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Items: 1 to 50 of 173

1.

Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.

Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, Lima PA, Hong Z, Zhao YY, Hindmarch C, Kutty S, Provencher S, Bonnet S, Sutendra G, Archer SL.

Circ Res. 2020 Mar 27. doi: 10.1161/CIRCRESAHA.120.316443. [Epub ahead of print]

PMID:
32216531
2.

Continuous reduction in cerebral oxygenation during endurance exercise in patients with pulmonary arterial hypertension.

Malenfant S, Brassard P, Paquette M, Le Blanc O, Chouinard A, Bonnet S, Provencher S.

Physiol Rep. 2020 Mar;8(6):e14389. doi: 10.14814/phy2.14389.

3.

DOAC compared to LMWH in the treatment of cancer related-venous thromboembolism: a systematic review and meta-analysis.

Mai V, Tanguay VF, Guay CA, Bertoletti L, Magnan S, Turgeon AF, Lacasse Y, Lega JC, Provencher S.

J Thromb Thrombolysis. 2020 Feb 12. doi: 10.1007/s11239-020-02055-1. [Epub ahead of print]

PMID:
32052314
4.

Current and future treatments of pulmonary arterial hypertension.

Sommer N, Ghofrani HA, Pak O, Bonnet S, Provencher S, Sitbon O, Rosenkranz S, Hoeper MM, Kiely DG.

Br J Pharmacol. 2020 Feb 7. doi: 10.1111/bph.15016. [Epub ahead of print] Review.

PMID:
32034759
5.

Reply to: BET Signaling, A Novel Therapeutic Target for Pulmonary Hypertension?

Provencher S, Boucherat O, Berger RMF, Goumans MJ, Bonnet S.

Am J Respir Crit Care Med. 2020 Feb 7. doi: 10.1164/rccm.202001-0059LE. [Epub ahead of print] No abstract available.

PMID:
32032495
6.

PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension.

Lampron MC, Vitry G, Nadeau V, Grobs Y, Paradis R, Samson N, Tremblay È, Boucherat O, Meloche J, Bonnet S, Provencher S, Potus F, Paulin R.

Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):783-801. doi: 10.1161/ATVBAHA.119.313763. Epub 2020 Jan 23.

PMID:
31969012
7.

New Insights Into HIMF (Hypoxia-Induced Mitogenic Factor)-Mediated Signaling Pathways in Pulmonary Hypertension.

Boucherat O, Paulin R, Provencher S, Bonnet S.

Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2451-2453. doi: 10.1161/ATVBAHA.119.313535. Epub 2019 Nov 26. No abstract available.

PMID:
31770028
8.

Journal Initiatives to Enhance Preclinical Research: Analyses of Stroke, Nature Medicine, Science Translational Medicine.

Ramirez FD, Jung RG, Motazedian P, Perry-Nguyen D, Di Santo P, MacDonald Z, Clancy AA, Labinaz A, Promislow S, Simard T, Provencher S, Bonnet S, Graham ID, Wells GA, Hibbert B.

Stroke. 2020 Jan;51(1):291-299. doi: 10.1161/STROKEAHA.119.026564. Epub 2019 Nov 13.

9.

Early Evidence for the Role of lncRNA TUG1 in Vascular Remodelling in Pulmonary Hypertension.

Bonnet S, Boucherat O, Provencher S, Paulin R.

Can J Cardiol. 2019 Nov;35(11):1433-1434. doi: 10.1016/j.cjca.2019.06.023. Epub 2019 Jun 28. No abstract available.

PMID:
31679615
10.

Pulmonary hypertension and chronic lung disease: where are we headed?

Elia D, Caminati A, Zompatori M, Cassandro R, Lonati C, Luisi F, Pelosi G, Provencher S, Harari S.

Eur Respir Rev. 2019 Oct 21;28(153). pii: 190065. doi: 10.1183/16000617.0065-2019. Print 2019 Sep 30. Review.

11.

Reply to Ning et al.: More Insights into the Association between RVX-208 and Pulmonary Arterial Hypertension.

Provencher S, Boucherat O, Berger RMF, Goumans MJ, Bonnet S.

Am J Respir Crit Care Med. 2020 Feb 1;201(3):389-391. doi: 10.1164/rccm.201909-1800LE. No abstract available.

12.

Beyond the Lungs: Systemic Manifestations of Pulmonary Arterial Hypertension.

Nickel NP, Yuan K, Dorfmuller P, Provencher S, Lai YC, Bonnet S, Austin ED, Koch CD, Morris A, Perros F, Montani D, Zamanian RT, de Jesus Perez VA.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):148-157. doi: 10.1164/rccm.201903-0656CI.

PMID:
31513751
13.

Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases.

Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB 4th, Provencher S, Zhang L, Uchida S.

Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C1-C28. doi: 10.1152/ajpcell.00078.2019. Epub 2019 Sep 4.

PMID:
31483703
14.

Reply to Piquereau and Perros and to Pullamsetti and de Jesus Perez.

Kurakula K, Boucherat O, Van der Feen DE, Bogaard HJ, Kulikowski E, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ.

Am J Respir Crit Care Med. 2019 Nov 1;200(9):1190-1191. doi: 10.1164/rccm.201905-1078LE. No abstract available.

15.

Extended Anticoagulation for VTE: A Systematic Review and Meta-Analysis.

Mai V, Guay CA, Perreault L, Bonnet S, Bertoletti L, Lacasse Y, Jardel S, Lega JC, Provencher S.

Chest. 2019 Jun;155(6):1199-1216. doi: 10.1016/j.chest.2019.02.402.

PMID:
31174635
16.

Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.

Ranchoux B, Nadeau V, Bourgeois A, Provencher S, Tremblay É, Omura J, Coté N, Abu-Alhayja'a R, Dumais V, Nachbar RT, Tastet L, Dahou A, Breuils-Bonnet S, Marette A, Pibarot P, Dupuis J, Paulin R, Boucherat O, Archer SL, Bonnet S, Potus F.

Circ Res. 2019 Aug 2;125(4):449-466. doi: 10.1161/CIRCRESAHA.118.314555. Epub 2019 Jun 3.

PMID:
31154939
17.

Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension.

Bourgeois A, Bonnet S, Breuils-Bonnet S, Habbout K, Paradis R, Tremblay E, Lampron MC, Orcholski ME, Potus F, Bertero T, Peterlini T, Chan SY, Norris KA, Paulin R, Provencher S, Boucherat O.

Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):1667-1681. doi: 10.1161/ATVBAHA.119.312537. Epub 2019 May 16.

18.

Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension.

Van der Feen DE, Kurakula K, Tremblay E, Boucherat O, Bossers GPL, Szulcek R, Bourgeois A, Lampron MC, Habbout K, Martineau S, Paulin R, Kulikowski E, Jahagirdar R, Schalij I, Bogaard HJ, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ.

Am J Respir Crit Care Med. 2019 Oct 1;200(7):910-920. doi: 10.1164/rccm.201812-2275OC.

PMID:
31042405
19.

Extended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis.

Mai V, Bertoletti L, Cucherat M, Jardel S, Grange C, Provencher S, Lega JC.

PLoS One. 2019 Apr 1;14(4):e0214134. doi: 10.1371/journal.pone.0214134. eCollection 2019.

20.

Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis.

Sofianopoulou E, Kaptoge S, Gräf S, Hadinnapola C, Treacy CM, Church C, Coghlan G, Gibbs JSR, Haimel M, Howard LS, Johnson M, Kiely DG, Lawrie A, Lordan J, MacKenzie Ross RV, Martin JM, Moledina S, Newnham M, Peacock AJ, Price LC, Rhodes CJ, Suntharalingam J, Swietlik EM, Toshner MR, Wharton J, Wilkins MR, Wort SJ, Pepke-Zaba J, Condliffe R, Corris PA, Di Angelantonio E, Provencher S, Morrell NW.

Eur Respir J. 2019 May 30;53(5). pii: 1801429. doi: 10.1183/13993003.01429-2018. Print 2019 May.

PMID:
30923185
21.

Interatrial shunting for heart failure: current evidence and future perspectives.

Guimaraes L, Lindenfeld J, Sandoval J, Bayés-Genis A, Bernier M, Provencher S, Rodés-Cabau J.

EuroIntervention. 2019 Jun 20;15(2):164-171. doi: 10.4244/EIJ-D-18-01211.

22.

Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis.

Barba T, Fort R, Cottin V, Provencher S, Durieu I, Jardel S, Hot A, Reynaud Q, Lega JC.

Autoimmun Rev. 2019 Feb;18(2):113-122. doi: 10.1016/j.autrev.2018.07.013. Epub 2018 Dec 17.

PMID:
30572131
23.

Enhanced Pulmonary Artery Radiodensity in Pulmonary Arterial Hypertension: A Sign of Early Calcification?

Tanguay VF, Babin C, Giardetti G, Sohier-Poirier C, Ménard-Cholette V, Ranchoux B, Ruffenach G, Montani D, Bonnet S, Provencher S.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):799-802. doi: 10.1164/rccm.201806-1027LE. No abstract available.

PMID:
30571924
24.

TAKling GDF-15 and skeletal muscle atrophy in pulmonary hypertension: are we there yet?

Lai YC, Provencher S, Goncharova EA.

Thorax. 2019 Feb;74(2):103-105. doi: 10.1136/thoraxjnl-2018-212680. Epub 2018 Dec 15. No abstract available.

PMID:
30554140
25.

Pulmonary hypertension in chronic lung disease and hypoxia.

Nathan SD, Barbera JA, Gaine SP, Harari S, Martinez FJ, Olschewski H, Olsson KM, Peacock AJ, Pepke-Zaba J, Provencher S, Weissmann N, Seeger W.

Eur Respir J. 2019 Jan 24;53(1). pii: 1801914. doi: 10.1183/13993003.01914-2018. Print 2019 Jan.

26.

Optimizing Lung Collapse With a Bronchial Blocker: It's Not What You Use, but How You Use It, Part II.

Bussières JS, Moreault O, Couture EJ, Provencher S.

J Cardiothorac Vasc Anesth. 2019 Jan;33(1):255. doi: 10.1053/j.jvca.2018.09.025. Epub 2018 Sep 28. No abstract available.

PMID:
30377052
27.

Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis.

Guay CA, Morin-Thibault LV, Bonnet S, Lacasse Y, Lambert C, Lega JC, Provencher S.

PLoS One. 2018 Oct 11;13(10):e0204610. doi: 10.1371/journal.pone.0204610. eCollection 2018.

28.

Management of Severe Pulmonary Hypertensive Disease for Surgical and Nonsurgical Procedures.

Couture EJ, Provencher S, Denault AY.

Int Anesthesiol Clin. 2018 Fall;56(4):e28-e55. doi: 10.1097/AIA.0000000000000202. Review. No abstract available.

PMID:
30204604
29.

Leading the Charge: Achievement of National Accreditation for a Nurse Residency Program.

Brown Tyo M, Gundlach M, Brennan C, Esdale L, Knight A, Provencher S, Tardy K.

J Nurses Prof Dev. 2018 Sep/Oct;34(5):270-276. doi: 10.1097/NND.0000000000000476.

PMID:
30188480
30.

Interpreting risk reduction in clinical trials for pulmonary arterial hypertension.

Lajoie AC, Bonnet S, Lacasse Y, Lega JC, Provencher S.

Eur Respir Rev. 2018 May 15;27(148). pii: 180020. doi: 10.1183/16000617.0020-2018. Print 2018 Jun 30. Review.

31.

Outcomes following a negative computed tomography pulmonary angiography according to pulmonary embolism prevalence: a meta-analysis of the management outcome studies.

Belzile D, Jacquet S, Bertoletti L, Lacasse Y, Lambert C, Lega JC, Provencher S.

J Thromb Haemost. 2018 Jun;16(6):1107-1120. doi: 10.1111/jth.14021. Epub 2018 May 17.

PMID:
29645405
32.

Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research.

Provencher S, Archer SL, Ramirez FD, Hibbert B, Paulin R, Boucherat O, Lacasse Y, Bonnet S.

Circ Res. 2018 Mar 30;122(7):1021-1032. doi: 10.1161/CIRCRESAHA.117.312579. Review.

PMID:
29599278
33.

Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension.

Adão R, Mendes-Ferreira P, Santos-Ribeiro D, Maia-Rocha C, Pimentel LD, Monteiro-Pinto C, Mulvaney EP, Reid HM, Kinsella BT, Potus F, Breuils-Bonnet S, Rademaker MT, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C.

Cardiovasc Res. 2018 Jul 1;114(8):1165-1177. doi: 10.1093/cvr/cvy076.

PMID:
29584808
34.

Effect of position and positive pressure ventilation on functional residual capacity in morbidly obese patients: a randomized trial.

Couture EJ, Provencher S, Somma J, Lellouche F, Marceau S, Bussières JS.

Can J Anaesth. 2018 May;65(5):522-528. doi: 10.1007/s12630-018-1050-1. Epub 2018 Jan 18.

PMID:
29435810
35.

Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.

Boucherat O, Peterlini T, Bourgeois A, Nadeau V, Breuils-Bonnet S, Boilet-Molez S, Potus F, Meloche J, Chabot S, Lambert C, Tremblay E, Chae YC, Altieri DC, Sutendra G, Michelakis ED, Paulin R, Provencher S, Bonnet S.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):90-103. doi: 10.1164/rccm.201708-1751OC.

36.

Pulmonary micro-tumor emboli resulting in paradoxical emboli: a case report.

Morin-Thibault LV, Wiseman D, Fortin M, Couture C, Provencher S.

Pulm Circ. 2018 Apr-Jun;8(2):2045893218754853. doi: 10.1177/2045893218754853. Epub 2018 Jan 8.

37.

FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension.

Bourgeois A, Lambert C, Habbout K, Ranchoux B, Paquet-Marceau S, Trinh I, Breuils-Bonnet S, Paradis R, Nadeau V, Paulin R, Provencher S, Bonnet S, Boucherat O.

J Mol Med (Berl). 2018 Feb;96(2):223-235. doi: 10.1007/s00109-017-1619-0. Epub 2017 Dec 30.

PMID:
29290032
38.

Identity crisis in pulmonary arterial hypertension.

Ruffenach G, Bonnet S, Rousseaux S, Khochbin S, Provencher S, Perros F.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217746054. doi: 10.1177/2045893217746054.

39.

Trial Duration and Risk Reduction in Combination Therapy Trials for Pulmonary Arterial Hypertension: A Systematic Review.

Lajoie AC, Guay CA, Lega JC, Lauzière G, Simard S, Lambert C, Lacasse Y, Bonnet S, Provencher S.

Chest. 2018 May;153(5):1142-1152. doi: 10.1016/j.chest.2017.11.014. Epub 2017 Nov 23.

PMID:
29175359
40.

Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.

Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC. Erratum in: Am J Respir Crit Care Med. 2019 Apr 1;199(7):932.

PMID:
29095649
41.

Dual ETA/ETB blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension.

Nadeau V, Potus F, Boucherat O, Paradis R, Tremblay E, Iglarz M, Paulin R, Bonnet S, Provencher S.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217741429. doi: 10.1177/2045893217741429. Epub 2017 Oct 24.

42.

Compromised Cerebrovascular Regulation and Cerebral Oxygenation in Pulmonary Arterial Hypertension.

Malenfant S, Brassard P, Paquette M, Le Blanc O, Chouinard A, Nadeau V, Allan PD, Tzeng YC, Simard S, Bonnet S, Provencher S.

J Am Heart Assoc. 2017 Oct 12;6(10). pii: e006126. doi: 10.1161/JAHA.117.006126.

43.

Therapeutic Value of ASK1 Inhibition in Pulmonary Arterial Hypertension.

Boucherat O, Provencher S, Bonnet S.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):284-286. doi: 10.1164/rccm.201708-1767ED. No abstract available.

PMID:
28930485
44.

HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension.

Boucherat O, Chabot S, Paulin R, Trinh I, Bourgeois A, Potus F, Lampron MC, Lambert C, Breuils-Bonnet S, Nadeau V, Paradis R, Goncharova EA, Provencher S, Bonnet S.

Sci Rep. 2017 Jul 3;7(1):4546. doi: 10.1038/s41598-017-04874-4.

45.

Clinical trial research in focus: improving drug development and trial design in pulmonary arterial hypertension.

Lajoie AC, Bonnet S, Provencher S.

Lancet Respir Med. 2017 Jul;5(7):544-546. doi: 10.1016/S2213-2600(17)30223-0. No abstract available.

PMID:
28664855
46.

Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges.

Lajoie AC, Bonnet S, Provencher S.

Pulm Circ. 2017 Apr-Jun;7(2):312-325. doi: 10.1177/2045893217710639. Epub 2017 May 30.

47.

The cancer theory of pulmonary arterial hypertension.

Boucherat O, Vitry G, Trinh I, Paulin R, Provencher S, Bonnet S.

Pulm Circ. 2017 Apr-Jun;7(2):285-299. doi: 10.1177/2045893217701438. Epub 2017 Mar 27.

48.

Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension.

Meloche J, Lampron MC, Nadeau V, Maltais M, Potus F, Lambert C, Tremblay E, Vitry G, Breuils-Bonnet S, Boucherat O, Charbonneau E, Provencher S, Paulin R, Bonnet S.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1513-1523. doi: 10.1161/ATVBAHA.117.309156. Epub 2017 May 4.

PMID:
28473439
49.

Use of β-Blockers in Pulmonary Hypertension.

Perros F, de Man FS, Bogaard HJ, Antigny F, Simonneau G, Bonnet S, Provencher S, Galiè N, Humbert M.

Circ Heart Fail. 2017 Apr;10(4). pii: e003703. doi: 10.1161/CIRCHEARTFAILURE.116.003703. Review.

PMID:
28364092
50.

Molecular imaging of the human pulmonary vascular endothelium in pulmonary hypertension: a phase II safety and proof of principle trial.

Harel F, Langleben D, Provencher S, Fournier A, Finnerty V, Nguyen QT, Letourneau M, Levac X, Abikhzer G, Guimond J, Mansour A, Guertin MC, Dupuis J.

Eur J Nucl Med Mol Imaging. 2017 Jul;44(7):1136-1144. doi: 10.1007/s00259-017-3655-y. Epub 2017 Feb 24.

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