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Clinically important associations of pleurodesis success in malignant pleural effusion: Analysis of the TIME1 data set.

Mercer RM, Macready J, Jeffries H, Speck N, Kanellakis NI, Maskell NA, Pepperell J, Saba T, West A, Ali N, Corcoran JP, Hallifax RJ, Psallidas I, Asciak R, Hassan M, Miller RF, Rahman NM.

Respirology. 2019 Dec 17. doi: 10.1111/resp.13755. [Epub ahead of print]


Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial.

Bhatnagar R, Piotrowska HEG, Laskawiec-Szkonter M, Kahan BC, Luengo-Fernandez R, Pepperell JCT, Evison MD, Holme J, Al-Aloul M, Psallidas I, Lim WS, Blyth KG, Roberts ME, Cox G, Downer NJ, Herre J, Sivasothy P, Menzies D, Munavvar M, Kyi MM, Ahmed L, West AG, Harrison RN, Prudon B, Hettiarachchi G, Chakrabarti B, Kavidasan A, Sutton BP, Zahan-Evans NJ, Quaddy JL, Edey AJ, Clive AO, Walker SP, Little MHR, Mei XW, Harvey JE, Hooper CE, Davies HE, Slade M, Sivier M, Miller RF, Rahman NM, Maskell NA.

JAMA. 2019 Dec 5. doi: 10.1001/jama.2019.19997. [Epub ahead of print]


Osteopontin drives KRAS-mutant lung adenocarcinoma.

Giopanou I, Kanellakis NI, Giannou AD, Lilis I, Marazioti A, Spella M, Papaleonidopoulos V, Simoes DCM, Zazara DE, Agalioti T, Moschos C, Magkouta S, Kalomenidis I, Panoutsakopoulou V, Lamort AS, Stathopoulos GT, Psallidas I.

Carcinogenesis. 2019 Nov 19. pii: bgz190. doi: 10.1093/carcin/bgz190. [Epub ahead of print]


Biological effect of tissue plasminogen activator (t-PA) and DNase intrapleural delivery in pleural infection patients.

Kanellakis NI, Wrightson JM, Hallifax R, Bedawi EO, Mercer R, Hassan M, Asciak R, Hedley E, Dobson M, Dong T, Psallidas I, Rahman NM.

BMJ Open Respir Res. 2019 Sep 24;6(1):e000440. doi: 10.1136/bmjresp-2019-000440. eCollection 2019.


Survival in patients with malignant pleural effusion undergoing talc pleurodesis.

Hassan M, Mercer RM, Maskell NA, Asciak R, McCracken DJ, Bedawi EO, Shaarawy H, El-Ganady A, Psallidas I, Miller RF, Rahman NM.

Lung Cancer. 2019 Nov;137:14-18. doi: 10.1016/j.lungcan.2019.09.003. Epub 2019 Sep 4.


Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight.

Lamort AS, Giopanou I, Psallidas I, Stathopoulos GT.

Cells. 2019 Aug 2;8(8). pii: E815. doi: 10.3390/cells8080815. Review.


The microbiology of pleural infection in adults: a systematic review.

Hassan M, Cargill T, Harriss E, Asciak R, Mercer RM, Bedawi EO, McCracken DJ, Psallidas I, Corcoran JP, Rahman NM.

Eur Respir J. 2019 Oct 1;54(3). pii: 1900542. doi: 10.1183/13993003.00542-2019. Print 2019 Sep.


Novel mouse model of indwelling pleural catheter in mice with malignant pleural effusion.

Merrick C, Sherrill T, Kanellakis NI, Asciak R, Stathopoulos GT, Maldonado F, Rahman NM, Blackwell T, Psallidas I.

ERJ Open Res. 2019 May 28;5(2). pii: 00226-2018. doi: 10.1183/23120541.00226-2018. eCollection 2019 Apr.


Cost-effectiveness of intrapleural use of tissue plasminogen activator and DNase in pleural infection: evidence from the MIST2 randomised controlled trial.

Luengo-Fernandez R, Penz E, Dobson M, Psallidas I, Nunn AJ, Maskell NA, Rahman NM.

Eur Respir J. 2019 Aug 1;54(2). pii: 1801550. doi: 10.1183/13993003.01550-2018. Print 2019 Aug.


Interpreting pleural fluid results .

Mercer RM, Corcoran JP, Porcel JM, Rahman NM, Psallidas I.

Clin Med (Lond). 2019 May;19(3):213-217. doi: 10.7861/clinmedicine.19-3-213. Review.


Prospective Analysis of the Predictive Value of Sonographic Pleural Fluid Echogenicity for the Diagnosis of Exudative Effusion.

Asciak R, Hassan M, Mercer RM, Hallifax RJ, Wrightson JM, Psallidas I, Rahman NM.

Respiration. 2019;97(5):451-456. doi: 10.1159/000496153. Epub 2019 Mar 19.



Psallidas I, Rahman NM.

Chest. 2019 Mar;155(3):650-651. doi: 10.1016/j.chest.2018.11.027. No abstract available.


Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter.

Kanellakis NI, Giannou AD, Pepe MAA, Agalioti T, Zazara DE, Giopanou I, Psallidas I, Spella M, Marazioti A, Arendt KAM, Lamort AS, Champeris Tsaniras S, Taraviras S, Papadaki H, Lilis I, Stathopoulos GT.

Carcinogenesis. 2019 Nov 25;40(11):1352-1362. doi: 10.1093/carcin/bgz047.


Palliative care in mesothelioma: Are current services RESPECT-able enough?

Kumar N, Alrifai D, Psallidas I.

Thorax. 2019 Apr;74(4):326-327. doi: 10.1136/thoraxjnl-2018-212967. Epub 2019 Mar 2. No abstract available.


Routine monitoring with pleural manometry during therapeutic large-volume thoracentesis to prevent pleural-pressure-related complications: a multicentre, single-blind randomised controlled trial.

Lentz RJ, Lerner AD, Pannu JK, Merrick CM, Roller L, Walston C, Valenti S, Goddard T, Chen H, Huggins JT, Rickman OB, Yarmus L, Psallidas I, Rahman NM, Light RW, Maldonado F.

Lancet Respir Med. 2019 May;7(5):447-455. doi: 10.1016/S2213-2600(18)30421-1. Epub 2019 Feb 13.


A Randomized Trial of Dual-Acting Bronchodilator AZD8871 for Chronic Obstructive Pulmonary Disease.

Singh D, Fuhr R, Jimenez L, Wählby Hamrén U, Jauhiainen A, Malice MP, Balaguer V, Lei A, Aggarwal A, Astbury C, Psallidas I.

Am J Respir Crit Care Med. 2019 May 15;199(10):1282-1284. doi: 10.1164/rccm.201812-2345LE. No abstract available.


Does attempting talc pleurodesis affect subsequent indwelling pleural catheter (IPC)-related non-draining septated pleural effusion and IPC-related spontaneous pleurodesis?

Asciak R, Mercer RM, Hallifax RJ, Hassan M, Bedawi E, McCracken D, Kanellakis NI, Wrightson JM, Psallidas I, Rahman NM.

ERJ Open Res. 2019 Feb 1;5(1). pii: 00208-2018. doi: 10.1183/23120541.00208-2018. eCollection 2019 Feb.


Combined modality treatment in mesothelioma: a systemic literature review with treatment recommendations.

De Bondt C, Psallidas I, Van Schil PEY, van Meerbeeck JP.

Transl Lung Cancer Res. 2018 Oct;7(5):562-573. doi: 10.21037/tlcr.2018.10.02. Review.


Thoracic Ultrasound as an Early Predictor of Pleurodesis Success in Malignant Pleural Effusion.

Corcoran JP, Hallifax RJ, Mercer RM, Yousuf A, Asciak R, Hassan M, Piotrowska HE, Psallidas I, Rahman NM.

Chest. 2018 Nov;154(5):1115-1120. doi: 10.1016/j.chest.2018.08.1031. Epub 2018 Sep 20.


The Hospital and Patient Burden of Indwelling Pleural Catheters: A Retrospective Case Series of 210 Indwelling Pleural Catheter Insertions.

Asciak R, Hallifax RJ, Mercer RM, Hassan M, Wigston C, Wrightson JM, Psallidas I, Rahman NM.

Respiration. 2019;97(1):70-77. doi: 10.1159/000491934. Epub 2018 Sep 18.


Activity and Outcomes From a Dedicated Pleural On-Call Service.

Asciak R, Hallifax RJ, Mercer RM, Hassan M, Bradley C, Corcoran JP, Wrightson JM, Psallidas I, Rahman NM.

Chest. 2018 Sep;154(3):717-718. doi: 10.1016/j.chest.2018.05.027. No abstract available.


Providing safe and effective pleural medicine services in the UK: an aspirational statement from UK pleural physicians.

Evison M, Blyth KG, Bhatnagar R, Corcoran J, Saba T, Duncan T, Hallifax R, Ahmed L, West A, Pepperell JCT, Roberts M, Sivasothy P, Psallidas I, Clive AO, Latham J, Stanton AE, Maskell N, Rahman N.

BMJ Open Respir Res. 2018 Aug 3;5(1):e000307. doi: 10.1136/bmjresp-2018-000307. eCollection 2018.


ERS/EACTS statement on the management of malignant pleural effusions.

Bibby AC, Dorn P, Psallidas I, Porcel JM, Janssen J, Froudarakis M, Subotic D, Astoul P, Licht P, Schmid R, Scherpereel A, Rahman NM, Maskell NA, Cardillo G.

Eur J Cardiothorac Surg. 2019 Jan 1;55(1):116-132. doi: 10.1093/ejcts/ezy258. Review.


ERS/EACTS statement on the management of malignant pleural effusions.

Bibby AC, Dorn P, Psallidas I, Porcel JM, Janssen J, Froudarakis M, Subotic D, Astoul P, Licht P, Schmid R, Scherpereel A, Rahman NM, Cardillo G, Maskell NA.

Eur Respir J. 2018 Jul 27;52(1). pii: 1800349. doi: 10.1183/13993003.00349-2018. Print 2018 Jul. Review.


Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis.

Psallidas I, Kanellakis NI, Gerry S, Thézénas ML, Charles PD, Samsonova A, Schiller HB, Fischer R, Asciak R, Hallifax RJ, Mercer R, Dobson M, Dong T, Pavord ID, Collins GS, Kessler BM, Pass HI, Maskell N, Stathopoulos GT, Rahman NM.

Lancet Oncol. 2018 Jul;19(7):930-939. doi: 10.1016/S1470-2045(18)30294-8. Epub 2018 Jun 13.


Chest Drain Fall-Out Rate According to Suturing Practices: A Retrospective Direct Comparison.

Asciak R, Addala D, Karimjee J, Rana MS, Tsikrika S, Hassan MF, Mercer RM, Hallifax RJ, Wrightson JM, Psallidas I, Benamore R, Rahman NM.

Respiration. 2018;96(1):48-51. doi: 10.1159/000489230. Epub 2018 Jun 14.


Outpatient Talc Administration by Indwelling Pleural Catheter for Malignant Effusion.

Bhatnagar R, Keenan EK, Morley AJ, Kahan BC, Stanton AE, Haris M, Harrison RN, Mustafa RA, Bishop LJ, Ahmed L, West A, Holme J, Evison M, Munavvar M, Sivasothy P, Herre J, Cooper D, Roberts M, Guhan A, Hooper C, Walters J, Saba TS, Chakrabarti B, Gunatilake S, Psallidas I, Walker SP, Bibby AC, Smith S, Stadon LJ, Zahan-Evans NJ, Lee YCG, Harvey JE, Rahman NM, Miller RF, Maskell NA.

N Engl J Med. 2018 Apr 5;378(14):1313-1322. doi: 10.1056/NEJMoa1716883.


A Pilot Feasibility Study in Establishing the Role of Ultrasound-Guided Pleural Biopsies in Pleural Infection (The AUDIO Study).

Psallidas I, Kanellakis NI, Bhatnagar R, Ravindran R, Yousuf A, Edey AJ, Mercer RM, Corcoran JP, Hallifax RJ, Asciak R, Shetty P, Dong T, Piotrowska HEG, Clelland C, Maskell NA, Rahman NM.

Chest. 2018 Oct;154(4):766-772. doi: 10.1016/j.chest.2018.02.031. Epub 2018 Mar 7.


Thoracic involvement in IgG4-related disease in a UK-based patient cohort.

Corcoran JP, Culver EL, Anstey RM, Talwar A, Manganis CD, Cargill TN, Hallifax RJ, Psallidas I, Rahman NM, Barnes E.

Respir Med. 2017 Nov;132:117-121. doi: 10.1016/j.rmed.2017.10.005. Epub 2017 Oct 10.


Efficacy of sonographic and biological pleurodesis indicators of malignant pleural effusion (SIMPLE): protocol of a randomised controlled trial.

Psallidas I, Piotrowska HEG, Yousuf A, Kanellakis NI, Kagithala G, Mohammed S, Clifton L, Corcoran JP, Russell N, Dobson M, Miller RF, Rahman NM.

BMJ Open Respir Res. 2017 Nov 20;4(1):e000225. doi: 10.1136/bmjresp-2017-000225. eCollection 2017.


Randomized Controlled Trial of Urokinase versus Placebo for Nondraining Malignant Pleural Effusion.

Mishra EK, Clive AO, Wills GH, Davies HE, Stanton AE, Al-Aloul M, Hart-Thomas A, Pepperell J, Evison M, Saba T, Harrison RN, Guhan A, Callister ME, Sathyamurthy R, Rehal S, Corcoran JP, Hallifax R, Psallidas I, Russell N, Shaw R, Dobson M, Wrightson JM, West A, Lee YCG, Nunn AJ, Miller RF, Maskell NA, Rahman NM.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):502-508. doi: 10.1164/rccm.201704-0809OC. Erratum in: Am J Respir Crit Care Med. 2018 Apr 15;197(8):1092-1093.


Respiratory training in Greece.

Drakopanagiotakis F, Trachalaki A, Psallidas I.

Breathe (Sheff). 2017 Sep;13(3):251-253. doi: 10.1183/20734735.009317.


Assessment of patient-reported outcome measures in pleural interventions.

Psallidas I, Yousuf A, Talwar A, Hallifax RJ, Mishra EK, Corcoran JP, Ali N, Rahman NM.

BMJ Open Respir Res. 2017 Jul 3;4(1):e000171. doi: 10.1136/bmjresp-2016-000171. eCollection 2017.


Treatment of limited disease small cell lung cancer: the multidisciplinary team.

Glatzer M, Rittmeyer A, Müller J, Opitz I, Papachristofilou A, Psallidas I, Früh M, Born D, Putora PM.

Eur Respir J. 2017 Aug 24;50(2). pii: 1700422. doi: 10.1183/13993003.00422-2017. Print 2017 Aug. Review.


Management of malignant pleural effusion: challenges and solutions.

Penz E, Watt KN, Hergott CA, Rahman NM, Psallidas I.

Cancer Manag Res. 2017 Jun 23;9:229-241. doi: 10.2147/CMAR.S95663. eCollection 2017. Review.


Oncolytic adenovirus expressing bispecific antibody targets T-cell cytotoxicity in cancer biopsies.

Freedman JD, Hagel J, Scott EM, Psallidas I, Gupta A, Spiers L, Miller P, Kanellakis N, Ashfield R, Fisher KD, Duffy MR, Seymour LW.

EMBO Mol Med. 2017 Aug;9(8):1067-1087. doi: 10.15252/emmm.201707567.


Pleural Diseases: Saline Irrigation in Pleural Infection, Epidemiology of Pneumothorax, and Bevacizumab in Mesothelioma.

Corcoran JP, Hallifax RJ, Psallidas I, Rahman NM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):382-385. doi: 10.1164/rccm.201608-1676RR. No abstract available.


Mutant KRAS promotes malignant pleural effusion formation.

Agalioti T, Giannou AD, Krontira AC, Kanellakis NI, Kati D, Vreka M, Pepe M, Spella M, Lilis I, Zazara DE, Nikolouli E, Spiropoulou N, Papadakis A, Papadia K, Voulgaridis A, Harokopos V, Stamou P, Meiners S, Eickelberg O, Snyder LA, Antimisiaris SG, Kardamakis D, Psallidas I, Marazioti A, Stathopoulos GT.

Nat Commun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205.


Ultrasound in the management of pleural disease.

Mercer RM, Psallidas I, Rahman NM.

Expert Rev Respir Med. 2017 Apr;11(4):323-331. doi: 10.1080/17476348.2017.1300531. Epub 2017 Mar 6. Review.


Chest Drain Size: the Debate Continues.

Hallifax RJ, Psallidas I, Rahman NM.

Curr Pulmonol Rep. 2017;6(1):26-29. doi: 10.1007/s13665-017-0162-3. Epub 2017 Jan 26. Review.


NRAS destines tumor cells to the lungs.

Giannou AD, Marazioti A, Kanellakis NI, Giopanou I, Lilis I, Zazara DE, Ntaliarda G, Kati D, Armenis V, Giotopoulou GA, Krontira AC, Lianou M, Agalioti T, Vreka M, Papageorgopoulou M, Fouzas S, Kardamakis D, Psallidas I, Spella M, Stathopoulos GT.

EMBO Mol Med. 2017 May;9(5):672-686. doi: 10.15252/emmm.201606978.


Provision of Day-Case Local Anesthetic Thoracoscopy: A Multicenter Review of Practice.

Psallidas I, Corcoran JP, Fallon J, Bintcliffe O, Sivasothy P, Maskell N, Maldonado F, Pepperell J, Rahman NM.

Chest. 2017 Feb;151(2):511-512. doi: 10.1016/j.chest.2016.11.002. No abstract available.


Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment.

Bibby AC, Tsim S, Kanellakis N, Ball H, Talbot DC, Blyth KG, Maskell NA, Psallidas I.

Eur Respir Rev. 2016 Dec;25(142):472-486. doi: 10.1183/16000617.0063-2016. Review.


Effectiveness of chemical pleurodesis in spontaneous pneumothorax recurrence prevention: a systematic review.

Hallifax RJ, Yousuf A, Jones HE, Corcoran JP, Psallidas I, Rahman NM.

Thorax. 2017 Dec;72(12):1121-1131. doi: 10.1136/thoraxjnl-2015-207967. Epub 2016 Nov 1. Review.


Targeted therapies for lung cancer: how did the game begin?

Kanellakis NI, Jacinto T, Psallidas I.

Breathe (Sheff). 2016 Jun;12(2):177-9. doi: 10.1183/20734735.006316.


Malignant pleural effusion: from bench to bedside.

Psallidas I, Kalomenidis I, Porcel JM, Robinson BW, Stathopoulos GT.

Eur Respir Rev. 2016 Jun;25(140):189-98. doi: 10.1183/16000617.0019-2016. Review. Erratum in: Eur Respir Rev. 2016 Sep;25(141):360. Eur Respir Rev. 2016 Sep;25(141):360.


Advances in pleural disease.

Psallidas I, Rahman NM.

Eur Respir Rev. 2016 Jun;25(140):108-9. doi: 10.1183/16000617.0031-2016. No abstract available.


Always Worth Another Look? Thoracic Ultrasonography before, during, and after Pleural Intervention.

Corcoran JP, Psallidas I, Ross CL, Hallifax RJ, Rahman NM.

Ann Am Thorac Soc. 2016 Jan;13(1):118-21. doi: 10.1513/AnnalsATS.201508-559CC. No abstract available.


Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial.

Rahman NM, Pepperell J, Rehal S, Saba T, Tang A, Ali N, West A, Hettiarachchi G, Mukherjee D, Samuel J, Bentley A, Dowson L, Miles J, Ryan CF, Yoneda KY, Chauhan A, Corcoran JP, Psallidas I, Wrightson JM, Hallifax R, Davies HE, Lee YC, Dobson M, Hedley EL, Seaton D, Russell N, Chapman M, McFadyen BM, Shaw RA, Davies RJ, Maskell NA, Nunn AJ, Miller RF.

JAMA. 2015 Dec 22-29;314(24):2641-53. doi: 10.1001/jama.2015.16840. Erratum in: JAMA. 2016 Feb 16;315(7):707. JAMA. 2016 Apr 19;315(15):1661.


Medical thoracoscopy: Survey of current practice-How successful are medical thoracoscopists at predicting malignancy?

Hallifax RJ, Corcoran JP, Psallidas I, Rahman NM.

Respirology. 2016 Jul;21(5):958-60. doi: 10.1111/resp.12725. Epub 2015 Dec 30.

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