Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 43

1.

Revisiting the Pharmacodynamic Uroselectivity of α 1-Adrenergic Receptor Antagonists.

Quaresma BMCS, Pimenta AR, Santos da Silva AC, Pupo AS, Romeiro LAS, Silva CLM, Noël F.

J Pharmacol Exp Ther. 2019 Oct;371(1):106-112. doi: 10.1124/jpet.119.260216. Epub 2019 Jul 8.

PMID:
31285236
2.

Mirabegron elicits rat corpus cavernosum relaxation and increases in vivo erectile response.

de Oliveira MG, Rojas-Moscoso JA, Bertollotto GM, Candido TZ, Kiguti LRA, Pupo AS, Antunes E, De Nucci G, Mónica FZ.

Eur J Pharmacol. 2019 Sep 5;858:172447. doi: 10.1016/j.ejphar.2019.172447. Epub 2019 Jun 19.

PMID:
31228454
3.

Contractile Effects of Serotonin (5-HT) in the Rat Cauda Epididymis: Expression and Functional Characterization of 5-HT Receptors.

Mueller A, Kiguti LRA, Silva EJR, Pupo AS.

J Pharmacol Exp Ther. 2019 Apr;369(1):98-106. doi: 10.1124/jpet.118.254110. Epub 2019 Feb 6.

PMID:
30728250
4.

Contraction of Rat Cauda Epididymis Smooth Muscle to α1-Adrenoceptor Activation Is Mediated by α1A-Adrenoceptors.

Pacini ESA, Castilho ACS, Hebeler-Barbosa F, Pupo AS, Kiguti LRA.

J Pharmacol Exp Ther. 2018 Jul;366(1):21-28. doi: 10.1124/jpet.117.246710. Epub 2018 Apr 23.

PMID:
29685886
5.

The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction.

Nunes-Neto PA, Peixoto-Sobrinho TJDS, da Silva Júnior ED, Leopoldina da Silva J, Rodrigo da Silva Oliveira A, Pupo AS, Araújo AV, da Costa-Silva JH, Wanderley AG.

Evid Based Complement Alternat Med. 2017;2017:1416375. doi: 10.1155/2017/1416375. Epub 2017 Aug 27.

6.

Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of α1A-adrenergic receptors.

Alcántara-Hernández R, Hernández-Méndez A, Romero-Ávila MT, Alfonzo-Méndez MA, Pupo AS, García-Sáinz JA.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2378-2388. doi: 10.1016/j.bbamcr.2017.09.002. Epub 2017 Sep 6.

7.

Gender-specific impairment of in vitro sinoatrial node chronotropic responses and of myocardial ischemia tolerance in rats exposed prenatally to betamethasone.

Kiguti LRA, Borges CS, Mueller A, Silva KP, Polo CM, Rosa JL, Silva PV, Missassi G, Valencise L, Kempinas WG, Pupo AS.

Toxicol Appl Pharmacol. 2017 Nov 1;334:66-74. doi: 10.1016/j.taap.2017.09.002. Epub 2017 Sep 5.

8.

Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase.

Dal-Secco D, DalBó S, Lautherbach NES, Gava FN, Celes MRN, Benedet PO, Souza AH, Akinaga J, Lima V, Silva KP, Kiguti LRA, Rossi MA, Kettelhut IC, Pupo AS, Cunha FQ, Assreuy J.

Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H149-H163. doi: 10.1152/ajpheart.00052.2016. Epub 2017 May 19.

9.

Betamethasone causes intergenerational reproductive impairment in male rats.

Borges CDS, Pacheco TL, da Silva KP, Fernandes FH, Gregory M, Pupo AS, Salvadori DMF, Cyr DG, Kempinas WG.

Reprod Toxicol. 2017 Aug;71:108-117. doi: 10.1016/j.reprotox.2017.04.012. Epub 2017 May 10.

PMID:
28501545
10.

Reproductive disorders in female rats after prenatal exposure to betamethasone.

Borges CS, Pacheco TL, Guerra MT, Barros AL, Silva PV, Missassi G, da Silva KP, Anselmo-Franci JA, Pupo AS, Kempinas WG.

J Appl Toxicol. 2017 Sep;37(9):1065-1072. doi: 10.1002/jat.3457. Epub 2017 Mar 21.

PMID:
28326570
11.

A Latin American Perspective on G Protein-Coupled Receptors.

Pupo AS, García-Sáinz JA.

Mol Pharmacol. 2016 Nov;90(5):570-572.

PMID:
27754900
12.

Long-term adverse effects on reproductive function in male rats exposed prenatally to the glucocorticoid betamethasone.

Borges CD, Dias AF, Silva PV, Rosa JL, Guerra MT, Silva RF, Kiguti LR, Pupo AS, Kempinas WG.

Toxicology. 2017 Feb 1;376:15-22. doi: 10.1016/j.tox.2016.04.005. Epub 2016 Apr 27.

PMID:
27132128
13.

Implication of Rho-kinase and soluble guanylyl cyclase enzymes in prostate smooth muscle dysfunction in middle-aged rats.

Calmasini FB, Silva FH, Alexandre EC, Rodrigues RL, Barbosa AP, Ferrucci DL, Carvalho HF, Anhê GF, Pupo AS, Antunes E.

Neurourol Urodyn. 2017 Mar;36(3):589-596. doi: 10.1002/nau.22990. Epub 2016 Mar 21.

PMID:
26999618
14.

The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System.

da Silva RF, Borges Cdos S, Villela E Silva P, Missassi G, Kiguti LR, Pupo AS, Barbosa Junior F, Anselmo-Franci JA, Kempinas Wde G.

Oxid Med Cell Longev. 2016;2016:4257498. doi: 10.1155/2016/4257498. Epub 2015 Dec 29.

15.

Recent updates on GPCR biased agonism.

Pupo AS, Duarte DA, Lima V, Teixeira LB, Parreiras-E-Silva LT, Costa-Neto CM.

Pharmacol Res. 2016 Oct;112:49-57. doi: 10.1016/j.phrs.2016.01.031. Epub 2016 Feb 2. Review.

PMID:
26836887
16.

Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities.

Beserra FP, Santos Rde C, Périco LL, Rodrigues VP, Kiguti LR, Saldanha LL, Pupo AS, da Rocha LR, Dokkedal AL, Vilegas W, Hiruma-Lima CA.

Int J Mol Sci. 2016 Jan 23;17(2). pii: E149. doi: 10.3390/ijms17020149.

17.

Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1 -adrenoceptor blockade.

Alexandre EC, Kiguti LR, Calmasini FB, Silva FH, da Silva KP, Ferreira R, Ribeiro CA, Mónica FZ, Pupo AS, Antunes E.

Br J Pharmacol. 2016 Feb;173(3):415-28. doi: 10.1111/bph.13367. Epub 2016 Jan 15.

18.

Bupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male rats.

Cavariani MM, de Almeida Kiguti LR, de Lima Rosa J, de Araújo Leite GA, Silva PV, Pupo AS, De Grava Kempinas W.

J Appl Toxicol. 2015 Sep;35(9):1007-16. doi: 10.1002/jat.3089. Epub 2015 Feb 2.

PMID:
25645087
19.

Involvement of α1B-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test.

Ribeiro CA, Pupo AS.

Eur J Pharmacol. 2015 Mar 5;750:39-42. doi: 10.1016/j.ejphar.2015.01.010. Epub 2015 Jan 21.

20.

Antidiarrheal and intestinal antiinflammatory activities of a methanolic extract of Qualea parviflora Mart. in experimental models.

Mazzolin LP, Kiguti LR, da Maia EO, Fernandes LT, da Rocha LR, Vilegas W, Pupo AS, Di Stasi LC, Hiruma-Lima CA.

J Ethnopharmacol. 2013 Dec 12;150(3):1016-23. doi: 10.1016/j.jep.2013.10.006. Epub 2013 Oct 21.

PMID:
24157378
21.

Cross-talk with β2 -adrenoceptors enhances ligand affinity properties from endothelial alpha1 D -adrenoceptors that mediates carotid relaxation.

Pernomian L, Gomes MS, Restini CB, Pupo AS, de Oliveira AM.

J Pharm Pharmacol. 2013 Sep;65(9):1337-46. doi: 10.1111/jphp.12105. Epub 2013 Jul 30.

PMID:
23927472
22.

Slimmer or fertile? Pharmacological mechanisms involved in reduced sperm quality and fertility in rats exposed to the anorexigen sibutramine.

Borges CS, Missassi G, Pacini ES, Kiguti LR, Sanabria M, Silva RF, Banzato TP, Perobelli JE, Pupo AS, Kempinas WG.

PLoS One. 2013 Jun 12;8(6):e66091. doi: 10.1371/journal.pone.0066091. Print 2013.

23.

Differential phosphorylation, desensitization, and internalization of α1A-adrenoceptors activated by norepinephrine and oxymetazoline.

Akinaga J, Lima V, Kiguti LR, Hebeler-Barbosa F, Alcántara-Hernández R, García-Sáinz JA, Pupo AS.

Mol Pharmacol. 2013 Apr;83(4):870-81. doi: 10.1124/mol.112.082313. Epub 2013 Jan 30.

PMID:
23364786
24.

Investigation of the effects of α1-adrenoceptor antagonism and L-type calcium channel blockade on ejaculation and vas deferens and seminal vesicle contractility in vitro.

de Almeida Kiguti LR, Pupo AS.

J Sex Med. 2012 Jan;9(1):159-68. doi: 10.1111/j.1743-6109.2011.02410.x. Epub 2011 Aug 2.

PMID:
21810189
25.

Acceleration of sperm transit time and reduction of sperm reserves in the epididymis of rats exposed to sibutramine.

Bellentani FF, Fernandes GS, Perobelli JE, Pacini ES, Kiguti LR, Pupo AS, Kempinas WD.

J Androl. 2011 Nov-Dec;32(6):718-24. doi: 10.2164/jandrol.111.013466. Epub 2011 Jul 15.

PMID:
21764897
26.

The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors.

Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS.

Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. doi: 10.1016/j.neuropharm.2010.03.015. Epub 2010 Apr 2.

PMID:
20363235
27.

Multiple effects of sibutramine on ejaculation and on vas deferens and seminal vesicle contractility.

Nojimoto FD, Piffer RC, Kiguti LR, Lameu C, de Camargo AC, Pereira OC, Pupo AS.

Toxicol Appl Pharmacol. 2009 Sep 15;239(3):233-40. doi: 10.1016/j.taap.2009.05.021. Epub 2009 May 29.

PMID:
19482040
28.

alpha1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised rats.

Kamikihara SY, Mueller A, Lima V, Akinaga J, Nojimoto FD, Castilho A, Buratini J Jr, Pupo AS.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Oct;376(1-2):117-26. Epub 2007 Aug 4.

PMID:
17676312
29.

Differential distribution of functional alph}1-adrenergic receptor subtypes along the rat tail artery.

Kamikihara SY, Mueller A, Lima V, Silva AR, da Costa IB, Buratini J Jr, Pupo AS.

J Pharmacol Exp Ther. 2005 Aug;314(2):753-61. Epub 2005 May 4.

PMID:
15872040
30.

Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta.

Lima V, Mueller A, Kamikihara SY, Raymundi V, Alewood D, Lewis RJ, Chen Z, Minneman KP, Pupo AS.

Eur J Pharmacol. 2005 Jan 31;508(1-3):183-92. Epub 2005 Jan 12.

PMID:
15680270
31.

Adrenergic pharmacology: focus on the central nervous system.

Pupo AS, Minneman KP.

CNS Spectr. 2001 Aug;6(8):656-62.

PMID:
15520613
32.

The N terminus of the human alpha1D-adrenergic receptor prevents cell surface expression.

Hague C, Chen Z, Pupo AS, Schulte NA, Toews ML, Minneman KP.

J Pharmacol Exp Ther. 2004 Apr;309(1):388-97. Epub 2004 Jan 12.

PMID:
14718583
33.

Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.

Pupo AS, Minneman KP.

J Recept Signal Transduct Res. 2003;23(2-3):185-95.

PMID:
14626446
34.

Effect of cyproterone acetate on alpha1-adrenoceptor subtypes in rat vas deferens.

Campos M, Morais PL, Pupo AS.

Braz J Med Biol Res. 2003 Nov;36(11):1571-81. Epub 2003 Oct 22.

35.

Effects of castration on alpha 1-adrenoceptor subtypes in the rat aorta.

Morais Pde L, Campos M, Pupo AS.

Vascul Pharmacol. 2002 Dec;39(6):335-41.

PMID:
14567072
36.

Functional characterisation of alpha(1)-adrenoceptors in denervated rat vas deferens.

Campos M, de Lucena Morais P, Pupo AS.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):72-8. Epub 2003 Jul 5.

PMID:
12845422
37.

Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens.

Campos M, Morais Pde L, Pupo AS.

Eur J Pharmacol. 2003 Jun 20;471(2):149-55.

PMID:
12818703
38.

N-terminal truncation of human alpha1D-adrenoceptors increases expression of binding sites but not protein.

Pupo AS, Uberti MA, Minneman KP.

Eur J Pharmacol. 2003 Feb 21;462(1-3):1-8.

PMID:
12591089
40.

Effects of indoramin in rat vas deferens and aorta: concomitant alpha1-adrenoceptor and neuronal uptake blockade.

Pupo AS, Cavenaghi DL, Campos M, Lucena Morais P, Jurkiewicz NH, Jurkiewicz A.

Br J Pharmacol. 1999 Aug;127(8):1832-6.

41.

Functional effects of castration on alpha1-adrenoceptors in rat vas deferens.

Pupo AS.

Eur J Pharmacol. 1998 Jun 19;351(2):217-23.

PMID:
9687006
42.

Functional change of the balance between alpha 1A and alpha 1B adrenoceptor populations after transplantation of the vas deferens to the intestine.

Pupo AS, Jurkiewicz NH, Jurkiewicz A.

Ann N Y Acad Sci. 1997 May 30;812:193-5. No abstract available.

PMID:
9186740
43.

Role of the epithelium in the release of contractile agents from the rat vas deferens by clonidine.

Caricati-Neto A, Pupo AS, Wanderley AG, Nuñez-Vergara M, Koh IH, Jurkiewicz NH, Jurkiewicz A.

Ann N Y Acad Sci. 1995 Jul 12;763:436-9. No abstract available.

PMID:
7677357

Supplemental Content

Support Center