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Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations.

Zhang P, Mocci J, Wahl DJ, Meleppat RK, Manna SK, Quintavalla M, Muradore R, Sarunic MV, Bonora S, Pugh EN Jr, Zawadzki RJ.

Exp Eye Res. 2018 Jul;172:86-93. doi: 10.1016/j.exer.2018.03.027. Epub 2018 Mar 28.


Loss of cone function without degeneration in a novel Gnat2 knock-out mouse.

Ronning KE, Allina GP, Miller EB, Zawadzki RJ, Pugh EN Jr, Herrmann R, Burns ME.

Exp Eye Res. 2018 Jun;171:111-118. doi: 10.1016/j.exer.2018.02.024. Epub 2018 Mar 5.


The discovery of the ability of rod photoreceptors to signal single photons.

Pugh EN Jr.

J Gen Physiol. 2018 Feb 21. pii: jgp.201711970. doi: 10.1085/jgp.201711970. [Epub ahead of print] Review.


Photoreceptor Layer Thickness Changes During Dark Adaptation Observed With Ultrahigh-Resolution Optical Coherence Tomography.

Lu CD, Lee B, Schottenhamml J, Maier A, Pugh EN Jr, Fujimoto JG.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4632-4643. doi: 10.1167/iovs.17-22171.


Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130.

Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN Jr, Burns ME.

J Neuroinflammation. 2017 Jun 23;14(1):121. doi: 10.1186/s12974-017-0886-6.


In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors.

Zhang P, Zawadzki RJ, Goswami M, Nguyen PT, Yarov-Yarovoy V, Burns ME, Pugh EN Jr.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2937-E2946. doi: 10.1073/pnas.1620572114. Epub 2017 Mar 20.


Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9.

Peinado Allina G, Fortenbach C, Naarendorp F, Gross OP, Pugh EN Jr, Burns ME.

J Gen Physiol. 2017 Apr 3;149(4):443-454. doi: 10.1085/jgp.201611692. Epub 2017 Mar 16.


The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy.

Zhang P, Goswami M, Zawadzki RJ, Pugh EN Jr.

Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3650-64. doi: 10.1167/iovs.16-19393.


Effect of scanning beam size on the lateral resolution of mouse retinal imaging with SLO.

Zhang P, Goswami M, Zam A, Pugh EN, Zawadzki RJ.

Opt Lett. 2015 Dec 15;40(24):5830-3. doi: 10.1364/OL.40.005830.


Photoreceptor disc morphogenesis: The classical evagination model prevails.

Pugh EN Jr.

J Cell Biol. 2015 Nov 9;211(3):491-3. doi: 10.1083/jcb.201510067. Epub 2015 Nov 2.


New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo.

Burns ME, Levine ES, Miller EB, Zam A, Zhang P, Zawadzki RJ, Pugh EN Jr.

Adv Exp Med Biol. 2016;854:269-75. doi: 10.1007/978-3-319-17121-0_36.


Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated multi-actuator adaptive lens.

Bonora S, Jian Y, Zhang P, Zam A, Pugh EN Jr, Zawadzki RJ, Sarunic MV.

Opt Express. 2015 Aug 24;23(17):21931-41. doi: 10.1364/OE.23.021931.


Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina.

Zawadzki RJ, Zhang P, Zam A, Miller EB, Goswami M, Wang X, Jonnal RS, Lee SH, Kim DY, Flannery JG, Werner JS, Burns ME, Pugh EN Jr.

Biomed Opt Express. 2015 May 21;6(6):2191-210. doi: 10.1364/BOE.6.002191. eCollection 2015 Jun 1.


cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses.

Gross OP, Pugh EN Jr, Burns ME.

Front Mol Neurosci. 2015 Mar 4;8:6. doi: 10.3389/fnmol.2015.00006. eCollection 2015. Review.


Genetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosis.

Zhang T, Enemchukwu NO, Jones A, Wang S, Dennis E, Watt CB, Pugh EN Jr, Fu Y.

Hum Mol Genet. 2015 Mar 15;24(6):1755-63. doi: 10.1093/hmg/ddu588. Epub 2014 Nov 20.


Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1.

Levine ES, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, Pugh EN Jr, Zawadzki RJ, Burns ME.

Vision Res. 2014 Sep;102:71-9. doi: 10.1016/j.visres.2014.07.011. Epub 2014 Aug 1.


Rhodopsin in the rod surface membrane regenerates more rapidly than bulk rhodopsin in the disc membranes in vivo.

Kessler C, Tillman M, Burns ME, Pugh EN Jr.

J Physiol. 2014 Jul 1;592(13):2785-97. doi: 10.1113/jphysiol.2014.272518. Epub 2014 May 6.


Regulation of rhodopsin-eGFP distribution in transgenic xenopus rod outer segments by light.

Haeri M, Calvert PD, Solessio E, Pugh EN Jr, Knox BE.

PLoS One. 2013 Nov 15;8(11):e80059. doi: 10.1371/journal.pone.0080059. eCollection 2013.


Embracing the principles of the San Francisco Declaration of Research Assessment: Robert Balaban's editorial.

Pugh EN Jr, Gordon SE.

J Gen Physiol. 2013 Sep;142(3):175. doi: 10.1085/jgp.201311077. No abstract available.


Spotlight summary: quantitative fundus autofluorescence and A2E increase with aging in wild-type and "Stargardt" mice.

Zawadzki R, Pugh EN Jr.

Invest Ophthalmol Vis Sci. 2013 Apr 23;54(4):2991. doi: 10.1167/iovs.13-12252. No abstract available.


Cones respond to light in the absence of transducin β subunit.

Nikonov SS, Lyubarsky A, Fina ME, Nikonova ES, Sengupta A, Chinniah C, Ding XQ, Smith RG, Pugh EN Jr, Vardi N, Dhingra A.

J Neurosci. 2013 Mar 20;33(12):5182-94. doi: 10.1523/JNEUROSCI.5204-12.2013.


Introducing the viewpoint.

Pugh EN Jr.

J Gen Physiol. 2012 Dec;140(6):579. doi: 10.1085/jgp.201210924. No abstract available.


Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes.

Gross OP, Pugh EN Jr, Burns ME.

Neuron. 2012 Oct 18;76(2):370-82. doi: 10.1016/j.neuron.2012.07.029. Epub 2012 Oct 17. Erratum in: Neuron. 2013 Jun 5;78(5):949.


Spatiotemporal cGMP dynamics in living mouse rods.

Gross OP, Pugh EN Jr, Burns ME.

Biophys J. 2012 Apr 18;102(8):1775-84. doi: 10.1016/j.bpj.2012.03.035.


An S-opsin knock-in mouse (F81Y) reveals a role for the native ligand 11-cis-retinal in cone opsin biosynthesis.

Insinna C, Daniele LL, Davis JA, Larsen DD, Kuemmel C, Wang J, Nikonov SS, Knox BE, Pugh EN Jr.

J Neurosci. 2012 Jun 6;32(23):8094-104. doi: 10.1523/JNEUROSCI.0131-12.2012.


Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage.

Sheu SS, Dirksen RT, Pugh EN Jr.

J Gen Physiol. 2012 Jun;139(6):391-3. doi: 10.1085/jgp.201210819. No abstract available.


The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine.

Sheu SS, Dirksen RT, Pugh EN Jr.

J Gen Physiol. 2011 Dec;138(6):563-7. doi: 10.1085/jgp.201110739. No abstract available.


Redefining our menu: communications and reviews.

Pugh EN Jr.

J Gen Physiol. 2011 Aug;138(2):131. doi: 10.1085/jgp.201110688. No abstract available.


The 64th Symposium of the Society for General Physiologists: optogenetics and superresolution microscopy take center stage.

Ellis-Davies GC, Pugh EN Jr.

J Gen Physiol. 2011 Jul;138(1):1-11. doi: 10.1085/jgp.201110673. No abstract available.


Good scientists do reach and hold divergent views on important issues.

Pugh EN Jr.

J Gen Physiol. 2011 Mar;137(3):253. doi: 10.1085/jgp.201110613. No abstract available.


A mouse M-opsin monochromat: retinal cone photoreceptors have increased M-opsin expression when S-opsin is knocked out.

Daniele LL, Insinna C, Chance R, Wang J, Nikonov SS, Pugh EN Jr.

Vision Res. 2011 Feb 23;51(4):447-58. doi: 10.1016/j.visres.2010.12.017. Epub 2011 Jan 8.


We were there...

Pugh EN Jr.

J Gen Physiol. 2010 Nov;136(5):495. doi: 10.1085/jgp.201010553. No abstract available.


Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision.

Naarendorp F, Esdaille TM, Banden SM, Andrews-Labenski J, Gross OP, Pugh EN Jr.

J Neurosci. 2010 Sep 15;30(37):12495-507. doi: 10.1523/JNEUROSCI.2186-10.2010.


Emerging questions about the macromolecular machines of muscle.

Dirksen RT, Pugh EN Jr.

J Gen Physiol. 2010 Jul;136(1):3-5. doi: 10.1085/jgp.201010481. No abstract available.


Lessons from photoreceptors: turning off g-protein signaling in living cells.

Burns ME, Pugh EN Jr.

Physiology (Bethesda). 2010 Apr;25(2):72-84. doi: 10.1152/physiol.00001.2010. Review.


Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.

Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B, St Germain DL, Hernandez A, Pugh EN Jr, Forrest D.

J Neurosci. 2010 Mar 3;30(9):3347-57. doi: 10.1523/JNEUROSCI.5267-09.2010.


Diffusion of a soluble protein, photoactivatable GFP, through a sensory cilium.

Calvert PD, Schiesser WE, Pugh EN Jr.

J Gen Physiol. 2010 Mar;135(3):173-96. doi: 10.1085/jgp.200910322.


Enlisting young physiologists.

Pugh EN Jr.

J Gen Physiol. 2009 Dec;134(6):451-2. doi: 10.1085/jgp.200910364. No abstract available.


RGS9 concentration matters in rod phototransduction.

Burns ME, Pugh EN Jr.

Biophys J. 2009 Sep 16;97(6):1538-47. doi: 10.1016/j.bpj.2009.06.037.


Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice.

Parry DA, Toomes C, Bida L, Danciger M, Towns KV, McKibbin M, Jacobson SG, Logan CV, Ali M, Bond J, Chance R, Swendeman S, Daniele LL, Springell K, Adams M, Johnson CA, Booth AP, Jafri H, Rashid Y, Banin E, Strom TM, Farber DB, Sharon D, Blobel CP, Pugh EN Jr, Pierce EA, Inglehearn CF.

Am J Hum Genet. 2009 May;84(5):683-91. doi: 10.1016/j.ajhg.2009.04.005. Epub 2009 Apr 30.


Kudos to reviewers for the JGP: you make our science better.

Pugh EN Jr.

J Gen Physiol. 2009 Feb;133(2):129-30. doi: 10.1085/jgp.200910193. No abstract available.


Mouse cones require an arrestin for normal inactivation of phototransduction.

Nikonov SS, Brown BM, Davis JA, Zuniga FI, Bragin A, Pugh EN Jr, Craft CM.

Neuron. 2008 Aug 14;59(3):462-74. doi: 10.1016/j.neuron.2008.06.011.


Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice.

Daniele LL, Sauer B, Gallagher SM, Pugh EN Jr, Philp NJ.

Am J Physiol Cell Physiol. 2008 Aug;295(2):C451-7. doi: 10.1152/ajpcell.00124.2008. Epub 2008 Jun 4.


Models and mechanistic insight.

Pugh EN Jr, Andersen OS.

J Gen Physiol. 2008 Jun;131(6):515-9. doi: 10.1085/jgp.200810041. No abstract available.


Safety and efficacy of gene transfer for Leber's congenital amaurosis.

Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, Rossi S, Lyubarsky A, Arruda VR, Konkle B, Stone E, Sun J, Jacobs J, Dell'Osso L, Hertle R, Ma JX, Redmond TM, Zhu X, Hauck B, Zelenaia O, Shindler KS, Maguire MG, Wright JF, Volpe NJ, McDonnell JW, Auricchio A, High KA, Bennett J.

N Engl J Med. 2008 May 22;358(21):2240-8. doi: 10.1056/NEJMoa0802315. Epub 2008 Apr 27.


Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments.

Feathers KL, Lyubarsky AL, Khan NW, Teofilo K, Swaroop A, Williams DS, Pugh EN Jr, Thompson DA.

Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1126-35. doi: 10.1167/iovs.07-1234.


Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup.

Lamb TD, Collin SP, Pugh EN Jr.

Nat Rev Neurosci. 2007 Dec;8(12):960-76. Review.


Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium.

Daniele LL, Adams RH, Durante DE, Pugh EN Jr, Philp NJ.

J Comp Neurol. 2007 Nov 10;505(2):166-76.

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