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Items: 34

1.

The humoral immune response is essential for successful vaccine protection against paratuberculosis in sheep.

Pooley HB, Begg DJ, Plain KM, Whittington RJ, Purdie AC, de Silva K.

BMC Vet Res. 2019 Jul 2;15(1):223. doi: 10.1186/s12917-019-1972-z.

2.

The immunogenicity and tissue reactivity of Mycobacterium avium subsp paratuberculosis inactivated whole cell vaccine is dependent on the adjuvant used.

Begg DJ, Dhungyel O, Naddi A, Dhand NK, Plain KM, de Silva K, Purdie AC, Whittington RJ.

Heliyon. 2019 Jun 18;5(6):e01911. doi: 10.1016/j.heliyon.2019.e01911. eCollection 2019 Jun.

3.

Gene expression profiles during subclinical Mycobacterium avium subspecies paratuberculosis infection in sheep can predict disease outcome.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Sci Rep. 2019 Jun 3;9(1):8245. doi: 10.1038/s41598-019-44670-w.

4.

Mycobacterium avium subspecies paratuberculosis is able to manipulate host lipid metabolism and accumulate cholesterol within macrophages.

Johansen MD, de Silva K, Plain KM, Whittington RJ, Purdie AC.

Microb Pathog. 2019 May;130:44-53. doi: 10.1016/j.micpath.2019.02.031. Epub 2019 Mar 1.

PMID:
30831227
5.

Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility.

Johansen MD, Hortle E, Kasparian JA, Romero A, Novoa B, Figueras A, Britton WJ, de Silva K, Purdie AC, Oehlers SH.

Fish Shellfish Immunol. 2018 Dec;83:238-242. doi: 10.1016/j.fsi.2018.09.037. Epub 2018 Sep 13.

PMID:
30219383
6.

Sheep and cattle exposed to Mycobacterium avium subspecies paratuberculosis exhibit altered total serum cholesterol profiles during the early stages of infection.

Johansen MD, de Silva K, Plain KM, Begg DJ, Whittington RJ, Purdie AC.

Vet Immunol Immunopathol. 2018 Aug;202:164-171. doi: 10.1016/j.vetimm.2018.07.009. Epub 2018 Jul 17.

PMID:
30078591
7.

Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models.

Johansen MD, Kasparian JA, Hortle E, Britton WJ, Purdie AC, Oehlers SH.

Dev Comp Immunol. 2018 Nov;88:169-172. doi: 10.1016/j.dci.2018.07.022. Epub 2018 Jul 21.

PMID:
30040967
8.

Immunopathological changes and apparent recovery from infection revealed in cattle in an experimental model of Johne's disease using a lyophilised culture of Mycobacterium avium subspecies paratuberculosis.

Begg DJ, Plain KM, de Silva K, Gurung R, Gunn A, Purdie AC, Whittington RJ.

Vet Microbiol. 2018 Jun;219:53-62. doi: 10.1016/j.vetmic.2018.03.029. Epub 2018 Mar 29.

PMID:
29778205
9.

Integrated vaccine screening system: using cellular functional capacity in vitro to assess genuine vaccine protectiveness in ruminants.

Pooley HB, Plain KM, Purdie AC, Begg DJ, Whittington RJ, de Silva K.

Pathog Dis. 2018 Apr 1;76(3). doi: 10.1093/femspd/fty029.

PMID:
29718267
10.

Case definition terminology for paratuberculosis (Johne's disease).

Whittington RJ, Begg DJ, de Silva K, Purdie AC, Dhand NK, Plain KM.

BMC Vet Res. 2017 Nov 9;13(1):328. doi: 10.1186/s12917-017-1254-6.

11.

Variation in susceptibility of different breeds of sheep to Mycobacterium avium subspecies paratuberculosis following experimental inoculation.

Begg DJ, Purdie AC, de Silva K, Dhand NK, Plain KM, Whittington RJ.

Vet Res. 2017 Jun 17;48(1):36. doi: 10.1186/s13567-017-0440-7.

12.

IFN-γ fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria.

Thirunavukkarasu S, Plain KM, Purdie AC, Whittington RJ, de Silva K.

PLoS One. 2017 May 15;12(5):e0176400. doi: 10.1371/journal.pone.0176400. eCollection 2017.

13.

A Rapid Method for Quantifying Viable Mycobacterium avium subsp. paratuberculosis in Cellular Infection Assays.

Pooley HB, de Silva K, Purdie AC, Begg DJ, Whittington RJ, Plain KM.

Appl Environ Microbiol. 2016 Aug 30;82(18):5553-62. doi: 10.1128/AEM.01668-16. Print 2016 Sep 15.

14.

Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle.

Swift BM, Huxley JN, Plain KM, Begg DJ, de Silva K, Purdie AC, Whittington RJ, Rees CE.

BMC Vet Res. 2016 Jun 16;12(1):115. doi: 10.1186/s12917-016-0728-2.

15.

Development of 316v antibody enzyme-linked immunosorbent assay for detection of paratuberculosis in sheep.

Gurung RB, Begg DJ, Purdie AC, Eamens GJ, Whittington RJ.

Rev Sci Tech. 2015 Dec;34(3):869-79.

PMID:
27044158
16.

Specific faecal antibody responses in sheep infected with Mycobacterium avium subspecies paratuberculosis.

Begg DJ, de Silva K, Plain KM, Purdie AC, Dhand N, Whittington RJ.

Vet Immunol Immunopathol. 2015 Aug 15;166(3-4):125-31. doi: 10.1016/j.vetimm.2015.06.011. Epub 2015 Jun 25.

PMID:
26144891
17.

Efficient, validated method for detection of mycobacterial growth in liquid culture media by use of bead beating, magnetic-particle-based nucleic acid isolation, and quantitative PCR.

Plain KM, Waldron AM, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

J Clin Microbiol. 2015 Apr;53(4):1121-8. doi: 10.1128/JCM.03521-14. Epub 2015 Jan 21.

18.

Cellular and humoral immune responses in sheep vaccinated with candidate antigens MAP2698c and MAP3567 from Mycobacterium avium subspecies paratuberculosis.

Gurung RB, Purdie AC, Whittington RJ, Begg DJ.

Front Cell Infect Microbiol. 2014 Jul 16;4:93. doi: 10.3389/fcimb.2014.00093. eCollection 2014.

19.

Expression of genes associated with cholesterol and lipid metabolism identified as a novel pathway in the early pathogenesis of Mycobacterium avium subspecies paratuberculosis-infection in cattle.

Thirunavukkarasu S, Plain KM, de Silva K, Begg D, Whittington RJ, Purdie AC.

Vet Immunol Immunopathol. 2014 Aug 15;160(3-4):147-57. doi: 10.1016/j.vetimm.2014.04.002. Epub 2014 Apr 18.

PMID:
24930699
20.

Immunoreactivity of protein tyrosine phosphatase A (PtpA) in sera from sheep infected with Mycobacterium avium subspecies paratuberculosis.

Gurung RB, Begg DJ, Purdie AC, Bach H, Whittington RJ.

Vet Immunol Immunopathol. 2014 Jul 15;160(1-2):129-32. doi: 10.1016/j.vetimm.2014.03.013. Epub 2014 Apr 3.

PMID:
24788024
21.

Lymphoproliferative and gamma interferon responses to stress-regulated Mycobacterium avium subsp. paratuberculosis recombinant proteins.

Gurung RB, Begg DJ, Purdie AC, de Silva K, Bannantine JP, Whittington RJ.

Clin Vaccine Immunol. 2014 Jun;21(6):831-7. doi: 10.1128/CVI.00775-13. Epub 2014 Apr 2.

22.

High-throughput direct fecal PCR assay for detection of Mycobacterium avium subsp. paratuberculosis in sheep and cattle.

Plain KM, Marsh IB, Waldron AM, Galea F, Whittington AM, Saunders VF, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

J Clin Microbiol. 2014 Mar;52(3):745-57. doi: 10.1128/JCM.03233-13. Epub 2013 Dec 18.

23.

Antigenicity of recombinant maltose binding protein-Mycobacterium avium subsp. paratuberculosis fusion proteins with and without factor Xa cleaving.

Gurung RB, Begg DJ, Purdie AC, Bannantine JP, Whittington RJ.

Clin Vaccine Immunol. 2013 Dec;20(12):1817-26. doi: 10.1128/CVI.00596-13. Epub 2013 Oct 16.

24.

Development and validation of a liquid medium (M7H9C) for routine culture of Mycobacterium avium subsp. paratuberculosis to replace modified Bactec 12B medium.

Whittington RJ, Whittington AM, Waldron A, Begg DJ, de Silva K, Purdie AC, Plain KM.

J Clin Microbiol. 2013 Dec;51(12):3993-4000. doi: 10.1128/JCM.01373-13. Epub 2013 Sep 18.

25.

Can early host responses to mycobacterial infection predict eventual disease outcomes?

de Silva K, Begg DJ, Plain KM, Purdie AC, Kawaji S, Dhand NK, Whittington RJ.

Prev Vet Med. 2013 Nov 1;112(3-4):203-12. doi: 10.1016/j.prevetmed.2013.08.006. Epub 2013 Aug 24.

PMID:
24034815
26.

Antigenicity in sheep of synthetic peptides derived from stress-regulated Mycobacterium avium subsp. paratuberculosis proteins and comparison with recombinant protein and complex native antigens.

Gurung RB, Begg DJ, Purdie AC, Whittington RJ.

Vet Immunol Immunopathol. 2014 Mar 15;158(1-2):46-52. doi: 10.1016/j.vetimm.2013.05.016. Epub 2013 Jun 8.

PMID:
23815825
27.

In silico screened Mycobacterium avium subsp. paratuberculosis (MAP) recombinant proteins upregulated under stress conditions are immunogenic in sheep.

Gurung RB, Purdie AC, Begg DJ, Whittington RJ.

Vet Immunol Immunopathol. 2012 Oct 15;149(3-4):186-96. doi: 10.1016/j.vetimm.2012.06.026. Epub 2012 Jul 7.

PMID:
22868202
28.

Enhancement of the interferon gamma assay to detect paratuberculosis using interleukin-7 and interleukin-12 potentiation.

Plain KM, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

Vet Immunol Immunopathol. 2012 Sep 15;149(1-2):28-37. doi: 10.1016/j.vetimm.2012.05.023. Epub 2012 Jun 9.

PMID:
22749292
29.

In silico identification of epitopes in Mycobacterium avium subsp. paratuberculosis proteins that were upregulated under stress conditions.

Gurung RB, Purdie AC, Begg DJ, Whittington RJ.

Clin Vaccine Immunol. 2012 Jun;19(6):855-64. doi: 10.1128/CVI.00114-12. Epub 2012 Apr 11.

30.

Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. paratuberculosis infection.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Comp Immunol Microbiol Infect Dis. 2012 Mar;35(2):151-62. doi: 10.1016/j.cimid.2011.12.007. Epub 2012 Jan 10.

PMID:
22239946
31.

Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.

Plain KM, de Silva K, Earl J, Begg DJ, Purdie AC, Whittington RJ.

Infect Immun. 2011 Sep;79(9):3821-32. doi: 10.1128/IAI.05204-11. Epub 2011 Jul 5.

32.

Comparative immunological and microbiological aspects of paratuberculosis as a model mycobacterial infection.

Whittington RJ, Begg DJ, de Silva K, Plain KM, Purdie AC.

Vet Immunol Immunopathol. 2012 Jul 15;148(1-2):29-47. doi: 10.1016/j.vetimm.2011.03.003. Epub 2011 Mar 29. Review.

PMID:
21450348
33.

Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: a review.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Comp Immunol Microbiol Infect Dis. 2011 May;34(3):197-208. doi: 10.1016/j.cimid.2010.12.003. Epub 2011 Jan 8. Review.

PMID:
21216466
34.

Toll-like receptor (TLR)6 and TLR1 differentiation in gene expression studies of Johne's disease.

Plain KM, Purdie AC, Begg DJ, de Silva K, Whittington RJ.

Vet Immunol Immunopathol. 2010 Sep 15;137(1-2):142-8. doi: 10.1016/j.vetimm.2010.04.002. Epub 2010 Apr 14.

PMID:
20434222

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