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Items: 20


Increased serum sialic acid is associated with morbidity and mortality in a murine model of dengue disease.

Espinosa DA, Beatty PR, Puerta-Guardo H, Islam MN, Belisle JT, Perera R, Harris E.

J Gen Virol. 2019 Nov;100(11):1515-1522. doi: 10.1099/jgv.0.001319.


Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation.

Wang C, Puerta-Guardo H, Biering SB, Glasner DR, Tran EB, Patana M, Gomberg TA, Malvar C, Lo NTN, Espinosa DA, Harris E.

PLoS Pathog. 2019 Jul 29;15(7):e1007938. doi: 10.1371/journal.ppat.1007938. eCollection 2019 Jul.


Zika Virus Non-Structural Protein 1 Disrupts Glycosaminoglycans and Causes Permeability in Developing Human Placentas.

Puerta-Guardo H, Tabata T, Petitt M, Dimitrova M, Glasner DR, Pereira L, Harris E.

J Infect Dis. 2019 Jun 27. pii: jiz331. doi: 10.1093/infdis/jiz331. [Epub ahead of print]


Magnitude and Functionality of the NS1-Specific Antibody Response Elicited by a Live-Attenuated Tetravalent Dengue Vaccine Candidate.

Sharma M, Glasner DR, Watkins H, Puerta-Guardo H, Kassa Y, Egan MA, Dean H, Harris E.

J Infect Dis. 2019 Feb 19. pii: jiz081. doi: 10.1093/infdis/jiz081. [Epub ahead of print]


Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism.

Puerta-Guardo H, Glasner DR, Espinosa DA, Biering SB, Patana M, Ratnasiri K, Wang C, Beatty PR, Harris E.

Cell Rep. 2019 Feb 5;26(6):1598-1613.e8. doi: 10.1016/j.celrep.2019.01.036.


The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis.

Glasner DR, Puerta-Guardo H, Beatty PR, Harris E.

Annu Rev Virol. 2018 Sep 29;5(1):227-253. doi: 10.1146/annurev-virology-101416-041848. Epub 2018 Jul 25. Review.


Longitudinal Analysis of Antibody Cross-neutralization Following Zika Virus and Dengue Virus Infection in Asia and the Americas.

Montoya M, Collins M, Dejnirattisai W, Katzelnick LC, Puerta-Guardo H, Jadi R, Schildhauer S, Supasa P, Vasanawathana S, Malasit P, Mongkolsapaya J, de Silva AD, Tissera H, Balmaseda A, Screaton G, de Silva AM, Harris E.

J Infect Dis. 2018 Jul 13;218(4):536-545. doi: 10.1093/infdis/jiy164.


Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo.

Petitt M, Tabata T, Puerta-Guardo H, Harris E, Pereira L.

Curr Opin Virol. 2017 Dec;27:48-56. doi: 10.1016/j.coviro.2017.11.008. Review.


Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components.

Glasner DR, Ratnasiri K, Puerta-Guardo H, Espinosa DA, Beatty PR, Harris E.

PLoS Pathog. 2017 Nov 9;13(11):e1006673. doi: 10.1371/journal.ppat.1006673. eCollection 2017 Nov.


Zika Virus Replicates in Proliferating Cells in Explants From First-Trimester Human Placentas, Potential Sites for Dissemination of Infection.

Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Harris E, Pereira L.

J Infect Dis. 2018 Mar 28;217(8):1202-1213. doi: 10.1093/infdis/jix552.


Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission.

Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J, Harris E, Pereira L.

Cell Host Microbe. 2016 Aug 10;20(2):155-66. doi: 10.1016/j.chom.2016.07.002. Epub 2016 Jul 18.


Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability.

Puerta-Guardo H, Glasner DR, Harris E.

PLoS Pathog. 2016 Jul 14;12(7):e1005738. doi: 10.1371/journal.ppat.1005738. eCollection 2016 Jul.


Primary dengue virus infections induce differential cytokine production in Mexican patients.

Cruz Hernández SI, Puerta-Guardo HN, Flores Aguilar H, González Mateos S, López Martinez I, Ortiz-Navarrete V, Ludert JE, Angel RM.

Mem Inst Oswaldo Cruz. 2016 Mar;111(3):161-7. doi: 10.1590/0074-02760150359.


Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination.

Beatty PR, Puerta-Guardo H, Killingbeck SS, Glasner DR, Hopkins K, Harris E.

Sci Transl Med. 2015 Sep 9;7(304):304ra141. doi: 10.1126/scitranslmed.aaa3787.


A strong interferon response correlates with a milder dengue clinical condition.

De La Cruz Hernández SI, Puerta-Guardo H, Flores-Aguilar H, González-Mateos S, López-Martinez I, Ortiz-Navarrete V, Ludert JE, Del Angel RM.

J Clin Virol. 2014 Jul;60(3):196-9. doi: 10.1016/j.jcv.2014.04.002. Epub 2014 Apr 13.


The increase in cholesterol levels at early stages after dengue virus infection correlates with an augment in LDL particle uptake and HMG-CoA reductase activity.

Soto-Acosta R, Mosso C, Cervantes-Salazar M, Puerta-Guardo H, Medina F, Favari L, Ludert JE, del Angel RM.

Virology. 2013 Aug 1;442(2):132-47. doi: 10.1016/j.virol.2013.04.003. Epub 2013 May 2.


Transmigration of neural stem cells across the blood brain barrier induced by glioma cells.

Díaz-Coránguez M, Segovia J, López-Ornelas A, Puerta-Guardo H, Ludert J, Chávez B, Meraz-Cruz N, González-Mariscal L.

PLoS One. 2013 Apr 5;8(4):e60655. doi: 10.1371/journal.pone.0060655. Print 2013.


The cytokine response of U937-derived macrophages infected through antibody-dependent enhancement of dengue virus disrupts cell apical-junction complexes and increases vascular permeability.

Puerta-Guardo H, Raya-Sandino A, González-Mariscal L, Rosales VH, Ayala-Dávila J, Chávez-Mungía B, Martínez-Fong D, Medina F, Ludert JE, del Angel RM.

J Virol. 2013 Jul;87(13):7486-501. doi: 10.1128/JVI.00085-13. Epub 2013 Apr 24.


The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes.

Puerta-Guardo H, Medina F, De la Cruz Hernández SI, Rosales VH, Ludert JE, del Angel RM.

Antiviral Res. 2012 Apr;94(1):57-61. doi: 10.1016/j.antiviral.2012.02.006. Epub 2012 Feb 22. Erratum in: Antiviral Res. 2012 Jun;94(3):297. Medina, Fernando [added].


Antibody-dependent enhancement of dengue virus infection in U937 cells requires cholesterol-rich membrane microdomains.

Puerta-Guardo H, Mosso C, Medina F, Liprandi F, Ludert JE, del Angel RM.

J Gen Virol. 2010 Feb;91(Pt 2):394-403. doi: 10.1099/vir.0.015420-0. Epub 2009 Oct 14.


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