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Items: 1 to 50 of 165

1.

West Nile Virus Infection Blocks Inflammatory Response and T Cell Costimulatory Capacity of Human Monocyte-Derived Dendritic Cells.

Zimmerman MG, Bowen JR, McDonald CE, Pulendran B, Suthar MS.

J Virol. 2019 Sep 18. pii: JVI.00664-19. doi: 10.1128/JVI.00664-19. [Epub ahead of print]

PMID:
31534040
2.

STAT5: A Target of Antagonism by Neurotropic Flaviviruses.

Zimmerman MG, Bowen JR, McDonald CE, Young E, Baric RS, Pulendran B, Suthar MS.

J Virol. 2019 Sep 18. pii: JVI.00665-19. doi: 10.1128/JVI.00665-19. [Epub ahead of print]

PMID:
31534033
3.

Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans.

Hagan T, Cortese M, Rouphael N, Boudreau C, Linde C, Maddur MS, Das J, Wang H, Guthmiller J, Zheng NY, Huang M, Uphadhyay AA, Gardinassi L, Petitdemange C, McCullough MP, Johnson SJ, Gill K, Cervasi B, Zou J, Bretin A, Hahn M, Gewirtz AT, Bosinger SE, Wilson PC, Li S, Alter G, Khurana S, Golding H, Pulendran B.

Cell. 2019 Sep 5;178(6):1313-1328.e13. doi: 10.1016/j.cell.2019.08.010.

PMID:
31491384
4.

N6-Methyladenosine Modification Controls Circular RNA Immunity.

Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, Chang HY.

Mol Cell. 2019 Oct 3;76(1):96-109.e9. doi: 10.1016/j.molcel.2019.07.016. Epub 2019 Aug 29.

PMID:
31474572
5.

ImmuneRegulation: a web-based tool for identifying human immune regulatory elements.

Kalayci S, Selvan ME, Ramos I, Cotsapas C, Harris E, Kim EY, Montgomery RR, Poland G, Pulendran B, Tsang JS, Klein RJ, Gümüş ZH.

Nucleic Acids Res. 2019 Jul 2;47(W1):W142-W150. doi: 10.1093/nar/gkz450.

6.

Understanding the immunology of the Zostavax shingles vaccine.

Sullivan NL, Eberhardt CS, Wieland A, Vora KA, Pulendran B, Ahmed R.

Curr Opin Immunol. 2019 Aug;59:25-30. doi: 10.1016/j.coi.2019.02.005. Epub 2019 Apr 7. Review.

PMID:
30970291
7.

Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.

Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B.

JCI Insight. 2019 Feb 21;4(4). pii: 126047. doi: 10.1172/jci.insight.126047. eCollection 2019 Feb 21.

8.

Clade C HIV-1 Envelope Vaccination Regimens Differ in Their Ability To Elicit Antibodies with Moderate Neutralization Breadth against Genetically Diverse Tier 2 HIV-1 Envelope Variants.

Burton S, Spicer LM, Charles TP, Gangadhara S, Reddy PBJ, Styles TM, Velu V, Kasturi SP, Legere T, Hunter E, Pulendran B, Amara R, Hraber P, Derdeyn CA.

J Virol. 2019 Mar 21;93(7). pii: e01846-18. doi: 10.1128/JVI.01846-18. Print 2019 Apr 1.

9.

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination.

Neu KE, Guthmiller JJ, Huang M, La J, Vieira MC, Kim K, Zheng NY, Cortese M, Tepora ME, Hamel NJ, Rojas KT, Henry C, Shaw D, Dulberger CL, Pulendran B, Cobey S, Khan AA, Wilson PC.

J Clin Invest. 2019 Jan 2;129(1):93-105. doi: 10.1172/JCI121341. Epub 2018 Nov 19.

10.

B Cell Competition for Restricted T Cell Help Suppresses Rare-Epitope Responses.

Woodruff MC, Kim EH, Luo W, Pulendran B.

Cell Rep. 2018 Oct 9;25(2):321-327.e3. doi: 10.1016/j.celrep.2018.09.029.

11.

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters.

da Silva Antunes R, Babor M, Carpenter C, Khalil N, Cortese M, Mentzer AJ, Seumois G, Petro CD, Purcell LA, Vijayanand P, Crotty S, Pulendran B, Peters B, Sette A.

J Clin Invest. 2018 Aug 31;128(9):3853-3865. doi: 10.1172/JCI121309. Epub 2018 Aug 6.

12.

Breadth and Functionality of Varicella-Zoster Virus Glycoprotein-Specific Antibodies Identified after Zostavax Vaccination in Humans.

Sullivan NL, Reuter-Monslow MA, Sei J, Durr E, Davis CW, Chang C, McCausland M, Wieland A, Krah D, Rouphael N, Mehta AK, Mulligan MJ, Pulendran B, Ahmed R, Vora KA.

J Virol. 2018 Jun 29;92(14). pii: e00269-18. doi: 10.1128/JVI.00269-18. Print 2018 Jul 15.

13.

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data.

Upadhyay AA, Kauffman RC, Wolabaugh AN, Cho A, Patel NB, Reiss SM, Havenar-Daughton C, Dawoud RA, Tharp GK, Sanz I, Pulendran B, Crotty S, Lee FE, Wrammert J, Bosinger SE.

Genome Med. 2018 Mar 20;10(1):20. doi: 10.1186/s13073-018-0528-3.

14.

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, Kasturi S, Pulendran B, Wilson IA, Montefiori DC, Sanders RW, Ward AB, Moore JP.

PLoS Pathog. 2018 Feb 23;14(2):e1006913. doi: 10.1371/journal.ppat.1006913. eCollection 2018 Feb.

15.

AS03- and MF59-Adjuvanted Influenza Vaccines in Children.

Wilkins AL, Kazmin D, Napolitani G, Clutterbuck EA, Pulendran B, Siegrist CA, Pollard AJ.

Front Immunol. 2017 Dec 13;8:1760. doi: 10.3389/fimmu.2017.01760. eCollection 2017. Review.

16.

Cell type discovery and representation in the era of high-content single cell phenotyping.

Bakken T, Cowell L, Aevermann BD, Novotny M, Hodge R, Miller JA, Lee A, Chang I, McCorrison J, Pulendran B, Qian Y, Schork NJ, Lasken RS, Lein ES, Scheuermann RH.

BMC Bioinformatics. 2017 Dec 21;18(Suppl 17):559. doi: 10.1186/s12859-017-1977-1.

17.

Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines? From Data to Understanding through Systems Biology.

Hagan T, Pulendran B.

Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8). pii: a028894. doi: 10.1101/cshperspect.a028894. Review.

18.

The potential of the microbiota to influence vaccine responses.

Lynn DJ, Pulendran B.

J Leukoc Biol. 2018 Feb;103(2):225-231. doi: 10.1189/jlb.5MR0617-216R. Epub 2017 Dec 28. Review.

19.

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.

Sinclair C, Bommakanti G, Gardinassi L, Loebbermann J, Johnson MJ, Hakimpour P, Hagan T, Benitez L, Todor A, Machiah D, Oriss T, Ray A, Bosinger S, Ravindran R, Li S, Pulendran B.

Science. 2017 Sep 8;357(6355):1014-1021. doi: 10.1126/science.aaj2155. Epub 2017 Aug 10.

20.

Metabolic Phenotypes of Response to Vaccination in Humans.

Li S, Sullivan NL, Rouphael N, Yu T, Banton S, Maddur MS, McCausland M, Chiu C, Canniff J, Dubey S, Liu K, Tran V, Hagan T, Duraisingham S, Wieland A, Mehta AK, Whitaker JA, Subramaniam S, Jones DP, Sette A, Vora K, Weinberg A, Mulligan MJ, Nakaya HI, Levin M, Ahmed R, Pulendran B.

Cell. 2017 May 18;169(5):862-877.e17. doi: 10.1016/j.cell.2017.04.026. Epub 2017 May 11.

21.

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.

Kazmin D, Nakaya HI, Lee EK, Johnson MJ, van der Most R, van den Berg RA, Ballou WR, Jongert E, Wille-Reece U, Ockenhouse C, Aderem A, Zak DE, Sadoff J, Hendriks J, Wrammert J, Ahmed R, Pulendran B.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2425-2430. doi: 10.1073/pnas.1621489114. Epub 2017 Feb 13.

22.

Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells.

Bowen JR, Quicke KM, Maddur MS, O'Neal JT, McDonald CE, Fedorova NB, Puri V, Shabman RS, Pulendran B, Suthar MS.

PLoS Pathog. 2017 Feb 2;13(2):e1006164. doi: 10.1371/journal.ppat.1006164. eCollection 2017 Feb.

23.

1st International Conference on Human &Translational Immunology.

Hope JL, Pulendran B, Schoenberger SP, Katsikis PD.

Nat Immunol. 2016 Dec 16;18(1):1-4. doi: 10.1038/ni.3635.

PMID:
27984565
24.

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques.

Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira ELV, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B.

J Virol. 2017 Jan 31;91(4). pii: e01844-16. doi: 10.1128/JVI.01844-16. Print 2017 Feb 15.

25.

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.

Havenar-Daughton C, Carnathan DG, Torrents de la Peña A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, Mohammed AUR, Huang J, Gumber S, Garcia A, Kasturi SP, Pulendran B, Moore JP, Ahmed R, Seumois G, Burton DR, Sanders RW, Silvestri G, Crotty S.

Cell Rep. 2016 Nov 22;17(9):2195-2209. doi: 10.1016/j.celrep.2016.10.085.

26.

Refined protocol for generating monoclonal antibodies from single human and murine B cells.

Ho IY, Bunker JJ, Erickson SA, Neu KE, Huang M, Cortese M, Pulendran B, Wilson PC.

J Immunol Methods. 2016 Nov;438:67-70. doi: 10.1016/j.jim.2016.09.001. Epub 2016 Sep 4.

27.

Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques.

Iyer SS, Gangadhara S, Victor B, Shen X, Chen X, Nabi R, Kasturi SP, Sabula MJ, Labranche CC, Reddy PB, Tomaras GD, Montefiori DC, Moss B, Spearman P, Pulendran B, Kozlowski PA, Amara RR.

J Virol. 2016 Sep 12;90(19):8842-54. doi: 10.1128/JVI.01163-16. Print 2016 Oct 1.

28.

Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique.

Havenar-Daughton C, Reiss SM, Carnathan DG, Wu JE, Kendric K, Torrents de la Peña A, Kasturi SP, Dan JM, Bothwell M, Sanders RW, Pulendran B, Silvestri G, Crotty S.

J Immunol. 2016 Aug 1;197(3):994-1002. doi: 10.4049/jimmunol.1600320. Epub 2016 Jun 22.

29.

Zika Virus Infects Human Placental Macrophages.

Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O'Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B, Schinazi RF, Chakraborty R, Suthar MS.

Cell Host Microbe. 2016 Jul 13;20(1):83-90. doi: 10.1016/j.chom.2016.05.015. Epub 2016 May 27.

30.

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.

Reese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly RP, Jameson SC, Masopust D, Haining WN, Virgin HW.

Cell Host Microbe. 2016 May 11;19(5):713-9. doi: 10.1016/j.chom.2016.04.003. Epub 2016 Apr 20.

31.

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.

Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC, Li S, Sharma P, Kaufman RJ, Martinez J, Pulendran B.

Nature. 2016 Mar 24;531(7595):523-527. doi: 10.1038/nature17186. Epub 2016 Mar 16.

32.

CXCL13 is a plasma biomarker of germinal center activity.

Havenar-Daughton C, Lindqvist M, Heit A, Wu JE, Reiss SM, Kendric K, Bélanger S, Kasturi SP, Landais E, Akondy RS, McGuire HM, Bothwell M, Vagefi PA, Scully E; IAVI Protocol C Principal Investigators, Tomaras GD, Davis MM, Poignard P, Ahmed R, Walker BD, Pulendran B, McElrath MJ, Kaufmann DE, Crotty S.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2702-7. doi: 10.1073/pnas.1520112113. Epub 2016 Feb 23.

33.

Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.

Nakaya HI, Clutterbuck E, Kazmin D, Wang L, Cortese M, Bosinger SE, Patel NB, Zak DE, Aderem A, Dong T, Del Giudice G, Rappuoli R, Cerundolo V, Pollard AJ, Pulendran B, Siegrist CA.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1853-8. doi: 10.1073/pnas.1519690113. Epub 2016 Jan 11.

34.

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures.

Nakaya HI, Hagan T, Duraisingham SS, Lee EK, Kwissa M, Rouphael N, Frasca D, Gersten M, Mehta AK, Gaujoux R, Li GM, Gupta S, Ahmed R, Mulligan MJ, Shen-Orr S, Blomberg BB, Subramaniam S, Pulendran B.

Immunity. 2015 Dec 15;43(6):1186-98. doi: 10.1016/j.immuni.2015.11.012.

35.

Signatures in Simian Immunodeficiency Virus SIVsmE660 Envelope gp120 Are Associated with Mucosal Transmission but Not Vaccination Breakthrough in Rhesus Macaques.

Smith SA, Kilgore KM, Kasturi SP, Pulendran B, Hunter E, Amara RR, Derdeyn CA.

J Virol. 2015 Dec 16;90(4):1880-7. doi: 10.1128/JVI.02711-15. Print 2016 Feb 15.

36.

Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.

Kilgore KM, Murphy MK, Burton SL, Wetzel KS, Smith SA, Xiao P, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Hunter E, Collman RG, Amara RR, Derdeyn CA.

J Virol. 2015 Aug;89(16):8130-51. doi: 10.1128/JVI.01221-14. Epub 2015 May 27.

37.

Vaccinology in the era of high-throughput biology.

Nakaya HI, Pulendran B.

Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). pii: 20140146. doi: 10.1098/rstb.2014.0146. Review.

38.

A vision and a prescription for big data-enabled medicine.

Chaussabel D, Pulendran B.

Nat Immunol. 2015 May;16(5):435-9. doi: 10.1038/ni.3151. No abstract available.

PMID:
25898187
39.

Systems vaccinology: Enabling rational vaccine design with systems biological approaches.

Hagan T, Nakaya HI, Subramaniam S, Pulendran B.

Vaccine. 2015 Sep 29;33(40):5294-301. doi: 10.1016/j.vaccine.2015.03.072. Epub 2015 Apr 6. Review.

40.

Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.

Napier RJ, Norris BA, Swimm A, Giver CR, Harris WA, Laval J, Napier BA, Patel G, Crump R, Peng Z, Bornmann W, Pulendran B, Buller RM, Weiss DS, Tirouvanziam R, Waller EK, Kalman D.

PLoS Pathog. 2015 Mar 30;11(3):e1004770. doi: 10.1371/journal.ppat.1004770. eCollection 2015 Mar.

41.

Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination.

Akondy RS, Johnson PL, Nakaya HI, Edupuganti S, Mulligan MJ, Lawson B, Miller JD, Pulendran B, Antia R, Ahmed R.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3050-5. doi: 10.1073/pnas.1500475112. Epub 2015 Feb 23.

42.

Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity.

Thapa M, Chinnadurai R, Velazquez VM, Tedesco D, Elrod E, Han JH, Sharma P, Ibegbu C, Gewirtz A, Anania F, Pulendran B, Suthar MS, Grakoui A.

Hepatology. 2015 Jun;61(6):2067-79. doi: 10.1002/hep.27761. Epub 2015 Mar 25.

43.

The varieties of immunological experience: of pathogens, stress, and dendritic cells.

Pulendran B.

Annu Rev Immunol. 2015;33:563-606. doi: 10.1146/annurev-immunol-020711-075049. Epub 2015 Feb 4. Review.

PMID:
25665078
44.

Activation of toll-like receptor-2 by endogenous matrix metalloproteinase-2 modulates dendritic-cell-mediated inflammatory responses.

Godefroy E, Gallois A, Idoyaga J, Merad M, Tung N, Monu N, Saenger Y, Fu Y, Ravindran R, Pulendran B, Jotereau F, Trombetta S, Bhardwaj N.

Cell Rep. 2014 Dec 11;9(5):1856-1870. doi: 10.1016/j.celrep.2014.10.067. Epub 2014 Nov 26.

45.

Vaccine-induced plasmablast responses in rhesus macaques: phenotypic characterization and a source for generating antigen-specific monoclonal antibodies.

Silveira EL, Kasturi SP, Kovalenkov Y, Rasheed AU, Yeiser P, Jinnah ZS, Legere TH, Pulendran B, Villinger F, Wrammert J.

J Immunol Methods. 2015 Jan;416:69-83. doi: 10.1016/j.jim.2014.11.003. Epub 2014 Nov 8.

46.

Emerging functions of the unfolded protein response in immunity.

Janssens S, Pulendran B, Lambrecht BN.

Nat Immunol. 2014 Oct;15(10):910-9. doi: 10.1038/ni.2991. Review.

47.

TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.

Oh JZ, Ravindran R, Chassaing B, Carvalho FA, Maddur MS, Bower M, Hakimpour P, Gill KP, Nakaya HI, Yarovinsky F, Sartor RB, Gewirtz AT, Pulendran B.

Immunity. 2014 Sep 18;41(3):478-492. doi: 10.1016/j.immuni.2014.08.009. Epub 2014 Sep 11.

48.

Systems vaccinology: probing humanity's diverse immune systems with vaccines.

Pulendran B.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12300-6. doi: 10.1073/pnas.1400476111. Epub 2014 Aug 18. Review.

49.

Innate immune sensing and response to influenza.

Pulendran B, Maddur MS.

Curr Top Microbiol Immunol. 2015;386:23-71. doi: 10.1007/82_2014_405.

50.

Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation.

Kwissa M, Nakaya HI, Onlamoon N, Wrammert J, Villinger F, Perng GC, Yoksan S, Pattanapanyasat K, Chokephaibulkit K, Ahmed R, Pulendran B.

Cell Host Microbe. 2014 Jul 9;16(1):115-27. doi: 10.1016/j.chom.2014.06.001. Epub 2014 Jun 26.

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