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Items: 33


KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.

Naiyer MM, Cassidy SA, Magri A, Cowton V, Chen K, Mansour S, Kranidioti H, Mbiribindi B, Rettman P, Harris S, Fanning LJ, Mulder A, Claas FHJ, Davidson AD, Patel AH, Purbhoo MA, Khakoo SI.

Sci Immunol. 2017 Sep 15;2(15). pii: eaal5296. doi: 10.1126/sciimmunol.aal5296.


easySTORM: a robust, lower-cost approach to localisation and TIRF microscopy.

Kwakwa K, Savell A, Davies T, Munro I, Parrinello S, Purbhoo MA, Dunsby C, Neil MA, French PM.

J Biophotonics. 2016 Sep;9(9):948-57. doi: 10.1002/jbio.201500324. Epub 2016 Mar 11.


Manufacture of GMP-compliant functional adenovirus-specific T-cell therapy for treatment of post-transplant infectious complications.

Horlock C, Skulte A, Mitra A, Stansfield A, Bhandari S, Ip W, Qasim W, Lowdell MW, Patel S, Friedetzky A, Purbhoo MA, Newton K.

Cytotherapy. 2016 Sep;18(9):1209-18. doi: 10.1016/j.jcyt.2016.06.009. Epub 2016 Jul 14.


STAT4-associated natural killer cell tolerance following liver transplantation.

Jamil KM, Hydes TJ, Cheent KS, Cassidy SA, Traherne JA, Jayaraman J, Trowsdale J, Alexander GJ, Little AM, McFarlane H, Heneghan MA, Purbhoo MA, Khakoo SI.

Gut. 2017 Feb;66(2):352-361. doi: 10.1136/gutjnl-2015-309395. Epub 2016 Feb 17.


Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals.

Cassidy S, Mukherjee S, Myint TM, Mbiribindi B, North H, Traherne J, Mulder A, Claas FH, Purbhoo MA, Das J, Khakoo SI.

Eur J Immunol. 2015 Feb;45(2):492-500. doi: 10.1002/eji.201444613. Epub 2014 Nov 29.


HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.

Stanton RJ, Prod'homme V, Purbhoo MA, Moore M, Aicheler RJ, Heinzmann M, Bailer SM, Haas J, Antrobus R, Weekes MP, Lehner PJ, Vojtesek B, Miners KL, Man S, Wilkie GS, Davison AJ, Wang ECY, Tomasec P, Wilkinson GWG.

Cell Host Microbe. 2014 Aug 13;16(2):201-214. doi: 10.1016/j.chom.2014.07.005.


Respiratory syncytial virus infection, TLR3 ligands, and proinflammatory cytokines induce CD161 ligand LLT1 expression on the respiratory epithelium.

Satkunanathan S, Kumar N, Bajorek M, Purbhoo MA, Culley FJ.

J Virol. 2014 Mar;88(5):2366-73. doi: 10.1128/JVI.02789-13. Epub 2013 Dec 18.


Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.

Cheent KS, Jamil KM, Cassidy S, Liu M, Mbiribindi B, Mulder A, Claas FH, Purbhoo MA, Khakoo SI.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16981-6. doi: 10.1073/pnas.1304366110. Epub 2013 Sep 30.


A peptide antagonist disrupts NK cell inhibitory synapse formation.

Borhis G, Ahmed PS, Mbiribindi B, Naiyer MM, Davis DM, Purbhoo MA, Khakoo SI.

J Immunol. 2013 Mar 15;190(6):2924-30. doi: 10.4049/jimmunol.1201032. Epub 2013 Feb 4.


The function of sub-synaptic vesicles during T-cell activation.

Purbhoo MA.

Immunol Rev. 2013 Jan;251(1):36-48. doi: 10.1111/imr.12012. Review.


SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.

Liu H, Purbhoo MA, Davis DM, Rudd CE.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10166-71. doi: 10.1073/pnas.0909112107. Epub 2010 May 13.


Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse.

Purbhoo MA, Liu H, Oddos S, Owen DM, Neil MA, Pageon SV, French PM, Rudd CE, Davis DM.

Sci Signal. 2010 May 11;3(121):ra36. doi: 10.1126/scisignal.2000645.


Peptide antagonism as a mechanism for NK cell activation.

Fadda L, Borhis G, Ahmed P, Cheent K, Pageon SV, Cazaly A, Stathopoulos S, Middleton D, Mulder A, Claas FH, Elliott T, Davis DM, Purbhoo MA, Khakoo SI.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10160-5. doi: 10.1073/pnas.0913745107. Epub 2010 May 3.


Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.

Varela-Rohena A, Molloy PE, Dunn SM, Li Y, Suhoski MM, Carroll RG, Milicic A, Mahon T, Sutton DH, Laugel B, Moysey R, Cameron BJ, Vuidepot A, Purbhoo MA, Cole DK, Phillips RE, June CH, Jakobsen BK, Sewell AK, Riley JL.

Nat Med. 2008 Dec;14(12):1390-5. doi: 10.1038/nm.1779. Epub 2008 Nov 9.


Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update.

Seggewiss R, Price DA, Purbhoo MA.

Cytotherapy. 2008;10(6):633-41. doi: 10.1080/14653240802317639. Review.


High-speed high-resolution imaging of intercellular immune synapses using optical tweezers.

Oddos S, Dunsby C, Purbhoo MA, Chauveau A, Owen DM, Neil MA, Davis DM, French PM.

Biophys J. 2008 Nov 15;95(10):L66-8. doi: 10.1529/biophysj.108.143198. Epub 2008 Aug 22.


Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission.

Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau Q, Davis DM.

Nat Cell Biol. 2008 Feb;10(2):211-9. doi: 10.1038/ncb1682. Epub 2008 Jan 13.


The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor.

Purbhoo MA, Li Y, Sutton DH, Brewer JE, Gostick E, Bossi G, Laugel B, Moysey R, Baston E, Liddy N, Cameron B, Bennett AD, Ashfield R, Milicic A, Price DA, Classon BJ, Sewell AK, Jakobsen BK.

Mol Cancer Ther. 2007 Jul;6(7):2081-91.


Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.

Onfelt B, Nedvetzki S, Benninger RK, Purbhoo MA, Sowinski S, Hume AN, Seabra MC, Neil MA, French PM, Davis DM.

J Immunol. 2006 Dec 15;177(12):8476-83.


Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses.

Treanor B, Lanigan PM, Kumar S, Dunsby C, Munro I, Auksorius E, Culley FJ, Purbhoo MA, Phillips D, Neil MA, Burshtyn DN, French PM, Davis DM.

J Cell Biol. 2006 Jul 3;174(1):153-61. Epub 2006 Jun 26.


Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors.

Purbhoo MA, Sutton DH, Brewer JE, Mullings RE, Hill ME, Mahon TM, Karbach J, Jäger E, Cameron BJ, Lissin N, Vyas P, Chen JL, Cerundolo V, Jakobsen BK.

J Immunol. 2006 Jun 15;176(12):7308-16.


Long-distance calls between cells connected by tunneling nanotubules.

Onfelt B, Purbhoo MA, Nedvetzki S, Sowinski S, Davis DM.

Sci STKE. 2005 Dec 6;2005(313):pe55. Review.


T cell killing does not require the formation of a stable mature immunological synapse.

Purbhoo MA, Irvine DJ, Huppa JB, Davis MM.

Nat Immunol. 2004 May;5(5):524-30. Epub 2004 Mar 28. Erratum in: Nat Immunol. 2004 Jun;5(6):658.


Linking molecular and cellular events in T-cell activation and synapse formation.

Krogsgaard M, Huppa JB, Purbhoo MA, Davis MM.

Semin Immunol. 2003 Dec;15(6):307-15. Review.


Dynamics of cell surface molecules during T cell recognition.

Davis MM, Krogsgaard M, Huppa JB, Sumen C, Purbhoo MA, Irvine DJ, Wu LC, Ehrlich L.

Annu Rev Biochem. 2003;72:717-42. Review.


Direct observation of ligand recognition by T cells.

Irvine DJ, Purbhoo MA, Krogsgaard M, Davis MM.

Nature. 2002 Oct 24;419(6909):845-9.


Sensory adaptation in naive peripheral CD4 T cells.

Smith K, Seddon B, Purbhoo MA, Zamoyska R, Fisher AG, Merkenschlager M.

J Exp Med. 2001 Nov 5;194(9):1253-61.


The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

Purbhoo MA, Boulter JM, Price DA, Vuidepot AL, Hourigan CS, Dunbar PR, Olson K, Dawson SJ, Phillips RE, Jakobsen BK, Bell JI, Sewell AK.

J Biol Chem. 2001 Aug 31;276(35):32786-92. Epub 2001 Jul 3.


A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex.

Xu XN, Purbhoo MA, Chen N, Mongkolsapaya J, Cox JH, Meier UC, Tafuro S, Dunbar PR, Sewell AK, Hourigan CS, Appay V, Cerundolo V, Burrows SR, McMichael AJ, Screaton GR.

Immunity. 2001 May;14(5):591-602.


Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent.

Whelan JA, Dunbar PR, Price DA, Purbhoo MA, Lechner F, Ogg GS, Griffiths G, Phillips RE, Cerundolo V, Sewell AK.

J Immunol. 1999 Oct 15;163(8):4342-8.


Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.

Sewell AK, Gerth UC, Price DA, Purbhoo MA, Boulter JM, Gao GF, Bell JI, Phillips RE, Jakobsen BK.

Nat Med. 1999 Apr;5(4):399-404.


The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection.

Price DA, Meier UC, Klenerman P, Purbhoo MA, Phillips RE, Sewell AK.

J Mol Med (Berl). 1998 Sep;76(10):699-708. Review.


Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.

Purbhoo MA, Sewell AK, Klenerman P, Goulder PJ, Hilyard KL, Bell JI, Jakobsen BK, Phillips RE.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4527-32.

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