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Year Number of Results
2002 4
2003 9
2004 27
2005 34
2006 45
2007 50
2008 51
2009 54
2010 64
2011 69
2012 66
2013 57
2014 53
2015 60
2016 48
2017 66
2018 53
2019 43
2020 44
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2022 32
2023 24
2024 10

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863 results

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Page 1
Targeting PTGES/PGE2 axis enhances sensitivity of colorectal cancer cells to 5-fluorouracil.
Geng S, Zhan H, Cao L, Geng L, Ren X. Geng S, et al. Biochem Cell Biol. 2023 Dec 1;101(6):501-512. doi: 10.1139/bcb-2023-0101. Epub 2023 Jun 26. Biochem Cell Biol. 2023. PMID: 37358009
Inhibition of PTGES enzymatic function, by either inducing loss-of-function mutant or treatment with selective inhibitors, phenocopied the PTGES depletion in terms of 5FU sensitization. ...Importantly, high PTGES expression is correlated with poor prognosis i …
Inhibition of PTGES enzymatic function, by either inducing loss-of-function mutant or treatment with selective inhibitors, phenocopie …
PTGES/PGE(2) signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.
Wang T, Jing B, Xu D, Liao Y, Song H, Sun B, Guo W, Xu J, Li K, Hu M, Liu S, Ling J, Kuang Y, Zhang T, Zhang S, Yao F, Zhou BP, Deng J. Wang T, et al. Oncogene. 2020 Apr;39(15):3179-3194. doi: 10.1038/s41388-020-1207-6. Epub 2020 Feb 14. Oncogene. 2020. PMID: 32060421 Free PMC article.
This suggests that the major role of PTGES/PGE(2) signaling in tumorigenicity and lung metastasis is through immunosuppression. ...Thus, PTGES/PGE(2) signaling links immunosuppression and metastasis in an inflammatory lung microenvironment of Gprc5a-ko mouse model.. …
This suggests that the major role of PTGES/PGE(2) signaling in tumorigenicity and lung metastasis is through immunosuppression. ...Th …
PTGES Expression Is Associated with Metabolic and Immune Reprogramming in Pancreatic Ductal Adenocarcinoma.
Murthy D, Attri KS. Murthy D, et al. Int J Mol Sci. 2023 Apr 15;24(8):7304. doi: 10.3390/ijms24087304. Int J Mol Sci. 2023. PMID: 37108468 Free PMC article.
PTGES expression was also correlated with higher mutational burden in key driver genes, such as TP53 and KRAS. ...Notably, the glycolysis pathway was positively correlated with PTGES and may fuel cancer cell growth. PTGES expression was also associated with d …
PTGES expression was also correlated with higher mutational burden in key driver genes, such as TP53 and KRAS. ...Notably, the glycol …
Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE(2) signaling.
Wang T, Jing B, Sun B, Liao Y, Song H, Xu D, Guo W, Li K, Hu M, Liu S, Ling J, Kuang Y, Feng Y, Zhou BP, Deng J. Wang T, et al. Am J Cancer Res. 2019 Jun 1;9(6):1145-1160. eCollection 2019. Am J Cancer Res. 2019. PMID: 31285948 Free PMC article.
Dysregulated PTGES was essential for the promotion of tumor migration and metastasis of NSCLC cells. ...Dysregulated PTGES is mainly attributed to protein stabilization by USP9X, a deubiquitination enzyme. ...
Dysregulated PTGES was essential for the promotion of tumor migration and metastasis of NSCLC cells. ...Dysregulated PTGES is …
The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma.
Ding X, Qin J, Huang F, Feng F, Luo L. Ding X, et al. Inflamm Res. 2023 May;72(5):1099-1119. doi: 10.1007/s00011-023-01732-0. Epub 2023 Apr 20. Inflamm Res. 2023. PMID: 37081162
RESULTS: Cholesterol 25-hydroxylase (CH25H) was finally localized as a core lipid metabolism gene in asthma and was verified to be highly expressed in two mouse models of asthma. Five-gene lipid metabolism constructed from CYP2E1, CH25H, PTGES, ALOX15 and ME1 was able to d …
RESULTS: Cholesterol 25-hydroxylase (CH25H) was finally localized as a core lipid metabolism gene in asthma and was verified to be highly ex …
Discovery of a Celecoxib Binding Site on Prostaglandin E Synthase (PTGES) with a Cleavable Chelation-Assisted Biotin Probe.
Miyamoto DK, Flaxman HA, Wu HY, Gao J, Woo CM. Miyamoto DK, et al. ACS Chem Biol. 2019 Dec 20;14(12):2527-2532. doi: 10.1021/acschembio.9b00511. Epub 2019 Oct 25. ACS Chem Biol. 2019. PMID: 31650837
Here, we report a novel binding site for celecoxib on prostaglandin E synthase (PTGES), which is an enzyme downstream of COX-2 in the prostaglandin signaling pathway, using a cleavable chelation-assisted biotin probe 6. ...Four binding sites to photo-celecoxib were mapped …
Here, we report a novel binding site for celecoxib on prostaglandin E synthase (PTGES), which is an enzyme downstream of COX-2 in the …
Effects of orexin A on PTGS2, PTGES, CBR1 and PGFS mRNA transcript abundances and prostaglandin E(2) and F(2alpha) concentrations in culture medium of pig uterine explants collected during early gestation and the estrogenic cycle.
Orzechowska K, Kiezun M, Rytelewska E, Gudelska M, Kisielewska K, Kopij G, Dobrzyn K, Zaobidna E, Szymanska K, Kaminski T, Smolinska N. Orzechowska K, et al. Anim Reprod Sci. 2022 Feb;237:106910. doi: 10.1016/j.anireprosci.2021.106910. Epub 2021 Dec 16. Anim Reprod Sci. 2022. PMID: 34974394
In this study, aims were to evaluate orexin A (OXA) effects on mRNA abundance of important enzymes involved in prostaglandin production, such as cyclooxygenase 2 (PTGS2), microsomal PGE(2) synthase-1 (PTGES), PGF(2alpha) synthase (PGFS) and carbonyl reductase 1 (CBR1), as …
In this study, aims were to evaluate orexin A (OXA) effects on mRNA abundance of important enzymes involved in prostaglandin production, suc …
Exogenous NAD(+) Stimulates MUC2 Expression in LS 174T Goblet Cells via the PLC-Delta/PTGES/PKC-Delta/ERK/CREB Signaling Pathway.
Ma S, Yeom J, Lim YH. Ma S, et al. Biomolecules. 2020 Apr 9;10(4):580. doi: 10.3390/biom10040580. Biomolecules. 2020. PMID: 32283838 Free PMC article.
NAD(+) treatment increased phospholipase C (PLC)-delta and prostaglandin E synthase (PTGES) expression, which was inhibited by the appropriate inhibitors. ...CONCLUSIONS: Exogenous NAD(+) increases MUC2 expression by stimulating the PLC-delta/PTGES/PKC-delta/ERK/CRE …
NAD(+) treatment increased phospholipase C (PLC)-delta and prostaglandin E synthase (PTGES) expression, which was inhibited by the ap …
Far upstream element-binding protein 1 confers lobaplatin resistance by transcriptionally activating PTGES and facilitating the arachidonic acid metabolic pathway in osteosarcoma.
Ma Q, Sun J, Wang H, Zhou C, Li C, Wu Y, Wen Y, Zhang X, Ren X, Guo Z, Gong L, Zhang W. Ma Q, et al. MedComm (2020). 2023 May 9;4(3):e257. doi: 10.1002/mco2.257. eCollection 2023 Jun. MedComm (2020). 2023. PMID: 37180822 Free PMC article.
It was revealed that FUBP1 could regulate the transcription of prostaglandin E synthase (PTGES) and subsequently activate the arachidonic acid (AA) metabolic pathway, which leads to resistance to lobaplatin. Our investigation provides evidence that FUBP1 is a potential the …
It was revealed that FUBP1 could regulate the transcription of prostaglandin E synthase (PTGES) and subsequently activate the arachid …
863 results