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Balance of benefits and harms of different blood pressure targets in people with multiple chronic conditions: a quantitative benefit-harm assessment.

Aschmann HE, Boyd CM, Robbins CW, Mularski RA, Chan WV, Sheehan OC, Wilson RF, Bennett WL, Bayliss EA, Yu T, Leff B, Armacost K, Glover C, Maslow K, Mintz S, Puhan MA.

BMJ Open. 2019 Aug 30;9(8):e028438. doi: 10.1136/bmjopen-2018-028438.


How do patients enter the healthcare system after the first onset of multiple sclerosis symptoms? The influence of setting and physician specialty on speed of diagnosis.

Barin L, Kamm CP, Salmen A, Dressel H, Calabrese P, Pot C, Schippling S, Gobbi C, Müller S, Chan A, Rodgers S, Kaufmann M, Ajdacic-Gross V, Steinemann N, Kesselring J, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry.

Mult Scler. 2019 Jan 18:1352458518823955. doi: 10.1177/1352458518823955. [Epub ahead of print]


Characteristics of stakeholder involvement in systematic and rapid reviews: a methodological review in the area of health services research.

Feldmann J, Puhan MA, Mütsch M.

BMJ Open. 2019 Aug 15;9(8):e024587. doi: 10.1136/bmjopen-2018-024587.


Predicting Fine-Scale Daily NO2 for 2005-2016 Incorporating OMI Satellite Data Across Switzerland.

de Hoogh K, Saucy A, Shtein A, Schwartz J, West EA, Strassmann A, Puhan M, Röösli M, Stafoggia M, Kloog I.

Environ Sci Technol. 2019 Sep 3;53(17):10279-10287. doi: 10.1021/acs.est.9b03107. Epub 2019 Aug 15.


Will the Swiss pavilion at Expo 2020 Dubai damage your health?

Künzli N, Puhan MA, Suggs LS.

Int J Public Health. 2019 Jul 30. doi: 10.1007/s00038-019-01286-1. [Epub ahead of print] No abstract available.


Commonalities and differences in legal euthanasia and physician-assisted suicide in three countries: a population-level comparison.

Dierickx S, Onwuteaka-Philipsen B, Penders Y, Cohen J, van der Heide A, Puhan MA, Ziegler S, Bosshard G, Deliens L, Chambaere K.

Int J Public Health. 2019 Jul 11. doi: 10.1007/s00038-019-01281-6. [Epub ahead of print]


Statins for Primary Prevention of Cardiovascular Disease.

Yebyo HG, Aschmann HE, Puhan MA.

Ann Intern Med. 2019 Jul 2;171(1):74-76. doi: 10.7326/L19-0262. No abstract available.


A benefit-harm analysis of adding basal insulin vs. sulfonylurea to metformin to manage type II diabetes mellitus in people with multiple chronic conditions.

Bennett WL, Aschmann HE, Puhan MA, Robbins CW, Bayliss EA, Wilson R, Mularski RA, Chan WV, Leff B, Sheehan O, Glover C, Maslow K, Armacost K, Mintz S, Boyd CM.

J Clin Epidemiol. 2019 Sep;113:92-100. doi: 10.1016/j.jclinepi.2019.03.014. Epub 2019 May 3.



Staiger RD, Puhan MA, Clavien PA.

Br J Surg. 2019 May;106(6):799-800. doi: 10.1002/bjs.11162. No abstract available.


A novel approach to increase physical activity in older adults in the community using citizen science: a mixed-methods study.

Frei A, Dalla Lana K, Radtke T, Stone E, Knöpfli N, Puhan MA.

Int J Public Health. 2019 Jun;64(5):669-678. doi: 10.1007/s00038-019-01230-3. Epub 2019 Apr 1.


External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study.

Almagro P, Martínez-Camblor P, Miravitlles M, Rodríguez-Carballeira M, Navarro A, Lamprecht B, Ramirez-Garcia Luna AS, Kaiser B, Alfageme I, Casanova C, Esteban C, Soler-Cataluña JJ, de-Torres JP, Celli BR, Marin JM, Ter Riet G, Sobradillo P, Lange P, Garcia-Aymerich J, Anto JM, Turner AM, Han MK, Langhammer A, Sternberg A, Leivseth L, Bakke P, Johannessen A, Oga T, Cosío B, Ancochea J, Echazarreta A, Roche N, Burgel PR, Sin DD, Puhan MA, Soriano JB; 3CIA collaboration.

COPD. 2019 Feb;16(1):8-17. doi: 10.1080/15412555.2018.1484440. Epub 2019 Mar 14.


COPD's early origins in low-and-middle income countries: what are the implications of a false start?

Brakema EA, van Gemert FA, van der Kleij RMJJ, Salvi S, Puhan M, Chavannes NH; FRESH AIR collaborators.

NPJ Prim Care Respir Med. 2019 Mar 5;29(1):6. doi: 10.1038/s41533-019-0117-y. No abstract available.


Benchmarks in Pancreatic Surgery: A Novel Tool for Unbiased Outcome Comparisons.

Sánchez-Velázquez P, Muller X, Malleo G, Park JS, Hwang HK, Napoli N, Javed AA, Inoue Y, Beghdadi N, Kalisvaart M, Vigia E, Walsh CD, Lovasik B, Busquets J, Scandavini C, Robin F, Yoshitomi H, Mackay TM, Busch OR, Hartog H, Heinrich S, Gleisner A, Perinel J, Passeri M, Lluis N, Raptis DA, Tschuor C, Oberkofler CE, DeOliveira ML, Petrowsky H, Martinie J, Asbun H, Adham M, Schulick R, Lang H, Koerkamp BG, Besselink MG, Han HS, Miyazaki M, Ferrone CR, Fernández-Del Castillo C, Lillemoe KD, Sulpice L, Boudjema K, Del Chiaro M, Fabregat J, Kooby DA, Allen P, Lavu H, Yeo CJ, Barroso E, Roberts K, Muiesan P, Sauvanet A, Saiura A, Wolfgang CL, Cameron JL, Boggi U, Yoon DS, Bassi C, Puhan MA, Clavien PA.

Ann Surg. 2019 Aug;270(2):211-218. doi: 10.1097/SLA.0000000000003223.


Mortality with antidepressants after acute MI: Antidepressant use after acute myocardial infarction (MI) is associated with an increased mortality 1 year after discharge from Swiss hospitals.

Witassek F, Radovanovic D, Erne P, Puhan M, Rickli H, Fehr N.

Eur Heart J. 2019 Feb 1;40(5):410. doi: 10.1093/eurheartj/ehy867. No abstract available.


Antidepressant prescription in acute myocardial infarction is associated with increased mortality 1 year after discharge.

Fehr N, Witassek F, Radovanovic D, Erne P, Puhan M, Rickli H.

Eur J Intern Med. 2019 Mar;61:75-80. doi: 10.1016/j.ejim.2018.12.003. Epub 2019 Jan 28.


Chronic obstructive pulmonary disease (COPD) among opioid-dependent patients in agonist treatment. A diagnostic study.

Grischott T, Falcato L, Senn O, Puhan MA, Bruggmann P.

Addiction. 2019 Jan 24. doi: 10.1111/add.14559. [Epub ahead of print]


Prevalence of nocturnal cough in asthma and its potential as a marker for asthma control (MAC) in combination with sleep quality: protocol of a smartphone-based, multicentre, longitudinal observational study with two stages.

Tinschert P, Rassouli F, Barata F, Steurer-Stey C, Fleisch E, Puhan MA, Brutsche M, Kowatsch T.

BMJ Open. 2019 Jan 7;9(1):e026323. doi: 10.1136/bmjopen-2018-026323.


Editorial comment: different perspectives on severity of postoperative morbidity.

Staiger RD, Puhan MA, Clavien PA.

Langenbecks Arch Surg. 2018 Dec;403(8):1029-1030. doi: 10.1007/s00423-018-1738-2. Epub 2019 Jan 3. No abstract available.


Factors associated with time from first-symptoms to diagnosis and treatment initiation of Multiple Sclerosis in Switzerland.

Kaufmann M, Kuhle J, Puhan MA, Kamm CP, Chan A, Salmen A, Kesselring J, Calabrese P, Gobbi C, Pot C, Steinemann N, Rodgers S, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).

Mult Scler J Exp Transl Clin. 2018 Dec 6;4(4):2055217318814562. doi: 10.1177/2055217318814562. eCollection 2018 Oct-Dec.


Patterns of care for Multiple Sclerosis in a setting of universal care access: A cross-sectional study.

Barin L, Kaufmann M, Salmen A, Kamm CP, Gobbi C, Kuhle J, Pot C, Chan A, Czaplinski A, Ajdacic-Gross V, Rodgers S, Kesselring J, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry.

Mult Scler Relat Disord. 2019 Feb;28:17-25. doi: 10.1016/j.msard.2018.11.033. Epub 2018 Dec 2.


Finding the Balance Between Benefits and Harms When Using Statins for Primary Prevention of Cardiovascular Disease: A Modeling Study.

Yebyo HG, Aschmann HE, Puhan MA.

Ann Intern Med. 2019 Jan 1;170(1):1-10. doi: 10.7326/M18-1279. Epub 2018 Dec 4.


Using sedative substances until death: A mortality follow-back study on the role of healthcare settings.

Ziegler S, Schmid M, Bopp M, Bosshard G, Puhan MA.

Palliat Med. 2019 Feb;33(2):213-220. doi: 10.1177/0269216318815799. Epub 2018 Dec 5. No abstract available.


Improving surgical outcomes through benchmarking.

Staiger RD, Schwandt H, Puhan MA, Clavien PA.

Br J Surg. 2019 Jan;106(1):59-64. doi: 10.1002/bjs.10976. Epub 2018 Nov 28.


Antibiotics for exacerbations of chronic obstructive pulmonary disease.

Vollenweider DJ, Frei A, Steurer-Stey CA, Garcia-Aymerich J, Puhan MA.

Cochrane Database Syst Rev. 2018 Oct 29;10:CD010257. doi: 10.1002/14651858.CD010257.pub2.


Considerations for ethics review of big data health research: A scoping review.

Ienca M, Ferretti A, Hurst S, Puhan M, Lovis C, Vayena E.

PLoS One. 2018 Oct 11;13(10):e0204937. doi: 10.1371/journal.pone.0204937. eCollection 2018. Review.


The Comprehensive Complication Index (CCI®) is a Novel Cost Assessment Tool for Surgical Procedures.

Staiger RD, Cimino M, Javed A, Biondo S, Fondevila C, Périnel J, Aragão AC, Torzilli G, Wolfgang C, Adham M, Pinto-Marques H, Dutkowski P, Puhan MA, Clavien PA.

Ann Surg. 2018 Nov;268(5):784-791. doi: 10.1097/SLA.0000000000002902.


Physician-related determinants of medical end-of-life decisions - A mortality follow-back study in Switzerland.

Bopp M, Penders YWH, Hurst SA, Bosshard G, Puhan MA; Swiss End-of-Life Decisions Study Group.

PLoS One. 2018 Sep 20;13(9):e0203960. doi: 10.1371/journal.pone.0203960. eCollection 2018.


The association between daily exacerbation symptoms and physical activity in patients with chronic obstructive pulmonary disease.

Crook S, Büsching G, Keusch S, Wieser S, Turk A, Frey M, Puhan MA, Frei A.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 18;13:2199-2206. doi: 10.2147/COPD.S156986. eCollection 2018.


Does the DOSPERT scale predict risk-taking behaviour during travel? A study using smartphones.

Farnham A, Ziegler S, Blanke U, Stone E, Hatz C, Puhan MA.

J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay064.


The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research.

Steinemann N, Kuhle J, Calabrese P, Kesselring J, Disanto G, Merkler D, Pot C, Ajdacic-Gross V, Rodgers S, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry.

BMC Neurol. 2018 Aug 13;18(1):111. doi: 10.1186/s12883-018-1118-0.


Minimum important difference of the Epworth Sleepiness Scale in obstructive sleep apnoea: estimation from three randomised controlled trials.

Crook S, Sievi NA, Bloch KE, Stradling JR, Frei A, Puhan MA, Kohler M.

Thorax. 2019 Apr;74(4):390-396. doi: 10.1136/thoraxjnl-2018-211959. Epub 2018 Aug 12.


Electronic patient-generated health data to facilitate prevention and health promotion: a scoping review protocol.

Nittas V, Mütsch M, Ehrler F, Puhan MA.

BMJ Open. 2018 Aug 10;8(8):e021245. doi: 10.1136/bmjopen-2017-021245.


The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model.

Ramon MA, Ter Riet G, Carsin AE, Gimeno-Santos E, Agustí A, Antó JM, Donaire-Gonzalez D, Ferrer J, Rodríguez E, Rodriguez-Roisin R, Puhan MA, Garcia-Aymerich J; PAC-COPD Study Group.

Eur Respir J. 2018 Sep 15;52(3). pii: 1800079. doi: 10.1183/13993003.00079-2018. Print 2018 Sep.


The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most?

Barin L, Salmen A, Disanto G, Babačić H, Calabrese P, Chan A, Kamm CP, Kesselring J, Kuhle J, Gobbi C, Pot C, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).

Mult Scler Relat Disord. 2018 Oct;25:112-121. doi: 10.1016/j.msard.2018.07.013. Epub 2018 Jul 21.


Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis.

Hovaguimian F, Tschopp C, Beck-Schimmer B, Puhan M.

Acta Anaesthesiol Scand. 2018 Oct;62(9):1182-1193. doi: 10.1111/aas.13168. Epub 2018 Jun 26. Review.


Meta-analysis of surgical strategies in perforated left colonic diverticulitis with generalized peritonitis.

Schmidt S, Ismail T, Puhan MA, Soll C, Breitenstein S.

Langenbecks Arch Surg. 2018 Jun;403(4):425-433. doi: 10.1007/s00423-018-1686-x. Epub 2018 Jun 9. Review.


Cost-effectiveness of low-dose CT screening for lung cancer in a European country with high prevalence of smoking-A modelling study.

Tomonaga Y, Ten Haaf K, Frauenfelder T, Kohler M, Kouyos RD, Shilaih M, Lorez M, de Koning HJ, Schwenkglenks M, Puhan MA.

Lung Cancer. 2018 Jul;121:61-69. doi: 10.1016/j.lungcan.2018.05.008. Epub 2018 May 26.


Chronic conditions and multimorbidity in a primary care population: a study in the Swiss Sentinel Surveillance Network (Sentinella).

Gnädinger M, Herzig L, Ceschi A, Conen D, Staehelin A, Zoller M, Puhan MA.

Int J Public Health. 2018 Dec;63(9):1017-1026. doi: 10.1007/s00038-018-1114-6. Epub 2018 May 21.


Corrigendum to "Advances in the GRADE approach to rate the certainty in estimates from a network meta-analysis" [J Clin Epidemiol 2018;93:36-44].

Brignardello-Petersen R, Bonner A, Alexander PE, Siemieniuk RA, Furukawa TA, Rochwerg B, Hazlewood GS, Alhazzani W, Mustafa RA, Murad MH, Puhan MA, Schünemann HJ, Guyatt GH; GRADE Working Group.

J Clin Epidemiol. 2018 Jun;98:162. doi: 10.1016/j.jclinepi.2018.04.013. No abstract available.


A digitally facilitated citizen-science driven approach accelerates participant recruitment and increases study population diversity.

Puhan MA, Steinemann N, Kamm CP, Müller S, Kuhle J, Kurmann R, Calabrese P, Kesselring J, von Wyl V, Swiss Multiple Sclerosis Registry Smsr.

Swiss Med Wkly. 2018 May 16;148:w14623. doi: 10.4414/smw.2018.14623. eCollection 2018.


Recommended outcome measures for inpatient rehabilitation of multiple sclerosis are not appropriate for the patients with substantially impaired mobility.

Barin L, Vaney C, Puhan MA, von Wyl V.

Mult Scler Relat Disord. 2018 May;22:108-114. doi: 10.1016/j.msard.2018.04.001. Epub 2018 Apr 4.


Variability of Very Low Birth Weight Infant Outcome and Practice in Swiss and US Neonatal Units.

Adams M, Bassler D, Bucher HU, Roth-Kleiner M, Berger TM, Braun J, Puhan MA, Edwards E, Soll R, Von Wyl V; Swiss Neonatal Network and the Vermont Oxford Network.

Pediatrics. 2018 May;141(5). pii: e20173436. doi: 10.1542/peds.2017-3436. Epub 2018 Apr 13.


A Clinical Patient Reporting Tool: Giving ADPKD Patients Back Their Data.

Abraham AG, Girardat-Rotar L, Ziegler S, Blum M, Galletti F, Puhan MA, Serra AL.

Praxis (Bern 1994). 2018 Apr;107(8):425-434. doi: 10.1024/1661-8157/a002946. No abstract available.


Secular trends in opportunistic infections, cancers and mortality in patients with AIDS during the era of modern combination antiretroviral therapy.

Sezgin E, Van Natta ML, Thorne JE, Puhan MA, Jabs DA; Longitudinal Studies of the Ocular Complications of AIDS (SOCA) Research Group.

HIV Med. 2018 Jul;19(6):411-419. doi: 10.1111/hiv.12609. Epub 2018 Mar 24.


Continuous Deep Sedation Until Death-a Swiss Death Certificate Study.

Ziegler S, Schmid M, Bopp M, Bosshard G, Puhan MA.

J Gen Intern Med. 2018 Jul;33(7):1052-1059. doi: 10.1007/s11606-018-4401-2. Epub 2018 Mar 20.


Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease.

Guerra B, Haile SR, Lamprecht B, Ramírez AS, Martinez-Camblor P, Kaiser B, Alfageme I, Almagro P, Casanova C, Esteban-González C, Soler-Cataluña JJ, de-Torres JP, Miravitlles M, Celli BR, Marin JM, Ter Riet G, Sobradillo P, Lange P, Garcia-Aymerich J, Antó JM, Turner AM, Han MK, Langhammer A, Leivseth L, Bakke P, Johannessen A, Oga T, Cosio B, Ancochea-Bermúdez J, Echazarreta A, Roche N, Burgel PR, Sin DD, Soriano JB, Puhan MA; 3CIA collaboration.

BMC Med. 2018 Mar 2;16(1):33. doi: 10.1186/s12916-018-1013-y.

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