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Items: 1 to 50 of 101

1.

Novel GLP-1 Analog Supaglutide Stimulates Insulin Secretion in Mouse and Human Islet Beta-Cells and Improves Glucose Homeostasis in Diabetic Mice.

Ren L, Cui Q, Liu W, Wang L, Liao Y, Feng Y, Sun W, Yang Y, Zhang Z, Jin T, Prud'homme GJ, Zhang L, Li Y, Leng Y, Wang Q.

Front Physiol. 2019 Jul 25;10:930. doi: 10.3389/fphys.2019.00930. eCollection 2019.

2.

GABAergic regulation of pancreatic islet cells: Physiology and antidiabetic effects.

Wang Q, Ren L, Wan Y, Prud'homme GJ.

J Cell Physiol. 2019 Jan 28. doi: 10.1002/jcp.28214. [Epub ahead of print] Review.

PMID:
30693506
3.

Combined effect of GABA and glucagon-like peptide-1 receptor agonist on cytokine-induced apoptosis in pancreatic β-cell line and isolated human islets.

Son DO, Liu W, Li X, Prud'homme GJ, Wang Q.

J Diabetes. 2019 Jul;11(7):563-572. doi: 10.1111/1753-0407.12881. Epub 2019 Jan 1.

PMID:
30520247
4.

Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer.

Matkar PN, Jong ED, Ariyagunarajah R, Prud'homme GJ, Singh KK, Leong-Poi H.

Cancer Med. 2018 Oct;7(10):5036-5046. doi: 10.1002/cam4.1715. Epub 2018 Sep 14. Review.

5.

The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells.

Prud'homme GJ, Glinka Y, Kurt M, Liu W, Wang Q.

Biochem Biophys Res Commun. 2017 Dec 2;493(4):1542-1547. doi: 10.1016/j.bbrc.2017.10.029. Epub 2017 Oct 6.

6.

Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice.

Liu W, Son DO, Lau HK, Zhou Y, Prud'homme GJ, Jin T, Wang Q.

Front Pharmacol. 2017 Jun 20;8:362. doi: 10.3389/fphar.2017.00362. eCollection 2017.

7.

Current indications and surgical approaches to corneal transplants at the University of Toronto: A clinical-pathological study.

Le R, Yucel N, Khattak S, Yucel YH, Prud'homme GJ, Gupta N.

Can J Ophthalmol. 2017 Feb;52(1):74-79. doi: 10.1016/j.jcjo.2016.07.005. Epub 2016 Sep 7.

8.

Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma.

Matkar PN, Singh KK, Rudenko D, Kim YJ, Kuliszewski MA, Prud'homme GJ, Hedley DW, Leong-Poi H.

Oncotarget. 2016 Oct 25;7(43):69489-69506. doi: 10.18632/oncotarget.11060.

9.

Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function.

Prud'homme GJ, Glinka Y, Lichner Z, Yousef GM.

Oncotarget. 2016 Oct 18;7(42):68057-68071. doi: 10.18632/oncotarget.10929.

10.

Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics.

Li J, Zhang Z, Liu X, Wang Y, Mao F, Mao J, Lu X, Jiang D, Wan Y, Lv JY, Cao G, Zhang J, Zhao N, Atkinson M, Greiner DL, Prud'homme GJ, Jiao Z, Li Y, Wang Q.

Front Pharmacol. 2015 Nov 10;6:260. doi: 10.3389/fphar.2015.00260. eCollection 2015.

11.

Immunological GABAergic interactions and therapeutic applications in autoimmune diseases.

Prud'homme GJ, Glinka Y, Wang Q.

Autoimmun Rev. 2015 Nov;14(11):1048-56. doi: 10.1016/j.autrev.2015.07.011. Epub 2015 Jul 29. Review.

PMID:
26226414
12.

CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia.

Ma L, Simpson E, Li J, Xuan M, Xu M, Baker L, Shi Y, Yougbaré I, Wang X, Zhu G, Chen P, Prud'homme GJ, Lazarus AH, Freedman J, Ni H.

Blood. 2015 Jul 9;126(2):247-56. doi: 10.1182/blood-2015-03-635417. Epub 2015 Jun 2.

13.

GABAergic system in the endocrine pancreas: a new target for diabetes treatment.

Wan Y, Wang Q, Prud'homme GJ.

Diabetes Metab Syndr Obes. 2015 Feb 3;8:79-87. doi: 10.2147/DMSO.S50642. eCollection 2015. Review.

14.

GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity.

Prud'homme GJ, Glinka Y, Udovyk O, Hasilo C, Paraskevas S, Wang Q.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):649-54. doi: 10.1016/j.bbrc.2014.08.135. Epub 2014 Sep 1.

PMID:
25193706
15.

miR-17 inhibition enhances the formation of kidney cancer spheres with stem cell/ tumor initiating cell properties.

Lichner Z, Saleh C, Subramaniam V, Seivwright A, Prud'homme GJ, Yousef GM.

Oncotarget. 2015 Mar 20;6(8):5567-81.

16.

GABA promotes human β-cell proliferation and modulates glucose homeostasis.

Purwana I, Zheng J, Li X, Deurloo M, Son DO, Zhang Z, Liang C, Shen E, Tadkase A, Feng ZP, Li Y, Hasilo C, Paraskevas S, Bortell R, Greiner DL, Atkinson M, Prud'homme GJ, Wang Q.

Diabetes. 2014 Dec;63(12):4197-205. doi: 10.2337/db14-0153. Epub 2014 Jul 9.

17.

GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone.

Prud'homme GJ, Glinka Y, Hasilo C, Paraskevas S, Li X, Wang Q.

Transplantation. 2013 Oct 15;96(7):616-23. doi: 10.1097/TP.0b013e31829c24be.

PMID:
23851932
18.

Optimization of Ultrasound-mediated Anti-angiogenic Cancer Gene Therapy.

Fujii H, Matkar P, Liao C, Rudenko D, Lee PJ, Kuliszewski MA, Prud'homme GJ, Leong-Poi H.

Mol Ther Nucleic Acids. 2013 May 21;2:e94. doi: 10.1038/mtna.2013.20.

19.
20.

Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-κB activation and tumor sphere formation.

Glinka Y, Mohammed N, Subramaniam V, Jothy S, Prud'homme GJ.

Biochem Biophys Res Commun. 2012 Sep 7;425(4):775-80. doi: 10.1016/j.bbrc.2012.07.151. Epub 2012 Aug 2.

PMID:
22885184
21.

Non-small cell bronchial carcinoma metastasizing into a prolactin-producing pituitary adenoma.

Rotondo F, Kovacs K, Macdonald RL, Prud'homme GJ, Latta E, Munoz D.

Int J Surg Pathol. 2013 Feb;21(1):68-71. doi: 10.1177/1066896912449478. Epub 2012 Jun 10.

PMID:
22689615
22.

Cancer stem cells and novel targets for antitumor strategies.

Prud'homme GJ.

Curr Pharm Des. 2012;18(19):2838-49. Review.

PMID:
22390767
23.

Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb.

Liang Y, Qiu H, Glinka Y, Lazarus AH, Ni H, Prud'homme GJ, Wang Q.

J Gene Med. 2011 Sep;13(9):470-7. doi: 10.1002/jgm.1598.

PMID:
21786368
24.

GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes.

Soltani N, Qiu H, Aleksic M, Glinka Y, Zhao F, Liu R, Li Y, Zhang N, Chakrabarti R, Ng T, Jin T, Zhang H, Lu WY, Feng ZP, Prud'homme GJ, Wang Q.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11692-7. doi: 10.1073/pnas.1102715108. Epub 2011 Jun 27.

25.

Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta.

Glinka Y, Stoilova S, Mohammed N, Prud'homme GJ.

Carcinogenesis. 2011 Apr;32(4):613-21. doi: 10.1093/carcin/bgq281. Epub 2010 Dec 24.

PMID:
21186301
26.

Breast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist.

Prud'homme GJ, Glinka Y, Toulina A, Ace O, Subramaniam V, Jothy S.

PLoS One. 2010 Nov 3;5(11):e13831. doi: 10.1371/journal.pone.0013831.

27.

A site-specific genomic integration strategy for sustained expression of glucagon-like peptide-1 in mouse muscle for controlling energy homeostasis.

Liu R, Li Y, Hu R, Jin T, Deng S, Liang W, Zhang N, Chen J, Prud'homme GJ, Jia WW, Ma D, Wang Q.

Biochem Biophys Res Commun. 2010 Dec 10;403(2):172-7. doi: 10.1016/j.bbrc.2010.10.131. Epub 2010 Nov 9.

PMID:
21070745
28.

Tranilast treatment decreases cell growth, migration and inhibits colony formation of human breast cancer cells.

Subramaniam V, Ace O, Prud'homme GJ, Jothy S.

Exp Mol Pathol. 2011 Feb;90(1):116-22. doi: 10.1016/j.yexmp.2010.10.012. Epub 2010 Oct 30.

PMID:
21040720
29.

Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist.

Wang Q, Chen K, Liu R, Zhao F, Gupta S, Zhang N, Prud'homme GJ.

PLoS One. 2010 Sep 15;5(9):e12734. doi: 10.1371/journal.pone.0012734.

30.

Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer.

Subramaniam V, Chakrabarti R, Prud'homme GJ, Jothy S.

Anticancer Drugs. 2010 Apr;21(4):351-61. doi: 10.1097/CAD.0b013e328334992c.

PMID:
20145538
31.

Tranilast inhibits the growth and metastasis of mammary carcinoma.

Chakrabarti R, Subramaniam V, Abdalla S, Jothy S, Prud'homme GJ.

Anticancer Drugs. 2009 Jun;20(5):334-45. doi: 10.1097/CAD.0b013e328327994e.

PMID:
19322072
32.

Impaired negative regulation of homeostatically proliferating T cells.

Shvets A, Chakrabarti R, Gonzalez-Quintial R, Baccala R, Theofilopoulos AN, Prud'homme GJ.

Blood. 2009 Jan 15;113(3):622-5. doi: 10.1182/blood-2008-03-139964. Epub 2008 Nov 20.

33.

Sarcoidosis complicated by cirrhosis and hepatopulmonary syndrome.

Gupta S, Faughnan ME, Prud'homme GJ, Hwang DM, Munoz DG, Kopplin P.

Can Respir J. 2008 Apr;15(3):124-6.

34.

Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity.

Glinka Y, Prud'homme GJ.

J Leukoc Biol. 2008 Jul;84(1):302-10. doi: 10.1189/jlb.0208090. Epub 2008 Apr 24.

35.
36.

In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes.

Soltani N, Kumar M, Glinka Y, Prud'homme GJ, Wang Q.

Gene Ther. 2007 Jun;14(12):981-8. Epub 2007 Apr 5.

PMID:
17410180
37.

Plasmid-based gene therapy of diabetes mellitus.

Prud'homme GJ, Draghia-Akli R, Wang Q.

Gene Ther. 2007 Apr;14(7):553-64. Epub 2007 Jan 11. Review.

PMID:
17215847
38.

Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice.

Kumar M, Hunag Y, Glinka Y, Prud'homme GJ, Wang Q.

Gene Ther. 2007 Jan;14(2):162-72. Epub 2006 Aug 31.

PMID:
16943856
39.
40.

Electroporation-enhanced nonviral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases.

Prud'homme GJ, Glinka Y, Khan AS, Draghia-Akli R.

Curr Gene Ther. 2006 Apr;6(2):243-73. Review.

PMID:
16611045
41.
42.

DNA vaccination against tumors.

Prud'homme GJ.

J Gene Med. 2005 Jan;7(1):3-17. Review.

PMID:
15538731
43.

Plasmids encoding membrane-bound IL-4 or IL-12 strongly costimulate DNA vaccination against carcinoembryonic antigen (CEA).

Chakrabarti R, Chang Y, Song K, Prud'homme GJ.

Vaccine. 2004 Mar 12;22(9-10):1199-205.

PMID:
15003648
44.

Prevention of autoimmune diabetes by DNA vaccination.

Prud'homme GJ.

Expert Rev Vaccines. 2003 Aug;2(4):533-40. Review.

PMID:
14711337
45.

Altering immune tolerance therapeutically: the power of negative thinking.

Prud'homme GJ.

J Leukoc Biol. 2004 Apr;75(4):586-99. Epub 2003 Dec 4. Review.

PMID:
14657212
46.

Intramuscular gene transfer of soluble B7.1/IgG(1) fusion cDNA induces potent antitumor immunity as an adjuvant for DNA vaccination.

Zhou ZF, Peretz Y, Chang Y, Miao DS, Li X, Prud'homme GJ.

Cancer Gene Ther. 2003 Jun;10(6):491-9.

PMID:
12768195
47.

Immunopathology and the gene therapy of lupus.

Mageed RA, Prud'homme GJ.

Gene Ther. 2003 May;10(10):861-74. Review.

PMID:
12732872
48.
49.

Regulatory cytokine production stimulated by DNA vaccination against an altered form of glutamic acid decarboxylase 65 in nonobese diabetic mice.

Glinka Y, De Pooter R, Croze F, Prud'homme GJ.

J Mol Med (Berl). 2003 Mar;81(3):175-84. Epub 2003 Feb 11.

PMID:
12682726
50.

Immune modulation by plasmid DNA-mediated cytokine gene transfer.

Piccirillo CA, Prud'homme GJ.

Curr Pharm Des. 2003;9(1):83-94. Review.

PMID:
12570678

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