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Items: 29


MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine.

Su CC, Klenotic PA, Bolla JR, Purdy GE, Robinson CV, Yu EW.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11241-11246. doi: 10.1073/pnas.1901346116. Epub 2019 May 21.


MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis.

Melly G, Purdy GE.

Microorganisms. 2019 Mar 5;7(3). pii: E70. doi: 10.3390/microorganisms7030070. Review.


Reply to Brennan, "Biofilms and Mycobacterium tuberculosis".

Purdy GE.

Infect Immun. 2017 Sep 20;85(10). pii: e00436-17. doi: 10.1128/IAI.00436-17. Print 2017 Oct. No abstract available.


Killing Mycobacterium tuberculosis In Vitro: What Model Systems Can Teach Us.

Keiser TL, Purdy GE.

Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.TBTB2-0028-2016. Review.


The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence.

Wright CC, Hsu FF, Arnett E, Dunaj JL, Davidson PM, Pacheco SA, Harriff MJ, Lewinsohn DM, Schlesinger LS, Purdy GE.

Infect Immun. 2017 Jul 19;85(8). pii: e00131-17. doi: 10.1128/IAI.00131-17. Print 2017 Aug.


Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis.

Foss MH, Pou S, Davidson PM, Dunaj JL, Winter RW, Pou S, Licon MH, Doh JK, Li Y, Kelly JX, Dodean RA, Koop DR, Riscoe MK, Purdy GE.

ACS Infect Dis. 2016 Jul 8;2(7):500-8. doi: 10.1021/acsinfecdis.6b00052. Epub 2016 May 13.


Structural Basis for the Regulation of the MmpL Transporters of Mycobacterium tuberculosis.

Delmar JA, Chou TH, Wright CC, Licon MH, Doh JK, Radhakrishnan A, Kumar N, Lei HT, Bolla JR, Rajashankar KR, Su CC, Purdy GE, Yu EW.

J Biol Chem. 2015 Nov 20;290(47):28559-74. doi: 10.1074/jbc.M115.683797. Epub 2015 Sep 22.


Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302.

Chou TH, Delmar JA, Wright CC, Kumar N, Radhakrishnan A, Doh JK, Licon MH, Bolla JR, Lei HT, Rajashankar KR, Su CC, Purdy GE, Yu EW.

Protein Sci. 2015 Dec;24(12):1942-55. doi: 10.1002/pro.2802. Epub 2015 Sep 29.


Confinement-Induced Drug-Tolerance in Mycobacteria Mediated by an Efflux Mechanism.

Luthuli BB, Purdy GE, Balagaddé FK.

PLoS One. 2015 Aug 21;10(8):e0136231. doi: 10.1371/journal.pone.0136231. eCollection 2015.


NtrBC and Nac contribute to efficient Shigella flexneri intracellular replication.

Waddell CD, Walter TJ, Pacheco SA, Purdy GE, Runyen-Janecky LJ.

J Bacteriol. 2014 Jul;196(14):2578-86. doi: 10.1128/JB.01613-14. Epub 2014 May 2.


Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.

Radhakrishnan A, Kumar N, Wright CC, Chou TH, Tringides ML, Bolla JR, Lei HT, Rajashankar KR, Su CC, Purdy GE, Yu EW.

J Biol Chem. 2014 Jun 6;289(23):16526-40. doi: 10.1074/jbc.M113.538959. Epub 2014 Apr 15.


Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis.

Kumar N, Radhakrishnan A, Wright CC, Chou TH, Lei HT, Bolla JR, Tringides ML, Rajashankar KR, Su CC, Purdy GE, Yu EW.

Protein Sci. 2014 Apr;23(4):423-32. doi: 10.1002/pro.2424. Epub 2014 Mar 10.


MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis.

Pacheco SA, Hsu FF, Powers KM, Purdy GE.

J Biol Chem. 2013 Aug 16;288(33):24213-22. doi: 10.1074/jbc.M113.473371. Epub 2013 Jul 8.


Autophagic Killing Effects against Mycobacterium tuberculosis by Alveolar Macrophages from Young and Aged Rhesus Macaques.

Pacheco SA, Powers KM, Engelmann F, Messaoudi I, Purdy GE.

PLoS One. 2013 Jun 18;8(6):e66985. doi: 10.1371/journal.pone.0066985. Print 2013.


Structural and functional characterization of mycobactericidal ubiquitin-derived peptides in model and bacterial membranes.

Foss MH, Powers KM, Purdy GE.

Biochemistry. 2012 Dec 11;51(49):9922-9. doi: 10.1021/bi301426j. Epub 2012 Nov 30.


Escape from the Phagosome: The Explanation for MHC-I Processing of Mycobacterial Antigens?

Harriff MJ, Purdy GE, Lewinsohn DM.

Front Immunol. 2012 Mar 5;3:40. doi: 10.3389/fimmu.2012.00040. eCollection 2012.


Mycobacterium smegmatis RoxY is a repressor of oxyS and contributes to resistance to oxidative stress and bactericidal ubiquitin-derived peptides.

Daugherty A, Powers KM, Standley MS, Kim CS, Purdy GE.

J Bacteriol. 2011 Dec;193(24):6824-33. doi: 10.1128/JB.05492-11. Epub 2011 Oct 7.


Taking Out TB-Lysosomal Trafficking and Mycobactericidal Ubiquitin-Derived Peptides.

Purdy GE.

Front Microbiol. 2011 Jan 31;2:7. doi: 10.3389/fmicb.2011.00007. eCollection 2011.


Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides.

Purdy GE, Niederweis M, Russell DG.

Mol Microbiol. 2009 Sep;73(5):844-57. doi: 10.1111/j.1365-2958.2009.06801.x. Epub 2009 Aug 6.


Mycobacterium tuberculosis and the environment within the phagosome.

Rohde K, Yates RM, Purdy GE, Russell DG.

Immunol Rev. 2007 Oct;219:37-54. Review.


Lysosomal ubiquitin and the demise of Mycobacterium tuberculosis.

Purdy GE, Russell DG.

Cell Microbiol. 2007 Dec;9(12):2768-74. Epub 2007 Aug 21. Review.


IcsA surface presentation in Shigella flexneri requires the periplasmic chaperones DegP, Skp, and SurA.

Purdy GE, Fisher CR, Payne SM.

J Bacteriol. 2007 Aug;189(15):5566-73. Epub 2007 May 25.


Ubiquitin trafficking to the lysosome: keeping the house tidy and getting rid of unwanted guests.

Purdy GE, Russell DG.

Autophagy. 2007 Jul-Aug;3(4):399-401. Epub 2007 Jul 12.


Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy.

Alonso S, Pethe K, Russell DG, Purdy GE.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6031-6. Epub 2007 Mar 26.


M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs).

Owens RM, Hsu FF, VanderVen BC, Purdy GE, Hesteande E, Giannakas P, Sacchettini JC, McKinney JD, Hill PJ, Belisle JT, Butcher BA, Pethe K, Russell DG.

Mol Microbiol. 2006 Jun;60(5):1152-63.


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