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Items: 1 to 50 of 65

1.

Retinoic Acid Receptor γ Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis.

Green AC, Rudolph-Stringer V, Straszkowski L, Tjin G, Crimeen-Irwin B, Walia M, Martin TJ, Sims NA, Purton LE.

J Bone Miner Res. 2018 Jul 24. doi: 10.1002/jbmr.3558. [Epub ahead of print]

PMID:
30040873
2.

Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells.

Grace CS, Mikkola HKA, Dou DR, Calvanese V, Ronn RE, Purton LE.

Exp Hematol. 2018 Sep;65:1-16. doi: 10.1016/j.exphem.2018.06.287. Epub 2018 Jul 4. Review.

PMID:
29981365
3.

Srsf2P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells.

Smeets MF, Tan SY, Xu JJ, Anande G, Unnikrishnan A, Chalk AM, Taylor SR, Pimanda JE, Wall M, Purton LE, Walkley CR.

Blood. 2018 Aug 9;132(6):608-621. doi: 10.1182/blood-2018-04-845602. Epub 2018 Jun 14.

PMID:
29903888
4.

Imaging methods used to study mouse and human HSC niches: Current and emerging technologies.

Tjin G, Flores-Figueroa E, Duarte D, Straszkowski L, Scott M, Khorshed RA, Purton LE, Lo Celso C.

Bone. 2018 Apr 25. pii: S8756-3282(18)30176-5. doi: 10.1016/j.bone.2018.04.022. [Epub ahead of print] Review.

PMID:
29704697
5.

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.

Duarte D, Hawkins ED, Akinduro O, Ang H, De Filippo K, Kong IY, Haltalli M, Ruivo N, Straszkowski L, Vervoort SJ, McLean C, Weber TS, Khorshed R, Pirillo C, Wei A, Ramasamy SK, Kusumbe AP, Duffy K, Adams RH, Purton LE, Carlin LM, Lo Celso C.

Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6. doi: 10.1016/j.stem.2017.11.006. Epub 2017 Dec 21.

6.

Mesenchymal lineage cells and their importance in B lymphocyte niches.

Green AC, Rudolph-Stringer V, Chantry AD, Wu JY, Purton LE.

Bone. 2017 Nov 26. pii: S8756-3282(17)30437-4. doi: 10.1016/j.bone.2017.11.018. [Epub ahead of print] Review.

PMID:
29183783
7.

Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells.

Green AC, Kocovski P, Jovic T, Walia MK, Chandraratna RAS, Martin TJ, Baker EK, Purton LE.

Exp Cell Res. 2017 Jan 1;350(1):284-297. doi: 10.1016/j.yexcr.2016.12.007. Epub 2016 Dec 10.

PMID:
27964926
8.

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments.

Hawkins ED, Duarte D, Akinduro O, Khorshed RA, Passaro D, Nowicka M, Straszkowski L, Scott MK, Rothery S, Ruivo N, Foster K, Waibel M, Johnstone RW, Harrison SJ, Westerman DA, Quach H, Gribben J, Robinson MD, Purton LE, Bonnet D, Lo Celso C.

Nature. 2016 Oct 27;538(7626):518-522. doi: 10.1038/nature19801. Epub 2016 Oct 17.

9.

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.

Liddicoat BJ, Hartner JC, Piskol R, Ramaswami G, Chalk AM, Kingsley PD, Sankaran VG, Wall M, Purton LE, Seeburg PH, Palis J, Orkin SH, Lu J, Li JB, Walkley CR.

Exp Hematol. 2016 Oct;44(10):947-63. doi: 10.1016/j.exphem.2016.06.250. Epub 2016 Jul 1.

10.

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Chandrakanthan V, Yeola A, Kwan JC, Oliver RA, Qiao Q, Kang YC, Zarzour P, Beck D, Boelen L, Unnikrishnan A, Villanueva JE, Nunez AC, Knezevic K, Palu C, Nasrallah R, Carnell M, Macmillan A, Whan R, Yu Y, Hardy P, Grey ST, Gladbach A, Delerue F, Ittner L, Mobbs R, Walkley CR, Purton LE, Ward RL, Wong JW, Hesson LB, Walsh W, Pimanda JE.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2306-15. doi: 10.1073/pnas.1518244113. Epub 2016 Apr 4.

11.

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death.

Bhattacharya S, Chalk AM, Ng AJ, Martin TJ, Zannettino AC, Purton LE, Lu J, Baker EK, Walkley CR.

Oncogene. 2016 Oct 6;35(40):5282-5294. doi: 10.1038/onc.2016.68. Epub 2016 Apr 4.

PMID:
27041566
12.

Retinoic Acid Receptor γ Regulates B and T Lymphopoiesis via Nestin-Expressing Cells in the Bone Marrow and Thymic Microenvironments.

Joseph C, Nota C, Fletcher JL, Maluenda AC, Green AC, Purton LE.

J Immunol. 2016 Mar 1;196(5):2132-44. doi: 10.4049/jimmunol.1501246. Epub 2016 Feb 3.

13.

Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.

Thoms JA, Knezevic K, Liu JJ, Glaros EN, Thai T, Qiao Q, Campbell H, Packham D, Huang Y, Papathanasiou P, Tunningley R, Whittle B, Yeung AW, Chandrakanthan V, Hesson L, Chen V, Wong JW, Purton LE, Ward RL, Thomas SR, Pimanda JE.

Mol Cell Biol. 2016 Mar 31;36(8):1222-36. doi: 10.1128/MCB.01035-15. Print 2016 Apr.

14.

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.

Askmyr M, White KE, Jovic T, King HA, Quach JM, Maluenda AC, Baker EK, Smeets MF, Walkley CR, Purton LE.

Sci Rep. 2015 Oct 21;5:15529. doi: 10.1038/srep15529.

15.

The role of vitamin A and retinoic acid receptor signaling in post-natal maintenance of bone.

Green AC, Martin TJ, Purton LE.

J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):135-46. doi: 10.1016/j.jsbmb.2015.09.036. Epub 2015 Nov 4. Review.

PMID:
26435449
16.

EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance.

Nguyen TM, Arthur A, Panagopoulos R, Paton S, Hayball JD, Zannettino AC, Purton LE, Matsuo K, Gronthos S.

Stem Cells. 2015 Sep;33(9):2838-49. doi: 10.1002/stem.2069. Epub 2015 Jun 23.

17.

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.

Ng AJ, Walia MK, Smeets MF, Mutsaers AJ, Sims NA, Purton LE, Walsh NC, Martin TJ, Walkley CR.

PLoS Genet. 2015 Apr 10;11(4):e1005160. doi: 10.1371/journal.pgen.1005160. eCollection 2015 Apr.

18.

RARγ is a negative regulator of osteoclastogenesis.

Green AC, Poulton IJ, Vrahnas C, Häusler KD, Walkley CR, Wu JY, Martin TJ, Gillespie MT, Chandraratna RA, Quinn JM, Sims NA, Purton LE.

J Steroid Biochem Mol Biol. 2015 Jun;150:46-53. doi: 10.1016/j.jsbmb.2015.03.005. Epub 2015 Mar 20.

PMID:
25800721
19.

Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma.

Baker EK, Taylor S, Gupte A, Chalk AM, Bhattacharya S, Green AC, Martin TJ, Strbenac D, Robinson MD, Purton LE, Walkley CR.

Bone. 2015 Apr;73:223-32. doi: 10.1016/j.bone.2014.12.063. Epub 2015 Jan 5.

PMID:
25571841
20.

Myelosuppressive therapies significantly increase pro-inflammatory cytokines and directly cause bone loss.

Quach JM, Askmyr M, Jovic T, Baker EK, Walsh NC, Harrison SJ, Neeson P, Ritchie D, Ebeling PR, Purton LE.

J Bone Miner Res. 2015 May;30(5):886-97. doi: 10.1002/jbmr.2415.

21.

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.

Smeets MF, DeLuca E, Wall M, Quach JM, Chalk AM, Deans AJ, Heierhorst J, Purton LE, Izon DJ, Walkley CR.

J Clin Invest. 2014 Aug;124(8):3551-65. doi: 10.1172/JCI75334. Epub 2014 Jun 24.

22.

Src family kinases and their role in hematological malignancies.

Ku M, Wall M, MacKinnon RN, Walkley CR, Purton LE, Tam C, Izon D, Campbell L, Cheng HC, Nandurkar H.

Leuk Lymphoma. 2015 Mar;56(3):577-86. doi: 10.3109/10428194.2014.907897. Epub 2015 Jan 21. Review.

PMID:
24898666
23.

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.

Dewamitta SR, Joseph C, Purton LE, Walkley CR.

Br J Haematol. 2014 Jan;164(2):280-5. doi: 10.1111/bjh.12578. Epub 2013 Sep 24.

PMID:
24383846
24.

Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies.

Joseph C, Quach JM, Walkley CR, Lane SW, Lo Celso C, Purton LE.

Cell Stem Cell. 2013 Nov 7;13(5):520-33. doi: 10.1016/j.stem.2013.10.010. Review.

25.

Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells.

Noll JE, Williams SA, Tong CM, Wang H, Quach JM, Purton LE, Pilkington K, To LB, Evdokiou A, Gronthos S, Zannettino AC.

Haematologica. 2014 Jan;99(1):163-71. doi: 10.3324/haematol.2013.090977. Epub 2013 Aug 9.

26.

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.

Mutsaers AJ, Ng AJ, Baker EK, Russell MR, Chalk AM, Wall M, Liddicoat BJ, Ho PW, Slavin JL, Goradia A, Martin TJ, Purton LE, Dickins RA, Walkley CR.

Bone. 2013 Jul;55(1):166-78. doi: 10.1016/j.bone.2013.02.016. Epub 2013 Feb 26.

PMID:
23486187
27.

ATRA and the specific RARα agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells.

Chee LC, Hendy J, Purton LE, McArthur GA.

Leukemia. 2013 Jun;27(6):1369-80. doi: 10.1038/leu.2012.362. Epub 2012 Dec 11.

PMID:
23228968
28.

The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation.

Chee LC, Hendy J, Purton LE, McArthur GA.

J Leukoc Biol. 2013 Feb;93(2):235-43. doi: 10.1189/jlb.1211609. Epub 2012 Nov 7.

PMID:
23136256
29.

Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?

Noll JE, Williams SA, Purton LE, Zannettino AC.

Blood Cancer J. 2012 Sep 14;2:e91. doi: 10.1038/bcj.2012.38.

30.

A novel population of cells expressing both hematopoietic and mesenchymal markers is present in the normal adult bone marrow and is augmented in a murine model of marrow fibrosis.

Ohishi M, Ono W, Ono N, Khatri R, Marzia M, Baker EK, Root SH, Wilson TL, Iwamoto Y, Kronenberg HM, Aguila HL, Purton LE, Schipani E.

Am J Pathol. 2012 Feb;180(2):811-8. doi: 10.1016/j.ajpath.2011.10.028. Epub 2011 Dec 5.

31.

A stressed niche not Wnted.

Baker EK, Purton LE.

Blood. 2011 Sep 1;118(9):2377-8. doi: 10.1182/blood-2011-07-362798. No abstract available.

32.

Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.

Wu JY, Aarnisalo P, Bastepe M, Sinha P, Fulzele K, Selig MK, Chen M, Poulton IJ, Purton LE, Sims NA, Weinstein LS, Kronenberg HM.

J Clin Invest. 2011 Sep;121(9):3492-504. doi: 10.1172/JCI46406. Epub 2011 Aug 1.

33.

Taking HSCs down a Notch in leukemia.

Walkley CR, Izon DJ, Purton LE.

Cell Stem Cell. 2011 Jun 3;8(6):602-3. doi: 10.1016/j.stem.2011.04.010.

34.

Defining the hematopoietic stem cell niche: the chicken and the egg conundrum.

Singbrant S, Askmyr M, Purton LE, Walkley CR.

J Cell Biochem. 2011 Jun;112(6):1486-90. doi: 10.1002/jcb.23085. Review.

PMID:
21503954
35.

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment.

Singbrant S, Russell MR, Jovic T, Liddicoat B, Izon DJ, Purton LE, Sims NA, Martin TJ, Sankaran VG, Walkley CR.

Blood. 2011 May 26;117(21):5631-42. doi: 10.1182/blood-2010-11-320564. Epub 2011 Mar 18.

36.

MicroRNA miR-125a controls hematopoietic stem cell number.

Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14229-34. doi: 10.1073/pnas.0913574107. Epub 2010 Jul 8.

37.

The hematopoietic stem cell niche.

Purton LE, Scadden DT.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2008 Nov 15.

38.

Effects of the bone marrow microenvironment on hematopoietic malignancy.

Askmyr M, Quach J, Purton LE.

Bone. 2011 Jan;48(1):115-20. doi: 10.1016/j.bone.2010.06.003. Epub 2010 Jun 9. Review.

PMID:
20541047
39.

What is the true nature of the osteoblastic hematopoietic stem cell niche?

Askmyr M, Sims NA, Martin TJ, Purton LE.

Trends Endocrinol Metab. 2009 Aug;20(6):303-9. doi: 10.1016/j.tem.2009.03.004. Review.

PMID:
19595609
40.

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways.

Wu JY, Purton LE, Rodda SJ, Chen M, Weinstein LS, McMahon AP, Scadden DT, Kronenberg HM.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16976-81. doi: 10.1073/pnas.0802898105. Epub 2008 Oct 28.

41.

Limiting factors in murine hematopoietic stem cell assays.

Purton LE, Scadden DT.

Cell Stem Cell. 2007 Sep 13;1(3):263-70. doi: 10.1016/j.stem.2007.08.016. Review.

42.

The role of p202 in regulating hematopoietic cell proliferation and differentiation.

Ludlow LE, Purton LE, Klarmann K, Gough DJ, Hii LL, Trapani JA, Keller JR, Clarke CJ, Johnstone RW.

J Interferon Cytokine Res. 2008 Jan;28(1):5-11. doi: 10.1089/jir.2007.0070.

PMID:
18370867
43.

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.

Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA.

Blood. 2008 May 1;111(9):4716-22. doi: 10.1182/blood-2007-10-113068. Epub 2008 Feb 25.

44.

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice.

Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT.

J Clin Invest. 2008 Feb;118(2):491-504. doi: 10.1172/JCI33102.

46.

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.

Walkley CR, Olsen GH, Dworkin S, Fabb SA, Swann J, McArthur GA, Westmoreland SV, Chambon P, Scadden DT, Purton LE.

Cell. 2007 Jun 15;129(6):1097-110.

47.

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.

Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH.

Cell. 2007 Jun 15;129(6):1081-95.

48.

Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells.

Herbert KE, Walkley CR, Winkler IG, Hendy J, Olsen GH, Yuan YD, Chandraratna RA, Prince HM, Lévesque JP, Purton LE.

Transplantation. 2007 Feb 27;83(4):375-84.

PMID:
17318068
49.

Osteoclasts eat stem cells out of house and home.

Purton LE, Scadden DT.

Nat Med. 2006 Jun;12(6):610-1. No abstract available.

PMID:
16761001
50.

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation.

Purton LE, Dworkin S, Olsen GH, Walkley CR, Fabb SA, Collins SJ, Chambon P.

J Exp Med. 2006 May 15;203(5):1283-93. Epub 2006 May 8. Erratum in: J Exp Med. 2006 Jun 12;203(6):1615.

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