(2):319-24. doi: 10.1124/mol.110.064261. Epub 2010 May 13.


Steady-state kinetic modeling constrains cellular resting states and dynamic behavior.

Purvis JE, Radhakrishnan R, Diamond SL.

PLoS Comput Biol. 2009 Mar;5(3):e1000298. doi: 10.1371/journal.pcbi.1000298. Epub 2009 Mar 6.


Molecular docking of cathepsin L inhibitors in the binding site of papain.

Beavers MP, Myers MC, Shah PP, Purvis JE, Diamond SL, Cooperman BS, Huryn DM, Smith AB 3rd.

J Chem Inf Model. 2008 Jul;48(7):1464-72. doi: 10.1021/ci800085c. Epub 2008 Jul 4. Erratum in: J Chem Inf Model. 2010 Dec 27;50(12):2274.


A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation.

Purvis JE, Chatterjee MS, Brass LF, Diamond SL.

Blood. 2008 Nov 15;112(10):4069-79. doi: 10.1182/blood-2008-05-157883. Epub 2008 Jul 2.


Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.

Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB 3rd, Diamond SL.

Mol Pharmacol. 2008 Jul;74(1):34-41. doi: 10.1124/mol.108.046219. Epub 2008 Apr 10.


Enhanced trehalose production improves growth of Escherichia coli under osmotic stress.

Purvis JE, Yomano LP, Ingram LO.

Appl Environ Microbiol. 2005 Jul;71(7):3761-9.


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