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Items: 1 to 50 of 76

1.

Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice.

Moye AR, Bedoni N, Cunningham JG, Sanzhaeva U, Tucker ES, Mathers P, Peter VG, Quinodoz M, Paris LP, Coutinho-Santos L, Camacho P, Purcell MG, Winkelmann AC, Foster JA, Pugacheva EN, Rivolta C, Ramamurthy V.

PLoS Genet. 2019 Aug 19;15(8):e1008315. doi: 10.1371/journal.pgen.1008315. eCollection 2019 Aug.

2.

BORIS Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through GALNT14.

Hillman JC, Pugacheva EM, Barger CJ, Sribenja S, Rosario S, Albahrani M, Truskinovsky AM, Stablewski A, Liu S, Loukinov DI, Zentner GE, Lobanenkov VV, Karpf AR, Higgins MJ.

Mol Cancer Res. 2019 Jul 10. doi: 10.1158/1541-7786.MCR-19-0310. [Epub ahead of print]

PMID:
31292201
3.

Targeting primary cilia - associated signaling in glioblastoma: guided approach for drug development.

Loskutov Y, Pugacheva EN.

Oncoscience. 2019 Jan 31;6(1-2):289-290. doi: 10.18632/oncoscience.475. eCollection 2019 Jan. No abstract available.

4.

Human Breast Cancer Xenograft Model Implicates Peroxisome Proliferator-activated Receptor Signaling as Driver of Cancer-induced Muscle Fatigue.

Wilson HE, Rhodes KK, Rodriguez D, Chahal I, Stanton DA, Bohlen J, Davis M, Infante AM, Hazard-Jenkins H, Klinke DJ, Pugacheva EN, Pistilli EE.

Clin Cancer Res. 2019 Apr 1;25(7):2336-2347. doi: 10.1158/1078-0432.CCR-18-1565. Epub 2018 Dec 17.

PMID:
30559167
5.

ADP-Ribosylation Factor-Like 2 (ARL2) regulates cilia stability and development of outer segments in rod photoreceptor neurons.

Wright ZC, Loskutov Y, Murphy D, Stoilov P, Pugacheva E, Goldberg AFX, Ramamurthy V.

Sci Rep. 2018 Nov 16;8(1):16967. doi: 10.1038/s41598-018-35395-3.

6.

LPA signaling is regulated through the primary cilium: a novel target in glioblastoma.

Loskutov YV, Griffin CL, Marinak KM, Bobko A, Margaryan NV, Geldenhuys WJ, Sarkaria JN, Pugacheva EN.

Oncogene. 2018 Mar;37(11):1457-1471. doi: 10.1038/s41388-017-0049-3. Epub 2018 Jan 11.

7.

[Diagnosis and treatment of neurogenic dysphagia after acute ischemic stroke].

Balashova IN, Vanchakova NP, Afanasiev VV, Barantzevich ER, Pugacheva EL, Golikov KV.

Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(12. Vyp. 2):64-69. doi: 10.17116/jnevro201811812264. Russian.

PMID:
30830119
8.

The downregulation of putative anticancer target BORIS/CTCFL in an addicted myeloid cancer cell line modulates the expression of multiple protein coding and ncRNA genes.

Teplyakov E, Wu Q, Liu J, Pugacheva EM, Loukinov D, Boukaba A, Lobanenkov V, Strunnikov A.

Oncotarget. 2017 Sep 2;8(43):73448-73468. doi: 10.18632/oncotarget.20627. eCollection 2017 Sep 26.

9.

Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior.

Jones BC, Kelley LC, Loskutov YV, Marinak KM, Kozyreva VK, Smolkin MB, Pugacheva EN.

Mol Cancer Res. 2017 Jun;15(6):670-682. doi: 10.1158/1541-7786.MCR-16-0411. Epub 2017 Feb 24.

10.

The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements.

Pugacheva EM, Teplyakov E, Wu Q, Li J, Chen C, Meng C, Liu J, Robinson S, Loukinov D, Boukaba A, Hutchins AP, Lobanenkov V, Strunnikov A.

Epigenetics Chromatin. 2016 Aug 31;9(1):35. doi: 10.1186/s13072-016-0084-2. eCollection 2016.

11.

Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells.

Burgett ME, Lathia JD, Roth P, Nowacki AS, Galileo DS, Pugacheva E, Huang P, Vasanji A, Li M, Byzova T, Mikkelsen T, Bao S, Rich JN, Weller M, Gladson CL.

Oncotarget. 2016 Jul 12;7(28):43852-43867. doi: 10.18632/oncotarget.9700.

12.

Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer.

Kozyreva VK, Kiseleva AA, Ice RJ, Jones BC, Loskutov YV, Matalkah F, Smolkin MB, Marinak K, Livengood RH, Salkeni MA, Wen S, Hazard HW, Layne GP, Walsh CM, Cantrell PS, Kilby GW, Mahavadi S, Shah N, Pugacheva EN.

Mol Cancer Ther. 2016 Aug;15(8):1809-22. doi: 10.1158/1535-7163.MCT-15-0688. Epub 2016 May 27.

13.

Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions.

Pugacheva EM, Rivero-Hinojosa S, Espinoza CA, Méndez-Catalá CF, Kang S, Suzuki T, Kosaka-Suzuki N, Robinson S, Nagarajan V, Ye Z, Boukaba A, Rasko JE, Strunnikov AV, Loukinov D, Ren B, Lobanenkov VV.

Genome Biol. 2015 Aug 14;16:161. doi: 10.1186/s13059-015-0736-8.

14.

AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.

Park J, Schlederer M, Schreiber M, Ice R, Merkel O, Bilban M, Hofbauer S, Kim S, Addison J, Zou J, Ji C, Bunting ST, Wang Z, Shoham M, Huang G, Bago-Horvath Z, Gibson LF, Rojanasakul Y, Remick S, Ivanov A, Pugacheva E, Bunting KD, Moriggl R, Kenner L, Tse W.

Oncotarget. 2015 Aug 21;6(24):20697-710.

15.

Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival.

Lin CC, Sharma SB, Farrugia MK, McLaughlin SL, Ice RJ, Loskutov YV, Pugacheva EN, Brundage KM, Chen D, Ruppert JM.

Oncogenesis. 2015 Jun 8;4:e155. doi: 10.1038/oncsis.2015.8.

16.

Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth.

Iida J, Dorchak J, Clancy R, Slavik J, Ellsworth R, Katagiri Y, Pugacheva EN, van Kuppevelt TH, Mural RJ, Cutler ML, Shriver CD.

Exp Cell Res. 2015 Jan 15;330(2):358-70. doi: 10.1016/j.yexcr.2014.11.002. Epub 2014 Nov 13.

PMID:
25445787
17.

KAP1 promotes proliferation and metastatic progression of breast cancer cells.

Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AV.

Cancer Res. 2015 Jan 15;75(2):344-55. doi: 10.1158/0008-5472.CAN-14-1561. Epub 2014 Nov 24.

18.

Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1-Dependent Trafficking of Integrins.

Kozyulina PY, Loskutov YV, Kozyreva VK, Rajulapati A, Ice RJ, Jones BC, Pugacheva EN.

Mol Cancer Res. 2015 Mar;13(3):423-38. doi: 10.1158/1541-7786.MCR-14-0353. Epub 2014 Oct 15.

19.

NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.

Loskutov YV, Kozyulina PY, Kozyreva VK, Ice RJ, Jones BC, Roston TJ, Smolkin MB, Ivanov AV, Wysolmerski RB, Pugacheva EN.

Oncogene. 2015 Jul;34(28):3662-75. doi: 10.1038/onc.2014.297. Epub 2014 Sep 22.

20.

NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.

Kozyreva VK, McLaughlin SL, Livengood RH, Calkins RA, Kelley LC, Rajulapati A, Ice RJ, Smolkin MB, Weed SA, Pugacheva EN.

Mol Cancer Res. 2014 May;12(5):681-93. doi: 10.1158/1541-7786.MCR-13-0654. Epub 2014 Feb 26.

21.

NORTHERN LEAF BLIGHT HELMINTHOSPORIUM TURCICUM ON MAIZE IN LATVIA.

Treikale O, Javoisha B, Pugacheva E, Vigule Z, Feodorova-Fedotova L.

Commun Agric Appl Biol Sci. 2014;79(3):481-5.

PMID:
26080484
22.

NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.

McLaughlin SL, Ice RJ, Rajulapati A, Kozyulina PY, Livengood RH, Kozyreva VK, Loskutov YV, Culp MV, Weed SA, Ivanov AV, Pugacheva EN.

Mol Cancer Res. 2014 Jan;12(1):69-81. doi: 10.1158/1541-7786.MCR-13-0300. Epub 2013 Nov 7.

23.

A novel mechanism for CTCF in the epigenetic regulation of Bax in breast cancer cells.

Méndez-Catalá CF, Gretton S, Vostrov A, Pugacheva E, Farrar D, Ito Y, Docquier F, Kita GX, Murrell A, Lobanenkov V, Klenova E.

Neoplasia. 2013 Aug;15(8):898-912.

24.

NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors.

Ice RJ, McLaughlin SL, Livengood RH, Culp MV, Eddy ER, Ivanov AV, Pugacheva EN.

Cancer Res. 2013 May 15;73(10):3168-80. doi: 10.1158/0008-5472.CAN-12-4008. Epub 2013 Mar 28.

25.

Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.

Gu JJ, Lavau CP, Pugacheva E, Soderblom EJ, Moseley MA, Pendergast AM.

Sci Signal. 2012 Jul 17;5(233):ra51. doi: 10.1126/scisignal.2002632.

26.

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis.

Plotnikova OV, Nikonova AS, Loskutov YV, Kozyulina PY, Pugacheva EN, Golemis EA.

Mol Biol Cell. 2012 Jul;23(14):2658-70. doi: 10.1091/mbc.E11-12-1056. Epub 2012 May 23.

27.

NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration.

Zhong J, Baquiran JB, Bonakdar N, Lees J, Ching YW, Pugacheva E, Fabry B, O'Neill GM.

PLoS One. 2012;7(4):e35058. doi: 10.1371/journal.pone.0035058. Epub 2012 Apr 11.

29.

Aurora A kinase activity influences calcium signaling in kidney cells.

Plotnikova OV, Pugacheva EN, Golemis EA.

J Cell Biol. 2011 Jun 13;193(6):1021-32. doi: 10.1083/jcb.201012061. Erratum in: J Cell Biol. 2011 Jul 11;194(1):157.

30.

Transcription factor BORIS (Brother of the Regulator of Imprinted Sites) directly induces expression of a cancer-testis antigen, TSP50, through regulated binding of BORIS to the promoter.

Kosaka-Suzuki N, Suzuki T, Pugacheva EM, Vostrov AA, Morse HC 3rd, Loukinov D, Lobanenkov V.

J Biol Chem. 2011 Aug 5;286(31):27378-88. doi: 10.1074/jbc.M111.243576. Epub 2011 Jun 9.

31.

The structural complexity of the human BORIS gene in gametogenesis and cancer.

Pugacheva EM, Suzuki T, Pack SD, Kosaka-Suzuki N, Yoon J, Vostrov AA, Barsov E, Strunnikov AV, Morse HC 3rd, Loukinov D, Lobanenkov V.

PLoS One. 2010 Nov 8;5(11):e13872. doi: 10.1371/journal.pone.0013872.

32.

Rapid calcium-dependent activation of Aurora-A kinase.

Plotnikova OV, Pugacheva EN, Dunbrack RL, Golemis EA.

Nat Commun. 2010 Sep 7;1:64. doi: 10.1038/ncomms1061.

33.

The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.

Moore FE, Osmundson EC, Koblinski J, Pugacheva E, Golemis EA, Ray D, Kiyokawa H.

Cell Div. 2010 Sep 8;5:22. doi: 10.1186/1747-1028-5-22.

34.

[Efficacy of the complex drug cytoflavin in the treatment of consequences of mild brain injury].

Skoromets AA, Pugacheva EL.

Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(3):31-6. Russian.

PMID:
20517223
35.

Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene BORIS.

Suzuki T, Kosaka-Suzuki N, Pack S, Shin DM, Yoon J, Abdullaev Z, Pugacheva E, Morse HC 3rd, Loukinov D, Lobanenkov V.

Mol Cell Biol. 2010 May;30(10):2473-84. doi: 10.1128/MCB.01093-09. Epub 2010 Mar 15.

36.

NEDD9 promotes oncogenic signaling in mammary tumor development.

Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA.

Cancer Res. 2009 Sep 15;69(18):7198-206. doi: 10.1158/0008-5472.CAN-09-0795. Epub 2009 Sep 8.

37.

Primary cilia and the cell cycle.

Plotnikova OV, Pugacheva EN, Golemis EA.

Methods Cell Biol. 2009;94:137-60. doi: 10.1016/S0091-679X(08)94007-3. Epub 2009 Dec 23.

38.

Cell cycle-dependent ciliogenesis and cancer.

Plotnikova OV, Golemis EA, Pugacheva EN.

Cancer Res. 2008 Apr 1;68(7):2058-61. doi: 10.1158/0008-5472.CAN-07-5838. Review.

39.

Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors.

Renaud S, Pugacheva EM, Delgado MD, Braunschweig R, Abdullaev Z, Loukinov D, Benhattar J, Lobanenkov V.

Nucleic Acids Res. 2007;35(21):7372-88. Epub 2007 Oct 25.

40.

HEF1-dependent Aurora A activation induces disassembly of the primary cilium.

Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA.

Cell. 2007 Jun 29;129(7):1351-63.

41.

Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1.

Fitzpatrick GV, Pugacheva EM, Shin JY, Abdullaev Z, Yang Y, Khatod K, Lobanenkov VV, Higgins MJ.

Mol Cell Biol. 2007 Apr;27(7):2636-47. Epub 2007 Jan 22.

42.

Identification of Protein-Protein Interactions with Glutathione-S-Transferase (GST) Fusion Proteins.

Einarson MB, Pugacheva EN, Orlinick JR.

CSH Protoc. 2007 Aug 1;2007:pdb.top11. doi: 10.1101/pdb.top11.

PMID:
21357153
43.

Far Western: probing membranes.

Einarson MB, Pugacheva EN, Orlinick JR.

CSH Protoc. 2007 Aug 1;2007:pdb.prot4759. doi: 10.1101/pdb.prot4759.

PMID:
21357139
44.

Far Western: Labeling GST Fusion Proteins.

Einarson MB, Pugacheva EN, Orlinick JR.

CSH Protoc. 2007 Aug 1;2007:pdb.prot4758. doi: 10.1101/pdb.prot4758.

PMID:
21357138
45.

GST Pull-down.

Einarson MB, Pugacheva EN, Orlinick JR.

CSH Protoc. 2007 Aug 1;2007:pdb.prot4757. doi: 10.1101/pdb.prot4757.

PMID:
21357137
46.

Preparation of GST Fusion Proteins.

Einarson MB, Pugacheva EN, Orlinick JR.

CSH Protoc. 2007 Apr 1;2007:pdb.prot4738. doi: 10.1101/pdb.prot4738.

PMID:
21357069
47.

Interdependence of cell attachment and cell cycle signaling.

Pugacheva EN, Roegiers F, Golemis EA.

Curr Opin Cell Biol. 2006 Oct;18(5):507-15. Epub 2006 Aug 17. Review.

48.

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2.

Kurukuti S, Tiwari VK, Tavoosidana G, Pugacheva E, Murrell A, Zhao Z, Lobanenkov V, Reik W, Ohlsson R.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10684-9. Epub 2006 Jun 30.

49.

Cloning and characterization of zebrafish CTCF: Developmental expression patterns, regulation of the promoter region, and evolutionary aspects of gene organization.

Pugacheva EM, Kwon YW, Hukriede NA, Pack S, Flanagan PT, Ahn JC, Park JA, Choi KS, Kim KW, Loukinov D, Dawid IB, Lobanenkov VV.

Gene. 2006 Jun 21;375:26-36. Epub 2006 May 2.

PMID:
16647825
50.

HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks.

Pugacheva EN, Golemis EA.

Cell Cycle. 2006 Feb;5(4):384-91. Epub 2006 Feb 15. Review.

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