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Items: 1 to 50 of 287

1.

Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1.

Lages A, Proud CG, Holloway JW, Vorechovsky I.

Mol Ther Nucleic Acids. 2019 Jun 7;16:770-777. doi: 10.1016/j.omtn.2019.04.026. Epub 2019 May 13.

2.

Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation.

Charitou T, Srihari S, Lynn MA, Jarboui MA, Fasterius E, Moldovan M, Shirasawa S, Tsunoda T, Ueffing M, Xie J, Xin J, Wang X, Proud CG, Boldt K, Al-Khalili Szigyarto C, Kolch W, Lynn DJ.

Br J Cancer. 2019 May 28. doi: 10.1038/s41416-019-0477-7. [Epub ahead of print]

PMID:
31133691
3.

Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress.

Xie J, Van Damme P, Fang D, Proud CG.

J Biol Chem. 2019 May 3;294(18):7169-7176. doi: 10.1074/jbc.AC119.008036. Epub 2019 Mar 19.

PMID:
30890561
4.

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan.

Xie J, de Souza Alves V, von der Haar T, O'Keefe L, Lenchine RV, Jensen KB, Liu R, Coldwell MJ, Wang X, Proud CG.

Curr Biol. 2019 Mar 4;29(5):737-749.e5. doi: 10.1016/j.cub.2019.01.029. Epub 2019 Feb 14.

PMID:
30773367
5.

The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1.

Lie S, Wang T, Forbes B, Proud CG, Petersen J.

Sci Rep. 2019 Feb 6;9(1):1461. doi: 10.1038/s41598-018-37509-3.

6.

The MAP kinase-interacting kinases (MNKs) as targets in oncology.

Xie J, Merrett JE, Jensen KB, Proud CG.

Expert Opin Ther Targets. 2019 Mar;23(3):187-199. doi: 10.1080/14728222.2019.1571043. Epub 2019 Jan 24.

PMID:
30650992
7.

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold.

Jin X, Merrett J, Tong S, Flower B, Xie J, Yu R, Tian S, Gao L, Zhao J, Wang X, Jiang T, Proud CG.

Eur J Med Chem. 2019 Jan 15;162:735-751. doi: 10.1016/j.ejmech.2018.10.070. Epub 2018 Nov 2.

PMID:
30496989
8.

Lysosomal N-acetyltransferase interacts with ALIX and is detected in extracellular vesicles.

Fedele AO, Isenmann S, Kamei M, Snel MF, Trim PJ, Proud CG, Hopwood JJ.

Biochim Biophys Acta Mol Cell Res. 2018 Jul 4;1865(10):1451-1464. doi: 10.1016/j.bbamcr.2018.07.001. [Epub ahead of print]

PMID:
29981367
9.

Phosphorylation and Signal Transduction Pathways in Translational Control.

Proud CG.

Cold Spring Harb Perspect Biol. 2018 Jun 29. pii: a033050. doi: 10.1101/cshperspect.a033050. [Epub ahead of print]

PMID:
29959191
10.

Who does TORC2 talk to?

Xie J, Wang X, Proud CG.

Biochem J. 2018 May 24;475(10):1721-1738. doi: 10.1042/BCJ20180130. Review.

PMID:
29794170
11.

Non-high-density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance.

Liu L, Li Q, Yuan Z, Zhao M, Zhang X, Zhang H, Zheng D, Xu J, Gao L, Guan Q, Zhao J, Proud CG, Wang X, Hou X; REACTION Study Group.

J Diabetes Investig. 2018 Nov;9(6):1304-1311. doi: 10.1111/jdi.12837. Epub 2018 Apr 19.

12.

Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro.

Wisse LE, Ter Braak TJ, van de Beek MC, van Berkel CGM, Wortel J, Heine VM, Proud CG, van der Knaap MS, Abbink TEM.

Sci Rep. 2018 Feb 28;8(1):3773. doi: 10.1038/s41598-018-21885-x.

13.

Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions.

Wisse LE, Penning R, Zaal EA, van Berkel CGM, Ter Braak TJ, Polder E, Kenney JW, Proud CG, Berkers CR, Altelaar MAF, Speijer D, van der Knaap MS, Abbink TEM.

Front Cell Neurosci. 2017 Dec 20;11:411. doi: 10.3389/fncel.2017.00411. eCollection 2017.

14.

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis.

Xie J, Shen K, Lenchine RV, Gethings LA, Trim PJ, Snel MF, Zhou Y, Kenney JW, Kamei M, Kochetkova M, Wang X, Proud CG.

Int J Cancer. 2018 May 1;142(9):1865-1877. doi: 10.1002/ijc.31210. Epub 2017 Dec 27.

15.

Osteocalcin-dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance.

Tangseefa P, Martin SK, Fitter S, Baldock PA, Proud CG, Zannettino ACW.

J Cell Physiol. 2018 May;233(5):3769-3783. doi: 10.1002/jcp.26163. Epub 2017 Sep 18. Review.

PMID:
28834550
16.

A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome.

Hein LK, Apaja PM, Hattersley K, Grose RH, Xie J, Proud CG, Sargeant TJ.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1554-1565. doi: 10.1016/j.bbamcr.2017.06.011. Epub 2017 Jun 19.

17.

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.

Brace PT, Tezera LB, Bielecka MK, Mellows T, Garay D, Tian S, Rand L, Green J, Jogai S, Steele AJ, Millar TM, Sanchez-Elsner T, Friedland JS, Proud CG, Elkington PT.

PLoS Pathog. 2017 Jun 1;13(6):e1006367. doi: 10.1371/journal.ppat.1006367. eCollection 2017 Jun.

18.

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1.

Tian S, Wang X, Proud CG.

Oncotarget. 2017 Jul 11;8(28):46121-46135. doi: 10.18632/oncotarget.17555.

19.

Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase.

Johanns M, Pyr Dit Ruys S, Houddane A, Vertommen D, Herinckx G, Hue L, Proud CG, Rider MH.

Cell Signal. 2017 Aug;36:212-221. doi: 10.1016/j.cellsig.2017.05.010. Epub 2017 May 11.

PMID:
28502587
20.

A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2.

Li Y, Song Y, Zhao M, Guo Y, Yu C, Chen W, Shao S, Xu C, Zhou X, Zhao L, Zhang Z, Bo T, Xia Y, Proud CG, Wang X, Wang L, Zhao J, Gao L.

Hepatology. 2017 Aug;66(2):481-497. doi: 10.1002/hep.29206. Epub 2017 Jun 27. Erratum in: Hepatology. 2018 Mar;67(3):1188.

21.

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation.

Fitter S, Matthews MP, Martin SK, Xie J, Ooi SS, Walkley CR, Codrington JD, Ruegg MA, Hall MN, Proud CG, Gronthos S, Zannettino ACW.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00668-16. doi: 10.1128/MCB.00668-16. Print 2017 Apr 1.

22.

A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors.

Xiao T, Liu R, Proud CG, Wang MW.

Acta Pharm Sin B. 2016 Nov;6(6):557-563. Epub 2016 May 21.

23.
24.

Depletion of ribosomal protein S19 causes a reduction of rRNA synthesis.

Juli G, Gismondi A, Monteleone V, Caldarola S, Iadevaia V, Aspesi A, Dianzani I, Proud CG, Loreni F.

Sci Rep. 2016 Oct 13;6:35026. doi: 10.1038/srep35026.

25.

mTOR inhibitors in cancer therapy.

Xie J, Wang X, Proud CG.

F1000Res. 2016 Aug 25;5. pii: F1000 Faculty Rev-2078. doi: 10.12688/f1000research.9207.1. eCollection 2016. Review.

26.

Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK-eIF4E Axis.

Bramham CR, Jensen KB, Proud CG.

Trends Biochem Sci. 2016 Oct;41(10):847-858. doi: 10.1016/j.tibs.2016.07.008. Epub 2016 Aug 12. Review.

PMID:
27527252
27.

Quantitative Non-canonical Amino Acid Tagging (QuaNCAT) Proteomics Identifies Distinct Patterns of Protein Synthesis Rapidly Induced by Hypertrophic Agents in Cardiomyocytes, Revealing New Aspects of Metabolic Remodeling.

Liu R, Kenney JW, Manousopoulou A, Johnston HE, Kamei M, Woelk CH, Xie J, Schwarzer M, Garbis SD, Proud CG.

Mol Cell Proteomics. 2016 Oct;15(10):3170-3189. Epub 2016 Aug 9.

28.

Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells.

Pan W, Kremer KL, Kaidonis X, Ludlow VE, Rogers ML, Xie J, Proud CG, Koblar SA.

Int J Dev Neurosci. 2016 Oct;53:90-98. doi: 10.1016/j.ijdevneu.2016.07.007. Epub 2016 Jul 26.

PMID:
27469433
29.

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.

Averous J, Lambert-Langlais S, Mesclon F, Carraro V, Parry L, Jousse C, Bruhat A, Maurin AC, Pierre P, Proud CG, Fafournoux P.

Sci Rep. 2016 Jun 14;6:27698. doi: 10.1038/srep27698.

30.

Glycine restores the anabolic response to leucine in a mouse model of acute inflammation.

Ham DJ, Caldow MK, Chhen V, Chee A, Wang X, Proud CG, Lynch GS, Koopman R.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E970-81. doi: 10.1152/ajpendo.00468.2015. Epub 2016 Apr 19.

31.

MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.

Moore CE, Pickford J, Cagampang FR, Stead RL, Tian S, Zhao X, Tang X, Byrne CD, Proud CG.

Sci Rep. 2016 Apr 18;6:23476. doi: 10.1038/srep23476.

32.

eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.

Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, Stephen MR, Kopanitsa M, Benfante R, Rusconi F, Braida D, Francolini M, Proud CG, Valtorta F, Passafaro M, Sala M, Bachi A, Verpelli C, Rosenblum K, Sala C.

Cereb Cortex. 2017 Mar 1;27(3):2226-2248. doi: 10.1093/cercor/bhw075.

33.

Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle.

Fritzen AM, Frøsig C, Jeppesen J, Jensen TE, Lundsgaard AM, Serup AK, Schjerling P, Proud CG, Richter EA, Kiens B.

Cell Signal. 2016 Jun;28(6):663-74. doi: 10.1016/j.cellsig.2016.03.005. Epub 2016 Mar 12.

PMID:
26976209
34.

mTORC2 is a tyrosine kinase.

Wang X, Proud CG.

Cell Res. 2016 Feb;26(2):266. doi: 10.1038/cr.2016.18. No abstract available.

35.

Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases.

Liu R, Proud CG.

Acta Pharmacol Sin. 2016 Mar;37(3):285-94. doi: 10.1038/aps.2015.123. Epub 2016 Jan 25. Review.

36.

Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy.

Moore CE, Wang X, Xie J, Pickford J, Barron J, Regufe da Mota S, Versele M, Proud CG.

Cell Signal. 2016 Apr;28(4):284-93. doi: 10.1016/j.cellsig.2016.01.005. Epub 2016 Jan 18.

37.

Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits.

Wortham NC, Stewart JD, Harris S, Coldwell MJ, Proud CG.

Biochem J. 2016 Mar 1;473(5):571-80. doi: 10.1042/BJ20150828. Epub 2015 Nov 27.

PMID:
26614765
38.

eIF2B: recent structural and functional insights into a key regulator of translation.

Wortham NC, Proud CG.

Biochem Soc Trans. 2015 Dec;43(6):1234-40. doi: 10.1042/BST20150164. Review.

PMID:
26614666
39.

mTORC2 is a tyrosine kinase.

Wang X, Proud CG.

Cell Res. 2016 Jan;26(1):1-2. doi: 10.1038/cr.2015.134. Epub 2015 Nov 20. Erratum in: Cell Res. 2016 Feb;26(2):266.

40.

Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule-related proteins in neurons.

Kenney JW, Genheden M, Moon KM, Wang X, Foster LJ, Proud CG.

J Neurochem. 2016 Jan;136(2):276-84. doi: 10.1111/jnc.13407. Epub 2015 Nov 17.

42.

Regulation and roles of elongation factor 2 kinase.

Proud CG.

Biochem Soc Trans. 2015 Jun;43(3):328-32. doi: 10.1042/BST20140323. Review.

PMID:
26009171
43.

Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway.

Bommer UA, Iadevaia V, Chen J, Knoch B, Engel M, Proud CG.

Cell Signal. 2015 Aug;27(8):1557-68. doi: 10.1016/j.cellsig.2015.04.011. Epub 2015 Apr 30.

PMID:
25936523
44.

Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival.

Xie J, Mikolajek H, Pigott CR, Hooper KJ, Mellows T, Moore CE, Mohammed H, Werner JM, Thomas GJ, Proud CG.

Mol Cell Biol. 2015 May;35(10):1805-24. doi: 10.1128/MCB.00012-15. Epub 2015 Mar 16.

45.

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia.

Moore CE, Mikolajek H, Regufe da Mota S, Wang X, Kenney JW, Werner JM, Proud CG.

Mol Cell Biol. 2015 May;35(10):1788-804. doi: 10.1128/MCB.01457-14. Epub 2015 Mar 9.

46.

Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity.

Kenney JW, Sorokina O, Genheden M, Sorokin A, Armstrong JD, Proud CG.

J Neurosci. 2015 Feb 18;35(7):3034-47. doi: 10.1523/JNEUROSCI.2866-14.2015.

47.

Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity.

Wang X, Xie J, da Mota SR, Moore CE, Proud CG.

Biochem J. 2015 Apr 15;467(2):321-31. doi: 10.1042/BJ20150089.

PMID:
25670349
48.

BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.

Genheden M, Kenney JW, Johnston HE, Manousopoulou A, Garbis SD, Proud CG.

J Neurosci. 2015 Jan 21;35(3):972-84. doi: 10.1523/JNEUROSCI.2641-14.2015.

49.

ABC50 mutants modify translation start codon selection.

Stewart JD, Cowan JL, Perry LS, Coldwell MJ, Proud CG.

Biochem J. 2015 Apr 15;467(2):217-29. doi: 10.1042/BJ20141453.

PMID:
25597744
50.

The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.

Beggs JE, Tian S, Jones GG, Xie J, Iadevaia V, Jenei V, Thomas G, Proud CG.

Biochem J. 2015 Apr 1;467(1):63-76. doi: 10.1042/BJ20141066.

PMID:
25588502

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