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Items: 20


High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR.

Nat Med. 2015 Nov;21(11):1318-25. doi: 10.1038/nm.3954. Epub 2015 Oct 19.


Mouse tumour models to guide drug development and identify resistance mechanisms.

Das Thakur M, Pryer NK, Singh M.

J Pathol. 2014 Jan;232(2):103-11. doi: 10.1002/path.4285. Review.


Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance.

Das Thakur M, Salangsang F, Landman AS, Sellers WR, Pryer NK, Levesque MP, Dummer R, McMahon M, Stuart DD.

Nature. 2013 Feb 14;494(7436):251-5. doi: 10.1038/nature11814. Epub 2013 Jan 9.


The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo.

Menezes DL, Taverna P, Jensen MR, Abrams T, Stuart D, Yu GK, Duhl D, Machajewski T, Sellers WR, Pryer NK, Gao Z.

Mol Cancer Ther. 2012 Mar;11(3):730-9. doi: 10.1158/1535-7163.MCT-11-0667. Epub 2012 Jan 12.


CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice.

Xin X, Abrams TJ, Hollenbach PW, Rendahl KG, Tang Y, Oei YA, Embry MG, Swinarski DE, Garrett EN, Pryer NK, Trudel S, Jallal B, Mendel DB, Heise CC.

Clin Cancer Res. 2006 Aug 15;12(16):4908-15.


Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

Fry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E, Albassam M, Zheng X, Leopold WR, Pryer NK, Toogood PL.

Mol Cancer Ther. 2004 Nov;3(11):1427-38.


SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model.

Murray LJ, Abrams TJ, Long KR, Ngai TJ, Olson LM, Hong W, Keast PK, Brassard JA, O'Farrell AM, Cherrington JM, Pryer NK.

Clin Exp Metastasis. 2003;20(8):757-66.


Proof of target for SU11654: inhibition of KIT phosphorylation in canine mast cell tumors.

Pryer NK, Lee LB, Zadovaskaya R, Yu X, Sukbuntherng J, Cherrington JM, London CA.

Clin Cancer Res. 2003 Nov 15;9(15):5729-34.


Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer.

Abrams TJ, Murray LJ, Pesenti E, Holway VW, Colombo T, Lee LB, Cherrington JM, Pryer NK.

Mol Cancer Ther. 2003 Oct;2(10):1011-21.


SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer.

Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM.

Mol Cancer Ther. 2003 May;2(5):471-8.


Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro.

Pryer NK, Salama NR, Schekman R, Kaiser CA.

J Cell Biol. 1993 Feb;120(4):865-75.


Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro. Real-time observations using video microscopy.

Pryer NK, Walker RA, Skeen VP, Bourns BD, Soboeiro MF, Salmon ED.

J Cell Sci. 1992 Dec;103 ( Pt 4):965-76.


Vesicle-mediated protein sorting.

Pryer NK, Wuestehube LJ, Schekman R.

Annu Rev Biochem. 1992;61:471-516. Review. No abstract available.


Effects of electric fields on fibroblast contractility and cytoskeleton.

Harris AK, Pryer NK, Paydarfar D.

J Exp Zool. 1990 Feb;253(2):163-76.


Video-enhanced differential interference contrast light microscopy.

Salmon T, Walker RA, Pryer NK.

Biotechniques. 1989 Jun;7(6):624-33. No abstract available.


Real-time observations of microtubule dynamic instability in living cells.

Cassimeris L, Pryer NK, Salmon ED.

J Cell Biol. 1988 Dec;107(6 Pt 1):2223-31.


Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

Walker RA, O'Brien ET, Pryer NK, Soboeiro MF, Voter WA, Erickson HP, Salmon ED.

J Cell Biol. 1988 Oct;107(4):1437-48.


Dynamic instability of microtubules.

Cassimeris LU, Walker RA, Pryer NK, Salmon ED.

Bioessays. 1987 Oct;7(4):149-54. Review. No abstract available.


Polarized microtubule gliding and particle saltations produced by soluble factors from sea urchin eggs and embryos.

Pryer NK, Wadsworth P, Salmon ED.

Cell Motil Cytoskeleton. 1986;6(6):537-48.


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