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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 1
1996 1
1997 2
1998 3
1999 3
2000 4
2001 5
2002 2
2003 4
2004 2
2005 5
2006 5
2007 6
2008 6
2009 12
2010 6
2011 9
2012 5
2013 11
2014 12
2015 11
2016 5
2017 12
2018 7
2019 11
2020 8
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2023 12
2024 7

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174 results

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Page 1
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G. Dai W, et al. Cancer Commun (Lond). 2022 Sep;42(9):848-867. doi: 10.1002/cac2.12341. Epub 2022 Jul 29. Cancer Commun (Lond). 2022. PMID: 35904817 Free PMC article.
PTPRO silencing significantly promoted cell growth and liver metastasis. Compared with PTPRO wild-type mice, PTPRO-knockout mice developed more tumors and harbored larger tumor loads under treatment with azoxymethane and dextran sulfate sodium. ...
PTPRO silencing significantly promoted cell growth and liver metastasis. Compared with PTPRO wild-type mice, PTPRO-knoc …
PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.
Dong H, Lin W, Du L, Yao Z, Li F, Chen S, Huang Y, Ren H, Luo Y, Cai S, Chen Y, Tang H, Qiu X, Pan Y, Huang X, Zhang D, Gao S, Yeung SJ, Zhang H. Dong H, et al. Cancer Lett. 2023 Jul 28;567:216283. doi: 10.1016/j.canlet.2023.216283. Epub 2023 Jun 17. Cancer Lett. 2023. PMID: 37331584
Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. ...Patients with PTPRO(low)/p-MET(high) had significan …
Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PT …
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment.
Yao Z, Dong H, Zhu J, Du L, Luo Y, Liu Q, Liu S, Lin Y, Wang L, Wang S, Wei W, Zhang K, Huang Q, Yu X, Zhao W, Xu H, Qiu X, Pan Y, Huang X, Jim Yeung SC, Zhang D, Zhang H. Yao Z, et al. JCI Insight. 2023 Jul 24;8(14):e166306. doi: 10.1172/jci.insight.166306. JCI Insight. 2023. PMID: 37485875 Free PMC article.
To understand the protective role of PTPRO in CRCI, a mouse model was generated by treating Ptpro-/- female mice with doxorubicin (DOX) because Ptpro-/- female mice are more vulnerable to DOX, showing cognitive impairments and neurodegeneration. ...On the oth …
To understand the protective role of PTPRO in CRCI, a mouse model was generated by treating Ptpro-/- female mice with doxorubi …
PTPRO activates TLR4/NF-kappaB signaling to intensify lipopolysaccharide-induced pneumonia cell injury.
Chen Y, Sun B. Chen Y, et al. Allergol Immunopathol (Madr). 2022 May 1;50(3):119-124. doi: 10.15586/aei.v50i3.589. eCollection 2022. Allergol Immunopathol (Madr). 2022. PMID: 35527665
However, overexpression of PTPRO aggravated lipopolysaccharide-induced cytotoxicity in HFL1. Overexpression of PTPRO upregulated protein expression of TLR4 and p-p65 in lipopolysaccharide-induced HFL1, while knockdown of PTPRO reduced the level of p-IkappaBal …
However, overexpression of PTPRO aggravated lipopolysaccharide-induced cytotoxicity in HFL1. Overexpression of PTPRO upregulat …
PTPRO-related CD8(+) T-cell signatures predict prognosis and immunotherapy response in patients with breast cancer.
Dong H, Xie C, Yao Z, Zhao R, Lin Y, Luo Y, Chen S, Qin Y, Chen Y, Zhang H. Dong H, et al. Front Immunol. 2022 Aug 8;13:947841. doi: 10.3389/fimmu.2022.947841. eCollection 2022. Front Immunol. 2022. PMID: 36003382 Free PMC article.
METHODS: ESTIMATE and single-sample gene set enrichment analysis (ssGSEA) were performed to uncover the TIME landscape. The correlation analysis of PTPRO and immune infiltration was performed to characterize the immune features of PTPRO. ...PTPRO-based PTS pr …
METHODS: ESTIMATE and single-sample gene set enrichment analysis (ssGSEA) were performed to uncover the TIME landscape. The correlation anal …
PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-kappaB signaling pathway.
Huan Z, Tang Y, Xu C, Cai J, Yao H, Wang Y, Bu F, Ge X. Huan Z, et al. Respir Res. 2022 Jul 29;23(1):195. doi: 10.1186/s12931-022-02118-2. Respir Res. 2022. PMID: 35906634 Free PMC article.
The rats were infected with lentivirus harboring short hairpin RNA (shRNA) targeting PTPRO by intratracheal instillation. RESULTS: PTPRO was significantly up-regulated in rat lungs after HS. ...Besides, HS-induced myeloperoxidase activity and inflammatory cell infil …
The rats were infected with lentivirus harboring short hairpin RNA (shRNA) targeting PTPRO by intratracheal instillation. RESULTS: …
PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF-kappaB pathway.
Zhao J, Yan S, Zhu X, Bai W, Li J, Liang C. Zhao J, et al. J Cell Biochem. 2020 Feb;121(2):1061-1071. doi: 10.1002/jcb.29343. Epub 2019 Aug 26. J Cell Biochem. 2020. PMID: 31452237
Besides, PTPRO inhibited the proliferation of intestinal epithelial cells (IECs) but enhanced the apoptosis of IECs in macrophages. ...Taken these, the present study shows strong evidence that PTPRO exaggerates inflammation in UC via TLR4/NF-kappaB signaling pathway …
Besides, PTPRO inhibited the proliferation of intestinal epithelial cells (IECs) but enhanced the apoptosis of IECs in macrophages. . …
PTPRO predicts patient prognosis and correlates with immune infiltrates in human clear cell renal cell carcinoma.
Gan J, Zhang H. Gan J, et al. Transl Cancer Res. 2020 Aug;9(8):4800-4810. doi: 10.21037/tcr-19-2808. Transl Cancer Res. 2020. PMID: 35117843 Free PMC article.
The impact of PTPRO methylation on overall survival was estimated by the MethSurv database. ...Furthermore, methylation of PTPRO was prevalently observed in ccRCC, and methylation of PTPRO predicted the poor outcome of ccRCC. ...
The impact of PTPRO methylation on overall survival was estimated by the MethSurv database. ...Furthermore, methylation of PTPRO …
PTPRO is a therapeutic target and correlated with immune infiltrates in pancreatic cancer.
Hou X, Du J, Fang H. Hou X, et al. J Cancer. 2021 Oct 30;12(24):7445-7453. doi: 10.7150/jca.64661. eCollection 2021. J Cancer. 2021. PMID: 35003364 Free PMC article.
Currently, the roles of PTPRO in human cancers remain elusive. Herein, we performed bioinformatic analyses and revealed the potential oncogenic role of PTPRO in specific cancer types. ...Our findings suggested PTPRO may serve as a potential drug target for pa …
Currently, the roles of PTPRO in human cancers remain elusive. Herein, we performed bioinformatic analyses and revealed the potential …
PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis.
Zhang W, Hou J, Wang X, Jiang R, Yin Y, Ji J, Deng L, Huang X, Wang K, Sun B. Zhang W, et al. Oncotarget. 2015 Apr 20;6(11):9420-33. doi: 10.18632/oncotarget.3353. Oncotarget. 2015. PMID: 25826083 Free PMC article.
Increased activation of AKT and accumulation of cytoplasmic p53 was detected in ptpro-/- mice, which in combination repressed autophagy. Intriguingly, hyperinsulinemia involving AKT activation was also exacerbated in HFD-fed mice due to PTPRO deletion. ...Due to hyp …
Increased activation of AKT and accumulation of cytoplasmic p53 was detected in ptpro-/- mice, which in combination repressed autopha …
174 results