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Items: 1 to 50 of 66

1.

A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis.

Doron H, Pukrop T, Erez N.

Cancer Res. 2019 Feb 1;79(3):423-436. doi: 10.1158/0008-5472.CAN-18-1805. Epub 2019 Jan 24. Review.

PMID:
30679177
2.

Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis.

Heudobler D, Rechenmacher M, Lüke F, Vogelhuber M, Klobuch S, Thomas S, Pukrop T, Hackl C, Herr W, Ghibelli L, Gerner C, Reichle A.

Front Pharmacol. 2018 Nov 28;9:1357. doi: 10.3389/fphar.2018.01357. eCollection 2018. Review.

3.

Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue.

Heudobler D, Rechenmacher M, Lüke F, Vogelhuber M, Pukrop T, Herr W, Ghibelli L, Gerner C, Reichle A.

Int J Mol Sci. 2018 Nov 9;19(11). pii: E3540. doi: 10.3390/ijms19113540. Review.

4.

PI3K: A master regulator of brain metastasis-promoting macrophages/microglia.

Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beißbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK, Pukrop T.

Glia. 2018 Nov;66(11):2438-2455. doi: 10.1002/glia.23485. Epub 2018 Oct 25.

PMID:
30357946
5.

Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment.

Lüke F, Blazquez R, Yamaci RF, Lu X, Pregler B, Hannus S, Menhart K, Hellwig D, Wester HJ, Kropf S, Heudobler D, Grosse J, Moosbauer J, Hutterer M, Hau P, Riemenschneider MJ, Bayerlová M, Bleckmann A, Polzer B, Beißbarth T, Klein CA, Pukrop T.

Oncotarget. 2018 Apr 10;9(27):18844-18857. doi: 10.18632/oncotarget.24787. eCollection 2018 Apr 10.

6.

Extent of Resection in Newly Diagnosed Glioblastoma: Impact of a Specialized Neuro-Oncology Care Center.

Haj A, Doenitz C, Schebesch KM, Ehrensberger D, Hau P, Putnik K, Riemenschneider MJ, Wendl C, Gerken M, Pukrop T, Brawanski A, Proescholdt MA.

Brain Sci. 2017 Dec 25;8(1). pii: E5. doi: 10.3390/brainsci8010005.

7.

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia.

Mayer RL, Schwarzmeier JD, Gerner MC, Bileck A, Mader JC, Meier-Menches SM, Gerner SM, Schmetterer KG, Pukrop T, Reichle A, Slany A, Gerner C.

Mol Cell Proteomics. 2018 Feb;17(2):290-303. doi: 10.1074/mcp.RA117.000425. Epub 2017 Dec 1.

8.

Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the International Extranodal Lymphoma Study Group-32 phase 2 trial.

Ferreri AJM, Cwynarski K, Pulczynski E, Fox CP, Schorb E, La Rosée P, Binder M, Fabbri A, Torri V, Minacapelli E, Falautano M, Ilariucci F, Ambrosetti A, Roth A, Hemmaway C, Johnson P, Linton KM, Pukrop T, Sønderskov Gørløv J, Balzarotti M, Hess G, Keller U, Stilgenbauer S, Panse J, Tucci A, Orsucci L, Pisani F, Levis A, Krause SW, Schmoll HJ, Hertenstein B, Rummel M, Smith J, Pfreundschuh M, Cabras G, Angrilli F, Ponzoni M, Deckert M, Politi LS, Finke J, Reni M, Cavalli F, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG).

Lancet Haematol. 2017 Nov;4(11):e510-e523. doi: 10.1016/S2352-3026(17)30174-6. Epub 2017 Oct 17.

PMID:
29054815
9.

Characterisation of tumour-derived microvesicles in cancer patients' blood and correlation with clinical outcome.

Menck K, Bleckmann A, Wachter A, Hennies B, Ries L, Schulz M, Balkenhol M, Pukrop T, Schatlo B, Rost U, Wenzel D, Klemm F, Binder C.

J Extracell Vesicles. 2017 Jul 16;6(1):1340745. doi: 10.1080/20013078.2017.1340745. eCollection 2017.

10.

Ror2 Signaling and Its Relevance in Breast Cancer Progression.

Bayerlová M, Menck K, Klemm F, Wolff A, Pukrop T, Binder C, Beißbarth T, Bleckmann A.

Front Oncol. 2017 Jun 26;7:135. doi: 10.3389/fonc.2017.00135. eCollection 2017.

11.

3D Coculture Model of the Brain Parenchyma-Metastasis Interface of Brain Metastasis.

Blazquez R, Pukrop T.

Methods Mol Biol. 2017;1612:213-222. doi: 10.1007/978-1-4939-7021-6_16.

PMID:
28634946
12.

PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression.

Hohensee I, Chuang HN, Grottke A, Werner S, Schulte A, Horn S, Lamszus K, Bartkowiak K, Witzel I, Westphal M, Matschke J, Glatzel M, Jücker M, Pukrop T, Pantel K, Wikman H.

Oncotarget. 2017 Jan 24;8(4):6155-6168. doi: 10.18632/oncotarget.14047.

13.

LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma.

Dräger J, Simon-Keller K, Pukrop T, Klemm F, Wilting J, Sticht C, Dittmann K, Schulz M, Leuschner I, Marx A, Hahn H.

Oncotarget. 2017 Jan 10;8(2):3259-3273. doi: 10.18632/oncotarget.13887.

14.

Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma.

Muqaku B, Eisinger M, Meier SM, Tahir A, Pukrop T, Haferkamp S, Slany A, Reichle A, Gerner C.

Mol Cell Proteomics. 2017 Jan;16(1):86-99. doi: 10.1074/mcp.M116.063313. Epub 2016 Nov 22.

15.

Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report.

Cidlinsky N, Dogliotti G, Pukrop T, Jung R, Weber F, Krahn MP.

Cell Oncol (Dordr). 2016 Aug;39(4):389-96. doi: 10.1007/s13402-016-0290-8. Epub 2016 Aug 1.

PMID:
27480082
16.

The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway.

Monin MB, Krause P, Stelling R, Bocuk D, Niebert S, Klemm F, Pukrop T, Koenig S.

J Surg Res. 2016 Jun 1;203(1):193-205. doi: 10.1016/j.jss.2016.03.051. Epub 2016 Mar 30.

PMID:
27338550
17.

WNT5A: a motility-promoting factor in Hodgkin lymphoma.

Linke F, Zaunig S, Nietert MM, von Bonin F, Lutz S, Dullin C, Janovská P, Beissbarth T, Alves F, Klapper W, Bryja V, Pukrop T, Trümper L, Wilting J, Kube D.

Oncogene. 2017 Jan 5;36(1):13-23. doi: 10.1038/onc.2016.183. Epub 2016 Jun 6.

PMID:
27270428
18.

Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation.

Schwartz H, Blacher E, Amer M, Livneh N, Abramovitz L, Klein A, Ben-Shushan D, Soffer S, Blazquez R, Barrantes-Freer A, Müller M, Müller-Decker K, Stein R, Tsarfaty G, Satchi-Fainaro R, Umansky V, Pukrop T, Erez N.

Cancer Res. 2016 Aug 1;76(15):4359-71. doi: 10.1158/0008-5472.CAN-16-0485. Epub 2016 Jun 3.

19.

Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.

Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG).

Lancet Haematol. 2016 May;3(5):e217-27. doi: 10.1016/S2352-3026(16)00036-3. Epub 2016 Apr 6.

PMID:
27132696
20.

β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases.

Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T.

Clin Exp Metastasis. 2016 Apr;33(4):309-23. doi: 10.1007/s10585-016-9780-3. Epub 2016 Feb 9.

21.

CD14 is a key organizer of microglial responses to CNS infection and injury.

Janova H, Böttcher C, Holtman IR, Regen T, van Rossum D, Götz A, Ernst AS, Fritsche C, Gertig U, Saiepour N, Gronke K, Wrzos C, Ribes S, Rolfes S, Weinstein J, Ehrenreich H, Pukrop T, Kopatz J, Stadelmann C, Salinas-Riester G, Weber MS, Prinz M, Brück W, Eggen BJ, Boddeke HW, Priller J, Hanisch UK.

Glia. 2016 Apr;64(4):635-49. doi: 10.1002/glia.22955. Epub 2015 Dec 18.

PMID:
26683584
22.

Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data.

Bayerlová M, Klemm F, Kramer F, Pukrop T, Beißbarth T, Bleckmann A.

PLoS One. 2015 Dec 3;10(12):e0144014. doi: 10.1371/journal.pone.0144014. eCollection 2015.

23.

The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study.

Siam L, Bleckmann A, Chaung HN, Mohr A, Klemm F, Barrantes-Freer A, Blazquez R, Wolff HA, Lüke F, Rohde V, Stadelmann C, Pukrop T.

Oncotarget. 2015 Oct 6;6(30):29254-67. doi: 10.18632/oncotarget.4201.

24.

Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia.

Rietkötter E, Bleckmann A, Bayerlová M, Menck K, Chuang HN, Wenske B, Schwartz H, Erez N, Binder C, Hanisch UK, Pukrop T.

Oncotarget. 2015 Jun 20;6(17):15482-93.

25.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.

Glia. 2015 Jun;63(6):1083-99. doi: 10.1002/glia.22803. Epub 2015 Mar 2.

PMID:
25731696
26.

Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN.

Menck K, Scharf C, Bleckmann A, Dyck L, Rost U, Wenzel D, Dhople VM, Siam L, Pukrop T, Binder C, Klemm F.

J Mol Cell Biol. 2015 Apr;7(2):143-53. doi: 10.1093/jmcb/mju047. Epub 2014 Dec 11.

27.

Isolation of human monocytes by double gradient centrifugation and their differentiation to macrophages in teflon-coated cell culture bags.

Menck K, Behme D, Pantke M, Reiling N, Binder C, Pukrop T, Klemm F.

J Vis Exp. 2014 Sep 9;(91):e51554. doi: 10.3791/51554.

28.

Integrated miRNA and mRNA profiling of tumor-educated macrophages identifies prognostic subgroups in estrogen receptor-positive breast cancer.

Bleckmann A, Leha A, Artmann S, Menck K, Salinas-Riester G, Binder C, Pukrop T, Beissbarth T, Klemm F.

Mol Oncol. 2015 Jan;9(1):155-66. doi: 10.1016/j.molonc.2014.07.023. Epub 2014 Aug 16.

29.

Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.

König S, Nitzki F, Uhmann A, Dittmann K, Theiss-Suennemann J, Herrmann M, Reichardt HM, Schwendener R, Pukrop T, Schulz-Schaeffer W, Hahn H.

PLoS One. 2014 Apr 1;9(4):e93555. doi: 10.1371/journal.pone.0093555. eCollection 2014.

30.

Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles.

Menck K, Klemm F, Gross JC, Pukrop T, Wenzel D, Binder C.

Oncotarget. 2013 Nov;4(11):2057-66.

31.

Coculture system with an organotypic brain slice and 3D spheroid of carcinoma cells.

Chuang HN, Lohaus R, Hanisch UK, Binder C, Dehghani F, Pukrop T.

J Vis Exp. 2013 Oct 9;(80). doi: 10.3791/50881.

32.

Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion.

Rietkötter E, Menck K, Bleckmann A, Farhat K, Schaffrinski M, Schulz M, Hanisch UK, Binder C, Pukrop T.

Oncotarget. 2013 Sep;4(9):1449-60.

33.

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP).

König S, Regen T, Dittmann K, Engelke M, Wienands J, Schwendener R, Hanisch UK, Pukrop T, Hahn H.

Cancer Immunol Immunother. 2013 Oct;62(10):1587-97. doi: 10.1007/s00262-013-1444-4. Epub 2013 Aug 6.

34.

Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice.

Buttler K, Becker J, Pukrop T, Wilting J.

Dev Biol. 2013 Sep 15;381(2):365-76. doi: 10.1016/j.ydbio.2013.06.028. Epub 2013 Jul 11.

35.

Carcinoma cells misuse the host tissue damage response to invade the brain.

Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch UK, Binder C, Pukrop T.

Glia. 2013 Aug;61(8):1331-46. doi: 10.1002/glia.22518. Epub 2013 Jul 6.

36.

Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma.

Walther N, Ulrich A, Vockerodt M, von Bonin F, Klapper W, Meyer K, Eberth S, Pukrop T, Spang R, Trümper L, Kube D.

Am J Pathol. 2013 Apr;182(4):1092-8. doi: 10.1016/j.ajpath.2012.12.013. Epub 2013 Jan 31.

PMID:
23375451
37.

Estimating learning outcomes from pre- and posttest student self-assessments: a longitudinal study.

Schiekirka S, Reinhardt D, Beißbarth T, Anders S, Pukrop T, Raupach T.

Acad Med. 2013 Mar;88(3):369-75. doi: 10.1097/ACM.0b013e318280a6f6.

PMID:
23348083
38.

Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear β-catenin in cerebral metastasis of lung adenocarcinomas.

Bleckmann A, Siam L, Klemm F, Rietkötter E, Wegner C, Kramer F, Beissbarth T, Binder C, Stadelmann C, Pukrop T.

Clin Exp Metastasis. 2013 Apr;30(4):471-82. doi: 10.1007/s10585-012-9552-7. Epub 2012 Dec 8.

39.

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia.

Scheffel J, Regen T, Van Rossum D, Seifert S, Ribes S, Nau R, Parsa R, Harris RA, Boddeke HW, Chuang HN, Pukrop T, Wessels JT, Jürgens T, Merkler D, Brück W, Schnaars M, Simons M, Kettenmann H, Hanisch UK.

Glia. 2012 Dec;60(12):1930-43. doi: 10.1002/glia.22409. Epub 2012 Aug 21.

PMID:
22911652
40.

Piloting an outcome-based programme evaluation tool in undergraduate medical education.

Raupach T, Schiekirka S, Münscher C, Beißbarth T, Himmel W, Burckhardt G, Pukrop T.

GMS Z Med Ausbild. 2012;29(3):Doc44. doi: 10.3205/zma000814. Epub 2012 May 15.

41.

Student perceptions of evaluation in undergraduate medical education: A qualitative study from one medical school.

Schiekirka S, Reinhardt D, Heim S, Fabry G, Pukrop T, Anders S, Raupach T.

BMC Med Educ. 2012 Jun 22;12:45. doi: 10.1186/1472-6920-12-45.

42.

German medical students lack knowledge of how to treat smoking and problem drinking.

Strobel L, Schneider NK, Krampe H, Beißbarth T, Pukrop T, Anders S, West R, Aveyard P, Raupach T.

Addiction. 2012 Oct;107(10):1878-82. doi: 10.1111/j.1360-0443.2012.03907.x. Epub 2012 May 3.

PMID:
22551065
43.

Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy.

Kendziorra E, Ahlborn K, Spitzner M, Rave-Fränk M, Emons G, Gaedcke J, Kramer F, Wolff HA, Becker H, Beissbarth T, Ebner R, Ghadimi BM, Pukrop T, Ried T, Grade M.

Carcinogenesis. 2011 Dec;32(12):1824-31. doi: 10.1093/carcin/bgr222. Epub 2011 Oct 8.

44.

Towards outcome-based programme evaluation: using student comparative self-assessments to determine teaching effectiveness.

Raupach T, Münscher C, Beissbarth T, Burckhardt G, Pukrop T.

Med Teach. 2011;33(8):e446-53. doi: 10.3109/0142159X.2011.586751.

PMID:
21774642
45.

β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis.

Klemm F, Bleckmann A, Siam L, Chuang HN, Rietkötter E, Behme D, Schulz M, Schaffrinski M, Schindler S, Trümper L, Kramer F, Beissbarth T, Stadelmann C, Binder C, Pukrop T.

Carcinogenesis. 2011 Mar;32(3):434-42. doi: 10.1093/carcin/bgq269. Epub 2010 Dec 20.

PMID:
21173432
46.

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way.

Pukrop T, Dehghani F, Chuang HN, Lohaus R, Bayanga K, Heermann S, Regen T, Van Rossum D, Klemm F, Schulz M, Siam L, Hoffmann A, Trümper L, Stadelmann C, Bechmann I, Hanisch UK, Binder C.

Glia. 2010 Sep;58(12):1477-89. doi: 10.1002/glia.21022.

PMID:
20549749
47.

Impact of teaching and assessment format on electrocardiogram interpretation skills.

Raupach T, Hanneforth N, Anders S, Pukrop T, Th J ten Cate O, Harendza S.

Med Educ. 2010 Jul;44(7):731-40. doi: 10.1111/j.1365-2923.2010.03687.x. Epub 2010 May 28.

PMID:
20528994
48.

Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.

Nitzki F, Zibat A, König S, Wijgerde M, Rosenberger A, Brembeck FH, Carstens PO, Frommhold A, Uhmann A, Klingler S, Reifenberger J, Pukrop T, Aberger F, Schulz-Schaeffer W, Hahn H.

Cancer Res. 2010 Apr 1;70(7):2739-48. doi: 10.1158/0008-5472.CAN-09-3743. Epub 2010 Mar 16.

49.

[A contribution to the needs assessment of faculty development measures in medical schools].

Raupach T, Spering C, Bäumler C, Burckhardt G, Trümper L, Pukrop T.

Med Klin (Munich). 2009 Nov 15;104(11):841-5. doi: 10.1007/s00063-009-1180-x. Epub 2009 Nov 17. German.

PMID:
19916073
50.

Web-based collaborative training of clinical reasoning: a randomized trial.

Raupach T, Muenscher C, Anders S, Steinbach R, Pukrop T, Hege I, Tullius M.

Med Teach. 2009 Sep;31(9):e431-7.

PMID:
19811180

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