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Items: 29

1.

A novel role for E2F3b in regulating cocaine action in the prefrontal cortex.

Cates HM, Bagot RC, Heller EA, Purushothaman I, Lardner CK, Walker DM, Peña CJ, Neve RL, Shen L, Nestler EJ.

Neuropsychopharmacology. 2019 Mar;44(4):776-784. doi: 10.1038/s41386-018-0296-1. Epub 2018 Dec 14.

PMID:
30552390
2.

Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons.

Miller ML, Chadwick B, Dickstein DL, Purushothaman I, Egervari G, Rahman T, Tessereau C, Hof PR, Roussos P, Shen L, Baxter MG, Hurd YL.

Mol Psychiatry. 2019 Apr;24(4):588-600. doi: 10.1038/s41380-018-0243-x. Epub 2018 Oct 3.

3.

Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine.

Ribeiro EA, Salery M, Scarpa JR, Calipari ES, Hamilton PJ, Ku SM, Kronman H, Purushothaman I, Juarez B, Heshmati M, Doyle M, Lardner C, Burek D, Strat A, Pirpinias S, Mouzon E, Han MH, Neve RL, Bagot RC, Kasarskis A, Koo JW, Nestler EJ.

Nat Commun. 2018 Aug 8;9(1):3149. doi: 10.1038/s41467-018-05657-9.

4.

Genome-wide transcriptional profiling of central amygdala and orbitofrontal cortex during incubation of methamphetamine craving.

Cates HM, Li X, Purushothaman I, Kennedy PJ, Shen L, Shaham Y, Nestler EJ.

Neuropsychopharmacology. 2018 Nov;43(12):2426-2434. doi: 10.1038/s41386-018-0158-x. Epub 2018 Jul 20.

PMID:
30072726
5.

Epigenetic regulation of brain region-specific microglia clearance activity.

Ayata P, Badimon A, Strasburger HJ, Duff MK, Montgomery SE, Loh YE, Ebert A, Pimenova AA, Ramirez BR, Chan AT, Sullivan JM, Purushothaman I, Scarpa JR, Goate AM, Busslinger M, Shen L, Losic B, Schaefer A.

Nat Neurosci. 2018 Aug;21(8):1049-1060. doi: 10.1038/s41593-018-0192-3. Epub 2018 Jul 23.

6.

Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry.

Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, Lardner CK, Godino A, Kronman HG, Rabkin J, Lorsch ZS, Mews P, Doyle MA, Feng J, Labonté B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES, Shen L, Nestler EJ.

Biol Psychiatry. 2018 Dec 15;84(12):867-880. doi: 10.1016/j.biopsych.2018.04.009. Epub 2018 Apr 25.

PMID:
29861096
7.

Corrigendum: Sex-specific transcriptional signatures in human depression.

Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kasarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525d.

PMID:
29634684
8.

Estrogen receptor α drives pro-resilient transcription in mouse models of depression.

Lorsch ZS, Loh YE, Purushothaman I, Walker DM, Parise EM, Salery M, Cahill ME, Hodes GE, Pfau ML, Kronman H, Hamilton PJ, Issler O, Labonté B, Symonds AE, Zucker M, Zhang TY, Meaney MJ, Russo SJ, Shen L, Bagot RC, Nestler EJ.

Nat Commun. 2018 Mar 16;9(1):1116. doi: 10.1038/s41467-018-03567-4.

9.

Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.

Gaspari S, Purushothaman I, Cogliani V, Sakloth F, Neve RL, Howland D, Ring RH, Ross EM, Shen L, Zachariou V.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2085-E2094. doi: 10.1073/pnas.1707887115. Epub 2018 Feb 12.

10.

Transcription Factor E2F3a in Nucleus Accumbens Affects Cocaine Action via Transcription and Alternative Splicing.

Cates HM, Heller EA, Lardner CK, Purushothaman I, Peña CJ, Walker DM, Cahill ME, Neve RL, Shen L, Bagot RC, Nestler EJ.

Biol Psychiatry. 2018 Aug 1;84(3):167-179. doi: 10.1016/j.biopsych.2017.11.027. Epub 2017 Dec 5.

11.

Different Donor-Acceptor Interactions of Carbene Ligands in Heteroleptic Divalent Group 14 Compounds, LEL' (E=C-Sn; L=N-Heterocyclic Carbene; L'=Cyclic Alkyl(Amino) Carbene).

Purushothaman I, De S, Parameswaran P.

Chemistry. 2018 Mar 12;24(15):3816-3824. doi: 10.1002/chem.201705719. Epub 2018 Feb 16.

PMID:
29315890
12.

Sex-specific transcriptional signatures in human depression.

Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ.

Nat Med. 2017 Sep;23(9):1102-1111. doi: 10.1038/nm.4386. Epub 2017 Aug 21. Erratum in: Nat Med. 2018 Apr 10;24(4):525.

13.

Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2.

Peña CJ, Kronman HG, Walker DM, Cates HM, Bagot RC, Purushothaman I, Issler O, Loh YE, Leong T, Kiraly DD, Goodman E, Neve RL, Shen L, Nestler EJ.

Science. 2017 Jun 16;356(6343):1185-1188. doi: 10.1126/science.aan4491.

14.

Trapping a Silicon(I) Radical with Carbenes: A Cationic cAAC-Silicon(I) Radical and an NHC-Parent-Silyliumylidene Cation.

Li Y, Chan YC, Leong BX, Li Y, Richards E, Purushothaman I, De S, Parameswaran P, So CW.

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7573-7578. doi: 10.1002/anie.201702760. Epub 2017 May 24.

PMID:
28544030
15.

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression.

Descalzi G, Mitsi V, Purushothaman I, Gaspari S, Avrampou K, Loh YE, Shen L, Zachariou V.

Sci Signal. 2017 Mar 21;10(471). pii: eaaj1549. doi: 10.1126/scisignal.aaj1549.

16.

Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors.

Feng J, Pena CJ, Purushothaman I, Engmann O, Walker D, Brown AN, Issler O, Doyle M, Harrigan E, Mouzon E, Vialou V, Shen L, Dawlaty MM, Jaenisch R, Nestler EJ.

Neuropsychopharmacology. 2017 Jul;42(8):1657-1669. doi: 10.1038/npp.2017.6. Epub 2017 Jan 11.

17.

Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens.

Pfau ML, Purushothaman I, Feng J, Golden SA, Aleyasin H, Lorsch ZS, Cates HM, Flanigan ME, Menard C, Heshmati M, Wang Z, Ma'ayan A, Shen L, Hodes GE, Russo SJ.

Front Mol Neurosci. 2016 Dec 23;9:144. doi: 10.3389/fnmol.2016.00144. eCollection 2016.

18.

Spectral characterisation, antiviral activities, in silico ADMET and molecular docking of the compounds isolated from Tectona grandis to chikungunya virus.

K S, Purushothaman I, S R.

Biomed Pharmacother. 2017 Mar;87:302-310. doi: 10.1016/j.biopha.2016.12.069. Epub 2017 Jan 4.

PMID:
28063412
19.

Ketamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles.

Bagot RC, Cates HM, Purushothaman I, Vialou V, Heller EA, Yieh L, LaBonté B, Peña CJ, Shen L, Wittenberg GM, Nestler EJ.

Biol Psychiatry. 2017 Feb 15;81(4):285-295. doi: 10.1016/j.biopsych.2016.06.012. Epub 2016 Jun 18.

20.

Synthesis of a Bent 2-Silaallene with a Perturbed Electronic Structure from a Cyclic Alkyl(amino) Carbene-Diiodosilylene.

Li Y, Chan YC, Li Y, Purushothaman I, De S, Parameswaran P, So CW.

Inorg Chem. 2016 Sep 6;55(17):9091-8. doi: 10.1021/acs.inorgchem.6b01716. Epub 2016 Aug 25.

PMID:
27560615
21.

Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility.

Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, Liu X, Doyle MA, Scobie KN, Sun HS, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ.

Neuron. 2016 Jun 1;90(5):969-83. doi: 10.1016/j.neuron.2016.04.015. Epub 2016 May 12.

22.

Stepwise isolation of an unprecedented silylene supported dinuclear gold(i) cation with aurophilic interaction.

Khan S, Pal S, Kathewad N, Purushothaman I, De S, Parameswaran P.

Chem Commun (Camb). 2016 Mar 11;52(20):3880-2. doi: 10.1039/c6cc00597g. Epub 2016 Feb 9.

PMID:
26857152
23.

In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward.

Calipari ES, Bagot RC, Purushothaman I, Davidson TJ, Yorgason JT, Peña CJ, Walker DM, Pirpinias ST, Guise KG, Ramakrishnan C, Deisseroth K, Nestler EJ.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2726-31. doi: 10.1073/pnas.1521238113. Epub 2016 Feb 1.

24.

Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.

Hodes GE, Pfau ML, Purushothaman I, Ahn HF, Golden SA, Christoffel DJ, Magida J, Brancato A, Takahashi A, Flanigan ME, Ménard C, Aleyasin H, Koo JW, Lorsch ZS, Feng J, Heshmati M, Wang M, Turecki G, Neve R, Zhang B, Shen L, Nestler EJ, Russo SJ.

J Neurosci. 2015 Dec 16;35(50):16362-76. doi: 10.1523/JNEUROSCI.1392-15.2015.

25.

Erratum to: Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens.

Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L.

Genome Biol. 2015 Oct 14;16:227. doi: 10.1186/s13059-015-0789-8. No abstract available.

26.

RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states.

Mitsi V, Terzi D, Purushothaman I, Manouras L, Gaspari S, Neve RL, Stratinaki M, Feng J, Shen L, Zachariou V.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5088-97. doi: 10.1073/pnas.1504283112. Epub 2015 Aug 24.

27.

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.

Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, Rafii S, Birtwistle MR, Akbarian S, Buchholz BA, Blitzer RD, Nestler EJ, Yuan ZF, Garcia BA, Shen L, Molina H, Allis CD.

Neuron. 2015 Jul 1;87(1):77-94. doi: 10.1016/j.neuron.2015.06.014.

28.

Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens.

Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L.

Genome Biol. 2014 Apr 22;15(4):R65. doi: 10.1186/gb-2014-15-4-r65. Erratum in: Genome Biol. 2015;16:227.

29.

A functionalized Ge3-compound with a dual character of the central germanium atom.

Li Y, Mondal KC, Lübben J, Zhu H, Dittrich B, Purushothaman I, Parameswaran P, Roesky HW.

Chem Commun (Camb). 2014 Mar 21;50(23):2986-9. doi: 10.1039/c3cc49635j.

PMID:
24469239

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