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Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.

Perković I, Raić-Malić S, Fontinha D, Prudêncio M, Pessanha de Carvalho L, Held J, Tandarić T, Vianello R, Zorc B, Rajić Z.

Eur J Med Chem. 2020 Feb 1;187:111927. doi: 10.1016/j.ejmech.2019.111927. Epub 2019 Nov 29.


Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins.

Azevedo R, Mendes AM, Prudêncio M.

Parasit Vectors. 2019 Nov 21;12(1):549. doi: 10.1186/s13071-019-3805-0.


Silver and copper as pollution tracers in Neogene to Holocene estuarine sediments from southwestern Spain.

Ruiz F, Vidal JR, Cáceres LM, Olías M, González-Regalado ML, Campos JM, Bermejo J, Abad M, Izquierdo T, Carretero MI, Pozo M, Monge G, Tosquella J, Prudencio MI, Dias MI, Marques R, Gómez P, Toscano A, Romero V.

Mar Pollut Bull. 2020 Jan;150:110704. doi: 10.1016/j.marpolbul.2019.110704. Epub 2019 Nov 16.


Trypanosoma brucei infection protects mice against malaria.

Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M.

PLoS Pathog. 2019 Nov 8;15(11):e1008145. doi: 10.1371/journal.ppat.1008145. eCollection 2019 Nov.


Spiro-Lactams as Novel Antimicrobial Agents.

Alves AJS, Alves NG, Caratão CC, I M Esteves M, Fontinha D, Bártolo I, Soares MIL, Lopes SMM, Prudêncio M, Taveira N, Pinho E Melo TMVD.

Curr Top Med Chem. 2019 Nov 4. doi: 10.2174/1568026619666191105110049. [Epub ahead of print]


On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities.

Sousa SA, Leitão JH, Silva RAL, Belo D, Santos IC, Guerreiro JF, Martins M, Fontinha D, Prudêncio M, Almeida M, Lorcy D, Marques F.

J Inorg Biochem. 2020 Jan;202:110904. doi: 10.1016/j.jinorgbio.2019.110904. Epub 2019 Oct 22.


Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection.

Arez F, Rebelo SP, Fontinha D, Simão D, Martins TR, Machado M, Fischli C, Oeuvray C, Badolo L, Carrondo MJT, Rottmann M, Spangenberg T, Brito C, Greco B, Prudêncio M, Alves PM.

ACS Infect Dis. 2019 Nov 8;5(11):1831-1842. doi: 10.1021/acsinfecdis.9b00144. Epub 2019 Sep 13.


Primaquine homodimers as potential antiplasmodial and anticancer agents.

Pavić K, Rubinić B, Rajić Z, Fontinha D, Prudêncio M, Uzelac L, Kralj M, Held J, Zorc B.

Bioorg Med Chem Lett. 2019 Oct 1;29(19):126614. doi: 10.1016/j.bmcl.2019.08.018. Epub 2019 Aug 10.


Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents.

Beus M, Fontinha D, Held J, Rajić Z, Uzelac L, Kralj M, Prudêncio M, Zorc B.

Molecules. 2019 Aug 1;24(15). pii: E2812. doi: 10.3390/molecules24152812.


A crucial role for the C-terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle.

Wolanin K, Fontinha D, Sanches-Vaz M, Nyboer B, Heiss K, Mueller AK, Prudêncio M.

Cell Microbiol. 2019 Oct;21(10):e13088. doi: 10.1111/cmi.13088. Epub 2019 Jul 30.


Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides.

Beus M, Fontinha D, Held J, Rajić Z, Prudêncio M, Zorc B.

Acta Pharm. 2019 Jun 1;69(2):233-248. doi: 10.2478/acph-2019-0019.


Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM.

Nat Neurosci. 2019 Jun;22(6):863-874. doi: 10.1038/s41593-019-0396-1. Epub 2019 May 20.


eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.

Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM.

Acta Neuropathol Commun. 2019 Apr 25;7(1):62. doi: 10.1186/s40478-019-0711-9.


Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites.

Aguiar L, Machado M, Sanches-Vaz M, Prudêncio M, Vale N, Gomes P.

Medchemcomm. 2018 Nov 16;10(2):221-226. doi: 10.1039/c8md00447a. eCollection 2019 Feb 1.


Naturally occurring radioactive material and risk assessment of tailings of polymetallic and Ra/U mines from legacy sites.

Paiva I, Marques R, Santos M, Reis M, Prudêncio MI, Waerenborgh JC, Dias MI, Russo D, Cardoso G, Vieira BJC, Carvalho E, Rosa C, Lobarinhas D, Diamantino C, Pinto R.

Chemosphere. 2019 May;223:171-179. doi: 10.1016/j.chemosphere.2019.02.057. Epub 2019 Feb 11.


Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L.

Science. 2019 Feb 15;363(6428). pii: eaav2606. doi: 10.1126/science.aav2606.


Chemical characterization of vines grown in incipient volcanic soils of Fogo Island (Cape Verde).

Marques R, Prudêncio MI, Abreu MM, Russo D, Marques JG, Rocha F.

Environ Monit Assess. 2019 Feb 5;191(3):128. doi: 10.1007/s10661-019-7267-9.


Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.

Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates C, Wittlin S, Prudêncio M, Chibale K.

J Med Chem. 2019 Jan 24;62(2):1022-1035. doi: 10.1021/acs.jmedchem.8b01769. Epub 2018 Dec 24.


Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.

Kumar M, Okombo J, Mambwe D, Taylor D, Lawrence N, Reader J, van der Watt M, Fontinha D, Sanches-Vaz M, Bezuidenhout BC, Lauterbach SB, Liebenberg D, Birkholtz LM, Coetzer TL, Prudêncio M, Egan TJ, Wittlin S, Chibale K.

ACS Infect Dis. 2019 Feb 8;5(2):303-315. doi: 10.1021/acsinfecdis.8b00272. Epub 2019 Jan 7.


Pre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate.

Mendes AM, Reuling IJ, Andrade CM, Otto TD, Machado M, Teixeira F, Pissarra J, Gonçalves-Rosa N, Bonaparte D, Sinfrónio J, Sanders M, Janse CJ, Khan SM, Newbold CI, Berriman M, Lee CK, Wu Y, Ockenhouse CF, Sauerwein RW, Prudêncio M.

NPJ Vaccines. 2018 Nov 27;3:54. doi: 10.1038/s41541-018-0091-3. eCollection 2018.


TRIO gene segregation in a family with cerebellar ataxia.

Hanna Al Shaikh R, Caulfield T, Strongosky AJ, Matthew M, Jansen-West KR, Prudencio M, Fryer JD, Petrucelli L, Uitti RJ, Wszolek ZK.

Neurol Neurochir Pol. 2018 Nov - Dec;52(6):743-749. doi: 10.1016/j.pjnns.2018.09.006. Epub 2018 Sep 22.


A Plasmodium berghei sporozoite-based vaccination platform against human malaria.

Mendes AM, Machado M, Gonçalves-Rosa N, Reuling IJ, Foquet L, Marques C, Salman AM, Yang ASP, Moser KA, Dwivedi A, Hermsen CC, Jiménez-Díaz B, Viera S, Santos JM, Albuquerque I, Bhatia SN, Bial J, Angulo-Barturen I, Silva JC, Leroux-Roels G, Janse CJ, Khan SM, Mota MM, Sauerwein RW, Prudêncio M.

NPJ Vaccines. 2018 Aug 24;3:33. doi: 10.1038/s41541-018-0068-2. eCollection 2018.


SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents.

Beus M, Rajić Z, Maysinger D, Mlinarić Z, Antunović M, Marijanović I, Fontinha D, Prudêncio M, Held J, Olgen S, Zorc B.

ChemistryOpen. 2018 Aug 21;7(8):624-638. doi: 10.1002/open.201800117. eCollection 2018 Aug.


Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: implications for clinical use and genetic discovery efforts in human disease.

Ebbert MTW, Farrugia SL, Sens JP, Jansen-West K, Gendron TF, Prudencio M, McLaughlin IJ, Bowman B, Seetin M, DeJesus-Hernandez M, Jackson J, Brown PH, Dickson DW, van Blitterswijk M, Rademakers R, Petrucelli L, Fryer JD.

Mol Neurodegener. 2018 Aug 21;13(1):46. doi: 10.1186/s13024-018-0274-4.


Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.

Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K.

Acta Neuropathol Commun. 2018 Jul 4;6(1):55. doi: 10.1186/s40478-018-0555-8.


Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.

Zhang YJ, Gendron TF, Ebbert MTW, O'Raw AD, Yue M, Jansen-West K, Zhang X, Prudencio M, Chew J, Cook CN, Daughrity LM, Tong J, Song Y, Pickles SR, Castanedes-Casey M, Kurti A, Rademakers R, Oskarsson B, Dickson DW, Hu W, Gitler AD, Fryer JD, Petrucelli L.

Nat Med. 2018 Aug;24(8):1136-1142. doi: 10.1038/s41591-018-0071-1. Epub 2018 Jun 25.


Redistribution of Cs 137 introduced into montmorillonite in association with organic matter coming from biomass composting.

Mihalik J, Madruga MJ, Casimiro MH, Ferreira LM, Prudêncio MI.

Chemosphere. 2018 Sep;207:147-153. doi: 10.1016/j.chemosphere.2018.05.078. Epub 2018 May 16.


Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability.

Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F.

Eur J Med Chem. 2018 Apr 10;149:69-78. doi: 10.1016/j.ejmech.2018.02.048. Epub 2018 Feb 19.


Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity.

Šafratová M, Hošťálková A, Hulcová D, Breiterová K, Hrabcová V, Machado M, Fontinha D, Prudêncio M, Kuneš J, Chlebek J, Jun D, Hrabinová M, Nováková L, Havelek R, Seifrtová M, Opletal L, Cahlíková L.

Arch Pharm Res. 2018 Feb;41(2):208-218. doi: 10.1007/s12272-017-1000-4. Epub 2017 Dec 14.


Primaquine hybrids as promising antimycobacterial and antimalarial agents.

Pavić K, Perković I, Pospíšilová Š, Machado M, Fontinha D, Prudêncio M, Jampilek J, Coffey A, Endersen L, Rimac H, Zorc B.

Eur J Med Chem. 2018 Jan 1;143:769-779. doi: 10.1016/j.ejmech.2017.11.083. Epub 2017 Dec 2.


Platinum(ii)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function.

Macedo TS, Villarreal W, Couto CC, Moreira DRM, Navarro M, Machado M, Prudêncio M, Batista AA, Soares MBP.

Metallomics. 2017 Nov 15;9(11):1548-1561. doi: 10.1039/c7mt00196g.


Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds.

Machado M, Sanches-Vaz M, Cruz JP, Mendes AM, Prudêncio M.

Front Cell Infect Microbiol. 2017 Jul 19;7:329. doi: 10.3389/fcimb.2017.00329. eCollection 2017.


The lysosomal protein cathepsin L is a progranulin protease.

Lee CW, Stankowski JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW, Petrucelli L.

Mol Neurodegener. 2017 Jul 25;12(1):55. doi: 10.1186/s13024-017-0196-6.


Uptake and metabolism of arginine impact Plasmodium development in the liver.

Meireles P, Mendes AM, Aroeira RI, Mounce BC, Vignuzzi M, Staines HM, Prudêncio M.

Sci Rep. 2017 Jun 22;7(1):4072. doi: 10.1038/s41598-017-04424-y.


Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.

Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, Petrucelli L, Link CD.

Hum Mol Genet. 2017 Sep 1;26(17):3421-3431. doi: 10.1093/hmg/ddx233.


[Haematopoietic stem cell transplantation in pyruvate kinase deficiency: When is it indicated?]

Pérez-Albert P, Guillen M, Prudencio M, Gonzalez-Vicent M, Sevilla J.

An Pediatr (Barc). 2018 Feb;88(2):106-107. doi: 10.1016/j.anpedi.2017.02.016. Epub 2017 Apr 25. Spanish. No abstract available.


Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.

Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, Tabassian LJ, Lee CW, Yue M, Tong J, Song Y, Castanedes-Casey M, Rousseau L, Phillips V, Dickson DW, Rademakers R, Fryer JD, Rush BK, Pedraza O, Caputo AM, Desaro P, Palmucci C, Robertson A, Heckman MG, Diehl NN, Wiggs E, Tierney M, Braun L, Farren J, Lacomis D, Ladha S, Fournier CN, McCluskey LF, Elman LB, Toledo JB, McBride JD, Tiloca C, Morelli C, Poletti B, Solca F, Prelle A, Wuu J, Jockel-Balsarotti J, Rigo F, Ambrose C, Datta A, Yang W, Raitcheva D, Antognetti G, McCampbell A, Van Swieten JC, Miller BL, Boxer AL, Brown RH, Bowser R, Miller TM, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Traynor BJ, Disney MD, Benatar M, Silani V, Glass JD, Floeter MK, Rothstein JD, Boylan KB, Petrucelli L.

Sci Transl Med. 2017 Mar 29;9(383). pii: eaai7866. doi: 10.1126/scitranslmed.aai7866.


Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds.

Azevedo R, Markovic M, Machado M, Franke-Fayard B, Mendes AM, Prudêncio M.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02699-16. doi: 10.1128/AAC.02699-16. Print 2017 Jun.


TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, Liddell JR, White AR.

Hum Mol Genet. 2017 May 1;26(9):1732-1746. doi: 10.1093/hmg/ddx093.


Immunomagnetic T Cell Depletion: an Analysis of Variables Affecting Final Cell Yield.

Sevilla J, Guillen M, Galvez E, Merino E, Castillo A, Prudencio M, Gonzalez-Vicent M, Ramirez M, Abad L, Madero L, Diaz-Perez MA.

Clin Lab. 2016 Jul 1;62(7):1243-1248. doi: 10.7754/Clin.Lab.2015.151026.


Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

Sá E Cunha C, Nyboer B, Heiss K, Sanches-Vaz M, Fontinha D, Wiedtke E, Grimm D, Przyborski JM, Mota MM, Prudêncio M, Mueller AK.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1138-E1147. doi: 10.1073/pnas.1606419114. Epub 2017 Jan 30.


Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz LM, Lauterbach S, Churchyard A, Coetzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K.

J Med Chem. 2017 Feb 23;60(4):1432-1448. doi: 10.1021/acs.jmedchem.6b01641. Epub 2017 Feb 7.


Inhibition of Plasmodium Liver Infection by Ivermectin.

Mendes AM, Albuquerque IS, Machado M, Pissarra J, Meireles P, Prudêncio M.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e02005-16. doi: 10.1128/AAC.02005-16. Print 2017 Feb.


National registry of hemoglobinopathies in Spain (REPHem).

Cela E, Bellón JM, de la Cruz M, Beléndez C, Berrueco R, Ruiz A, Elorza I, Díaz de Heredia C, Cervera A, Vallés G, Salinas JA, Coll MT, Bermúdez M, Prudencio M, Argilés B, Vecilla C; SEHOP-Hemoglobinopathies Study Group (Sociedad Española de Hematología y Oncología Pediátricas).

Pediatr Blood Cancer. 2017 Jul;64(7). doi: 10.1002/pbc.26322. Epub 2016 Nov 2.


Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.

Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, Dos Santos DJ, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R.

ChemMedChem. 2016 Oct 6;11(19):2194-2204. doi: 10.1002/cmdc.201600327. Epub 2016 Aug 19.


Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts.

Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW 3rd, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD.

Science. 2016 Aug 12;353(6300):708-12. doi: 10.1126/science.aaf7791.


Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents.

Macedo TS, Colina-Vegas L, DA Paixão M, Navarro M, Barreto BC, Oliveira PC, Macambira SG, Machado M, Prudêncio M, D'Alessandro S, Basilico N, Moreira DR, Batista AA, Soares MB.

Parasitology. 2016 Oct;143(12):1543-56. doi: 10.1017/S0031182016001153. Epub 2016 Jul 21.


GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection.

Meireles P, Sales-Dias J, Andrade CM, Mello-Vieira J, Mancio-Silva L, Simas JP, Staines HM, Prudêncio M.

Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12646. Epub 2016 Aug 2.


Novel squaramides with in vitro liver stage antiplasmodial activity.

Ribeiro CJ, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PJ, Prudêncio M, Moreira R, Santos MM.

Bioorg Med Chem. 2016 Apr 15;24(8):1786-92. doi: 10.1016/j.bmc.2016.03.005. Epub 2016 Mar 3.


Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Terzić N, Konstantinović J, Tot M, Burojević J, Djurković-Djaković O, Srbljanović J, Štajner T, Verbić T, Zlatović M, Machado M, Albuquerque IS, Prudêncio M, Sciotti RJ, Pecic S, D'Alessandro S, Taramelli D, Šolaja BA.

J Med Chem. 2016 Jan 14;59(1):264-81. doi: 10.1021/acs.jmedchem.5b01374. Epub 2015 Dec 18.


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