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Items: 24


Acidosis induces antimicrobial peptide expression and resistance to uropathogenic E. coli infection in kidney collecting duct cells via HIF-1α.

Peng H, Purkerson JM, Freeman RS, Schwaderer AL, Schwartz GJ.

Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F468-F474. doi: 10.1152/ajprenal.00228.2019. Epub 2019 Dec 16.


Metabolic acidosis stimulates the production of the antimicrobial peptide cathelicidin in rabbit urine.

Peng H, Purkerson JM, Schwaderer AL, Schwartz GJ.

Am J Physiol Renal Physiol. 2017 Nov 1;313(5):F1061-F1067. doi: 10.1152/ajprenal.00701.2016. Epub 2017 Jul 26.


Cell-specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct.

Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F812-F823. doi: 10.1152/ajprenal.00512.2016. Epub 2017 May 3.


SDF1 induction by acidosis from principal cells regulates intercalated cell subtype distribution.

Schwartz GJ, Gao X, Tsuruoka S, Purkerson JM, Peng H, D'Agati V, Picard N, Eladari D, Al-Awqati Q.

J Clin Invest. 2015 Oct 26;125(12):4365-74. doi: 10.1172/JCI80225.


Distinct α-intercalated cell morphology and its modification by acidosis define regions of the collecting duct.

Purkerson JM, Schwaderer AL, Nakamori A, Schwartz GJ.

Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F464-73. doi: 10.1152/ajprenal.00161.2015. Epub 2015 Jun 17.


Insights into acidosis-induced regulation of SLC26A4 (pendrin) and SLC4A9 (AE4) transporters using three-dimensional morphometric analysis of β-intercalated cells.

Purkerson JM, Heintz EV, Nakamori A, Schwartz GJ.

Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F601-11. doi: 10.1152/ajprenal.00404.2013. Epub 2014 Jul 2.


Renal intercalated cells are rather energized by a proton than a sodium pump.

Chambrey R, Kurth I, Peti-Peterdi J, Houillier P, Purkerson JM, Leviel F, Hentschke M, Zdebik AA, Schwartz GJ, Hübner CA, Eladari D.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7928-33. doi: 10.1073/pnas.1221496110. Epub 2013 Apr 22.


Adaptation to metabolic acidosis and its recovery are associated with changes in anion exchanger distribution and expression in the cortical collecting duct.

Purkerson JM, Tsuruoka S, Suter DZ, Nakamori A, Schwartz GJ.

Kidney Int. 2010 Nov;78(10):993-1005. doi: 10.1038/ki.2010.195. Epub 2010 Jun 30.


Secreted cyclophilin A, a peptidylprolyl cis-trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiation.

Peng H, Vijayakumar S, Schiene-Fischer C, Li H, Purkerson JM, Malesevic M, Liebscher J, Al-Awqati Q, Schwartz GJ.

J Biol Chem. 2009 Mar 6;284(10):6465-75. doi: 10.1074/jbc.M808964200. Epub 2008 Dec 26.


Basolateral carbonic anhydrase IV in the proximal tubule is a glycosylphosphatidylinositol-anchored protein.

Purkerson JM, Kittelberger AM, Schwartz GJ.

Kidney Int. 2007 Mar;71(5):407-16. Epub 2007 Jan 17.


The role of carbonic anhydrases in renal physiology.

Purkerson JM, Schwartz GJ.

Kidney Int. 2007 Jan;71(2):103-15. Epub 2006 Dec 13. Review.


Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis.

Tsuruoka S, Watanabe S, Purkerson JM, Fujimura A, Schwartz GJ.

Am J Physiol Renal Physiol. 2006 Oct;291(4):F866-73. Epub 2006 May 16.


The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts.

Purkerson JM, Smith RS, Pollock SJ, Phipps RP.

Eur J Immunol. 2005 Oct;35(10):2920-8.


Nitric oxide production modulates cyclosporin A-induced distal renal tubular acidosis in the rat.

Tsuruoka S, Schwartz GJ, Wakaumi M, Nishiki K, Yamamoto H, Purkerson JM, Fujimura A.

J Pharmacol Exp Ther. 2003 Jun;305(3):840-5. Epub 2003 Mar 6.


Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L.

Hwang Yi, Nahm MH, Briles DE, Thomas D, Purkerson JM.

Infect Immun. 2000 Feb;68(2):511-7.


Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/CD40.

Evans DE, Munks MW, Purkerson JM, Parker DC.

J Immunol. 2000 Jan 15;164(2):688-97.


Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells.

Purkerson JM, Newberg M, Wise G, Lynch KR, Isakson PC.

J Exp Med. 1988 Sep 1;168(3):1175-80.

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