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Reliability of frailty assessment in the critically ill: a multicentre prospective observational study.

Pugh RJ, Battle CE, Thorpe C, Lynch C, Williams JP, Campbell A, Subbe CP, Whitaker R, Szakmany T, Clegg AP, Lone NI.

Anaesthesia. 2019 Jun;74(6):758-764. doi: 10.1111/anae.14596. Epub 2019 Feb 21.


Transarterial chemoembolization in a patient with severe reactions to iodinated contrast: Successful treatment using gadolinium contrast with C-arm computed tomography.

Pugh R, Wessel B, Barve A, Vyleta MS.

Radiol Case Rep. 2018 Dec 4;14(3):299-303. doi: 10.1016/j.radcr.2018.11.011. eCollection 2019 Mar.


Red-flag sepsis and SOFA identifies different patient population at risk of sepsis-related deaths on the general ward.

Kopczynska M, Sharif B, Cleaver S, Spencer N, Kurani A, Lee C, Davis J, Durie C, Joseph-Gubral J, Sharma A, Allen L, Atkins B, Gordon A, Jones L, Noble A, Bradley M, Atkinson H, Inns J, Penney H, Gilbert C, Walford R, Pike L, Edwards R, Howcroft R, Preston H, Gee J, Doyle N, Maden C, Smith C, Azis NSN, Vadivale N, Battle C, Lyons R, Morgan P, Pugh R, Szakmany T; Welsh Digital Data Collection Platform Collaborators.

Medicine (Baltimore). 2018 Dec;97(49):e13238. doi: 10.1097/MD.0000000000013238.


Incidence and risk factors for alopecia in survivors of critical illness: A multi-centre observational study.

Battle CE, Lynch C, Thorpe C, Biggs S, Grobbelaar K, Morgan A, Roberts S, Thornton E, Hobrok M, Pugh R.

J Crit Care. 2019 Apr;50:31-35. doi: 10.1016/j.jcrc.2018.11.015. Epub 2018 Nov 16.


Risk Factors for 1-Year Mortality and Hospital Utilization Patterns in Critical Care Survivors: A Retrospective, Observational, Population-Based Data Linkage Study.

Szakmany T, Walters AM, Pugh R, Battle C, Berridge DM, Lyons RA.

Crit Care Med. 2019 Jan;47(1):15-22. doi: 10.1097/CCM.0000000000003424.


Iliac bone biopsy complicated by hematoma: Hemostasis achieved with glue injection.

Pugh R, Wessel B, Zuberi OS, Vyleta MS.

Radiol Case Rep. 2018 Sep 13;13(6):1112-1115. doi: 10.1016/j.radcr.2018.08.005. eCollection 2018 Dec.


Experimental Technique to Study the Interaction Between a Bubble and the Particle-Laden Interface.

Yang X, Mayer A, Bournival G, Pugh R, Ata S.

Front Chem. 2018 Aug 14;6:348. doi: 10.3389/fchem.2018.00348. eCollection 2018. Erratum in: Front Chem. 2018 Oct 09;6:474.


Feasibility and reliability of frailty assessment in the critically ill: a systematic review.

Pugh RJ, Ellison A, Pye K, Subbe CP, Thorpe CM, Lone NI, Clegg A.

Crit Care. 2018 Feb 26;22(1):49. doi: 10.1186/s13054-018-1953-9. Review.


Feasibility of using the National Marine Mammal Tissue Bank for retrospective exploratory studies of perfluorinated alkyl acids.

Lynch JM, Ragland JM, Reagen WK, Wolf ST, Malinsky MD, Ellisor MB, Moors AJ, Pugh RS, Reiner JL.

Sci Total Environ. 2018 May 15;624:781-789. doi: 10.1016/j.scitotenv.2017.11.299. Epub 2017 Dec 27.


The Baby Boom and later life: is critical care fit for the future?

Pugh R, Subbe CP, Thorpe C, Szakmany T.

Anaesthesiol Intensive Ther. 2017;49(5):441-444. doi: 10.5603/AIT.a2017.0078. Epub 2017 Nov 24. Review.


Defining sepsis on the wards: results of a multi-centre point-prevalence study comparing two sepsis definitions.

Szakmany T, Pugh R, Kopczynska M, Lundin RM, Sharif B, Morgan P, Ellis G, Abreu J, Kulikouskaya S, Bashir K, Galloway L, Al-Hassan H, Grother T, McNulty P, Seal ST, Cains A, Vreugdenhil M, Abdimalik M, Dennehey N, Evans G, Whitaker J, Beasant E, Hall C, Lazarou M, Vanderpump CV, Harding K, Duffy L, Guerrier Sadler A, Keeling R, Banks C, Ng SWY, Heng SY, Thomas D, Puw EW, Otahal I, Battle C, Minik O, Lyons RA, Hall JE; Welsh Digital Data Collection Platform collaborators.

Anaesthesia. 2018 Feb;73(2):195-204. doi: 10.1111/anae.14062. Epub 2017 Nov 17.


Ventilator-associated events … perhaps not the answer.

Pugh R, Harrison W, Battle C, Hancock C, Szakmany T.

J Intensive Care Soc. 2017 Aug;18(3):263-264. doi: 10.1177/1751143717694917. Epub 2017 Jul 24. No abstract available.


A multicentre prospective evaluation of alcohol-related admissions to intensive care units in Wales.

Lynch C, Pugh R, Battle C; Welsh Intensive Care Society Audit and Research Group (WICSARG).

J Intensive Care Soc. 2017 Aug;18(3):193-197. doi: 10.1177/1751143717698977. Epub 2017 Mar 21.


Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.

J Lipid Res. 2017 Dec;58(12):2275-2288. doi: 10.1194/jlr.M079012. Epub 2017 Oct 6.


A critical age: can we reliably measure frailty in critical care?

Pugh RJ, Thorpe CM, Subbe CP.

Crit Care. 2017 May 31;21(1):121. doi: 10.1186/s13054-017-1704-3. No abstract available.


An innovative solution to raise public awareness using a mobile colorectal clinic - The 'bowel bus'.

Naguib N, Lewis M, Iredale R, Pugh R, Haray PN.

Int J Surg. 2017 Mar;39:188-191. doi: 10.1016/j.ijsu.2017.01.107. Epub 2017 Feb 2.


Is HELICS the Right Way? Lack of Chest Radiography Limits Ventilator-Associated Pneumonia Surveillance in Wales.

Pugh R, Harrison W, Harris S, Roberts H, Scholey G, Szakmany T; WICSARG Investigators and WHAIP.

Front Microbiol. 2016 Aug 18;7:1271. doi: 10.3389/fmicb.2016.01271. eCollection 2016.


The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers.

Batty M, Pugh R, Rathinam I, Simmonds J, Walker E, Forbes A, Anoopkumar-Dukie S, McDermott CM, Spencer B, Christie D, Chess-Williams R.

Int J Mol Sci. 2016 Aug 16;17(8). pii: E1339. doi: 10.3390/ijms17081339. Review.


Spatial colocalization and functional link of purinosomes with mitochondria.

French JB, Jones SA, Deng H, Pedley AM, Kim D, Chan CY, Hu H, Pugh RJ, Zhao H, Zhang Y, Huang TJ, Fang Y, Zhuang X, Benkovic SJ.

Science. 2016 Feb 12;351(6274):733-7. doi: 10.1126/science.aac6054.


Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin.

Pugh RJ, Slee JB, Farwell SL, Li Y, Barthol T, Patton WA, Lowe-Krentz LJ.

J Biol Chem. 2016 Mar 4;291(10):5326-41. doi: 10.1074/jbc.M115.681122. Epub 2016 Jan 14.


The ManVan: a mobile cancer support service for men with prostate, testicular and penile cancer in Wales.

Iredale R, Skilton R, Pugh R, Blake H.

Ecancermedicalscience. 2015 Dec 1;9:603. doi: 10.3332/ecancer.2015.603. eCollection 2015.


Short-course versus prolonged-course antibiotic therapy for hospital-acquired pneumonia in critically ill adults.

Pugh R, Grant C, Cooke RP, Dempsey G.

Cochrane Database Syst Rev. 2015 Aug 24;(8):CD007577. doi: 10.1002/14651858.CD007577.pub3. Review.


Following up on ISBER 2015: Call for Environmental Biobanking Papers.

Mullins P, Pugh R, Vaught J.

Biopreserv Biobank. 2015 Aug;13(4):229-30. doi: 10.1089/ No abstract available.


Organohalogen Contaminants and Vitamins in Northern Fur Seals (Callorhinus ursinus) Collected During Subsistence Hunts in Alaska.

Reiner JL, Becker PR, Gribble MO, Lynch JM, Moors AJ, Ness J, Peterson D, Pugh RS, Ragland T, Rimmer C, Rhoderick J, Schantz MM, Trevillian J, Kucklick JR.

Arch Environ Contam Toxicol. 2016 Jan;70(1):96-105. doi: 10.1007/s00244-015-0179-y. Epub 2015 Jul 4.


Long-term stability and temporal trends of organic contaminants in four collections of mussel tissue frozen standard reference materials.

Schantz MM, Pugh RS, Pol SS, Wise SA.

Anal Bioanal Chem. 2015 Apr;407(11):3253-8. doi: 10.1007/s00216-015-8524-6. Epub 2015 Feb 25.


Purinosome formation as a function of the cell cycle.

Chan CY, Zhao H, Pugh RJ, Pedley AM, French J, Jones SA, Zhuang X, Jinnah H, Huang TJ, Benkovic SJ.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1368-73. doi: 10.1073/pnas.1423009112. Epub 2015 Jan 20.


Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis.

Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ.

J Biol Chem. 2015 Mar 13;290(11):6705-13. doi: 10.1074/jbc.M114.628701. Epub 2015 Jan 20.


Tracheal stenosis following percutaneous dilatational tracheostomy using the single tapered dilator: an MRI study.

Young E, Pugh R, Hanlon R, O'Callaghan E, Wright C, Jeanrenaud P, Jones TM.

Anaesth Intensive Care. 2014 Nov;42(6):745-51.


Overview of the International Society for Biological and Environmental Repositories (ISBER) Working Groups.

Pugh RS.

Biopreserv Biobank. 2014 Oct;12(5):358-60. doi: 10.1089/bio.2014.1252. No abstract available.


High-throughput assay to phenotype Salmonella enterica Typhimurium association, invasion, and replication in macrophages.

Wu J, Pugh R, Laughlin RC, Andrews-Polymenis H, McClelland M, Bäumler AJ, Adams LG.

J Vis Exp. 2014 Aug 11;(90):e51759. doi: 10.3791/51759.


Heparin responses in vascular smooth muscle cells involve cGMP-dependent protein kinase (PKG).

Gilotti AC, Nimlamool W, Pugh R, Slee JB, Barthol TC, Miller EA, Lowe-Krentz LJ.

J Cell Physiol. 2014 Dec;229(12):2142-52. doi: 10.1002/jcp.24677.


The efficacy of Acanthamoeba cyst kill and effects upon contact lenses of a novel ultraviolet lens disinfection system.

Lonnen J, Putt KS, Kernick ER, Lakkis C, May L, Pugh RB.

Am J Ophthalmol. 2014 Sep;158(3):460-8.e2. doi: 10.1016/j.ajo.2014.05.032. Epub 2014 May 29.


Spatial segregation of virulence gene expression during acute enteric infection with Salmonella enterica serovar Typhimurium.

Laughlin RC, Knodler LA, Barhoumi R, Payne HR, Wu J, Gomez G, Pugh R, Lawhon SD, Bäumler AJ, Steele-Mortimer O, Adams LG.

MBio. 2014 Feb 4;5(1):e00946-13. doi: 10.1128/mBio.00946-13.


The International Environmental Specimen Banks--let's get visible.

Küster A, Becker PR, Kucklick JR, Pugh RS, Koschorreck J.

Environ Sci Pollut Res Int. 2015 Feb;22(3):1559-61. doi: 10.1007/s11356-013-2482-3. Epub 2014 Jan 5.


Nature of child sexual abuse and psychopathology in adult survivors: results from a clinical sample in Scotland.

Bak-Klimek A, Karatzias T, Elliott L, Campbell J, Pugh R, Laybourn P.

J Psychiatr Ment Health Nurs. 2014 Aug;21(6):550-7. doi: 10.1111/jpm.12127. Epub 2013 Dec 4.


A high-throughput microtiter plate based method for the determination of peracetic acid and hydrogen peroxide.

Putt KS, Pugh RB.

PLoS One. 2013 Nov 18;8(11):e79218. doi: 10.1371/journal.pone.0079218. eCollection 2013.


Environmental specimen banks as a resource for mercury and mercury isotope research in marine ecosystems.

Day RD, Becker PR, Donard OF, Pugh RS, Wise SA.

Environ Sci Process Impacts. 2014 Jan;16(1):10-27. doi: 10.1039/c3em00261f. Review.


Immunogenicity of a recombinant Rift Valley fever MP-12-NSm deletion vaccine candidate in calves.

Morrill JC, Laughlin RC, Lokugamage N, Wu J, Pugh R, Kanani P, Adams LG, Makino S, Peters CJ.

Vaccine. 2013 Oct 9;31(43):4988-94. doi: 10.1016/j.vaccine.2013.08.003. Epub 2013 Aug 27.


Sequence-dependent base pair stepping dynamics in XPD helicase unwinding.

Qi Z, Pugh RA, Spies M, Chemla YR.

Elife. 2013 May 28;2:e00334. doi: 10.7554/eLife.00334.


Spatial and temporal trends of persistent organic pollutants and mercury in beluga whales (Delphinapterus leucas) from Alaska.

Hoguet J, Keller JM, Reiner JL, Kucklick JR, Bryan CE, Moors AJ, Pugh RS, Becker PR.

Sci Total Environ. 2013 Apr 1;449:285-94. doi: 10.1016/j.scitotenv.2013.01.072. Epub 2013 Feb 26.


Breakfast cereal sampling study for nutritional elements.

Wood LJ, Lippa KA, Phillips MM, Rimmer CA, Heckert NA, Leigh SD, Moors AJ, Pugh RS, Rust LB.

Anal Bioanal Chem. 2013 May;405(13):4569-78. doi: 10.1007/s00216-013-6727-2. Epub 2013 Feb 5.


The world's first mobile lymphoedema unit: Wales leads the way.

Iredale R, Pugh R, Thomas M.

Ecancermedicalscience. 2013 Sep 3;7:ed25. doi: 10.3332/ecancer.2013.ed25. eCollection 2013. No abstract available.


Serologic response in bottlenose dolphins Tursiops truncatus infected with Brucella sp. using a dolphin-specific indirect ELISA.

Meegan J, Dunn JL, Venn-Watson SK, Smith CR, Sidor I, Jensen ED, Van Bonn WG, Pugh R, Ficht T, Adams LG, Nielsen K, Romano TA.

Dis Aquat Organ. 2012 Dec 3;102(1):73-85. doi: 10.3354/dao02528.


Safety and immunogenicity of recombinant Rift Valley fever MP-12 vaccine candidates in sheep.

Morrill JC, Laughlin RC, Lokugamage N, Pugh R, Sbrana E, Weise WJ, Adams LG, Makino S, Peters CJ.

Vaccine. 2013 Jan 7;31(3):559-65. doi: 10.1016/j.vaccine.2012.10.118. Epub 2012 Nov 12.


The use of chromophore and fluorophore degradation to quantitate UV dose: FD&C dyes as chemical identicators for UV sterilization.

Putt KS, Kernick ER, Lohse BK, Lomboy J, O'Brien T, Pugh RB.

J Microbiol Methods. 2012 Nov;91(2):215-21. doi: 10.1016/j.mimet.2012.08.015. Epub 2012 Sep 4.


Regional, temporal, and species patterns of mercury in Alaskan seabird eggs: mercury sources and cycling or food web effects?

Day RD, Roseneau DG, Vander Pol SS, Hobson KA, Donard OF, Pugh RS, Moors AJ, Becker PR.

Environ Pollut. 2012 Jul;166:226-32. doi: 10.1016/j.envpol.2012.03.004. Epub 2012 Apr 21.


Mercury stable isotopes in seabird eggs reflect a gradient from terrestrial geogenic to oceanic mercury reservoirs.

Day RD, Roseneau DG, Berail S, Hobson KA, Donard OF, Vander Pol SS, Pugh RS, Moors AJ, Long SE, Becker PR.

Environ Sci Technol. 2012 May 15;46(10):5327-35. doi: 10.1021/es2047156. Epub 2012 Apr 27.


Development of the ISBER Best Practices for Repositories: Collection, Storage, Retrieval and Distribution of Biological Materials for Research.

Campbell LD, Betsou F, Garcia DL, Giri JG, Pitt KE, Pugh RS, Sexton KC, Skubitz AP, Somiari SB.

Biopreserv Biobank. 2012 Apr;10(2):232-3. doi: 10.1089/bio.2012.1025. No abstract available.


The ISBER Best Practices: Insight from the Editors of the Third Edition.

Vaught J, Campbell LD, Betsou F, Garcia DL, Pugh RS, Sexton KC, Skubitz AP.

Biopreserv Biobank. 2012 Apr;10(2):76-8. doi: 10.1089/bio.2012.1024. No abstract available.


Regulation of translocation polarity by helicase domain 1 in SF2B helicases.

Pugh RA, Wu CG, Spies M.

EMBO J. 2012 Jan 18;31(2):503-14. doi: 10.1038/emboj.2011.412. Epub 2011 Nov 11.

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