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Items: 26


5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia.

Roos J, Oancea C, Heinssmann M, Khan D, Held H, Kahnt AS, Capelo R, la Buscató E, Proschak E, Puccetti E, Steinhilber D, Fleming I, Maier TJ, Ruthardt M.

Cancer Res. 2014 Sep 15;74(18):5244-55. doi: 10.1158/0008-5472.CAN-13-3012. Epub 2014 Jul 31.


Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides.

Beez S, Demmer P, Puccetti E.

PLoS One. 2012;7(11):e48636. doi: 10.1371/journal.pone.0048636. Epub 2012 Nov 9.


Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter binding.

Seshire A, Rößiger T, Frech M, Beez S, Hagemeyer H, Puccetti E.

Leukemia. 2012 Jun;26(6):1338-47. doi: 10.1038/leu.2011.331. Epub 2011 Nov 22. Erratum in: Leukemia. 2012 Nov;26(11):2445-6.


Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα.

Steinert G, Oancea C, Roos J, Hagemeyer H, Maier T, Ruthardt M, Puccetti E.

PLoS One. 2011;6(7):e22540. doi: 10.1371/journal.pone.0022540. Epub 2011 Jul 19.


The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation.

Oancea C, Rüster B, Henschler R, Puccetti E, Ruthardt M.

Leukemia. 2010 Nov;24(11):1910-9. doi: 10.1038/leu.2010.180. Epub 2010 Sep 9.


The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells.

Schwarz K, Romanski A, Puccetti E, Wietbrauk S, Vogel A, Keller M, Scott JW, Serve H, Bug G.

Leuk Res. 2011 Jan;35(1):119-25. doi: 10.1016/j.leukres.2010.06.024. Epub 2010 Jul 31.


Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.

Zheng X, Seshire A, Rüster B, Bug G, Beissert T, Puccetti E, Hoelzer D, Henschler R, Ruthardt M.

Haematologica. 2007 Mar;92(3):323-31.


Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.

Boehrer S, Nowak D, Puccetti E, Ruthardt M, Sattler N, Trepohl B, Schneider B, Hoelzer D, Mitrou PS, Chow KU.

Leuk Res. 2006 May;30(5):597-605. Epub 2006 Mar 2.


The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.

Puccetti E, Zheng X, Brambilla D, Seshire A, Beissert T, Boehrer S, Nürnberger H, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M.

Cancer Res. 2005 Jul 15;65(14):6080-8.


Upon drug-induced apoptosis expression of prostate-apoptosis-response-gene-4 promotes cleavage of caspase-8, bid and mitochondrial release of cytochrome c.

Boehrer S, Kukoc-Zivojnov N, Nowak D, Bergmann M, Baum C, Puccetti E, Weidmann E, Hoelzer D, Mitrou PS, Chow KU.

Hematology. 2004 Oct-Dec;9(5-6):425-31.


Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells.

Kukoc-Zivojnov N, Puccetti E, Chow KU, Bergmann M, Ruthardt M, Hoelzer D, Mitrou PS, Weidmann E, Boehrer S.

Exp Hematol. 2004 Jul;32(7):649-56.


Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell.

Puccetti E, Ruthardt M.

Leukemia. 2004 Jul;18(7):1169-75. Review.


Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

Müller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Köhler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H.

Mol Cell Biol. 2004 Apr;24(7):2890-904.


Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.

Zheng X, Beissert T, Kukoc-Zivojnov N, Puccetti E, Altschmied J, Strolz C, Boehrer S, Gul H, Schneider O, Ottmann OG, Hoelzer D, Henschler R, Ruthardt M.

Blood. 2004 May 1;103(9):3535-43. Epub 2004 Jan 22.


Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.

Puccetti E, Beissert T, Güller S, Li JE, Hoelzer D, Ottmann OG, Ruthardt M.

Oncogene. 2003 Oct 9;22(44):6900-8.


Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571.

Beissert T, Puccetti E, Bianchini A, Güller S, Boehrer S, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M.

Blood. 2003 Oct 15;102(8):2985-93. Epub 2003 Jun 26.


AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.

Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M.

Cancer Res. 2002 Dec 1;62(23):7050-8.


Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.

Möller B, Kukoc-Zivojnov N, Okamgba S, Kessler U, Puccetti E, Ottmann OG, Kaltwasser JP, Hoelzer D, Ruthardt M.

Rheumatol Int. 2002 Jun;22(2):60-7. Epub 2002 Apr 20.


Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.

Puccetti E, Sennewald B, Fosca-Ferrara F, Boehrer S, Bianchini A, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M.

Hematol J. 2001;2(6):385-92.


In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation.

Boehrer S, Chow KU, Beske F, Kukoc-Zivojnov N, Puccetti E, Ruthardt M, Baum C, Rangnekar VM, Hoelzer D, Mitrou PS, Weidmann E.

Cancer Res. 2002 Mar 15;62(6):1768-75.


Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia.

Boehrer S, Chow KU, Puccetti E, Ruthardt M, Godzisard S, Krapohl A, Schneider B, Hoelzer D, Mitrou PS, Rangnekar VM, Weidmann E.

Hematol J. 2001;2(2):103-7.


BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity.

Puccetti E, Güller S, Orleth A, Brüggenolte N, Hoelzer D, Ottmann OG, Ruthardt M.

Cancer Res. 2000 Jul 1;60(13):3409-13.


PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.

Sternsdorf T, Puccetti E, Jensen K, Hoelzer D, Will H, Ottmann OG, Ruthardt M.

Mol Cell Biol. 1999 Jul;19(7):5170-8.


The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies.

Ruthardt M, Orleth A, Tomassoni L, Puccetti E, Riganelli D, Alcalay M, Mannucci R, Nicoletti I, Grignani F, Fagioli M, Pelicci PG.

Oncogene. 1998 Apr 16;16(15):1945-53.


Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.

Ruthardt M, Testa U, Nervi C, Ferrucci PF, Grignani F, Puccetti E, Grignani F, Peschle C, Pelicci PG.

Mol Cell Biol. 1997 Aug;17(8):4859-69.

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