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Role of Nrf2 in Fracture Healing: Clinical Aspects of Oxidative Stress.

Kubo Y, Wruck CJ, Fragoulis A, Drescher W, Pape HC, Lichte P, Fischer H, Tohidnezhad M, Hildebrand F, Pufe T, Jahr H.

Calcif Tissue Int. 2019 Jun 24. doi: 10.1007/s00223-019-00576-3. [Epub ahead of print] Review.


Bioreactor-Controlled Physoxia Regulates TGF-β Signaling to Alter Extracellular Matrix Synthesis by Human Chondrocytes.

Jahr H, Gunes S, Kuhn AR, Nebelung S, Pufe T.

Int J Mol Sci. 2019 Apr 6;20(7). pii: E1715. doi: 10.3390/ijms20071715.


Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Fragoulis A, Schenkel J, Herzog M, Schellenberg T, Jahr H, Pufe T, Trautwein C, Kensler TW, Streetz KL, Wruck CJ.

Toxicol Sci. 2019 Jun 1;169(2):485-498. doi: 10.1093/toxsci/kfz055.


Correction to: A new multiple trauma model of the mouse.

Fitschen-Oestern S, Lippross S, Klueter T, Weuster M, Varoga D, Tohidnezhad M, Pufe T, Rose-John S, Andruszkow H, Hildebrand F, Steubesand N, Seekamp A, Neunaber C.

BMC Musculoskelet Disord. 2019 Feb 11;20(1):72. doi: 10.1186/s12891-018-2330-1. No abstract available.


Lack of chemokine (C-C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis.

Aust V, Kress E, Abraham S, Schröder N, Kipp M, Stope MB, Pufe T, Tauber SC, Brandenburg LO.

Cytokine. 2018 Nov;111:246-254. doi: 10.1016/j.cyto.2018.09.001. Epub 2018 Sep 7.


Bone-preserving total hip arthroplasty in avascular necrosis of the hip-a matched-pairs analysis.

Merschin D, Häne R, Tohidnezhad M, Pufe T, Drescher W.

Int Orthop. 2018 Jul;42(7):1509-1516. doi: 10.1007/s00264-018-3896-9. Epub 2018 Mar 22.


Expansion of functional personalized cells with specific transgene combinations.

Lipps C, Klein F, Wahlicht T, Seiffert V, Butueva M, Zauers J, Truschel T, Luckner M, Köster M, MacLeod R, Pezoldt J, Hühn J, Yuan Q, Müller PP, Kempf H, Zweigerdt R, Dittrich-Breiholz O, Pufe T, Beckmann R, Drescher W, Riancho J, Sañudo C, Korff T, Opalka B, Rebmann V, Göthert JR, Alves PM, Ott M, Schucht R, Hauser H, Wirth D, May T.

Nat Commun. 2018 Mar 8;9(1):994. doi: 10.1038/s41467-018-03408-4.


Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease.

Tohidnezhad M, Bayer A, Rasuo B, Hock JVP, Kweider N, Fragoulis A, Sönmez TT, Jahr H, Pufe T, Lippross S.

Mediators Inflamm. 2017;2017:1046438. doi: 10.1155/2017/1046438. Epub 2017 Nov 19.


Toll-Like Receptor 2-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination.

Esser S, Göpfrich L, Bihler K, Kress E, Nyamoya S, Tauber SC, Clarner T, Stope MB, Pufe T, Kipp M, Brandenburg LO.

Mol Neurobiol. 2018 Aug;55(8):6237-6249. doi: 10.1007/s12035-017-0838-2. Epub 2017 Dec 29.


A new multiple trauma model of the mouse.

Fitschen-Oestern S, Lippross S, Klueter T, Weuster M, Varoga D, Tohidnezhad M, Pufe T, Rose-John S, Andruszkow H, Hildebrand F, Steubesand N, Seekamp A, Neunaber C.

BMC Musculoskelet Disord. 2017 Nov 21;18(1):468. doi: 10.1186/s12891-017-1813-9. Erratum in: BMC Musculoskelet Disord. 2019 Feb 11;20(1):72.


Platelet-released growth factors inhibit proliferation of primary keratinocytes in vitro.

Bayer A, Tohidnezhad M, Berndt R, Lippross S, Behrendt P, Klüter T, Pufe T, Jahr H, Cremer J, Rademacher F, Simanski M, Gläser R, Harder J.

Ann Anat. 2018 Jan;215:1-7. doi: 10.1016/j.aanat.2017.09.002. Epub 2017 Sep 18.


CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens.

Kress E, Merres J, Albrecht LJ, Hammerschmidt S, Pufe T, Tauber SC, Brandenburg LO.

Cell Commun Signal. 2017 Sep 16;15(1):32. doi: 10.1186/s12964-017-0190-1.


The Antimicrobial Peptide Human Beta-Defensin-3 Is Induced by Platelet-Released Growth Factors in Primary Keratinocytes.

Bayer A, Lammel J, Tohidnezhad M, Lippross S, Behrendt P, Klüter T, Pufe T, Cremer J, Jahr H, Rademacher F, Gläser R, Harder J.

Mediators Inflamm. 2017;2017:6157491. doi: 10.1155/2017/6157491. Epub 2017 Jul 25.


Platelet-Released Growth Factors Induce Differentiation of Primary Keratinocytes.

Bayer A, Tohidnezhad M, Lammel J, Lippross S, Behrendt P, Klüter T, Pufe T, Jahr H, Cremer J, Rademacher F, Gläser R, Harder J.

Mediators Inflamm. 2017;2017:5671615. doi: 10.1155/2017/5671615. Epub 2017 Jul 20.


The protective effect of platelet released growth factors and bone augmentation (Bio-Oss®) on ethanol impaired osteoblasts.

Sönmez TT, Bayer A, Cremer T, Hock JVP, Lethaus B, Kweider N, Wruck CJ, Drescher W, Jahr H, Lippross S, Pufe T, Tohidnezhad M.

Ann Anat. 2017 Nov;214:36-42. doi: 10.1016/j.aanat.2017.07.002. Epub 2017 Jul 31.


Platelet-released growth factors induce psoriasin in keratinocytes: Implications for the cutaneous barrier.

Bayer A, Lammel J, Lippross S, Klüter T, Behrendt P, Tohidnezhad M, Pufe T, Cremer J, Jahr H, Rademacher F, Gläser R, Harder J.

Ann Anat. 2017 Sep;213:25-32. doi: 10.1016/j.aanat.2017.04.002. Epub 2017 May 25.


Formyl Peptide Receptor 1-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination.

Bihler K, Kress E, Esser S, Nyamoya S, Tauber SC, Clarner T, Stope MB, Pufe T, Brandenburg LO.

J Mol Neurosci. 2017 Jun;62(2):232-243. doi: 10.1007/s12031-017-0924-y. Epub 2017 May 2.


Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.

Fragoulis A, Siegl S, Fendt M, Jansen S, Soppa U, Brandenburg LO, Pufe T, Weis J, Wruck CJ.

Redox Biol. 2017 Aug;12:843-853. doi: 10.1016/j.redox.2017.04.024. Epub 2017 Apr 19.


Hepatocytes express the antimicrobial peptide HBD-2 after multiple trauma: an experimental study in human and mice.

Fitschen-Oestern S, Weuster M, Lippross S, Behrendt P, Fuchs S, Pufe T, Tohidnezhad M, Bayer A, Seekamp A, Varoga D, Klüter T.

BMC Musculoskelet Disord. 2017 Mar 7;18(1):100. doi: 10.1186/s12891-017-1458-8.


Psoriasin has divergent effects on the innate immune responses of murine glial cells.

Jansen S, Kress E, Fragoulis A, Wruck CJ, Wolf R, Grötzinger J, Michalek M, Pufe T, Tauber SC, Brandenburg LO.

J Neurochem. 2017 Apr;141(1):86-99. doi: 10.1111/jnc.13959. Epub 2017 Feb 27.


Ex vivo quantitative multiparametric MRI mapping of human meniscus degeneration.

Nebelung S, Tingart M, Pufe T, Kuhl C, Jahr H, Truhn D.

Skeletal Radiol. 2016 Dec;45(12):1649-1660. Epub 2016 Sep 17.


Lack of Toll-like receptor 2 results in higher mortality of bacterial meningitis by impaired host resistance.

Böhland M, Kress E, Stope MB, Pufe T, Tauber SC, Brandenburg LO.

J Neuroimmunol. 2016 Oct 15;299:90-97. doi: 10.1016/j.jneuroim.2016.09.003. Epub 2016 Sep 6.


The effects of Nrf2 deletion on placental morphology and exchange capacity in the mouse.

Kweider N, Huppertz B, Rath W, Lambertz J, Caspers R, ElMoursi M, Pecks U, Kadyrov M, Fragoulis A, Pufe T, Wruck CJ.

J Matern Fetal Neonatal Med. 2017 Sep;30(17):2068-2073. doi: 10.1080/14767058.2016.1236251. Epub 2016 Oct 3.


Functional MR Imaging Mapping of Human Articular Cartilage Response to Loading.

Nebelung S, Sondern B, Oehrl S, Tingart M, Rath B, Pufe T, Raith S, Fischer H, Kuhl C, Jahr H, Truhn D.

Radiology. 2017 Feb;282(2):464-474. doi: 10.1148/radiol.2016160053. Epub 2016 Aug 26.


Effect of platelet mediator concentrate (PMC) on Achilles tenocytes: an in vitro study.

Arslan E, Nellesen T, Bayer A, Prescher A, Lippross S, Nebelung S, Jahr H, Jaeger C, Huebner WD, Fischer H, Stoffel M, Shakibaei M, Pufe T, Tohidnezhad M.

BMC Musculoskelet Disord. 2016 Jul 22;17:307. doi: 10.1186/s12891-016-1160-2.


Local pamidronate influences fracture healing in a rodent femur fracture model: an experimental study.

Menzdorf L, Weuster M, Klüter T, Brüggemann S, Behrendt P, Fitchen-Oestern S, Varoga D, Seekamp A, Purcz N, Glueer CC, Pufe T, Lippross S.

BMC Musculoskelet Disord. 2016 Jun 9;17:255. doi: 10.1186/s12891-016-1113-9.


Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis.

Albrecht LJ, Tauber SC, Merres J, Kress E, Stope MB, Jansen S, Pufe T, Brandenburg LO.

Mediators Inflamm. 2016;2016:7678542. doi: 10.1155/2016/7678542. Epub 2016 Jan 28.


Platelet-released growth factors induce the antimicrobial peptide human beta-defensin-2 in primary keratinocytes.

Bayer A, Lammel J, Rademacher F, Groß J, Siggelkow M, Lippross S, Klüter T, Varoga D, Tohidnezhad M, Pufe T, Cremer J, Gläser R, Harder J.

Exp Dermatol. 2016 Jun;25(6):460-5. doi: 10.1111/exd.12966. Epub 2016 May 18.


Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration.

Nebelung S, Brill N, Tingart M, Pufe T, Kuhl C, Jahr H, Truhn D.

Skeletal Radiol. 2016 Apr;45(4):505-16. doi: 10.1007/s00256-016-2334-6. Epub 2016 Jan 19.


Towards Optical Coherence Tomography-based elastographic evaluation of human cartilage.

Nebelung S, Brill N, Müller F, Tingart M, Pufe T, Merhof D, Schmitt R, Jahr H, Truhn D.

J Mech Behav Biomed Mater. 2016 Mar;56:106-119. doi: 10.1016/j.jmbbm.2015.11.025. Epub 2015 Dec 4.


3D Human cartilage surface characterization by optical coherence tomography.

Brill N, Riedel J, Schmitt R, Tingart M, Truhn D, Pufe T, Jahr H, Nebelung S.

Phys Med Biol. 2015 Oct 7;60(19):7747-62.


Nrf2 in health and disease: current and future clinical implications.

Al-Sawaf O, Clarner T, Fragoulis A, Kan YW, Pufe T, Streetz K, Wruck CJ.

Clin Sci (Lond). 2015 Dec;129(12):989-99. doi: 10.1042/CS20150436. Review.


Abrasion arthroplasty increases mesenchymal stem cell content of postoperative joint effusions.

Beckmann R, Lippross S, Hartz C, Tohidnezhad M, Ferreira MS, Neuss-Stein S, Seekamp A, Nebelung S, Kweider N, Rath B, Jahr H, Pufe T, Varoga DJ.

BMC Musculoskelet Disord. 2015 Sep 12;16:250. doi: 10.1186/s12891-015-0705-0.


Corrigendum to "Enoxaparin Prevents Steroid-Related Avascular Necrosis of the Femoral Head".

Beckmann R, Shaheen H, Kweider N, Ghassemi A, Fragoulis A, Hermanns-Sachweh B, Pufe T, Kadyrov M, Drescher W.

ScientificWorldJournal. 2015;2015:264241. doi: 10.1155/2015/264241. Epub 2015 Aug 26. No abstract available.


Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography.

de Bont F, Brill N, Schmitt R, Tingart M, Rath B, Pufe T, Jahr H, Nebelung S.

Biomed Res Int. 2015;2015:486794. doi: 10.1155/2015/486794. Epub 2015 Jul 1.


Optical coherence tomography-based parameterization and quantification of articular cartilage surface integrity.

Brill N, Riedel J, Rath B, Tingart M, Jahr H, Betsch M, Quack V, Pufe T, Schmitt R, Nebelung S.

Biomed Opt Express. 2015 Jun 8;6(7):2398-411. doi: 10.1364/BOE.6.002398. eCollection 2015 Jul 1.


Impaired Fracture Healing after Hemorrhagic Shock.

Lichte P, Kobbe P, Pfeifer R, Campbell GC, Beckmann R, Tohidnezhad M, Bergmann C, Kadyrov M, Fischer H, Glüer CC, Hildebrand F, Pape HC, Pufe T.

Mediators Inflamm. 2015;2015:132451. doi: 10.1155/2015/132451. Epub 2015 Apr 1.


Intrathecal application of the antimicrobial peptide CRAMP reduced mortality and neuroinflammation in an experimental model of pneumococcal meningitis.

Dörr A, Kress E, Podschun R, Pufe T, Tauber SC, Brandenburg LO.

J Infect. 2015 Aug;71(2):188-99. doi: 10.1016/j.jinf.2015.04.006. Epub 2015 Apr 17.


Rivaroxaban does not impair fracture healing in a rat femur fracture model: an experimental study.

Klüter T, Weuster M, Brüggemann S, Menzdorf L, Fitschen-Oestern S, Steubesand N, Acil Y, Pufe T, Varoga D, Seekamp A, Lippross S.

BMC Musculoskelet Disord. 2015 Apr 9;16:79. doi: 10.1186/s12891-015-0502-9.


Inhalative IL-10 treatment after bilateral femoral fractures affect pulmonary inflammation in mice.

Lichte P, Pfeifer R, Kobbe P, Tohidnezhad M, Pufe T, Almahmoud K, Hildebrand F, Pape HC.

Ann Anat. 2015 Jul;200:73-8. doi: 10.1016/j.aanat.2015.02.005. Epub 2015 Mar 10.


The antimicrobial peptide lysozyme is induced after multiple trauma.

Klüter T, Fitschen-Oestern S, Lippross S, Weuster M, Mentlein R, Steubesand N, Neunaber C, Hildebrand F, Pufe T, Tohidnezhad M, Beyer A, Seekamp A, Varoga D.

Mediators Inflamm. 2014;2014:303106. doi: 10.1155/2014/303106. Epub 2014 Aug 31.


Mechanical forces induce changes in VEGF and VEGFR-1/sFlt-1 expression in human chondrocytes.

Beckmann R, Houben A, Tohidnezhad M, Kweider N, Fragoulis A, Wruck CJ, Brandenburg LO, Hermanns-Sachweh B, Goldring MB, Pufe T, Jahr H.

Int J Mol Sci. 2014 Sep 1;15(9):15456-74. doi: 10.3390/ijms150915456.


[(68)Ga]PSMA-HBED uptake mimicking lymph node metastasis in coeliac ganglia: an important pitfall in clinical practice.

Krohn T, Verburg FA, Pufe T, Neuhuber W, Vogg A, Heinzel A, Mottaghy FM, Behrendt FF.

Eur J Nucl Med Mol Imaging. 2015 Feb;42(2):210-4. doi: 10.1007/s00259-014-2915-3. Epub 2014 Sep 24.


Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury.

Al-Sawaf O, Fragoulis A, Rosen C, Keimes N, Liehn EA, Hölzle F, Kan YW, Pufe T, Sönmez TT, Wruck CJ.

J Pathol. 2014 Dec;234(4):538-47. doi: 10.1002/path.4418. Epub 2014 Sep 16.


Enoxaparin prevents steroid-related avascular necrosis of the femoral head.

Beckmann R, Shaheen H, Kweider N, Ghassemi A, Fragoulis A, Hermanns-Sachweh B, Pufe T, Kadyrov M, Drescher W.

ScientificWorldJournal. 2014;2014:347813. doi: 10.1155/2014/347813. Epub 2014 Jul 2. Erratum in: ScientificWorldJournal. 2015;2015:264241.


Nrf2 deficiency impairs fracture healing in mice.

Lippross S, Beckmann R, Streubesand N, Ayub F, Tohidnezhad M, Campbell G, Kan YW, Horst F, Sönmez TT, Varoga D, Lichte P, Jahr H, Pufe T, Wruck CJ.

Calcif Tissue Int. 2014 Oct;95(4):349-61. doi: 10.1007/s00223-014-9900-5. Epub 2014 Aug 6.


Role of phospholipase d in g-protein coupled receptor function.

Brandenburg LO, Pufe T, Koch T.

Membranes (Basel). 2014 Jul 3;4(3):302-18. doi: 10.3390/membranes4030302.


A possible protective role of Nrf2 in preeclampsia.

Kweider N, Huppertz B, Kadyrov M, Rath W, Pufe T, Wruck CJ.

Ann Anat. 2014 Sep;196(5):268-77. doi: 10.1016/j.aanat.2014.04.002. Epub 2014 May 27. Review.


Interplay between nuclear factor erythroid 2-related factor 2 and amphiregulin during mechanical ventilation.

Reiss LK, Fragoulis A, Siegl S, Platen C, Kan YW, Nautiyal J, Parker M, Pufe T, Uhlig U, Martin C, Uhlig S, Wruck CJ.

Am J Respir Cell Mol Biol. 2014 Nov;51(5):668-77. doi: 10.1165/rcmb.2013-0279OC.


Dehydroepiandrosterone modulates the inflammatory response in a bilateral femoral shaft fracture model.

Lichte P, Pfeifer R, Werner BE, Ewers P, Tohidnezhad M, Pufe T, Hildebrand F, Pape HC, Kobbe P.

Eur J Med Res. 2014 May 19;19:27. doi: 10.1186/2047-783X-19-27.

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