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60/30: 60% of the Morbidity-Associated Multiple Sclerosis Disease Burden Comes From the 30% of Persons With Higher Impairments.

Kaufmann M, Puhan MA, Salmen A, Kamm CP, Manjaly ZM, Calabrese P, Schippling S, Müller S, Kuhle J, Pot C, Gobbi C, Steinemann N, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).

Front Neurol. 2020 Mar 6;11:156. doi: 10.3389/fneur.2020.00156. eCollection 2020.


Preferences for Sun Protection With a Self-Monitoring App: Protocol of a Discrete Choice Experiment Study.

Nittas V, Mütsch M, Puhan MA.

JMIR Res Protoc. 2020 Feb 8;9(2):e16087. doi: 10.2196/16087.


The role of causal inference in health services research I: tasks in health services research.

Moser A, Puhan MA, Zwahlen M.

Int J Public Health. 2020 Mar;65(2):227-230. doi: 10.1007/s00038-020-01333-2. Epub 2020 Feb 12. No abstract available.


The role of causal inference in health services research II: a framework for causal inference.

Moser A, Puhan MA, Zwahlen M.

Int J Public Health. 2020 Feb 12. doi: 10.1007/s00038-020-01334-1. [Epub ahead of print] No abstract available.


Increase in Airway Obstruction between 1993 and 2012 in Switzerland: An Observational Study.

West EA, Strassmann A, Wang C, Turk A, De Hoogh K, Röösli M, Bopp M, Buist AS, Dressel H, Puhan MA; SNC Study Group.

Ann Am Thorac Soc. 2020 Jan 28. doi: 10.1513/AnnalsATS.201907-542OC. [Epub ahead of print]


Adverse Drug Reaction Risk Measures: A Comparison of Estimates from Drug Surveillance and Randomised Trials.

Beau-Lejdstrom R, Crook S, Spanu A, Yu T, Puhan MA.

Pharmaceut Med. 2019 Aug;33(4):331-339. doi: 10.1007/s40290-019-00287-y.


Outcome preferences of older people with multiple chronic conditions and hypertension: a cross-sectional survey using best-worst scaling.

Aschmann HE, Puhan MA, Robbins CW, Bayliss EA, Chan WV, Mularski RA, Wilson RF, Bennett WL, Sheehan OC, Yu T, Yebyo HG, Leff B, Tabano H, Armacost K, Glover C, Maslow K, Mintz S, Boyd CM.

Health Qual Life Outcomes. 2019 Dec 19;17(1):186. doi: 10.1186/s12955-019-1250-6.


ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases.

Radtke T, Crook S, Kaltsakas G, Louvaris Z, Berton D, Urquhart DS, Kampouras A, Rabinovich RA, Verges S, Kontopidis D, Boyd J, Tonia T, Langer D, De Brandt J, Goërtz YMJ, Burtin C, Spruit MA, Braeken DCW, Dacha S, Franssen FME, Laveneziana P, Eber E, Troosters T, Neder JA, Puhan MA, Casaburi R, Vogiatzis I, Hebestreit H.

Eur Respir Rev. 2019 Dec 18;28(154). pii: 180101. doi: 10.1183/16000617.0101-2018. Print 2019 Dec 31. Review.


Procedural Surgical RCTs in Daily Practice: Do Surgeons Adopt Or Is It Just a Waste of Time?

Oberkofler CE, Hamming JF, Staiger RD, Brosi P, Biondo S, Farges O, Legemate DA, Morino M, Pinna AD, Pinto-Marques H, Reynolds JV, Campos RR, Rogiers X, Soreide K, Puhan MA, Clavien PA, Rinkes IB.

Ann Surg. 2019 Nov;270(5):727-734. doi: 10.1097/SLA.0000000000003546.


Interventions to improve children's access to mental health care: a systematic review and meta-analysis.

Werlen L, Gjukaj D, Mohler-Kuo M, Puhan MA.

Epidemiol Psychiatr Sci. 2019 Oct 17;29:e58. doi: 10.1017/S2045796019000544.


Electronic Patient-Generated Health Data to Facilitate Disease Prevention and Health Promotion: Scoping Review.

Nittas V, Lun P, Ehrler F, Puhan MA, Mütsch M.

J Med Internet Res. 2019 Oct 14;21(10):e13320. doi: 10.2196/13320. Review.


Net benefit of statins for primary prevention of cardiovascular disease in people 75 years or older: a benefit-harm balance modeling study.

Yebyo HG, Aschmann HE, Menges D, Boyd CM, Puhan MA.

Ther Adv Chronic Dis. 2019 Sep 25;10:2040622319877745. doi: 10.1177/2040622319877745. eCollection 2019.


Factors influencing patient satisfaction with the first diagnostic consultation in multiple sclerosis: a Swiss Multiple Sclerosis Registry (SMSR) study.

Kamm CP, Barin L, Gobbi C, Pot C, Calabrese P, Salmen A, Achtnichts L, Kesselring J, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).

J Neurol. 2020 Jan;267(1):153-161. doi: 10.1007/s00415-019-09563-y. Epub 2019 Oct 8.


Defining Global Benchmarks in Bariatric Surgery: A Retrospective Multicenter Analysis of Minimally Invasive Roux-en-Y Gastric Bypass and Sleeve Gastrectomy.

Gero D, Raptis DA, Vleeschouwers W, van Veldhuisen SL, Martin AS, Xiao Y, Galvao M, Giorgi M, Benois M, Espinoza F, Hollyman M, Lloyd A, Hosa H, Schmidt H, Garcia-Galocha JL, van de Vrande S, Chiappetta S, Menzo EL, Aboud CM, Lüthy SG, Orchard P, Rothe S, Prager G, Pournaras DJ, Cohen R, Rosenthal R, Weiner R, Himpens J, Torres A, Higa K, Welbourn R, Berry M, Boza C, Iannelli A, Vithiananthan S, Ramos A, Olbers T, Sepúlveda M, Hazebroek EJ, Dillemans B, Staiger RD, Puhan MA, Peterli R, Bueter M.

Ann Surg. 2019 Nov;270(5):859-867. doi: 10.1097/SLA.0000000000003512.


A Framework for Estimating the Burden of Chronic Diseases: Design and Application in the Context of Multiple Sclerosis.

Kaufmann M, Puhan MA, Kuhle J, Yaldizli Ö, Magnusson T, Kamm CP, Calabrese P, von Wyl V.

Front Neurol. 2019 Sep 4;10:953. doi: 10.3389/fneur.2019.00953. eCollection 2019.


Chronic respiratory symptoms but normal lung function: substantial disease burden but little evidence to inform practice.

Puhan MA.

Eur Respir J. 2019 Sep 19;54(3). pii: 1901363. doi: 10.1183/13993003.01363-2019. Print 2019 Sep. No abstract available.


Balance of benefits and harms of different blood pressure targets in people with multiple chronic conditions: a quantitative benefit-harm assessment.

Aschmann HE, Boyd CM, Robbins CW, Mularski RA, Chan WV, Sheehan OC, Wilson RF, Bennett WL, Bayliss EA, Yu T, Leff B, Armacost K, Glover C, Maslow K, Mintz S, Puhan MA.

BMJ Open. 2019 Aug 30;9(8):e028438. doi: 10.1136/bmjopen-2018-028438.


How do patients enter the healthcare system after the first onset of multiple sclerosis symptoms? The influence of setting and physician specialty on speed of diagnosis.

Barin L, Kamm CP, Salmen A, Dressel H, Calabrese P, Pot C, Schippling S, Gobbi C, Müller S, Chan A, Rodgers S, Kaufmann M, Ajdacic-Gross V, Steinemann N, Kesselring J, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry.

Mult Scler. 2019 Jan 18:1352458518823955. doi: 10.1177/1352458518823955. [Epub ahead of print]


Characteristics of stakeholder involvement in systematic and rapid reviews: a methodological review in the area of health services research.

Feldmann J, Puhan MA, Mütsch M.

BMJ Open. 2019 Aug 15;9(8):e024587. doi: 10.1136/bmjopen-2018-024587.


Will the Swiss pavilion at Expo 2020 Dubai damage your health?

Künzli N, Puhan MA, Suggs LS.

Int J Public Health. 2019 Nov;64(8):1125-1126. doi: 10.1007/s00038-019-01286-1. Epub 2019 Jul 30. No abstract available.


Commonalities and differences in legal euthanasia and physician-assisted suicide in three countries: a population-level comparison.

Dierickx S, Onwuteaka-Philipsen B, Penders Y, Cohen J, van der Heide A, Puhan MA, Ziegler S, Bosshard G, Deliens L, Chambaere K.

Int J Public Health. 2020 Jan;65(1):65-73. doi: 10.1007/s00038-019-01281-6. Epub 2019 Jul 11.


Statins for Primary Prevention of Cardiovascular Disease.

Yebyo HG, Aschmann HE, Puhan MA.

Ann Intern Med. 2019 Jul 2;171(1):74-76. doi: 10.7326/L19-0262. No abstract available.


A benefit-harm analysis of adding basal insulin vs. sulfonylurea to metformin to manage type II diabetes mellitus in people with multiple chronic conditions.

Bennett WL, Aschmann HE, Puhan MA, Robbins CW, Bayliss EA, Wilson R, Mularski RA, Chan WV, Leff B, Sheehan O, Glover C, Maslow K, Armacost K, Mintz S, Boyd CM.

J Clin Epidemiol. 2019 Sep;113:92-100. doi: 10.1016/j.jclinepi.2019.03.014. Epub 2019 May 3.



Staiger RD, Puhan MA, Clavien PA.

Br J Surg. 2019 May;106(6):799-800. doi: 10.1002/bjs.11162. No abstract available.


A novel approach to increase physical activity in older adults in the community using citizen science: a mixed-methods study.

Frei A, Dalla Lana K, Radtke T, Stone E, Knöpfli N, Puhan MA.

Int J Public Health. 2019 Jun;64(5):669-678. doi: 10.1007/s00038-019-01230-3. Epub 2019 Apr 1.


External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study.

Almagro P, Martínez-Camblor P, Miravitlles M, Rodríguez-Carballeira M, Navarro A, Lamprecht B, Ramirez-Garcia Luna AS, Kaiser B, Alfageme I, Casanova C, Esteban C, Soler-Cataluña JJ, de-Torres JP, Celli BR, Marin JM, Ter Riet G, Sobradillo P, Lange P, Garcia-Aymerich J, Anto JM, Turner AM, Han MK, Langhammer A, Sternberg A, Leivseth L, Bakke P, Johannessen A, Oga T, Cosío B, Ancochea J, Echazarreta A, Roche N, Burgel PR, Sin DD, Puhan MA, Soriano JB; 3CIA collaboration.

COPD. 2019 Feb;16(1):8-17. doi: 10.1080/15412555.2018.1484440. Epub 2019 Mar 14.


Benchmarks in Pancreatic Surgery: A Novel Tool for Unbiased Outcome Comparisons.

Sánchez-Velázquez P, Muller X, Malleo G, Park JS, Hwang HK, Napoli N, Javed AA, Inoue Y, Beghdadi N, Kalisvaart M, Vigia E, Walsh CD, Lovasik B, Busquets J, Scandavini C, Robin F, Yoshitomi H, Mackay TM, Busch OR, Hartog H, Heinrich S, Gleisner A, Perinel J, Passeri M, Lluis N, Raptis DA, Tschuor C, Oberkofler CE, DeOliveira ML, Petrowsky H, Martinie J, Asbun H, Adham M, Schulick R, Lang H, Koerkamp BG, Besselink MG, Han HS, Miyazaki M, Ferrone CR, Fernández-Del Castillo C, Lillemoe KD, Sulpice L, Boudjema K, Del Chiaro M, Fabregat J, Kooby DA, Allen P, Lavu H, Yeo CJ, Barroso E, Roberts K, Muiesan P, Sauvanet A, Saiura A, Wolfgang CL, Cameron JL, Boggi U, Yoon DS, Bassi C, Puhan MA, Clavien PA.

Ann Surg. 2019 Aug;270(2):211-218. doi: 10.1097/SLA.0000000000003223.


Chronic obstructive pulmonary disease (COPD) among opioid-dependent patients in agonist treatment. A diagnostic study.

Grischott T, Falcato L, Senn O, Puhan MA, Bruggmann P.

Addiction. 2019 May;114(5):868-876. doi: 10.1111/add.14559. Epub 2019 Mar 10.


Prevalence of nocturnal cough in asthma and its potential as a marker for asthma control (MAC) in combination with sleep quality: protocol of a smartphone-based, multicentre, longitudinal observational study with two stages.

Tinschert P, Rassouli F, Barata F, Steurer-Stey C, Fleisch E, Puhan MA, Brutsche M, Kowatsch T.

BMJ Open. 2019 Jan 7;9(1):e026323. doi: 10.1136/bmjopen-2018-026323.


Editorial comment: different perspectives on severity of postoperative morbidity.

Staiger RD, Puhan MA, Clavien PA.

Langenbecks Arch Surg. 2018 Dec;403(8):1029-1030. doi: 10.1007/s00423-018-1738-2. Epub 2019 Jan 3. No abstract available.


Factors associated with time from first-symptoms to diagnosis and treatment initiation of Multiple Sclerosis in Switzerland.

Kaufmann M, Kuhle J, Puhan MA, Kamm CP, Chan A, Salmen A, Kesselring J, Calabrese P, Gobbi C, Pot C, Steinemann N, Rodgers S, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).

Mult Scler J Exp Transl Clin. 2018 Dec 6;4(4):2055217318814562. doi: 10.1177/2055217318814562. eCollection 2018 Oct-Dec.


Patterns of care for Multiple Sclerosis in a setting of universal care access: A cross-sectional study.

Barin L, Kaufmann M, Salmen A, Kamm CP, Gobbi C, Kuhle J, Pot C, Chan A, Czaplinski A, Ajdacic-Gross V, Rodgers S, Kesselring J, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry.

Mult Scler Relat Disord. 2019 Feb;28:17-25. doi: 10.1016/j.msard.2018.11.033. Epub 2018 Dec 2.


Finding the Balance Between Benefits and Harms When Using Statins for Primary Prevention of Cardiovascular Disease: A Modeling Study.

Yebyo HG, Aschmann HE, Puhan MA.

Ann Intern Med. 2019 Jan 1;170(1):1-10. doi: 10.7326/M18-1279. Epub 2018 Dec 4.


Using sedative substances until death: A mortality follow-back study on the role of healthcare settings.

Ziegler S, Schmid M, Bopp M, Bosshard G, Puhan MA.

Palliat Med. 2019 Feb;33(2):213-220. doi: 10.1177/0269216318815799. Epub 2018 Dec 5. No abstract available.


Improving surgical outcomes through benchmarking.

Staiger RD, Schwandt H, Puhan MA, Clavien PA.

Br J Surg. 2019 Jan;106(1):59-64. doi: 10.1002/bjs.10976. Epub 2018 Nov 28.


Antibiotics for exacerbations of chronic obstructive pulmonary disease.

Vollenweider DJ, Frei A, Steurer-Stey CA, Garcia-Aymerich J, Puhan MA.

Cochrane Database Syst Rev. 2018 Oct 29;10:CD010257. doi: 10.1002/14651858.CD010257.pub2.


The Comprehensive Complication Index (CCI®) is a Novel Cost Assessment Tool for Surgical Procedures.

Staiger RD, Cimino M, Javed A, Biondo S, Fondevila C, Périnel J, Aragão AC, Torzilli G, Wolfgang C, Adham M, Pinto-Marques H, Dutkowski P, Puhan MA, Clavien PA.

Ann Surg. 2018 Nov;268(5):784-791. doi: 10.1097/SLA.0000000000002902.


Physician-related determinants of medical end-of-life decisions - A mortality follow-back study in Switzerland.

Bopp M, Penders YWH, Hurst SA, Bosshard G, Puhan MA; Swiss End-of-Life Decisions Study Group.

PLoS One. 2018 Sep 20;13(9):e0203960. doi: 10.1371/journal.pone.0203960. eCollection 2018.


The association between daily exacerbation symptoms and physical activity in patients with chronic obstructive pulmonary disease.

Crook S, Büsching G, Keusch S, Wieser S, Turk A, Frey M, Puhan MA, Frei A.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 18;13:2199-2206. doi: 10.2147/COPD.S156986. eCollection 2018.


Does the DOSPERT scale predict risk-taking behaviour during travel? A study using smartphones.

Farnham A, Ziegler S, Blanke U, Stone E, Hatz C, Puhan MA.

J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay064.


The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research.

Steinemann N, Kuhle J, Calabrese P, Kesselring J, Disanto G, Merkler D, Pot C, Ajdacic-Gross V, Rodgers S, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry.

BMC Neurol. 2018 Aug 13;18(1):111. doi: 10.1186/s12883-018-1118-0.


Minimum important difference of the Epworth Sleepiness Scale in obstructive sleep apnoea: estimation from three randomised controlled trials.

Crook S, Sievi NA, Bloch KE, Stradling JR, Frei A, Puhan MA, Kohler M.

Thorax. 2019 Apr;74(4):390-396. doi: 10.1136/thoraxjnl-2018-211959. Epub 2018 Aug 12.


Electronic patient-generated health data to facilitate prevention and health promotion: a scoping review protocol.

Nittas V, Mütsch M, Ehrler F, Puhan MA.

BMJ Open. 2018 Aug 10;8(8):e021245. doi: 10.1136/bmjopen-2017-021245.


The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model.

Ramon MA, Ter Riet G, Carsin AE, Gimeno-Santos E, Agustí A, Antó JM, Donaire-Gonzalez D, Ferrer J, Rodríguez E, Rodriguez-Roisin R, Puhan MA, Garcia-Aymerich J; PAC-COPD Study Group.

Eur Respir J. 2018 Sep 15;52(3). pii: 1800079. doi: 10.1183/13993003.00079-2018. Print 2018 Sep.


The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most?

Barin L, Salmen A, Disanto G, Babačić H, Calabrese P, Chan A, Kamm CP, Kesselring J, Kuhle J, Gobbi C, Pot C, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).

Mult Scler Relat Disord. 2018 Oct;25:112-121. doi: 10.1016/j.msard.2018.07.013. Epub 2018 Jul 21.


Meta-analysis of surgical strategies in perforated left colonic diverticulitis with generalized peritonitis.

Schmidt S, Ismail T, Puhan MA, Soll C, Breitenstein S.

Langenbecks Arch Surg. 2018 Jun;403(4):425-433. doi: 10.1007/s00423-018-1686-x. Epub 2018 Jun 9. Review.


Cost-effectiveness of low-dose CT screening for lung cancer in a European country with high prevalence of smoking-A modelling study.

Tomonaga Y, Ten Haaf K, Frauenfelder T, Kohler M, Kouyos RD, Shilaih M, Lorez M, de Koning HJ, Schwenkglenks M, Puhan MA.

Lung Cancer. 2018 Jul;121:61-69. doi: 10.1016/j.lungcan.2018.05.008. Epub 2018 May 26.


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