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Items: 12


Dupilumab does not affect correlates of vaccine-induced immunity: A randomized, placebo-controlled trial in adults with moderate-to-severe atopic dermatitis.

Blauvelt A, Simpson EL, Tyring SK, Purcell LA, Shumel B, Petro CD, Akinlade B, Gadkari A, Eckert L, Graham NMH, Pirozzi G, Evans R.

J Am Acad Dermatol. 2019 Jan;80(1):158-167.e1. doi: 10.1016/j.jaad.2018.07.048. Epub 2018 Aug 6.


Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters.

da Silva Antunes R, Babor M, Carpenter C, Khalil N, Cortese M, Mentzer AJ, Seumois G, Petro CD, Purcell LA, Vijayanand P, Crotty S, Pulendran B, Peters B, Sette A.

J Clin Invest. 2018 Aug 31;128(9):3853-3865. doi: 10.1172/JCI121309. Epub 2018 Aug 6.


Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC.

Sci Transl Med. 2016 Sep 28;8(358):358ra128. doi: 10.1126/scitranslmed.aaf6812.


Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

Valderramos SG, Valderramos JC, Musset L, Purcell LA, Mercereau-Puijalon O, Legrand E, Fidock DA.

PLoS Pathog. 2010 May 13;6(5):e1000887. doi: 10.1371/journal.ppat.1000887.


A putative kinase-related protein (PKRP) from Plasmodium berghei mediates infection in the midgut and salivary glands of the mosquito.

Purcell LA, Leitao R, Ono T, Yanow SK, Pradel G, Spithill TW, Rodriguez A.

Int J Parasitol. 2010 Jul;40(8):979-88. doi: 10.1016/j.ijpara.2010.02.010. Epub 2010 Mar 12.


The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.

Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR Jr, Sacchettini JC, Heussler V, Sinnis P, Fidock DA.

Cell Host Microbe. 2008 Dec 11;4(6):567-78. doi: 10.1016/j.chom.2008.11.001.


Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge.

Purcell LA, Wong KA, Yanow SK, Lee M, Spithill TW, Rodriguez A.

Vaccine. 2008 Sep 8;26(38):4880-4. doi: 10.1016/j.vaccine.2008.07.017. Epub 2008 Jul 29.


Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection.

Ono T, Cabrita-Santos L, Leitao R, Bettiol E, Purcell LA, Diaz-Pulido O, Andrews LB, Tadakuma T, Bhanot P, Mota MM, Rodriguez A.

PLoS Pathog. 2008 Feb 29;4(2):e1000008. doi: 10.1371/journal.ppat.1000008.


Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agent.

Yanow SK, Purcell LA, Pradel G, Sato A, Rodriguez A, Lee M, Spithill TW.

J Infect Dis. 2008 Feb 15;197(4):527-34. doi: 10.1086/526788.


Chemical attenuation of Plasmodium berghei sporozoites induces sterile immunity in mice.

Purcell LA, Yanow SK, Lee M, Spithill TW, Rodriguez A.

Infect Immun. 2008 Mar;76(3):1193-9. doi: 10.1128/IAI.01399-07. Epub 2008 Jan 3.


Genomics-based drug design targets the AT-rich malaria parasite: implications for antiparasite chemotherapy.

Yanow SK, Purcell LA, Lee M, Spithill TW.

Pharmacogenomics. 2007 Sep;8(9):1267-72.


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