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124 results

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Page 1
Association between Genetic Variants of CELSR2-PSRC1-SORT1 and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.
Castillo-Avila RG, González-Castro TB, Tovilla-Zárate CA, Martínez-Magaña JJ, López-Narváez ML, Juárez-Rojop IE, Arias-Vázquez PI, Borgonio-Cuadra VM, Pérez-Hernández N, Rodríguez-Pérez JM. Castillo-Avila RG, et al. J Cardiovasc Dev Dis. 2023 Feb 21;10(3):91. doi: 10.3390/jcdd10030091. J Cardiovasc Dev Dis. 2023. PMID: 36975855 Free PMC article. Review.
A cluster of three genes CELSR2, PSRC1, and SORT1 has been associated with cardiovascular diseases. ...PheWas analysis showed associations with coronary artery disease and total cholesterol. Our results suggest a possible involvement of the CELSR2-PSRC1-SORT1 cluste …
A cluster of three genes CELSR2, PSRC1, and SORT1 has been associated with cardiovascular diseases. ...PheWas analysis showed associa …
PSRC1 Regulated by DNA Methylation Is a Novel Target for LGG Immunotherapy.
Liu Z, Liang W, Zhu Q, Cheng X, Qian R, Gao Y. Liu Z, et al. J Mol Neurosci. 2023 Aug;73(7-8):516-528. doi: 10.1007/s12031-023-02133-y. Epub 2023 Jun 16. J Mol Neurosci. 2023. PMID: 37326762
Proline and serine-rich coiled-coil 1 (PSRC1) has been reported to function as an oncogene in several cancers by regulating mitosis, while there are few reports on the role of PSRC1 in lower-grade glioma (LGG). ...Finally, co-expression analysis and KEGG analysis sh …
Proline and serine-rich coiled-coil 1 (PSRC1) has been reported to function as an oncogene in several cancers by regulating mitosis, …
Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3.
Luo T, Guo Z, Liu D, Guo Z, Wu Q, Li Q, Lin R, Chen P, Ou C, Chen M. Luo T, et al. Gut Microbes. 2022 Jan-Dec;14(1):2077602. doi: 10.1080/19490976.2022.2077602. Gut Microbes. 2022. PMID: 35613310 Free PMC article.
To investigate the role of dysbiosis induced by PSRC1 deletion in atherogenesis, apoE(-/-) mice were transplanted with the fecal microbiota from either apoE(-/-) or PSRC1(-/-)apoE(-/-) donor mice. ...Thus, PSRC1 holds great potential for manipulating the gut …
To investigate the role of dysbiosis induced by PSRC1 deletion in atherogenesis, apoE(-/-) mice were transplanted with the fecal micr …
High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma.
Han R, Guan Y, Tang M, Li M, Zhang B, Fei G, Zhou S, Wang R. Han R, et al. J Cancer. 2023 Oct 7;14(17):3321-3334. doi: 10.7150/jca.88635. eCollection 2023. J Cancer. 2023. PMID: 37928428 Free PMC article.
The function of PSRC1 was identified using enrichment analysis, and the relationship between PSRC1 expression and immune cell infiltration was studied. ...Multivariable analysis showed that PSRC1 was an independent risk factor for LUAD. Functional enrichment …
The function of PSRC1 was identified using enrichment analysis, and the relationship between PSRC1 expression and immune cell …
PSRC1 overexpression attenuates atherosclerosis progression in apoE(-/-) mice by modulating cholesterol transportation and inflammation.
Guo K, Hu L, Xi D, Zhao J, Liu J, Luo T, Ma Y, Lai W, Guo Z. Guo K, et al. J Mol Cell Cardiol. 2018 Mar;116:69-80. doi: 10.1016/j.yjmcc.2018.01.013. Epub 2018 Feb 3. J Mol Cell Cardiol. 2018. PMID: 29378206
In addition, our previous study showed that the cholesterol efflux capacity is decreased in macrophages following a treatment silencing Psrc1, indicating that PSRC1 has anti-atherosclerotic effects. However, the role of PSRC1 in the development of atheroscler …
In addition, our previous study showed that the cholesterol efflux capacity is decreased in macrophages following a treatment silencing P …
Proline/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2.
Pan H, Guo Z, Lv P, Hu K, Wu T, Lin Z, Xue Y, Zhang Y, Guo Z. Pan H, et al. Clin Transl Med. 2023 Mar;13(3):e1220. doi: 10.1002/ctm2.1220. Clin Transl Med. 2023. PMID: 36932468 Free PMC article.
In addition, SP1 is a PSRC1 upstream repressive transcription factor, and the SP1 inhibitor mithramycin (Mith) elevated PSRC1 expression and exerted anti-AS effects in AS model mice. ...SP1 is an upstream transcription factor of PSRC1 and inhibits the transcr …
In addition, SP1 is a PSRC1 upstream repressive transcription factor, and the SP1 inhibitor mithramycin (Mith) elevated PSRC1 …
Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE(-/-) mice.
Luo T, Liu D, Guo Z, Chen P, Guo Z, Ou C, Chen M. Luo T, et al. J Mol Cell Cardiol. 2022 Sep;170:60-74. doi: 10.1016/j.yjmcc.2022.05.013. Epub 2022 Jun 8. J Mol Cell Cardiol. 2022. PMID: 35690006
We further deleted PSRC1 in apoE(-/-) mice and PSRC1 deficiency significantly accelerated choline-induced atherogenesis, characterized by increased macrophage infiltration, foam cell formation and M1 macrophage polarization. ...Therefore, PSRC1 overexpression …
We further deleted PSRC1 in apoE(-/-) mice and PSRC1 deficiency significantly accelerated choline-induced atherogenesis, chara …
Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis.
Kim MS, Song M, Kim B, Shim I, Kim DS, Natarajan P, Do R, Won HH. Kim MS, et al. Cell Rep Med. 2023 Sep 19;4(9):101112. doi: 10.1016/j.xcrm.2023.101112. Epub 2023 Aug 14. Cell Rep Med. 2023. PMID: 37582372 Free PMC article.
Given that a multi-trait approach increases the power to detect meaningful variants/genes, we conduct multi-omics and multi-trait analyses, followed by network connectivity investigations, and prioritize 30 potential therapeutic targets for dyslipidemia, including SORT1, PSRC1 …
Given that a multi-trait approach increases the power to detect meaningful variants/genes, we conduct multi-omics and multi-trait analyses, …
PSRC1 May Affect Coronary Artery Disease Risk by Altering CELSR2, PSRC1, and SORT1 Gene Expression and Circulating Granulin and Apolipoprotein B Protein Levels.
Chai T, Wang Z, Yang X, Qiu Z, Chen L. Chai T, et al. Front Cardiovasc Med. 2022 Feb 18;9:763015. doi: 10.3389/fcvm.2022.763015. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35252377 Free PMC article.
PSRC1 variants were strongly associated with SORT1, PSRC1, and CELSR2 gene expression in liver cells. ...CONCLUSION: This study showed that regulatory SNPs in PSRC1 may affect CAD risk by altering CELSR2, PSRC1, and SORT1 gene expression in liver cells …
PSRC1 variants were strongly associated with SORT1, PSRC1, and CELSR2 gene expression in liver cells. ...CONCLUSION: This stud …
124 results