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Items: 27


Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection.

Nhan JD, Turner CD, Anderson SM, Yen CA, Dalton HM, Cheesman HK, Ruter DL, Uma Naresh N, Haynes CM, Soukas AA, Pukkila-Worley R, Curran SP.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22322-22330. doi: 10.1073/pnas.1909666116. Epub 2019 Oct 14.


The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans.

Anderson SM, Cheesman HK, Peterson ND, Salisbury JE, Soukas AA, Pukkila-Worley R.

PLoS Pathog. 2019 Jun 17;15(6):e1007893. doi: 10.1371/journal.ppat.1007893. eCollection 2019 Jun.


Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3.

Deng P, Uma Naresh N, Du Y, Lamech LT, Yu J, Zhu LJ, Pukkila-Worley R, Haynes CM.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6146-6151. doi: 10.1073/pnas.1817259116. Epub 2019 Mar 8.


The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans.

Peterson ND, Cheesman HK, Liu P, Anderson SM, Foster KJ, Chhaya R, Perrat P, Thekkiniath J, Yang Q, Haynes CM, Pukkila-Worley R.

PLoS Genet. 2019 Jan 22;15(1):e1007935. doi: 10.1371/journal.pgen.1007935. eCollection 2019 Jan.


Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine.

Ding W, Higgins DP, Yadav DK, Godbole AA, Pukkila-Worley R, Walker AK.

PLoS Genet. 2018 Nov 28;14(11):e1007812. doi: 10.1371/journal.pgen.1007812. eCollection 2018 Nov.


Caenorhabditis elegans in high-throughput screens for anti-infective compounds.

Peterson ND, Pukkila-Worley R.

Curr Opin Immunol. 2018 Oct;54:59-65. doi: 10.1016/j.coi.2018.06.003. Epub 2018 Jun 20. Review.


Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans.

Pukkila-Worley R.

PLoS Pathog. 2016 Sep 15;12(9):e1005795. doi: 10.1371/journal.ppat.1005795. eCollection 2016 Sep. Review. No abstract available.


Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans.

Cheesman HK, Feinbaum RL, Thekkiniath J, Dowen RH, Conery AL, Pukkila-Worley R.

G3 (Bethesda). 2016 Jan 27;6(3):541-9. doi: 10.1534/g3.115.025650.


Case 28-2014: A man with a rash, headache, fever, nausea, and photophobia.

Pukkila-Worley R.

N Engl J Med. 2014 Dec 4;371(23):2239. doi: 10.1056/NEJMc1412237. No abstract available.


Case records of the Massachusetts General Hospital. Case 28-2014. A 39-year-old man with a rash, headache, fever, nausea, and photophobia.

Pukkila-Worley R, Nardi V, Branda JA.

N Engl J Med. 2014 Sep 11;371(11):1051-60. doi: 10.1056/NEJMcpc1405886. No abstract available.


The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification.

Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM.

PLoS Pathog. 2014 May 29;10(5):e1004143. doi: 10.1371/journal.ppat.1004143. eCollection 2014 May.


The role of Candida albicans SPT20 in filamentation, biofilm formation and pathogenesis.

Tan X, Fuchs BB, Wang Y, Chen W, Yuen GJ, Chen RB, Jayamani E, Anastassopoulou C, Pukkila-Worley R, Coleman JJ, Mylonakis E.

PLoS One. 2014 Apr 14;9(4):e94468. doi: 10.1371/journal.pone.0094468. eCollection 2014.


Treatment of listeriosis in first trimester of pregnancy.

Chan BT, Hohmann E, Barshak MB, Pukkila-Worley R.

Emerg Infect Dis. 2013 May;19(5):839-41. doi: 10.3201/eid1905.121397. No abstract available.


Physiologic expression of the Candida albicans pescadillo homolog is required for virulence in a murine model of hematogenously disseminated candidiasis.

Uppuluri P, Chaturvedi AK, Jani N, Pukkila-Worley R, Monteagudo C, Mylonakis E, Köhler JR, Lopez Ribot JL.

Eukaryot Cell. 2012 Dec;11(12):1552-6. doi: 10.1128/EC.00171-12. Epub 2012 Oct 26.


Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection.

Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM.

PLoS Genet. 2012;8(6):e1002733. doi: 10.1371/journal.pgen.1002733. Epub 2012 Jun 14.


Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium.

Pukkila-Worley R, Ausubel FM.

Curr Opin Immunol. 2012 Feb;24(1):3-9. doi: 10.1016/j.coi.2011.10.004. Epub 2012 Jan 9. Review.


Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses.

Pukkila-Worley R, Ausubel FM, Mylonakis E.

PLoS Pathog. 2011 Jun;7(6):e1002074. doi: 10.1371/journal.ppat.1002074. Epub 2011 Jun 23.


From the outside in and the inside out: Antifungal immune responses in Caenorhabditis elegans.

Pukkila-Worley R, Mylonakis E.

Virulence. 2010 May-Jun;1(3):111-2. doi: 10.4161/viru.1.3.11746. No abstract available.


Association of low birth weight and placental malarial infection in Nigeria.

Aribodor DN, Nwaorgu OC, Eneanya CI, Okoli I, Pukkila-Worley R, Etaga HO.

J Infect Dev Ctries. 2009 Sep 15;3(8):620-3.


Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model.

Pukkila-Worley R, Peleg AY, Tampakakis E, Mylonakis E.

Eukaryot Cell. 2009 Nov;8(11):1750-8. doi: 10.1128/EC.00163-09. Epub 2009 Aug 7.


Antifungal drug discovery through the study of invertebrate model hosts.

Pukkila-Worley R, Holson E, Wagner F, Mylonakis E.

Curr Med Chem. 2009;16(13):1588-95. Review.


Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36.

Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J.

J Exp Med. 2009 Mar 16;206(3):637-53. doi: 10.1084/jem.20082109. Epub 2009 Feb 23.


Epidemiology and management of cryptococcal meningitis: developments and challenges.

Pukkila-Worley R, Mylonakis E.

Expert Opin Pharmacother. 2008 Mar;9(4):551-60. doi: 10.1517/14656566.9.4.551. Review.


Chromosomal translocation and segmental duplication in Cryptococcus neoformans.

Fraser JA, Huang JC, Pukkila-Worley R, Alspaugh JA, Mitchell TG, Heitman J.

Eukaryot Cell. 2005 Feb;4(2):401-6.


Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade.

Pukkila-Worley R, Gerrald QD, Kraus PR, Boily MJ, Davis MJ, Giles SS, Cox GM, Heitman J, Alspaugh JA.

Eukaryot Cell. 2005 Jan;4(1):190-201.


Cyclic AMP signaling in Cryptococcus neoformans.

Pukkila-Worley R, Alspaugh JA.

FEMS Yeast Res. 2004 Jan;4(4-5):361-7. Review.


Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.

Alspaugh JA, Pukkila-Worley R, Harashima T, Cavallo LM, Funnell D, Cox GM, Perfect JR, Kronstad JW, Heitman J.

Eukaryot Cell. 2002 Feb;1(1):75-84.

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