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Items: 19


Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics.

Zelanis A, Oliveira AK, Prudova A, Huesgen PF, Tashima AK, Kizhakkedathu J, Overall CM, Serrano SMT.

J Proteome Res. 2019 Sep 6;18(9):3419-3428. doi: 10.1021/acs.jproteome.9b00325. Epub 2019 Aug 8.


Transcriptomic and proteomic host response to Aspergillus fumigatus conidia in an air-liquid interface model of human bronchial epithelium.

Toor A, Culibrk L, Singhera GK, Moon KM, Prudova A, Foster LJ, Moore MM, Dorscheid DR, Tebbutt SJ.

PLoS One. 2018 Dec 27;13(12):e0209652. doi: 10.1371/journal.pone.0209652. eCollection 2018.


Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.

Tharmarajah G, Eckhard U, Jain F, Marino G, Prudova A, Urtatiz O, Fuchs H, de Angelis MH, Overall CM, Van Raamsdonk CD.

Pigment Cell Melanoma Res. 2018 Nov;31(6):693-707. doi: 10.1111/pcmr.12711. Epub 2018 Jun 5.


A Targeted Proteomics Analysis of Cerebrospinal Fluid after Acute Human Spinal Cord Injury.

Streijger F, Skinnider MA, Rogalski JC, Balshaw R, Shannon CP, Prudova A, Belanger L, Ritchie L, Tsang A, Christie S, Parent S, Mac-Thiong JM, Bailey C, Urquhart J, Ailon T, Paquette S, Boyd M, Street J, Fisher CG, Dvorak MF, Borchers CH, Foster LJ, Kwon BK.

J Neurotrauma. 2017 Jun 15;34(12):2054-2068. doi: 10.1089/neu.2016.4879. Epub 2017 Apr 7.


Interactome disassembly during apoptosis occurs independent of caspase cleavage.

Scott NE, Rogers LD, Prudova A, Brown NF, Fortelny N, Overall CM, Foster LJ.

Mol Syst Biol. 2017 Jan 12;13(1):906. doi: 10.15252/msb.20167067.


TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM.

Cell Rep. 2016 Aug 9;16(6):1762-1773. doi: 10.1016/j.celrep.2016.06.086. Epub 2016 Jul 28.


Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun.


Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UAD, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Matrix Biol. 2016 Jan;49:37-60. doi: 10.1016/j.matbio.2015.09.003. Epub 2015 Sep 25.


TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage.

Prudova A, Serrano K, Eckhard U, Fortelny N, Devine DV, Overall CM.

Blood. 2014 Dec 18;124(26):e49-60. doi: 10.1182/blood-2014-04-569640. Epub 2014 Oct 20.


Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation.

auf dem Keller U, Prudova A, Eckhard U, Fingleton B, Overall CM.

Sci Signal. 2013 Jan 15;6(258):rs2. doi: 10.1126/scisignal.2003512.


Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates.

Kleifeld O, Doucet A, Prudova A, auf dem Keller U, Gioia M, Kizhakkedathu JN, Overall CM.

Nat Protoc. 2011 Sep 22;6(10):1578-611. doi: 10.1038/nprot.2011.382.


Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics.

Prudova A, auf dem Keller U, Butler GS, Overall CM.

Mol Cell Proteomics. 2010 May;9(5):894-911. doi: 10.1074/mcp.M000050-MCP201. Epub 2010 Mar 20.


A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products.

auf dem Keller U, Prudova A, Gioia M, Butler GS, Overall CM.

Mol Cell Proteomics. 2010 May;9(5):912-27. doi: 10.1074/mcp.M000032-MCP201. Epub 2010 Mar 20.


Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products.

Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM.

Nat Biotechnol. 2010 Mar;28(3):281-8. doi: 10.1038/nbt.1611. Epub 2010 Mar 7.


Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

Doucet A, Butler GS, Rodríguez D, Prudova A, Overall CM.

Mol Cell Proteomics. 2008 Oct;7(10):1925-51. doi: 10.1074/mcp.R800012-MCP200. Epub 2008 Jul 2. Review.


Testosterone regulation of homocysteine metabolism modulates redox status in human prostate cancer cells.

Prudova A, Albin M, Bauman Z, Lin A, Vitvitsky V, Banerjee R.

Antioxid Redox Signal. 2007 Nov;9(11):1875-81.


Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels.

Vitvitsky V, Prudova A, Stabler S, Dayal S, Lentz SR, Banerjee R.

Am J Physiol Renal Physiol. 2007 Aug;293(2):F594-600. Epub 2007 May 30.


S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.

Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6489-94. Epub 2006 Apr 13.


Analysis of pathological defects in methionine metabolism using a simple mathematical model.

Prudova A, Martinov MV, Vitvitsky VM, Ataullakhanov FI, Banerjee R.

Biochim Biophys Acta. 2005 Sep 25;1741(3):331-8.

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