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Items: 15


Noncompetitive antagonists induce cooperative AMPA receptor channel gating.

Shi EY, Yuan CL, Sipple MT, Srinivasan J, Ptak CP, Oswald RE, Nowak LM.

J Gen Physiol. 2019 Jan 8. pii: jgp.201812209. doi: 10.1085/jgp.201812209. [Epub ahead of print]


Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design.

Ptak CP, Akif M, Hsieh CL, Devarajan A, He P, Xu Y, Oswald RE, Chang YF.

Biotechnol Bioeng. 2019 Feb;116(2):260-271. doi: 10.1002/bit.26864. Epub 2018 Dec 5.


7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.

Goffin E, Drapier T, Larsen AP, Geubelle P, Ptak CP, Laulumaa S, Rovinskaja K, Gilissen J, Tullio P, Olsen L, Frydenvang K, Pirotte B, Hanson J, Oswald RE, Kastrup JS, Francotte P.

J Med Chem. 2018 Jan 11;61(1):251-264. doi: 10.1021/acs.jmedchem.7b01323. Epub 2017 Dec 19.


Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design.

Hsieh CL, Ptak CP, Tseng A, Suguiura IMS, McDonough SP, Sritrakul T, Li T, Lin YP, Gillilan RE, Oswald RE, Chang YF.

Elife. 2017 Dec 6;6. pii: e30051. doi: 10.7554/eLife.30051.


Effects of L-arabinose efflux on λ Red recombination-mediated gene knockout in multiple-antimicrobial-resistant Salmonella enterica serovar Choleraesuis.

Liao SW, Lee JJ, Ptak CP, Wu YC, Hsuan SL, Kuo CJ, Chen TH.

Arch Microbiol. 2018 Mar;200(2):219-225. doi: 10.1007/s00203-017-1436-4. Epub 2017 Oct 3.


Comparative genomic and phenomic analysis of Clostridium difficile and Clostridium sordellii, two related pathogens with differing host tissue preference.

Scaria J, Suzuki H, Ptak CP, Chen JW, Zhu Y, Guo XK, Chang YF.

BMC Genomics. 2015 Jun 10;16:448. doi: 10.1186/s12864-015-1663-5.


NMR solution structure of the terminal immunoglobulin-like domain from the leptospira host-interacting outer membrane protein, LigB.

Ptak CP, Hsieh CL, Lin YP, Maltsev AS, Raman R, Sharma Y, Oswald RE, Chang YF.

Biochemistry. 2014 Aug 19;53(32):5249-60. doi: 10.1021/bi500669u. Epub 2014 Aug 4.


Role of stoichiometry in the dimer-stabilizing effect of AMPA receptor allosteric modulators.

Ptak CP, Hsieh CL, Weiland GA, Oswald RE.

ACS Chem Biol. 2014 Jan 17;9(1):128-33. doi: 10.1021/cb4007166. Epub 2013 Nov 1.


Dynamics of cleft closure of the GluA2 ligand-binding domain in the presence of full and partial agonists revealed by hydrogen-deuterium exchange.

Ahmed AH, Ptak CP, Fenwick MK, Hsieh CL, Weiland GA, Oswald RE.

J Biol Chem. 2013 Sep 20;288(38):27658-66. doi: 10.1074/jbc.M113.495564. Epub 2013 Aug 12.


The perturbation of tryptophan fluorescence by phenylalanine to alanine mutations identifies the hydrophobic core in a subset of bacterial Ig-like domains.

Raman R, Ptak CP, Hsieh CL, Oswald RE, Chang YF, Sharma Y.

Biochemistry. 2013 Jul 9;52(27):4589-91. doi: 10.1021/bi400128r. Epub 2013 Jun 28.


Elastin, a novel extracellular matrix protein adhering to mycobacterial antigen 85 complex.

Kuo CJ, Ptak CP, Hsieh CL, Akey BL, Chang YF.

J Biol Chem. 2013 Feb 8;288(6):3886-96. doi: 10.1074/jbc.M112.415679. Epub 2012 Dec 17.


Novel mycobacteria antigen 85 complex binding motif on fibronectin.

Kuo CJ, Bell H, Hsieh CL, Ptak CP, Chang YF.

J Biol Chem. 2012 Jan 13;287(3):1892-902. doi: 10.1074/jbc.M111.298687. Epub 2011 Nov 29.


Probing the allosteric modulator binding site of GluR2 with thiazide derivatives.

Ptak CP, Ahmed AH, Oswald RE.

Biochemistry. 2009 Sep 15;48(36):8594-602. doi: 10.1021/bi901127s.


Electrostatic interaction of a K+ channel RCK domain with charged membrane surfaces.

Ptak CP, Cuello LG, Perozo E.

Biochemistry. 2005 Jan 11;44(1):62-71.


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