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Items: 40


Activation of Ras in the Vascular Endothelium Induces Brain Vascular Malformations and Hemorrhagic Stroke.

Li QF, Decker-Rockefeller B, Bajaj A, Pumiglia K.

Cell Rep. 2018 Sep 11;24(11):2869-2882. doi: 10.1016/j.celrep.2018.08.025.


mTORc1 activity is necessary and sufficient for phosphorylation of eNOSS1177.

Decker B, Pumiglia K.

Physiol Rep. 2018 Jun;6(12):e13733. doi: 10.14814/phy2.13733.


BranchAnalysis2D/3D automates morphometry analyses of branching structures.

Srinivasan A, Muñoz-Estrada J, Bourgeois JR, Nalwalk JW, Pumiglia KM, Sheen VL, Ferland RJ.

J Neurosci Methods. 2018 Jan 15;294:1-6. doi: 10.1016/j.jneumeth.2017.10.017. Epub 2017 Oct 20.


Suppression of integrin α3β1 by α9β1 in the epidermis controls the paracrine resolution of wound angiogenesis.

Longmate WM, Lyons SP, Chittur SV, Pumiglia KM, Van De Water L, DiPersio CM.

J Cell Biol. 2017 May 1;216(5):1473-1488. doi: 10.1083/jcb.201510042. Epub 2017 Apr 17.


Integrins promote cytokinesis through the RSK signaling axis.

Mathew SS, Nieves B, Sequeira S, Sambandamoorthy S, Pumiglia K, Larsen M, Laflamme SE.

J Cell Sci. 2014 Feb 1;127(Pt 3):534-45. doi: 10.1242/jcs.133280. Epub 2013 Nov 27.


Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells.

Bryant PW, Zheng Q, Pumiglia KM.

Biol Open. 2012 Aug 15;1(8):723-30. doi: 10.1242/bio.20121008. Epub 2012 Jun 12.


Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis.

Bajaj A, Li QF, Zheng Q, Pumiglia K.

PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7.


Pro-inflammatory angiogenesis is mediated by p38 MAP kinase.

Rajashekhar G, Kamocka M, Marin A, Suckow MA, Wolter WR, Badve S, Sanjeevaiah AR, Pumiglia K, Rosen E, Clauss M.

J Cell Physiol. 2011 Mar;226(3):800-8. doi: 10.1002/jcp.22404.


Activation of endothelial ras signaling bypasses senescence and causes abnormal vascular morphogenesis.

Bajaj A, Zheng Q, Adam A, Vincent P, Pumiglia K.

Cancer Res. 2010 May 1;70(9):3803-12. doi: 10.1158/0008-5472.CAN-09-2648. Epub 2010 Apr 13.


Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers.

Adam AP, Sharenko AL, Pumiglia K, Vincent PA.

J Biol Chem. 2010 Mar 5;285(10):7045-55. doi: 10.1074/jbc.M109.079277. Epub 2010 Jan 4.


Endostatin and anastellin inhibit distinct aspects of the angiogenic process.

Neskey DM, Ambesi A, Pumiglia KM, McKeown-Longo PJ.

J Exp Clin Cancer Res. 2008 Nov 4;27:61. doi: 10.1186/1756-9966-27-61.


An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion.

Lamar JM, Pumiglia KM, DiPersio CM.

Cancer Res. 2008 Sep 15;68(18):7371-9. doi: 10.1158/0008-5472.CAN-08-1080.


Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC.

Ciccarelli M, Cipolletta E, Santulli G, Campanile A, Pumiglia K, Cervero P, Pastore L, Astone D, Trimarco B, Iaccarino G.

Cell Signal. 2007 Sep;19(9):1949-55. Epub 2007 May 29.


Integrin alpha3beta1-dependent activation of FAK/Src regulates Rac1-mediated keratinocyte polarization on laminin-5.

Choma DP, Milano V, Pumiglia KM, DiPersio CM.

J Invest Dermatol. 2007 Jan;127(1):31-40. Epub 2006 Aug 17.


PEDF: bridging neurovascular interactions in the stem cell niche.

Pumiglia K, Temple S.

Nat Neurosci. 2006 Mar;9(3):299-300. No abstract available.


CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation.

Cabioglu N, Summy J, Miller C, Parikh NU, Sahin AA, Tuzlali S, Pumiglia K, Gallick GE, Price JE.

Cancer Res. 2005 Aug 1;65(15):6493-7.


Activation of p38 has opposing effects on the proliferation and migration of endothelial cells.

McMullen ME, Bryant PW, Glembotski CC, Vincent PA, Pumiglia KM.

J Biol Chem. 2005 Jun 3;280(22):20995-1003. Epub 2005 Mar 24.


Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling.

Bhatt KV, Spofford LS, Aram G, McMullen M, Pumiglia K, Aplin AE.

Oncogene. 2005 May 12;24(21):3459-71.


Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway.

Manohar A, Shome SG, Lamar J, Stirling L, Iyer V, Pumiglia K, DiPersio CM.

J Cell Sci. 2004 Aug 15;117(Pt 18):4043-54. Epub 2004 Jul 27.


Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1.

Choma DP, Pumiglia K, DiPersio CM.

J Cell Sci. 2004 Aug 1;117(Pt 17):3947-59. Epub 2004 Jul 20.


Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells.

Shen Q, Goderie SK, Jin L, Karanth N, Sun Y, Abramova N, Vincent P, Pumiglia K, Temple S.

Science. 2004 May 28;304(5675):1338-40. Epub 2004 Apr 1.


PKC-delta and CaMKII-delta 2 mediate ATP-dependent activation of ERK1/2 in vascular smooth muscle.

Ginnan R, Pfleiderer PJ, Pumiglia K, Singer HA.

Am J Physiol Cell Physiol. 2004 Jun;286(6):C1281-9. Epub 2004 Jan 28.


Activated Ras induces a proangiogenic phenotype in primary endothelial cells.

Meadows KN, Bryant P, Vincent PA, Pumiglia KM.

Oncogene. 2004 Jan 8;23(1):192-200.


Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2.

McMullen M, Keller R, Sussman M, Pumiglia K.

Oncogene. 2004 Feb 12;23(6):1275-82.


Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis.

Nelson KK, Ranganathan AC, Mansouri J, Rodriguez AM, Providence KM, Rutter JL, Pumiglia K, Bennett JA, Melendez JA.

Clin Cancer Res. 2003 Jan;9(1):424-32.


Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin.

Venkiteswaran K, Xiao K, Summers S, Calkins CC, Vincent PA, Pumiglia K, Kowalczyk AP.

Am J Physiol Cell Physiol. 2002 Sep;283(3):C811-21.


Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation.

Meadows KN, Bryant P, Pumiglia K.

J Biol Chem. 2001 Dec 28;276(52):49289-98. Epub 2001 Oct 26.


Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway.

Pumiglia KM, Decker SJ.

Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):448-52.


A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase.

Pumiglia KM, LeVine H, Haske T, Habib T, Jove R, Decker SJ.

J Biol Chem. 1995 Jun 16;270(24):14251-4.


Functional mapping of the N-terminal regulatory domain in the human Raf-1 protein kinase.

Chow YH, Pumiglia K, Jun TH, Dent P, Sturgill TW, Jove R.

J Biol Chem. 1995 Jun 9;270(23):14100-6.


Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction.

Pumiglia K, Chow YH, Fabian J, Morrison D, Decker S, Jove R.

Mol Cell Biol. 1995 Jan;15(1):398-406.


Tyrosine phosphorylation in platelets: its regulation and possible roles in platelet functions.

Feinstein MB, Pumiglia K, Lau LF.

Adv Exp Med Biol. 1993;344:129-48. Review. No abstract available.


Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide).

Pumiglia KM, Lau LF, Huang CK, Burroughs S, Feinstein MB.

Biochem J. 1992 Sep 1;286 ( Pt 2):441-9.


Elevation of cAMP, but not cGMP, inhibits thrombin-stimulated tyrosine phosphorylation in human platelets.

Pumiglia KM, Huang CK, Feinstein MB.

Biochem Biophys Res Commun. 1990 Sep 14;171(2):738-45.


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