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aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model.

Chen J, Ma Q, King JS, Sun Y, Xu B, Zhang X, Zohrabian S, Guo H, Cai W, Li G, Bruno I, Cooke JP, Wang C, Kontaridis M, Wang DZ, Luo H, Pu WT, Lin Z.

Life Sci Alliance. 2019 Dec 16;3(1). pii: e201900424. doi: 10.26508/lsa.201900424. Print 2020 Jan.


Genetic and Epigenetic Control of Heart Development.

Akerberg BN, Pu WT.

Cold Spring Harb Perspect Biol. 2019 Dec 9. pii: a036756. doi: 10.1101/cshperspect.a036756. [Epub ahead of print]


A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers.

Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT.

Nat Commun. 2019 Oct 28;10(1):4907. doi: 10.1038/s41467-019-12812-3.


Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue.

Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK.

Circulation. 2019 Jul 30;140(5):390-404. doi: 10.1161/CIRCULATIONAHA.119.039711. Epub 2019 Jul 17.


Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.

Bezzerides VJ, Caballero A, Wang S, Ai Y, Hylind RJ, Lu F, Heims-Waldron DA, Chambers KD, Zhang D, Abrams DJ, Pu WT.

Circulation. 2019 Jul 30;140(5):405-419. doi: 10.1161/CIRCULATIONAHA.118.038514. Epub 2019 Jun 3.


Molecular mechanisms of arrhythmogenic cardiomyopathy.

Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT.

Nat Rev Cardiol. 2019 Sep;16(9):519-537. doi: 10.1038/s41569-019-0200-7. Review.


A tissue-engineered scale model of the heart ventricle.

MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT, Parker KK.

Nat Biomed Eng. 2018 Dec;2(12):930-941. doi: 10.1038/s41551-018-0271-5. Epub 2018 Jul 23.


Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction.

Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu WT, Wang J, Chen J, Wang DZ.

Nat Commun. 2019 Apr 17;10(1):1802. doi: 10.1038/s41467-019-09530-1.


A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA.

Wang S, Chen J, Garcia SP, Liang X, Zhang F, Yan P, Yu H, Wei W, Li Z, Wang J, Le H, Han Z, Luo X, Day DS, Stevens SM, Zhang Y, Park PJ, Liu ZJ, Sun K, Yuan GC, Pu WT, Zhang B.

Genome Res. 2019 Feb;29(2):193-207. doi: 10.1101/gr.239053.118. Epub 2019 Jan 22.


Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J.

Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216.


Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association.

Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW; American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.

Circulation. 2018 Nov 20;138(21):e653-e711. doi: 10.1161/CIR.0000000000000606. Review. Erratum in: Circulation. 2018 Nov 20;138(21):e713.


Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor.

Guo Y, Jardin BD, Zhou P, Sethi I, Akerberg BN, Toepfer CN, Ai Y, Li Y, Ma Q, Guatimosim S, Hu Y, Varuzhanyan G, VanDusen NJ, Zhang D, Chan DC, Yuan GC, Seidman CE, Seidman JG, Pu WT.

Nat Commun. 2018 Sep 21;9(1):3837. doi: 10.1038/s41467-018-06347-2.


Genetic Mosaics for Greater Precision in Cardiovascular Research.

Guo Y, Pu WT.

Circ Res. 2018 Jun 22;123(1):27-29. doi: 10.1161/CIRCRESAHA.118.313386. No abstract available.


Exercising engineered heart muscle to maturity.

Zhang D, Pu WT.

Nat Rev Cardiol. 2018 Jul;15(7):383-384. doi: 10.1038/s41569-018-0032-x. No abstract available.


Enhancing the precision of genetic lineage tracing using dual recombinases.

He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B.

Nat Med. 2017 Dec;23(12):1488-1498. doi: 10.1038/nm.4437. Epub 2017 Nov 13.


Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation.

Zhang D, Li Y, Heims-Waldron D, Bezzerides V, Guatimosim S, Guo Y, Gu F, Zhou P, Lin Z, Ma Q, Liu J, Wang DZ, Pu WT.

Circ Res. 2018 Jan 5;122(1):74-87. doi: 10.1161/CIRCRESAHA.117.311349. Epub 2017 Oct 11.


CASAAV: A CRISPR-Based Platform for Rapid Dissection of Gene Function In Vivo.

VanDusen NJ, Guo Y, Gu W, Pu WT.

Curr Protoc Mol Biol. 2017 Oct 2;120:31.11.1-31.11.14. doi: 10.1002/cpmb.46.


Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks.

Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S, Melero-Martin JM.

Nat Biomed Eng. 2017;1. pii: 0081. doi: 10.1038/s41551-017-0081. Epub 2017 Jun 13.


VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis.

Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT.

Nat Commun. 2017 Aug 29;8(1):383. doi: 10.1038/s41467-017-00405-x.


Identification of a hybrid myocardial zone in the mammalian heart after birth.

Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang QD, Wu SM, Pu WT, Anderson RH, Zhou B.

Nat Commun. 2017 Jul 20;8(1):87. doi: 10.1038/s41467-017-00118-1.


Divergent Requirements for EZH1 in Heart Development Versus Regeneration.

Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C, Pu WT, He A.

Circ Res. 2017 Jul 7;121(2):106-112. doi: 10.1161/CIRCRESAHA.117.311212. Epub 2017 May 16.


Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos.

Sun Y, Lin Z, Liu CH, Gong Y, Liegl R, Fredrick TW, Meng SS, Burnim SB, Wang Z, Akula JD, Pu WT, Chen J, Smith LEH.

J Exp Med. 2017 Jun 5;214(6):1753-1767. doi: 10.1084/jem.20161645. Epub 2017 May 2.


Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis.

Yu W, Zhang F, Wang S, Fu Y, Chen J, Liang X, Le H, Pu WT, Zhang B.

Cell Death Dis. 2017 Apr 13;8(4):e2744. doi: 10.1038/cddis.2017.163.


EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.

Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A.

Elife. 2017 Apr 10;6. pii: e24570. doi: 10.7554/eLife.24570.


Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo.

Guo Y, VanDusen NJ, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT.

Circ Res. 2017 Jun 9;120(12):1874-1888. doi: 10.1161/CIRCRESAHA.116.310283. Epub 2017 Mar 29. Review.


Cardiac Regeneration: Lessons From Development.

Galdos FX, Guo Y, Paige SL, VanDusen NJ, Wu SM, Pu WT.

Circ Res. 2017 Mar 17;120(6):941-959. doi: 10.1161/CIRCRESAHA.116.309040. Review.


Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq.

Zhou P, Gu F, Zhang L, Akerberg BN, Ma Q, Li K, He A, Lin Z, Stevens SM, Zhou B, Pu WT.

Elife. 2017 Jan 25;6. pii: e22039. doi: 10.7554/eLife.22039.


Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts.

Ding J, Lin ZQ, Jiang JM, Seidman CE, Seidman JG, Pu WT, Wang DZ.

J Vis Exp. 2016 Dec 17;(118). doi: 10.3791/54787.


Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies.

Wang G, Yang L, Grishin D, Rios X, Ye LY, Hu Y, Li K, Zhang D, Church GM, Pu WT.

Nat Protoc. 2017 Jan;12(1):88-103. doi: 10.1038/nprot.2016.152. Epub 2016 Dec 8.


Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Bezzerides VJ, Zhang D, Pu WT.

Circ J. 2016 Dec 22;81(1):12-21. doi: 10.1253/circj.CJ-16-1113. Epub 2016 Dec 3. Review.


Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury.

Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR.

Circulation. 2017 Jan 3;135(1):59-72. doi: 10.1161/CIRCULATIONAHA.116.022064. Epub 2016 Nov 1.


Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth.

Lin Z, Guo H, Cao Y, Zohrabian S, Zhou P, Ma Q, VanDusen N, Guo Y, Zhang J, Stevens SM, Liang F, Quan Q, van Gorp PR, Li A, Dos Remedios C, He A, Bezzerides VJ, Pu WT.

Dev Cell. 2016 Nov 21;39(4):466-479. doi: 10.1016/j.devcel.2016.09.005. Epub 2016 Oct 6.


Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy.

Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG, Pu WT, Wang DZ.

Cardiovasc Res. 2016 Nov 1;112(2):543-554. doi: 10.1093/cvr/cvw201.


Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types.

Day DS, Zhang B, Stevens SM, Ferrari F, Larschan EN, Park PJ, Pu WT.

Genome Biol. 2016 Jun 3;17(1):120. doi: 10.1186/s13059-016-0984-2.


Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart.

Stevens SM, von Gise A, VanDusen N, Zhou B, Pu WT.

Dev Biol. 2016 May 15;413(2):153-159. doi: 10.1016/j.ydbio.2016.03.014. Epub 2016 Mar 14.


Recounting Cardiac Cellular Composition.

Zhou P, Pu WT.

Circ Res. 2016 Feb 5;118(3):368-70. doi: 10.1161/CIRCRESAHA.116.308139. No abstract available.


Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.

Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ.

J Clin Invest. 2015 Nov 2;125(11):4122-34. doi: 10.1172/JCI82423. Epub 2015 Oct 5.


SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth.

Sun Y, Ju M, Lin Z, Fredrick TW, Evans LP, Tian KT, Saba NJ, Morss PC, Pu WT, Chen J, Stahl A, Joyal JS, Smith LE.

Sci Signal. 2015 Sep 22;8(395):ra94. doi: 10.1126/scisignal.aaa8695.


Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction.

Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR.

PLoS One. 2015 Sep 21;10(9):e0136025. doi: 10.1371/journal.pone.0136025. eCollection 2015.


Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation.

Sun Y, Liu CH, SanGiovanni JP, Evans LP, Tian KT, Zhang B, Stahl A, Pu WT, Kamenecka TM, Solt LA, Chen J.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10401-6. doi: 10.1073/pnas.1504387112. Epub 2015 Aug 4.


Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis.

von Gise A, Stevens SM, Honor LB, Oh JH, Gao C, Zhou B, Pu WT.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):222-30. doi: 10.1165/rcmb.2014-0461OC.


Trbp regulates heart function through microRNA-mediated Sox6 repression.

Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng ZL, Pu WT, Wang DZ.

Nat Genet. 2015 Jul;47(7):776-83. doi: 10.1038/ng.3324. Epub 2015 Jun 1.


Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase.

Prendiville TW, Guo H, Lin Z, Zhou P, Stevens SM, He A, VanDusen N, Chen J, Zhong L, Wang DZ, Gao G, Pu WT.

PLoS One. 2015 May 29;10(5):e0128105. doi: 10.1371/journal.pone.0128105. eCollection 2015.


Cellular origin and developmental program of coronary angiogenesis.

Tian X, Pu WT, Zhou B.

Circ Res. 2015 Jan 30;116(3):515-30. doi: 10.1161/CIRCRESAHA.116.305097. Review.


Releasing YAP from an α-catenin trap increases cardiomyocyte proliferation.

Lin Z, Pu WT.

Circ Res. 2015 Jan 2;116(1):9-11. doi: 10.1161/CIRCRESAHA.114.305496. No abstract available.


Introduction to the special issue on heart regeneration and rejuvenation.

Harvey RP, Graham RM, Pu WT.

Stem Cell Res. 2014 Nov;13(3 Pt B):521-2. doi: 10.1016/j.scr.2014.10.003. Epub 2014 Oct 12.


Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders.

Prendiville T, Jay PY, Pu WT.

Cold Spring Harb Perspect Med. 2014 Oct 1;4(10). pii: a013946. doi: 10.1101/cshperspect.a013946. Review.


Epicardium-to-fat transition in injured heart.

Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B.

Cell Res. 2014 Nov;24(11):1367-9. doi: 10.1038/cr.2014.125. Epub 2014 Sep 26. No abstract available.


Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.

Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, Pu WT.

Circ Res. 2015 Jan 2;116(1):35-45. doi: 10.1161/CIRCRESAHA.115.304457. Epub 2014 Sep 23.


Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease.

He A, Gu F, Hu Y, Ma Q, Ye LY, Akiyama JA, Visel A, Pennacchio LA, Pu WT.

Nat Commun. 2014 Sep 24;5:4907. doi: 10.1038/ncomms5907.

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