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Items: 1 to 50 of 52


Modeling distributed forces within cell adhesions of varying size on continuous substrates.

Hou JC, Shamsan GA, Anderson SM, McMahon MM, Tyler LP, Castle BT, Heussner RK, Provenzano PP, Keefe DF, Barocas VH, Odde DJ.

Cytoskeleton (Hoboken). 2019 Sep 12. doi: 10.1002/cm.21561. [Epub ahead of print]


The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance.

Zhovmer AS, Tabdanov ED, Miao H, Wen H, Chen J, Luo X, Ma X, Provenzano PP, Adelstein RS.

Mol Biol Cell. 2019 Jul 22;30(16):1961-1973. doi: 10.1091/mbc.E19-01-0071. Epub 2019 Jul 18.


Non-Invasive Monitoring of Stromal Biophysics with Targeted Depletion of Hyaluronan in Pancreatic Ductal Adenocarcinoma.

Maloney E, DuFort CC, Provenzano PP, Farr N, Carlson MA, Vohra R, Park J, Hingorani SR, Lee D.

Cancers (Basel). 2019 Jun 4;11(6). pii: E772. doi: 10.3390/cancers11060772.


Bimodal sensing of guidance cues in mechanically distinct microenvironments.

Tabdanov ED, Puram VV, Win Z, Alamgir A, Alford PW, Provenzano PP.

Nat Commun. 2018 Nov 20;9(1):4891. doi: 10.1038/s41467-018-07290-y.


Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma.

Elahi-Gedwillo KY, Carlson M, Zettervall J, Provenzano PP.

Cancer Res. 2019 Jan 15;79(2):372-386. doi: 10.1158/0008-5472.CAN-18-1334. Epub 2018 Nov 6.


Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing.

Tabdanov ED, Puram V, Zhovmer A, Provenzano PP.

Cell Rep. 2018 Oct 9;25(2):328-338.e5. doi: 10.1016/j.celrep.2018.09.030.


Cancer Stem Cell Migration in Three-Dimensional Aligned Collagen Matrices.

Ray A, Morford RK, Provenzano PP.

Curr Protoc Stem Cell Biol. 2018 Aug;46(1):e57. doi: 10.1002/cpsc.57. Epub 2018 May 24.


Dynamics of 3D carcinoma cell invasion into aligned collagen.

Ray A, Morford RK, Ghaderi N, Odde DJ, Provenzano PP.

Integr Biol (Camb). 2018 Feb 19;10(2):100-112. doi: 10.1039/c7ib00152e.


Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors.

Carlson M, Watson AL, Anderson L, Largaespada DA, Provenzano PP.

J Biomed Opt. 2017 Nov;22(11):1-9. doi: 10.1117/1.JBO.22.11.116010.


Physical and Chemical Enhancement of and Adaptive Resistance to Irreversible Electroporation of Pancreatic Cancer.

Shao Q, Liu F, Chung C, Elahi-Gedwillo K, Provenzano PP, Forsyth B, Bischof JC.

Ann Biomed Eng. 2018 Jan;46(1):25-36. doi: 10.1007/s10439-017-1932-3. Epub 2017 Oct 5.


Tug of War at the Cell-Matrix Interface.

Provenzano PP.

Biophys J. 2017 May 9;112(9):1739-1741. doi: 10.1016/j.bpj.2017.03.032. No abstract available.


Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration.

Ray A, Lee O, Win Z, Edwards RM, Alford PW, Kim DH, Provenzano PP.

Nat Commun. 2017 Apr 12;8:14923. doi: 10.1038/ncomms14923.


Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices.

Ray A, Slama ZM, Morford RK, Madden SA, Provenzano PP.

Biophys J. 2017 Mar 14;112(5):1023-1036. doi: 10.1016/j.bpj.2017.01.007.


Multiscale Cues Drive Collective Cell Migration.

Nam KH, Kim P, Wood DK, Kwon S, Provenzano PP, Kim DH.

Sci Rep. 2016 Jul 27;6:29749. doi: 10.1038/srep29749.


Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase.

DuFort CC, DelGiorno KE, Carlson MA, Osgood RJ, Zhao C, Huang Z, Thompson CB, Connor RJ, Thanos CD, Scott Brockenbrough J, Provenzano PP, Frost GI, Michael Shepard H, Hingorani SR.

Biophys J. 2016 May 10;110(9):2106-19. doi: 10.1016/j.bpj.2016.03.040.


Heterogeneous Differentiation of Human Mesenchymal Stem Cells in 3D Extracellular Matrix Composites.

Jung JP, Bache-Wiig MK, Provenzano PP, Ogle BM.

Biores Open Access. 2016 Jan 1;5(1):37-48. doi: 10.1089/biores.2015.0044. eCollection 2016.


Response to Chauhan et Al.: interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning.

DelGiorno KE, Carlson MA, Osgood R, Provenzano PP, Brockenbough JS, Thompson CB, Shepard HM, Frost GI, Potter JD, Hingorani SR.

Cancer Cell. 2014 Jul 14;26(1):16-7. doi: 10.1016/j.ccr.2014.06.004. No abstract available.


Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer.

Provenzano PP, Hingorani SR.

Br J Cancer. 2013 Jan 15;108(1):1-8. doi: 10.1038/bjc.2012.569. Epub 2013 Jan 8. Review.


Matrix nanotopography as a regulator of cell function.

Kim DH, Provenzano PP, Smith CL, Levchenko A.

J Cell Biol. 2012 Apr 30;197(3):351-60. doi: 10.1083/jcb.201108062. Review.


Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.

Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR.

Cancer Cell. 2012 Mar 20;21(3):418-29. doi: 10.1016/j.ccr.2012.01.007.


Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.

Provenzano PP, Keely PJ.

J Cell Sci. 2011 Apr 15;124(Pt 8):1195-205. doi: 10.1242/jcs.067009.


Aligned collagen is a prognostic signature for survival in human breast carcinoma.

Conklin MW, Eickhoff JC, Riching KM, Pehlke CA, Eliceiri KW, Provenzano PP, Friedl A, Keely PJ.

Am J Pathol. 2011 Mar;178(3):1221-32. doi: 10.1016/j.ajpath.2010.11.076.


Engineering three-dimensional collagen matrices to provide contact guidance during 3D cell migration.

Provenzano PP, Eliceiri KW, Inman DR, Keely PJ.

Curr Protoc Cell Biol. 2010 Jun;Chapter 10:Unit 10.17. doi: 10.1002/0471143030.cb1017s47.


Nonlinear optical microscopy and computational analysis of intrinsic signatures in breast cancer.

Rueden CT, Conklin MW, Provenzano PP, Keely PJ, Eliceiri KW.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:4077-80. doi: 10.1109/IEMBS.2009.5334523.


Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage.

Provenzano PP, Inman DR, Eliceiri KW, Keely PJ.

Oncogene. 2009 Dec 10;28(49):4326-43. doi: 10.1038/onc.2009.299.


Shining new light on 3D cell motility and the metastatic process.

Provenzano PP, Eliceiri KW, Keely PJ.

Trends Cell Biol. 2009 Nov;19(11):638-48. doi: 10.1016/j.tcb.2009.08.009. Epub 2009 Oct 8. Review.


The role of focal adhesion kinase in tumor initiation and progression.

Provenzano PP, Keely PJ.

Cell Adh Migr. 2009 Oct-Dec;3(4):347-50. Epub 2009 Oct 3. Review.


Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast.

Conklin MW, Provenzano PP, Eliceiri KW, Sullivan R, Keely PJ.

Cell Biochem Biophys. 2009;53(3):145-57. doi: 10.1007/s12013-009-9046-7.


Nonlinear optical imaging of cellular processes in breast cancer.

Provenzano PP, Eliceiri KW, Yan L, Ada-Nguema A, Conklin MW, Inman DR, Keely PJ.

Microsc Microanal. 2008 Dec;14(6):532-48. doi: 10.1017/S1431927608080884.


Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.

Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ.

Am J Pathol. 2008 Nov;173(5):1551-65. doi: 10.2353/ajpath.2008.080308. Epub 2008 Oct 9.


Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization.

Provenzano PP, Inman DR, Eliceiri KW, Trier SM, Keely PJ.

Biophys J. 2008 Dec;95(11):5374-84. doi: 10.1529/biophysj.108.133116. Epub 2008 Sep 5.


Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment.

Provenzano PP, Eliceiri KW, Keely PJ.

Clin Exp Metastasis. 2009;26(4):357-70. doi: 10.1007/s10585-008-9204-0. Epub 2008 Sep 3. Review.


Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer.

Provenzano PP, Rueden CT, Trier SM, Yan L, Ponik SM, Inman DR, Keely PJ, Eliceiri KW.

J Biomed Opt. 2008 May-Jun;13(3):031220. doi: 10.1117/1.2940365.


Collagen density promotes mammary tumor initiation and progression.

Provenzano PP, Inman DR, Eliceiri KW, Knittel JG, Yan L, Rueden CT, White JG, Keely PJ.

BMC Med. 2008 Apr 28;6:11. doi: 10.1186/1741-7015-6-11.


Investigating integrin regulation and signaling events in three-dimensional systems.

Keely PJ, Conklin MW, Gehler S, Ponik SM, Provenzano PP.

Methods Enzymol. 2007;426:27-45. Review.


Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: evaluation of loaded and unloaded ligaments.

Provenzano PP, Alejandro-Osorio AL, Grorud KW, Martinez DA, Vailas AC, Grindeland RE, Vanderby R Jr.

BMC Physiol. 2007 Mar 26;7:2.


Adjuvant neuropeptides can improve neuropathic ligament healing in a rat model.

Grorud KW, Jensen KT, Provenzano PP, Vanderby R Jr.

J Orthop Res. 2007 Jun;25(6):703-12.


Collagen reorganization at the tumor-stromal interface facilitates local invasion.

Provenzano PP, Eliceiri KW, Campbell JM, Inman DR, White JG, Keely PJ.

BMC Med. 2006 Dec 26;4(1):38.


Collagen fibril morphology and organization: implications for force transmission in ligament and tendon.

Provenzano PP, Vanderby R Jr.

Matrix Biol. 2006 Mar;25(2):71-84. Epub 2005 Nov 3.


Intrinsic fibroblast-mediated remodeling of damaged collagenous matrices in vivo.

Provenzano PP, Alejandro-Osorio AL, Valhmu WB, Jensen KT, Vanderby R Jr.

Matrix Biol. 2005 Jan;23(8):543-55. Epub 2004 Dec 1.


Nonlinear viscoelasticity in rabbit medial collateral ligament.

Hingorani RV, Provenzano PP, Lakes RS, Escarcega A, Vanderby R Jr.

Ann Biomed Eng. 2004 Feb;32(2):306-12.


Application of nonlinear viscoelastic models to describe ligament behavior.

Provenzano PP, Lakes RS, Corr DT, Vanderby R Jr.

Biomech Model Mechanobiol. 2002 Jun;1(1):45-57.


Blockade of the sympathetic nervous system degrades ligament in a rat MCL model.

Dwyer KW, Provenzano PP, Muir P, Valhmu WB, Vanderby R Jr.

J Appl Physiol (1985). 2004 Feb;96(2):711-8. Epub 2003 Oct 3.


Collagen in connective tissue: from tendon to bone.

Vanderby R, Provenzano PP.

J Biomech. 2003 Oct;36(10):1523-7. Review. No abstract available.


Required test duration for group comparisons in ligament viscoelasticity: a statistical approach.

Manley E Jr, Provenzano PP, Heisey D, Lakes R, Vanderby R Jr.

Biorheology. 2003;40(4):441-50.


A boundary layer model for wall shear stress in arterial stenosis.

Provenzano PP, Rutland CJ.

Biorheology. 2002;39(6):743-54.


Hindlimb unloading alters ligament healing.

Provenzano PP, Martinez DA, Grindeland RE, Dwyer KW, Turner J, Vailas AC, Vanderby R Jr.

J Appl Physiol (1985). 2003 Jan;94(1):314-24. Epub 2002 Sep 20.


Healing of subfailure ligament injury: comparison between immature and mature ligaments in a rat model.

Provenzano PP, Hayashi K, Kunz DN, Markel MD, Vanderby R Jr.

J Orthop Res. 2002 Sep;20(5):975-83.

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