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Items: 1 to 50 of 68

1.

Mechanisms Contributing to Persistently Activated Cell Phenotypes in Pulmonary Hypertension.

Hu CJ, Zhang H, Laux A, Pullamsetti SS, Stenmark KR.

J Physiol. 2018 Jun 19. doi: 10.1113/JP275857. [Epub ahead of print]

PMID:
29920674
2.

How Many Foxs Are There on the Road to Pulmonary Hypertension?

Stenmark KR, Hu CJ, Pullamsetti SS.

Am J Respir Crit Care Med. 2018 Apr 25. doi: 10.1164/rccm.201804-0702ED. [Epub ahead of print] No abstract available.

PMID:
29694238
3.

Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension.

Pullamsetti SS, Seeger W, Savai R.

J Clin Invest. 2018 May 1;128(5):1720-1723. doi: 10.1172/JCI120415. Epub 2018 Apr 9.

4.

Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell function.

Josipovic I, Pflüger B, Fork C, Vasconez AE, Oo JA, Hitzel J, Seredinski S, Gamen E, Heringdorf DMZ, Chen W, Looso M, Pullamsetti SS, Brandes RP, Leisegang MS.

J Mol Cell Cardiol. 2018 Mar;116:57-68. doi: 10.1016/j.yjmcc.2018.01.015. Epub 2018 Feb 3.

PMID:
29408197
5.

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.

Al-Tamari HM, Dabral S, Schmall A, Sarvari P, Ruppert C, Paik J, DePinho RA, Grimminger F, Eickelberg O, Guenther A, Seeger W, Savai R, Pullamsetti SS.

EMBO Mol Med. 2018 Feb;10(2):276-293. doi: 10.15252/emmm.201606261.

6.

Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk.

Pullamsetti SS, Kojonazarov B, Storn S, Gall H, Salazar Y, Wolf J, Weigert A, El-Nikhely N, Ghofrani HA, Krombach GA, Fink L, Gattenlöhner S, Rapp UR, Schermuly RT, Grimminger F, Seeger W, Savai R.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaai9048. doi: 10.1126/scitranslmed.aai9048.

PMID:
29141888
7.

Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension.

Hautefort A, Chesné J, Preussner J, Pullamsetti SS, Tost J, Looso M, Antigny F, Girerd B, Riou M, Eddahibi S, Deleuze JF, Seeger W, Fadel E, Simonneau G, Montani D, Humbert M, Perros F.

Oncotarget. 2017 May 19;8(32):52995-53016. doi: 10.18632/oncotarget.18031. eCollection 2017 Aug 8.

8.

Vascular Stiffness and Mechanotransduction: Back in the Limelight.

Dabral S, Pullamsetti SS.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):527-530. doi: 10.1164/rccm.201611-2254LE. No abstract available.

PMID:
28809511
9.

Restoration of Megalin-Mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury.

Vohwinkel CU, Buchäckert Y, Al-Tamari HM, Mazzocchi LC, Eltzschig HK, Mayer K, Morty RE, Herold S, Seeger W, Pullamsetti SS, Vadász I.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):589-602. doi: 10.1165/rcmb.2016-0358OC.

PMID:
28678521
10.

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer.

Kiehl S, Zimmermann T, Savai R, Pullamsetti SS, Seeger W, Bartkuhn M, Dammann RH.

Sci Rep. 2017 Jun 20;7(1):3896. doi: 10.1038/s41598-017-04248-w.

11.

Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes.

Bischoff FC, Werner A, John D, Boeckel JN, Melissari MT, Grote P, Glaser SF, Demolli S, Uchida S, Michalik KM, Meder B, Katus HA, Haas J, Chen W, Pullamsetti SS, Seeger W, Zeiher AM, Dimmeler S, Zehendner CM.

Circ Res. 2017 Aug 4;121(4):368-375. doi: 10.1161/CIRCRESAHA.116.310531. Epub 2017 Jun 13.

PMID:
28611075
12.

Macrophage Regulation during Vascular Remodeling: Implications for Pulmonary Hypertension Therapy.

Pullamsetti SS, Savai R.

Am J Respir Cell Mol Biol. 2017 May;56(5):556-558. doi: 10.1165/rcmb.2017-0033ED. No abstract available.

PMID:
28459385
13.

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP.

Circulation. 2017 Jul 4;136(1):65-79. doi: 10.1161/CIRCULATIONAHA.116.026991. Epub 2017 Mar 28.

15.

[Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016].

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S4-S9. Epub 2016 Oct 19. German.

PMID:
27760444
16.

Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs.

Pullamsetti SS, Savai R, Seeger W, Goncharova EA.

Am J Respir Crit Care Med. 2017 Feb 15;195(4):425-437. doi: 10.1164/rccm.201606-1226PP. Review. No abstract available.

17.

The emerging role of epigenetics in pulmonary hypertension.

Gamen E, Seeger W, Pullamsetti SS.

Eur Respir J. 2016 Sep;48(3):903-17. doi: 10.1183/13993003.01714-2015. Epub 2016 Aug 4. Review.

18.

Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives.

Chelladurai P, Seeger W, Pullamsetti SS.

Eur Respir Rev. 2016 Jun;25(140):135-40. doi: 10.1183/16000617.0036-2016. Review.

19.

PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells.

Josipovic I, Fork C, Preussner J, Prior KK, Iloska D, Vasconez AE, Labocha S, Angioni C, Thomas D, Ferreirós N, Looso M, Pullamsetti SS, Geisslinger G, Steinhilber D, Brandes RP, Leisegang MS.

Acta Physiol (Oxf). 2016 Sep;218(1):13-27. doi: 10.1111/apha.12700. Epub 2016 May 20.

PMID:
27124368
20.

miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach.

Shi L, Kojonazarov B, Elgheznawy A, Popp R, Dahal BK, Böhm M, Pullamsetti SS, Ghofrani HA, Gödecke A, Jungmann A, Katus HA, Müller OJ, Schermuly RT, Fisslthaler B, Seeger W, Fleming I.

Cardiovasc Res. 2016 Aug 1;111(3):184-93. doi: 10.1093/cvr/cvw065. Epub 2016 Mar 24.

PMID:
27013635
21.

Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.

Plecitá-Hlavatá L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'Alessandro A, El Kasmi KC, Ježek P, Stenmark KR.

Am J Respir Cell Mol Biol. 2016 Jul;55(1):47-57. doi: 10.1165/rcmb.2015-0142OC.

22.

Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma.

Banat GA, Tretyn A, Pullamsetti SS, Wilhelm J, Weigert A, Olesch C, Ebel K, Stiewe T, Grimminger F, Seeger W, Fink L, Savai R.

PLoS One. 2015 Sep 28;10(9):e0139073. doi: 10.1371/journal.pone.0139073. eCollection 2015.

23.

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis.

Korfei M, Skwarna S, Henneke I, MacKenzie B, Klymenko O, Saito S, Ruppert C, von der Beck D, Mahavadi P, Klepetko W, Bellusci S, Crestani B, Pullamsetti SS, Fink L, Seeger W, Krämer OH, Guenther A.

Thorax. 2015 Nov;70(11):1022-32. doi: 10.1136/thoraxjnl-2014-206411. Epub 2015 Sep 10.

PMID:
26359372
24.

5-HT2B receptor antagonists inhibit fibrosis and protect from RV heart failure.

Janssen W, Schymura Y, Novoyatleva T, Kojonazarov B, Boehm M, Wietelmann A, Luitel H, Murmann K, Krompiec DR, Tretyn A, Pullamsetti SS, Weissmann N, Seeger W, Ghofrani HA, Schermuly RT.

Biomed Res Int. 2015;2015:438403. doi: 10.1155/2015/438403. Epub 2015 Feb 1.

25.

Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer.

Schmall A, Al-Tamari HM, Herold S, Kampschulte M, Weigert A, Wietelmann A, Vipotnik N, Grimminger F, Seeger W, Pullamsetti SS, Savai R.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):437-47. doi: 10.1164/rccm.201406-1137OC.

PMID:
25536148
26.

[Pulmonary arterial hypertension--a disease of the immune system?].

Riemekasten G, Kuebler WM, Schermuly R, Seyfarth HJ, Behr J, Grohe C, Hoeper MM, Olschewski A, Kwapiszewska G, Ulrich S, Voswinckel R, Weissmann N, Worth H, Viales RR, Pullamsetti SS, Grunig G.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S116-20. doi: 10.1055/s-0034-1387452. Epub 2014 Dec 9. Review. German. No abstract available.

PMID:
25489680
27.

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS.

Nat Med. 2014 Nov;20(11):1289-300. doi: 10.1038/nm.3695. Epub 2014 Oct 26.

PMID:
25344740
28.

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.

El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR.

J Immunol. 2014 Jul 15;193(2):597-609. doi: 10.4049/jimmunol.1303048. Epub 2014 Jun 13.

29.

Novel and emerging therapies for pulmonary hypertension.

Pullamsetti SS, Schermuly R, Ghofrani A, Weissmann N, Grimminger F, Seeger W.

Am J Respir Crit Care Med. 2014 Feb 15;189(4):394-400. doi: 10.1164/rccm.201308-1543PP. Review.

PMID:
24401129
30.

MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts.

Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA, Yeager ME, Fini MA, Morrell NW, Pullamsetti SS, Velegala S, Seeger W, McKinsey TA, Sucharov CC, Stenmark KR.

Circ Res. 2014 Jan 3;114(1):67-78. doi: 10.1161/CIRCRESAHA.114.301633. Epub 2013 Oct 11.

31.

Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.

Zhao L, Ashek A, Wang L, Fang W, Dabral S, Dubois O, Cupitt J, Pullamsetti SS, Cotroneo E, Jones H, Tomasi G, Nguyen QD, Aboagye EO, El-Bahrawy MA, Barnes G, Howard LS, Gibbs JS, Gsell W, He JG, Wilkins MR.

Circulation. 2013 Sep 10;128(11):1214-24. doi: 10.1161/CIRCULATIONAHA.113.004136. Epub 2013 Jul 30.

32.

Mechanics and mechanisms of pulmonary hypertension-Conference summary and translational perspectives.

Seeger W, Pullamsetti SS.

Pulm Circ. 2013 Jan;3(1):128-36. No abstract available.

33.

The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis.

Janssen W, Pullamsetti SS, Cooke J, Weissmann N, Guenther A, Schermuly RT.

J Pathol. 2013 Jan;229(2):242-9. doi: 10.1002/path.4127. Review.

PMID:
23097221
34.

Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.

Savai R, Pullamsetti SS, Kolbe J, Bieniek E, Voswinckel R, Fink L, Scheed A, Ritter C, Dahal BK, Vater A, Klussmann S, Ghofrani HA, Weissmann N, Klepetko W, Banat GA, Seeger W, Grimminger F, Schermuly RT.

Am J Respir Crit Care Med. 2012 Nov 1;186(9):897-908. doi: 10.1164/rccm.201202-0335OC. Epub 2012 Sep 6.

PMID:
22955318
35.

Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling.

Kojonazarov B, Sydykov A, Pullamsetti SS, Luitel H, Dahal BK, Kosanovic D, Tian X, Majewski M, Baumann C, Evans S, Phillips P, Fairman D, Davie N, Wayman C, Kilty I, Weissmann N, Grimminger F, Seeger W, Ghofrani HA, Schermuly RT.

Int J Cardiol. 2013 Sep 10;167(6):2630-7. doi: 10.1016/j.ijcard.2012.06.129. Epub 2012 Jul 31.

PMID:
22854298
36.

Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats.

Mihaylova S, Killian A, Mayer K, Pullamsetti SS, Schermuly R, Rosengarten B.

J Neuroinflammation. 2012 Jul 25;9:183. doi: 10.1186/1742-2094-9-183.

37.

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.

Pullamsetti SS, Banat GA, Schmall A, Szibor M, Pomagruk D, Hänze J, Kolosionek E, Wilhelm J, Braun T, Grimminger F, Seeger W, Schermuly RT, Savai R.

Oncogene. 2013 Feb 28;32(9):1121-34. doi: 10.1038/onc.2012.136. Epub 2012 Apr 23.

PMID:
22525277
38.

Matrix metalloproteinases and their inhibitors in pulmonary hypertension.

Chelladurai P, Seeger W, Pullamsetti SS.

Eur Respir J. 2012 Sep;40(3):766-82. doi: 10.1183/09031936.00209911. Epub 2012 Apr 20. Review.

39.

Role of Src tyrosine kinases in experimental pulmonary hypertension.

Pullamsetti SS, Berghausen EM, Dabral S, Tretyn A, Butrous E, Savai R, Butrous G, Dahal BK, Brandes RP, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Rosenkranz S, Schermuly RT.

Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1354-65. doi: 10.1161/ATVBAHA.112.248500. Epub 2012 Apr 19.

40.

Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension.

Pullamsetti SS, Doebele C, Fischer A, Savai R, Kojonazarov B, Dahal BK, Ghofrani HA, Weissmann N, Grimminger F, Bonauer A, Seeger W, Zeiher AM, Dimmeler S, Schermuly RT.

Am J Respir Crit Care Med. 2012 Feb 15;185(4):409-19. doi: 10.1164/rccm.201106-1093OC. Epub 2011 Dec 8.

PMID:
22161164
41.

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.

Dahal BK, Heuchel R, Pullamsetti SS, Wilhelm J, Ghofrani HA, Weissmann N, Seeger W, Grimminger F, Schermuly RT.

Pulm Circ. 2011 Apr-Jun;1(2):259-68. doi: 10.4103/2045-8932.83448.

42.

The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.

Pullamsetti SS, Savai R, Dumitrascu R, Dahal BK, Wilhelm J, Konigshoff M, Zakrzewicz D, Ghofrani HA, Weissmann N, Eickelberg O, Guenther A, Leiper J, Seeger W, Grimminger F, Schermuly RT.

Sci Transl Med. 2011 Jun 15;3(87):87ra53. doi: 10.1126/scitranslmed.3001725.

43.

Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.

Sklepkiewicz P, Schermuly RT, Tian X, Ghofrani HA, Weissmann N, Sedding D, Kashour T, Seeger W, Grimminger F, Pullamsetti SS.

PLoS One. 2011 Apr 18;6(4):e18883. doi: 10.1371/journal.pone.0018883.

44.

Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.

Tian X, Vroom C, Ghofrani HA, Weissmann N, Bieniek E, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS.

PLoS One. 2011 Apr 11;6(4):e18136. doi: 10.1371/journal.pone.0018136.

45.

cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.

Pullamsetti SS, Savai R, Schaefer MB, Wilhelm J, Ghofrani HA, Weissmann N, Schudt C, Fleming I, Mayer K, Leiper J, Seeger W, Grimminger F, Schermuly RT.

Circulation. 2011 Mar 22;123(11):1194-204. doi: 10.1161/CIRCULATIONAHA.110.941484. Epub 2011 Mar 7.

46.

Tyrosine kinase inhibitors with antiangiogenic properties for the treatment of non-small cell lung cancer.

Nguewa PA, Calvo A, Pullamsetti SS, Banat GA, Grimminger F, Savai R.

Expert Opin Investig Drugs. 2011 Jan;20(1):61-74. doi: 10.1517/13543784.2011.541153. Epub 2010 Dec 11. Review.

PMID:
21142806
47.

Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.

Nikolova S, Guenther A, Savai R, Weissmann N, Ghofrani HA, Konigshoff M, Eickelberg O, Klepetko W, Voswinckel R, Seeger W, Grimminger F, Schermuly RT, Pullamsetti SS.

Respir Res. 2010 Oct 27;11:146. doi: 10.1186/1465-9921-11-146.

48.

Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.

Dumitrascu R, Kulcke C, Königshoff M, Kouri F, Yang X, Morrell N, Ghofrani HA, Weissmann N, Reiter R, Seeger W, Grimminger F, Eickelberg O, Schermuly RT, Pullamsetti SS.

Eur Respir J. 2011 May;37(5):1104-18. doi: 10.1183/09031936.00126010. Epub 2010 Oct 14.

49.

Inflammation, immunological reaction and role of infection in pulmonary hypertension.

Pullamsetti SS, Savai R, Janssen W, Dahal BK, Seeger W, Grimminger F, Ghofrani HA, Weissmann N, Schermuly RT.

Clin Microbiol Infect. 2011 Jan;17(1):7-14. doi: 10.1111/j.1469-0691.2010.03285.x. Review.

50.

Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.

Udalov S, Dumitrascu R, Pullamsetti SS, Al-tamari HM, Weissmann N, Ghofrani HA, Guenther A, Voswinckel R, Seeger W, Grimminger F, Schermuly RT.

BMC Pulm Med. 2010 May 5;10:26. doi: 10.1186/1471-2466-10-26.

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