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Items: 1 to 50 of 175

1.

Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine.

Kudla L, Bugno R, Skupio U, Wiktorowska L, Solecki W, Wojtas A, Golembiowska K, Zádor F, Benyhe S, Buda S, Makuch W, Przewlocka B, Bojarski AJ, Przewlocki R.

Br J Pharmacol. 2019 Jul 26. doi: 10.1111/bph.14805. [Epub ahead of print]

PMID:
31347704
2.

Alterations in the Activity of Spinal and Thalamic Opioid Systems in a Mice Neuropathic Pain Model.

Rojewska E, Wawrzczak-Bargiela A, Szucs E, Benyhe S, Starnowska J, Mika J, Przewlocki R, Przewlocka B.

Neuroscience. 2018 Oct 15;390:293-302. doi: 10.1016/j.neuroscience.2018.08.013. Epub 2018 Sep 1.

PMID:
30176322
3.

Tapentadol - A representative of a new class of MOR-NRI analgesics.

Zajączkowska R, Przewłocka B, Kocot-Kępska M, Mika J, Leppert W, Wordliczek J.

Pharmacol Rep. 2018 Aug;70(4):812-820. doi: 10.1016/j.pharep.2018.01.005. Epub 2018 Jan 31. Review.

PMID:
29921501
4.

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

Starnowska J, Costante R, Guillemyn K, Popiolek-Barczyk K, Chung NN, Lemieux C, Keresztes A, Van Duppen J, Mollica A, Streicher J, Vanden Broeck J, Schiller PW, Tourwé D, Mika J, Ballet S, Przewlocka B.

ACS Chem Neurosci. 2017 Oct 18;8(10):2315-2324. doi: 10.1021/acschemneuro.7b00226. Epub 2017 Jul 26.

5.

Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain-related behaviour in a rat model of neuropathy.

Starnowska J, Guillemyn K, Makuch W, Mika J, Ballet S, Przewlocka B.

Eur J Pharm Sci. 2017 Jun 15;104:221-229. doi: 10.1016/j.ejps.2017.03.029. Epub 2017 Mar 24.

PMID:
28347772
6.

Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model.

Jurga AM, Piotrowska A, Makuch W, Przewlocka B, Mika J.

Front Pharmacol. 2017 Feb 16;8:48. doi: 10.3389/fphar.2017.00048. eCollection 2017.

7.

Dataset of botulinum toxin A influence on interleukins under neuropathy.

Zychowska M, Rojewska E, Makuch W, Luvisetto S, Pavone F, Marinelli S, Przewlocka B, Mika J.

Data Brief. 2016 Nov 15;9:1020-1023. eCollection 2016 Dec.

8.

Participation of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain.

Zychowska M, Rojewska E, Makuch W, Luvisetto S, Pavone F, Marinelli S, Przewlocka B, Mika J.

Eur J Pharmacol. 2016 Nov 15;791:377-388. doi: 10.1016/j.ejphar.2016.09.019. Epub 2016 Sep 9.

PMID:
27619001
9.

Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain - In vivo and in vitro evidence.

Piotrowska A, Kwiatkowski K, Rojewska E, Slusarczyk J, Makuch W, Basta-Kaim A, Przewlocka B, Mika J.

J Neuroimmunol. 2016 Aug 15;297:9-19. doi: 10.1016/j.jneuroim.2016.04.017. Epub 2016 May 3.

PMID:
27397071
10.

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain.

Malek N, Kostrzewa M, Makuch W, Pajak A, Kucharczyk M, Piscitelli F, Przewlocka B, Di Marzo V, Starowicz K.

Pharmacol Res. 2016 Sep;111:251-263. doi: 10.1016/j.phrs.2016.06.012. Epub 2016 Jun 17.

PMID:
27326920
11.

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.

Guillemyn K, Starnowska J, Lagard C, Dyniewicz J, Rojewska E, Mika J, Chung NN, Utard V, Kosson P, Lipkowski AW, Chevillard L, Arranz-Gibert P, Teixidó M, Megarbane B, Tourwé D, Simonin F, Przewlocka B, Schiller PW, Ballet S.

J Med Chem. 2016 Apr 28;59(8):3777-92. doi: 10.1021/acs.jmedchem.5b01976. Epub 2016 Apr 14.

12.

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model.

Jurga AM, Rojewska E, Piotrowska A, Makuch W, Pilat D, Przewlocka B, Mika J.

Neural Plast. 2016;2016:5238730. doi: 10.1155/2016/5238730. Epub 2015 Dec 29.

13.

Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine.

Pilat D, Piotrowska A, Rojewska E, Jurga A, Ślusarczyk J, Makuch W, Basta-Kaim A, Przewlocka B, Mika J.

Mol Cell Neurosci. 2016 Mar;71:114-24. doi: 10.1016/j.mcn.2015.12.013. Epub 2016 Jan 5.

PMID:
26763728
14.

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.

Betti C, Starnowska J, Mika J, Dyniewicz J, Frankiewicz L, Novoa A, Bochynska M, Keresztes A, Kosson P, Makuch W, Van Duppen J, Chung NN, Vanden Broeck J, Lipkowski AW, Schiller PW, Janssens F, Ceusters M, Sommen F, Meert T, Przewlocka B, Tourwé D, Ballet S.

ACS Med Chem Lett. 2015 Oct 31;6(12):1209-14. doi: 10.1021/acsmedchemlett.5b00359. eCollection 2015 Dec 10.

15.

Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model.

Rojewska E, Piotrowska A, Makuch W, Przewlocka B, Mika J.

Neuropharmacology. 2016 Mar;102:80-91. doi: 10.1016/j.neuropharm.2015.10.040. Epub 2015 Oct 31.

PMID:
26524415
16.

PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy.

Rojewska E, Popiolek-Barczyk K, Kolosowska N, Piotrowska A, Zychowska M, Makuch W, Przewlocka B, Mika J.

PLoS One. 2015 Oct 1;10(10):e0138583. doi: 10.1371/journal.pone.0138583. eCollection 2015.

17.

Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.

Malek N, Popiolek-Barczyk K, Mika J, Przewlocka B, Starowicz K.

Neural Plast. 2015;2015:130639. doi: 10.1155/2015/130639. Epub 2015 May 18.

18.

IL-1 receptor antagonist improves morphine and buprenorphine efficacy in a rat neuropathic pain model.

Pilat D, Rojewska E, Jurga AM, Piotrowska A, Makuch W, Przewlocka B, Mika J.

Eur J Pharmacol. 2015 Oct 5;764:240-8. doi: 10.1016/j.ejphar.2015.05.058. Epub 2015 Jun 1.

PMID:
26043968
19.

Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.

Mika J, Jurga AM, Starnowska J, Wasylewski M, Rojewska E, Makuch W, Kwiatkowski K, Malek N, Przewlocka B.

Neuroscience. 2015 May 21;294:38-50. doi: 10.1016/j.neuroscience.2015.03.003. Epub 2015 Mar 10.

PMID:
25769941
20.

A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.

Malek N, Mrugala M, Makuch W, Kolosowska N, Przewlocka B, Binkowski M, Czaja M, Morera E, Di Marzo V, Starowicz K.

Pain. 2015 May;156(5):890-903. doi: 10.1097/j.pain.0000000000000132. Erratum in: Pain. 2015 Jul;156(7):1370.

PMID:
25719612
21.

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.

Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, Van Duppen J, Przewlocka B, Vanden Broeck J, Lipkowski AW, Schiller PW, Tourwé D, Ballet S.

Eur J Med Chem. 2015 Mar 6;92:64-77. doi: 10.1016/j.ejmech.2014.12.033. Epub 2014 Dec 19.

22.

The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain.

Zychowska M, Rojewska E, Makuch W, Przewlocka B, Mika J.

Eur J Pharmacol. 2015 Feb 15;749:115-23. doi: 10.1016/j.ejphar.2014.11.022. Epub 2014 Nov 25.

PMID:
25460025
23.

Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model.

Rojewska E, Popiolek-Barczyk K, Jurga AM, Makuch W, Przewlocka B, Mika J.

J Neuroimmunol. 2014 Dec 15;277(1-2):57-66. doi: 10.1016/j.jneuroim.2014.09.020. Epub 2014 Oct 2.

24.

Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain.

Popiolek-Barczyk K, Rojewska E, Jurga AM, Makuch W, Zador F, Borsodi A, Piotrowska A, Przewlocka B, Mika J.

Biomed Res Int. 2014;2014:762930. doi: 10.1155/2014/762930. Epub 2014 Sep 3.

25.

Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats.

Rojewska E, Makuch W, Przewlocka B, Mika J.

Neuropharmacology. 2014 Nov;86:301-10. doi: 10.1016/j.neuropharm.2014.08.001. Epub 2014 Aug 27.

26.

Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain.

Mika J, Popiolek-Barczyk K, Rojewska E, Makuch W, Starowicz K, Przewlocka B.

PLoS One. 2014 Aug 8;9(8):e104420. doi: 10.1371/journal.pone.0104420. eCollection 2014.

27.

Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain.

Rojewska E, Korostynski M, Przewlocki R, Przewlocka B, Mika J.

Mol Pain. 2014 Jul 19;10:47. doi: 10.1186/1744-8069-10-47.

28.

Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.

Jagla G, Mika J, Makuch W, Obara I, Wordliczek J, Przewlocka B.

Pharmacol Rep. 2014 Jun;66(3):459-65. doi: 10.1016/j.pharep.2013.11.004. Epub 2014 Apr 3.

PMID:
24905524
29.

Neuronal and immunological basis of action of antidepressants in chronic pain - clinical and experimental studies.

Mika J, Zychowska M, Makuch W, Rojewska E, Przewlocka B.

Pharmacol Rep. 2013;65(6):1611-21. Review.

30.

Mechanisms and pharmacology of diabetic neuropathy - experimental and clinical studies.

Zychowska M, Rojewska E, Przewlocka B, Mika J.

Pharmacol Rep. 2013;65(6):1601-10. Review.

31.

Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats.

Makuch W, Mika J, Rojewska E, Zychowska M, Przewlocka B.

Neuropharmacology. 2013 Dec;75:445-57. doi: 10.1016/j.neuropharm.2013.08.031. Epub 2013 Sep 10.

PMID:
24035921
32.

Minocycline influences the anti-inflammatory interleukins and enhances the effectiveness of morphine under mice diabetic neuropathy.

Zychowska M, Rojewska E, Kreiner G, Nalepa I, Przewlocka B, Mika J.

J Neuroimmunol. 2013 Sep 15;262(1-2):35-45. doi: 10.1016/j.jneuroim.2013.06.005. Epub 2013 Jul 17.

PMID:
23870534
33.

Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.

Starowicz K, Makuch W, Korostynski M, Malek N, Slezak M, Zychowska M, Petrosino S, De Petrocellis L, Cristino L, Przewlocka B, Di Marzo V.

PLoS One. 2013;8(4):e60040. doi: 10.1371/journal.pone.0060040. Epub 2013 Apr 3.

34.

Importance of glial activation in neuropathic pain.

Mika J, Zychowska M, Popiolek-Barczyk K, Rojewska E, Przewlocka B.

Eur J Pharmacol. 2013 Sep 15;716(1-3):106-19. doi: 10.1016/j.ejphar.2013.01.072. Epub 2013 Mar 13. Review.

PMID:
23500198
35.

Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.

Starowicz K, Przewlocka B.

Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3286-99. doi: 10.1098/rstb.2011.0392. Review.

36.

The glutamatergic system as a target for neuropathic pain relief.

Osikowicz M, Mika J, Przewlocka B.

Exp Physiol. 2013 Feb;98(2):372-84. doi: 10.1113/expphysiol.2012.069922. Epub 2012 Sep 21. Review.

37.

Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms.

Starowicz K, Makuch W, Osikowicz M, Piscitelli F, Petrosino S, Di Marzo V, Przewlocka B.

Neuropharmacology. 2012 Mar;62(4):1746-55. doi: 10.1016/j.neuropharm.2011.11.021. Epub 2011 Dec 8.

PMID:
22178705
38.

The role of nociceptin and dynorphin in chronic pain: implications of neuro-glial interaction.

Mika J, Obara I, Przewlocka B.

Neuropeptides. 2011 Aug;45(4):247-61. doi: 10.1016/j.npep.2011.03.002. Epub 2011 Apr 8. Review.

PMID:
21477860
39.

New operant model of reinstatement of food-seeking behavior in mice.

Martín-García E, Burokas A, Kostrzewa E, Gieryk A, Korostynski M, Ziolkowska B, Przewlocka B, Przewlocki R, Maldonado R.

Psychopharmacology (Berl). 2011 May;215(1):49-70. doi: 10.1007/s00213-010-2110-6. Epub 2010 Dec 14.

PMID:
21161187
40.

The effect of botulinum neurotoxin A on sciatic nerve injury-induced neuroimmunological changes in rat dorsal root ganglia and spinal cord.

Mika J, Rojewska E, Makuch W, Korostynski M, Luvisetto S, Marinelli S, Pavone F, Przewlocka B.

Neuroscience. 2011 Feb 23;175:358-66. doi: 10.1016/j.neuroscience.2010.11.040. Epub 2010 Nov 25.

PMID:
21111791
41.

Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models.

Marinelli S, Luvisetto S, Cobianchi S, Makuch W, Obara I, Mezzaroma E, Caruso M, Straface E, Przewlocka B, Pavone F.

Neuroscience. 2010 Nov 24;171(1):316-28. doi: 10.1016/j.neuroscience.2010.08.067. Epub 2010 Sep 6.

PMID:
20826198
42.

Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists.

Nalepa I, Vetulani J, Borghi V, Kowalska M, Przewłocka B, Roman A, Pavone F.

J Neural Transm (Vienna). 2010 May;117(5):549-58. doi: 10.1007/s00702-010-0387-6. Epub 2010 Mar 23.

PMID:
20309590
43.

Agonist-dependent attenuation of mu-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats.

Obara I, Gunduz Cinar O, Starowicz K, Benyhe S, Borsodi A, Przewlocka B.

J Neural Transm (Vienna). 2010 Apr;117(4):421-9. doi: 10.1007/s00702-010-0382-y. Epub 2010 Mar 6.

PMID:
20213428
44.

Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study.

Starowicz K, Mousa SA, Obara I, Chocyk A, Przewłocki R, Wedzony K, Machelska H, Przewłocka B.

Pharmacol Rep. 2009 Nov-Dec;61(6):1086-95.

46.

Minocycline reduces the injury-induced expression of prodynorphin and pronociceptin in the dorsal root ganglion in a rat model of neuropathic pain.

Mika J, Rojewska E, Makuch W, Przewlocka B.

Neuroscience. 2010 Feb 17;165(4):1420-8. doi: 10.1016/j.neuroscience.2009.11.064. Epub 2009 Dec 1.

PMID:
19961904
47.

Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain.

Osikowicz M, Skup M, Mika J, Makuch W, Czarkowska-Bauch J, Przewlocka B.

Pain. 2009 Dec 15;147(1-3):175-86. doi: 10.1016/j.pain.2009.09.002. Epub 2009 Sep 25.

PMID:
19782473
48.

Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain.

Mika J, Osikowicz M, Rojewska E, Korostynski M, Wawrzczak-Bargiela A, Przewlocki R, Przewlocka B.

Eur J Pharmacol. 2009 Nov 25;623(1-3):65-72. doi: 10.1016/j.ejphar.2009.09.030. Epub 2009 Sep 17.

PMID:
19766105
49.

Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain.

Obara I, Parkitna JR, Korostynski M, Makuch W, Kaminska D, Przewlocka B, Przewlocki R.

Pain. 2009 Feb;141(3):283-91. doi: 10.1016/j.pain.2008.12.006. Epub 2009 Jan 14.

PMID:
19147290
50.

Attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice.

Mika J, Wawrzczak-Bargiela A, Osikowicz M, Makuch W, Przewlocka B.

Brain Behav Immun. 2009 Jan;23(1):75-84. doi: 10.1016/j.bbi.2008.07.005. Epub 2008 Jul 22.

PMID:
18684397

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