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Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels.

Ma Q, Decker Y, Müller A, Ineichen BV, Proulx ST.

J Exp Med. 2019 Aug 27. pii: jem.20190351. doi: 10.1084/jem.20190351. [Epub ahead of print]


Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation.

Vranova M, Friess MC, Haghayegh Jahromi N, Collado-Diaz V, Vallone A, Hagedorn O, Jadhav M, Willrodt AH, Polomska A, Leroux JC, Proulx ST, Halin C.

Sci Rep. 2019 Aug 12;9(1):11714. doi: 10.1038/s41598-019-48046-y.


Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability.

Dieterich LC, Kapaklikaya K, Cetintas T, Proulx ST, Commerford CD, Ikenberg K, Bachmann SB, Scholl J, Detmar M.

Int J Cancer. 2019 Nov 15;145(10):2804-2815. doi: 10.1002/ijc.32594. Epub 2019 Aug 8.


An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth.

Yoon SY, Dieterich LC, Karaman S, Proulx ST, Bachmann SB, Sciaroni C, Detmar M.

PLoS One. 2019 Jul 25;14(7):e0220341. doi: 10.1371/journal.pone.0220341. eCollection 2019.


A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions.

Bachmann SB, Gsponer D, Montoya-Zegarra JA, Schneider M, Scholkmann F, Tacconi C, Noerrelykke SF, Proulx ST, Detmar M.

Cell Rep. 2019 Jun 11;27(11):3305-3314.e13. doi: 10.1016/j.celrep.2019.05.050.


Therapeutic Regeneration of Lymphatic and Immune Cell Functions upon Lympho-organoid Transplantation.

Lenti E, Bianchessi S, Proulx ST, Palano MT, Genovese L, Raccosta L, Spinelli A, Drago D, Andolfo A, Alfano M, Petrova TV, Mukenge S, Russo V, Brendolan A.

Stem Cell Reports. 2019 Jun 11;12(6):1260-1268. doi: 10.1016/j.stemcr.2019.04.021. Epub 2019 May 30.


Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo.

Bachmann SB, Proulx ST, He Y, Ries M, Detmar M.

J Physiol. 2019 Jun;597(11):2841-2852. doi: 10.1113/JP277254. Epub 2019 Mar 20.


Minimally invasive method for the point-of-care quantification of lymphatic vessel function.

Polomska AK, Proulx ST, Brambilla D, Fehr D, Bonmarin M, Brändli S, Meboldt M, Steuer C, Vasileva T, Reinke N, Leroux JC, Detmar M.

JCI Insight. 2019 Feb 21;4(4). pii: 126515. doi: 10.1172/jci.insight.126515. eCollection 2019 Feb 21.


Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation.

Schwager S, Renner S, Hemmerle T, Karaman S, Proulx ST, Fetz R, Golding-Ochsenbein AM, Probst P, Halin C, Neri D, Detmar M.

JCI Insight. 2018 Dec 6;3(23). pii: 124850. doi: 10.1172/jci.insight.124850.


Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain.

Ma Q, Ries M, Decker Y, Müller A, Riner C, Bücker A, Fassbender K, Detmar M, Proulx ST.

Acta Neuropathol. 2019 Jan;137(1):151-165. doi: 10.1007/s00401-018-1916-x. Epub 2018 Oct 10.


Visualization and Measurement of Lymphatic Function In Vivo.

Bachmann SB, Detmar M, Proulx ST.

Methods Mol Biol. 2018;1846:197-211. doi: 10.1007/978-1-4939-8712-2_13.


Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.

Ma Q, Dieterich LC, Ikenberg K, Bachmann SB, Mangana J, Proulx ST, Amann VC, Levesque MP, Dummer R, Baluk P, McDonald DM, Detmar M.

Sci Adv. 2018 Aug 8;4(8):eaat4758. doi: 10.1126/sciadv.aat4758. eCollection 2018 Aug.


Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice.

Ma Q, Ineichen BV, Detmar M, Proulx ST.

Nat Commun. 2017 Nov 10;8(1):1434. doi: 10.1038/s41467-017-01484-6.


An Important Role of VEGF-C in Promoting Lymphedema Development.

Gousopoulos E, Proulx ST, Bachmann SB, Dieterich LC, Scholl J, Karaman S, Bianchi R, Detmar M.

J Invest Dermatol. 2017 Sep;137(9):1995-2004. doi: 10.1016/j.jid.2017.04.033. Epub 2017 May 17.


High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.

Gousopoulos E, Karaman S, Proulx ST, Leu K, Buschle D, Detmar M.

Eur Surg Res. 2017;58(3-4):180-192. doi: 10.1159/000461579. Epub 2017 Mar 17.


T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions.

Teijeira A, Hunter MC, Russo E, Proulx ST, Frei T, Debes GF, Coles M, Melero I, Detmar M, Rouzaut A, Halin C.

Cell Rep. 2017 Jan 24;18(4):857-865. doi: 10.1016/j.celrep.2016.12.078.


Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein.

Proulx ST, Ma Q, Andina D, Leroux JC, Detmar M.

JCI Insight. 2017 Jan 12;2(1):e90861. doi: 10.1172/jci.insight.90861.


New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.

Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M.

Oncotarget. 2017 Jan 3;8(1):1007-1022. doi: 10.18632/oncotarget.13537.


Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes.

Bianchi R, Russo E, Bachmann SB, Proulx ST, Sesartic M, Smaadahl N, Watson SP, Buckley CD, Halin C, Detmar M.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):108-117. doi: 10.1161/ATVBAHA.116.308020. Epub 2016 Nov 3.


Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation.

Christiansen AJ, Dieterich LC, Ohs I, Bachmann SB, Bianchi R, Proulx ST, Hollmén M, Aebischer D, Detmar M.

Oncotarget. 2016 Jun 28;7(26):39421-39435. doi: 10.18632/oncotarget.9820.


Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function.

Gousopoulos E, Proulx ST, Bachmann SB, Scholl J, Dionyssiou D, Demiri E, Halin C, Dieterich LC, Detmar M.

JCI Insight. 2016 Oct 6;1(16):e89081. doi: 10.1172/jci.insight.89081.


Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling.

Ochsenbein AM, Karaman S, Proulx ST, Goldmann R, Chittazhathu J, Dasargyri A, Chong C, Leroux JC, Stanley ER, Detmar M.

Angiogenesis. 2016 Oct;19(4):513-24. doi: 10.1007/s10456-016-9523-8. Epub 2016 Jul 27.


Prominent Lymphatic Vessel Hyperplasia with Progressive Dysfunction and Distinct Immune Cell Infiltration in Lymphedema.

Gousopoulos E, Proulx ST, Scholl J, Uecker M, Detmar M.

Am J Pathol. 2016 Aug;186(8):2193-2203. doi: 10.1016/j.ajpath.2016.04.006. Epub 2016 Jun 15.


Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice.

Escobedo N, Proulx ST, Karaman S, Dillard ME, Johnson N, Detmar M, Oliver G.

JCI Insight. 2016 Feb 1;1(2). pii: e85096. Epub 2016 Feb 25.


In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging.

Chong C, Scholkmann F, Bachmann SB, Luciani P, Leroux JC, Detmar M, Proulx ST.

Sci Rep. 2016 Mar 10;6:22930. doi: 10.1038/srep22930.


Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells.

Ochsenbein AM, Karaman S, Proulx ST, Berchtold M, Jurisic G, Stoeckli ET, Detmar M.

Development. 2016 Feb 15;143(4):589-94. doi: 10.1242/dev.127670.


Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles.

Dasargyri A, Hervella P, Christiansen A, Proulx ST, Detmar M, Leroux JC.

J Control Release. 2016 Feb 28;224:229-238. doi: 10.1016/j.jconrel.2016.01.021. Epub 2016 Jan 13.


Microneedles for the Noninvasive Structural and Functional Assessment of Dermal Lymphatic Vessels.

Brambilla D, Proulx ST, Marschalkova P, Detmar M, Leroux JC.

Small. 2016 Feb 24;12(8):1053-61. doi: 10.1002/smll.201503093. Epub 2016 Jan 4.


Decline of lymphatic vessel density and function in murine skin during aging.

Karaman S, Buschle D, Luciani P, Leroux JC, Detmar M, Proulx ST.

Angiogenesis. 2015 Oct;18(4):489-98. doi: 10.1007/s10456-015-9479-0. Epub 2015 Aug 11.


A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K.

J Exp Med. 2015 Jun 29;212(7):991-9. doi: 10.1084/jem.20142290. Epub 2015 Jun 15.


A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.

Bianchi R, Teijeira A, Proulx ST, Christiansen AJ, Seidel CD, Rülicke T, Mäkinen T, Hägerling R, Halin C, Detmar M.

PLoS One. 2015 Apr 7;10(4):e0122976. doi: 10.1371/journal.pone.0122976. eCollection 2015.


Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells.

Moalli F, Proulx ST, Schwendener R, Detmar M, Schlapbach C, Stein JV.

Front Immunol. 2015 Mar 13;6:114. doi: 10.3389/fimmu.2015.00114. eCollection 2015.


Chronic high-fat diet impairs collecting lymphatic vessel function in mice.

Blum KS, Karaman S, Proulx ST, Ochsenbein AM, Luciani P, Leroux JC, Wolfrum C, Detmar M.

PLoS One. 2014 Apr 8;9(4):e94713. doi: 10.1371/journal.pone.0094713. eCollection 2014.


Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage.

Iolyeva M, Aebischer D, Proulx ST, Willrodt AH, Ecoiffier T, Häner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D, Halin C.

Blood. 2013 Sep 26;122(13):2271-81. doi: 10.1182/blood-2013-01-478073. Epub 2013 Aug 20.


In vitro fabrication of autologous living tissue-engineered vascular grafts based on prenatally harvested ovine amniotic fluid-derived stem cells.

Weber B, Kehl D, Bleul U, Behr L, Sammut S, Frese L, Ksiazek A, Achermann J, Stranzinger G, Robert J, Sanders B, Sidler M, Brokopp CE, Proulx ST, Frauenfelder T, Schoenauer R, Emmert MY, Falk V, Hoerstrup SP.

J Tissue Eng Regen Med. 2016 Jan;10(1):52-70. doi: 10.1002/term.1781. Epub 2013 Jul 24.


VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis.

Alitalo AK, Proulx ST, Karaman S, Aebischer D, Martino S, Jost M, Schneider N, Bry M, Detmar M.

Cancer Res. 2013 Jul 15;73(14):4212-21. doi: 10.1158/0008-5472.CAN-12-4539. Epub 2013 May 21.


Expansion of the lymphatic vasculature in cancer and inflammation: new opportunities for in vivo imaging and drug delivery.

Proulx ST, Luciani P, Dieterich LC, Karaman S, Leroux JC, Detmar M.

J Control Release. 2013 Dec 10;172(2):550-7. doi: 10.1016/j.jconrel.2013.04.027. Epub 2013 May 9.


Dynamics of lymphatic regeneration and flow patterns after lymph node dissection.

Blum KS, Proulx ST, Luciani P, Leroux JC, Detmar M.

Breast Cancer Res Treat. 2013 May;139(1):81-6. doi: 10.1007/s10549-013-2537-7. Epub 2013 Apr 24.


Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis.

Proulx ST, Luciani P, Christiansen A, Karaman S, Blum KS, Rinderknecht M, Leroux JC, Detmar M.

Biomaterials. 2013 Jul;34(21):5128-37. doi: 10.1016/j.biomaterials.2013.03.034. Epub 2013 Apr 6.


Molecular mechanisms and imaging of lymphatic metastasis.

Proulx ST, Detmar M.

Exp Cell Res. 2013 Jul 1;319(11):1611-7. doi: 10.1016/j.yexcr.2013.03.009. Epub 2013 Mar 13. Review.


Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo.

Proulx ST, Luciani P, Alitalo A, Mumprecht V, Christiansen AJ, Huggenberger R, Leroux JC, Detmar M.

Angiogenesis. 2013 Jul;16(3):525-40. doi: 10.1007/s10456-013-9332-2. Epub 2013 Jan 17.


Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice.

Duong T, Proulx ST, Luciani P, Leroux JC, Detmar M, Koopman P, Francois M.

Cancer Res. 2012 Jun 15;72(12):3105-14. doi: 10.1158/0008-5472.CAN-11-4026. Epub 2012 Apr 20.


Watching lymphatic vessels grow by making them glow.

Proulx ST, Detmar M.

Cell Res. 2012 Jan;22(1):12-3. doi: 10.1038/cr.2011.191. Epub 2011 Nov 29. No abstract available.


In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography.

Mumprecht V, Honer M, Vigl B, Proulx ST, Trachsel E, Kaspar M, Banziger-Tobler NE, Schibli R, Neri D, Detmar M.

Cancer Res. 2010 Nov 1;70(21):8842-51. doi: 10.1158/0008-5472.CAN-10-0896. Epub 2010 Oct 26.


Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation.

Huggenberger R, Ullmann S, Proulx ST, Pytowski B, Alitalo K, Detmar M.

J Exp Med. 2010 Sep 27;207(10):2255-69. doi: 10.1084/jem.20100559. Epub 2010 Sep 13.


Quantitative imaging of lymphatic function with liposomal indocyanine green.

Proulx ST, Luciani P, Derzsi S, Rinderknecht M, Mumprecht V, Leroux JC, Detmar M.

Cancer Res. 2010 Sep 15;70(18):7053-62. doi: 10.1158/0008-5472.CAN-10-0271. Epub 2010 Sep 7.


Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium.

Jurisic G, Iolyeva M, Proulx ST, Halin C, Detmar M.

Exp Cell Res. 2010 Oct 15;316(17):2982-92. doi: 10.1016/j.yexcr.2010.06.013. Epub 2010 Jun 23.


Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy.

Li J, Kuzin I, Moshkani S, Proulx ST, Xing L, Skrombolas D, Dunn R, Sanz I, Schwarz EM, Bottaro A.

J Immunol. 2010 Jun 1;184(11):6142-50. doi: 10.4049/jimmunol.0903489. Epub 2010 Apr 30.


Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw.

Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM.

Ann N Y Acad Sci. 2010 Mar;1192:84-94. doi: 10.1111/j.1749-6632.2009.05210.x.


Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity.

Papuga MO, Proulx ST, Kwok E, You Z, Rubery PT, Dougherty PE, Hilton MJ, Awad HA, Schwarz EM.

J Orthop Res. 2010 Sep;28(9):1220-8. doi: 10.1002/jor.21103.

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