Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 182


Hepatic injury caused by the environmental toxicant vinyl chloride is sex-dependent in mice.

Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner KC, Prough RA, Cave MC, Beier JI.

Toxicol Sci. 2019 Nov 27. pii: kfz236. doi: 10.1093/toxsci/kfz236. [Epub ahead of print]


Mechanisms of Environmental Contributions to Fatty Liver Disease.

Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC.

Curr Environ Health Rep. 2019 Sep;6(3):80-94. doi: 10.1007/s40572-019-00232-w. Review.


Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease.

Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC.

Food Chem Toxicol. 2019 Jul;129:64-76. doi: 10.1016/j.fct.2019.04.007. Epub 2019 Apr 23.


Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures.

Shi H, Hardesty JE, Jin J, Head KZ, Falkner KC, Cave MC, Prough RA.

Xenobiotica. 2019 Dec;49(12):1414-1422. doi: 10.1080/00498254.2019.1566582. Epub 2019 Apr 16.


Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis.

Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey DW, Merchant ML, Watson CT, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC.

J Proteome Res. 2019 Apr 5;18(4):1582-1594. doi: 10.1021/acs.jproteome.8b00886. Epub 2019 Mar 15.


Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes.

Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam SP, Chari ST, Cave MC.

Toxicol Appl Pharmacol. 2019 Jan 15;363:22-33. doi: 10.1016/j.taap.2018.10.011. Epub 2018 Oct 9.


Hepatic signalling disruption by pollutant Polychlorinated biphenyls in steatohepatitis.

Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant M, Watson C, Prough RA, Cave MC.

Cell Signal. 2019 Jan;53:132-139. doi: 10.1016/j.cellsig.2018.10.004. Epub 2018 Oct 6.


Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease.

Warner DR, Liu H, Ghosh Dastidar S, Warner JB, Prodhan MAI, Yin X, Zhang X, Feldstein AE, Gao B, Prough RA, McClain CJ, Kirpich IA.

PLoS One. 2018 Sep 26;13(9):e0204119. doi: 10.1371/journal.pone.0204119. eCollection 2018.


Mechanisms of Action of Dehydroepiandrosterone.

Clark BJ, Prough RA, Klinge CM.

Vitam Horm. 2018;108:29-73. doi: 10.1016/bs.vh.2018.02.003. Epub 2018 Mar 22.


Dehydroepiandrosterone Research: Past, Current, and Future.

Klinge CM, Clark BJ, Prough RA.

Vitam Horm. 2018;108:1-28. doi: 10.1016/bs.vh.2018.02.002. Epub 2018 Mar 16. Review.


Liver Disease in a Residential Cohort With Elevated Polychlorinated Biphenyl Exposures.

Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC.

Toxicol Sci. 2018 Jul 1;164(1):39-49. doi: 10.1093/toxsci/kfy076.


Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals.

Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC.

Toxicol Sci. 2018 Apr 1;162(2):622-634. doi: 10.1093/toxsci/kfy004.


Dietary copper-fructose interactions alter gut microbial activity in male rats.

Song M, Li X, Zhang X, Shi H, Vos MB, Wei X, Wang Y, Gao H, Rouchka EC, Yin X, Zhou Z, Prough RA, Cave MC, McClain CJ.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G119-G130. doi: 10.1152/ajpgi.00378.2016. Epub 2017 Oct 12.


Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling.

Hardesty JE, Wahlang B, Falkner KC, Clair HB, Clark BJ, Ceresa BP, Prough RA, Cave MC.

Xenobiotica. 2017 Sep;47(9):807-820. doi: 10.1080/00498254.2016.1217572. Epub 2017 Jun 21.


Nuclear receptors and nonalcoholic fatty liver disease.

Cave MC, Clair HB, Hardesty JE, Falkner KC, Feng W, Clark BJ, Sidey J, Shi H, Aqel BA, McClain CJ, Prough RA.

Biochim Biophys Acta. 2016 Sep;1859(9):1083-1099. doi: 10.1016/j.bbagrm.2016.03.002. Epub 2016 Mar 4. Review.


Novel mechanisms for DHEA action.

Prough RA, Clark BJ, Klinge CM.

J Mol Endocrinol. 2016 Apr;56(3):R139-55. doi: 10.1530/JME-16-0013. Epub 2016 Feb 23. Review.


Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response.

Song M, Chen T, Prough RA, Cave MC, McClain CJ.

Alcohol Clin Exp Res. 2016 Mar;40(3):518-28. doi: 10.1111/acer.12994. Epub 2016 Feb 9.


Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis.

Wahlang B, Prough RA, Falkner KC, Hardesty JE, Song M, Clair HB, Clark BJ, States JC, Arteel GE, Cave MC.

Toxicol Sci. 2016 Feb;149(2):396-410. doi: 10.1093/toxsci/kfv250. Epub 2015 Nov 25.


Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism.

Wahlang B, Falkner KC, Cave MC, Prough RA.

Adv Pharmacol. 2015;74:1-33. doi: 10.1016/bs.apha.2015.04.004. Epub 2015 May 29. Review.


Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury.

Conklin DJ, Guo Y, Jagatheesan G, Kilfoil PJ, Haberzettl P, Hill BG, Baba SP, Guo L, Wetzelberger K, Obal D, Rokosh DG, Prough RA, Prabhu SD, Velayutham M, Zweier JL, Hoetker JD, Riggs DW, Srivastava S, Bolli R, Bhatnagar A.

Circ Res. 2015 Aug 14;117(5):437-49. doi: 10.1161/CIRCRESAHA.114.305518. Epub 2015 Jul 13.


Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.

Teng Y, Radde BN, Litchfield LM, Ivanova MM, Prough RA, Clark BJ, Doll MA, Hein DW, Klinge CM.

J Biol Chem. 2015 Jun 19;290(25):15799-811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.


Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in mice.

Conklin DJ, Haberzettl P, Jagatheesan G, Baba S, Merchant ML, Prough RA, Williams JD, Prabhu SD, Bhatnagar A.

Toxicol Appl Pharmacol. 2015 Jun 1;285(2):136-48. doi: 10.1016/j.taap.2015.03.029. Epub 2015 Apr 10.


Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents.

Al-Eryani L, Wahlang B, Falkner KC, Guardiola JJ, Clair HB, Prough RA, Cave M.

Toxicol Pathol. 2015 Jun;43(4):482-97. doi: 10.1177/0192623314549960. Epub 2014 Oct 16. Review.


Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease.

Wahlang B, Song M, Beier JI, Cameron Falkner K, Al-Eryani L, Clair HB, Prough RA, Osborne TS, Malarkey DE, States JC, Cave MC.

Toxicol Appl Pharmacol. 2014 Sep 15;279(3):380-390. doi: 10.1016/j.taap.2014.06.019. Epub 2014 Jul 3.


Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor.

Teng Y, Litchfield LM, Ivanova MM, Prough RA, Clark BJ, Klinge CM.

Mol Cell Endocrinol. 2014 Jul 5;392(1-2):23-36. doi: 10.1016/j.mce.2014.05.007. Epub 2014 May 17.


Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping.

Makia NL, Surapureddi S, Monostory K, Prough RA, Goldstein JA.

Mol Pharmacol. 2014 Aug;86(2):125-37. doi: 10.1124/mol.114.092585. Epub 2014 May 15.


Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.

Wahlang B, Falkner KC, Clair HB, Al-Eryani L, Prough RA, States JC, Coslo DM, Omiecinski CJ, Cave MC.

Toxicol Sci. 2014 Aug 1;140(2):283-97. doi: 10.1093/toxsci/kfu083. Epub 2014 May 8.


Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.

Xu X, Prough RA, Samuelson DJ.

Mol Carcinog. 2015 Feb;54(2):134-47. doi: 10.1002/mc.22081. Epub 2013 Sep 5.


Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction.

Green ML, Pisano MM, Prough RA, Knudsen TB.

Cell Signal. 2013 Dec;25(12):2383-90. doi: 10.1016/j.cellsig.2013.07.019. Epub 2013 Jul 27.


Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).

Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ.

Mol Carcinog. 2014 Apr;53(4):300-13. doi: 10.1002/mc.21977. Epub 2012 Nov 8.


DHEA metabolites activate estrogen receptors alpha and beta.

Miller KK, Al-Rayyan N, Ivanova MM, Mattingly KA, Ripp SL, Klinge CM, Prough RA.

Steroids. 2013 Jan;78(1):15-25. doi: 10.1016/j.steroids.2012.10.002. Epub 2012 Nov 2.


Activator protein-1 regulation of murine aldehyde dehydrogenase 1a1.

Makia NL, Amunom I, Falkner KC, Conklin DJ, Surapureddi S, Goldstein JA, Prough RA.

Mol Pharmacol. 2012 Oct;82(4):601-13. Epub 2012 Jun 26.


Metabolomic analysis of the effects of polychlorinated biphenyls in nonalcoholic fatty liver disease.

Shi X, Wahlang B, Wei X, Yin X, Falkner KC, Prough RA, Kim SH, Mueller EG, McClain CJ, Cave M, Zhang X.

J Proteome Res. 2012 Jul 6;11(7):3805-15. doi: 10.1021/pr300297z. Epub 2012 Jun 21.


Differential programming of p53-deficient embryonic cells during rotenone block.

Green ML, Singh AV, Ruest LB, Pisano MM, Prough RA, Knudsen TB.

Toxicology. 2011 Nov 28;290(1):31-41. doi: 10.1016/j.tox.2011.08.013. Epub 2011 Aug 27.


Acrolein-induced dyslipidemia and acute-phase response are independent of HMG-CoA reductase.

Conklin DJ, Prough RA, Juvan P, Rezen T, Rozman D, Haberzettl P, Srivastava S, Bhatnagar A.

Mol Nutr Food Res. 2011 Sep;55(9):1411-22. doi: 10.1002/mnfr.201100225. Epub 2011 Aug 3.


Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes.

Amunom I, Dieter LJ, Tamasi V, Cai J, Conklin DJ, Srivastava S, Martin MV, Guengerich FP, Prough RA.

Chem Res Toxicol. 2011 Aug 15;24(8):1223-30. doi: 10.1021/tx200080b. Epub 2011 Jul 29.


Aldehyde reduction by cytochrome P450.

Amunom I, Srivastava S, Prough RA.

Curr Protoc Toxicol. 2011 May;Chapter 4:Unit4.37. doi: 10.1002/0471140856.tx0437s48.


Murine hepatic aldehyde dehydrogenase 1a1 is a major contributor to oxidation of aldehydes formed by lipid peroxidation.

Makia NL, Bojang P, Falkner KC, Conklin DJ, Prough RA.

Chem Biol Interact. 2011 May 30;191(1-3):278-87. doi: 10.1016/j.cbi.2011.01.013. Epub 2011 Jan 20.


Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s.

Tamási V, Monostory K, Prough RA, Falus A.

Cell Mol Life Sci. 2011 Apr;68(7):1131-46. doi: 10.1007/s00018-010-0600-7. Epub 2010 Dec 24. Review.


MicroRNA group disorganization in aging.

Lanceta J, Prough RA, Liang R, Wang E.

Exp Gerontol. 2010 Apr;45(4):269-78. doi: 10.1016/j.exger.2009.12.009. Epub 2009 Dec 23. Review.


Acrolein consumption induces systemic dyslipidemia and lipoprotein modification.

Conklin DJ, Barski OA, Lesgards JF, Juvan P, Rezen T, Rozman D, Prough RA, Vladykovskaya E, Liu S, Srivastava S, Bhatnagar A.

Toxicol Appl Pharmacol. 2010 Feb 15;243(1):1-12. doi: 10.1016/j.taap.2009.12.010. Epub 2009 Dec 23.


Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity.

Conklin DJ, Haberzettl P, Lesgards JF, Prough RA, Srivastava S, Bhatnagar A.

J Pharmacol Exp Ther. 2009 Nov;331(2):456-69. doi: 10.1124/jpet.109.156513. Epub 2009 Aug 20.


A novel NADP(+)-dependent dehydrogenase activity for 7alpha/beta- and 11beta-hydroxysteroids in human liver nuclei: A third 11beta-hydroxysteroid dehydrogenase.

Robinzon B, Prough RA.

Arch Biochem Biophys. 2009 Jun 15;486(2):170-6. doi: 10.1016/ Epub 2009 May 3.


Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke.

Conklin DJ, Haberzettl P, Prough RA, Bhatnagar A.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1586-97. doi: 10.1152/ajpheart.00867.2008. Epub 2009 Mar 6.


Regulation of the rat UGT1A6 by glucocorticoids involves a cryptic glucocorticoid response element.

Falkner KC, Ritter JK, Prough RA.

Drug Metab Dispos. 2008 Feb;36(2):409-17. Epub 2007 Nov 26.


Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes.

Amunom I, Stephens LJ, Tamasi V, Cai J, Pierce WM Jr, Conklin DJ, Bhatnagar A, Srivastava S, Martin MV, Guengerich FP, Prough RA.

Arch Biochem Biophys. 2007 Aug 15;464(2):187-96. Epub 2007 Jun 8.


Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor.

Kohalmy K, Tamási V, Kóbori L, Sárváry E, Pascussi JM, Porrogi P, Rozman D, Prough RA, Meyer UA, Monostory K.

Drug Metab Dispos. 2007 Sep;35(9):1495-501. Epub 2007 Jun 25.


The biological actions of dehydroepiandrosterone involves multiple receptors.

Webb SJ, Geoghegan TE, Prough RA, Michael Miller KK.

Drug Metab Rev. 2006;38(1-2):89-116. Review.

Supplemental Content

Loading ...
Support Center