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Items: 29


The Endocannabinoid System: A Target for Cancer Treatment.

Laezza C, Pagano C, Navarra G, Pastorino O, Proto MC, Fiore D, Piscopo C, Gazzerro P, Bifulco M.

Int J Mol Sci. 2020 Jan 23;21(3). pii: E747. doi: 10.3390/ijms21030747. Review.


N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor.

Fiore D, Piscopo C, Proto MC, Vasaturo M, Dal Piaz F, Fusco BM, Pagano C, Laezza C, Bifulco M, Gazzerro P.

Cancers (Basel). 2019 Sep 28;11(10). pii: E1456. doi: 10.3390/cancers11101456.


Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells.

Proto MC, Fiore D, Forte G, Cuozzo P, Ramunno A, Fattorusso C, Gazzerro P, Pascale M, Franceschelli S.

Invest New Drugs. 2019 Jun 26. doi: 10.1007/s10637-019-00813-4. [Epub ahead of print]


Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids.

Fiore D, Ramesh P, Proto MC, Piscopo C, Franceschelli S, Anzelmo S, Medema JP, Bifulco M, Gazzerro P.

Front Pharmacol. 2018 Jan 4;8:949. doi: 10.3389/fphar.2017.00949. eCollection 2017.


N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux.

Ranieri R, Ciaglia E, Amodio G, Picardi P, Proto MC, Gazzerro P, Laezza C, Remondelli P, Bifulco M, Pisanti S.

Cell Death Differ. 2018 Feb;25(2):353-367. doi: 10.1038/cdd.2017.165. Epub 2017 Oct 13.


Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer.

Proto MC, Fiore D, Piscopo C, Franceschelli S, Bizzarro V, Laezza C, Lauro G, Feoli A, Tosco A, Bifulco G, Sbardella G, Bifulco M, Gazzerro P.

Sci Rep. 2017 Sep 15;7(1):11678. doi: 10.1038/s41598-017-11688-x.


Cannabidiol: State of the art and new challenges for therapeutic applications.

Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M.

Pharmacol Ther. 2017 Jul;175:133-150. doi: 10.1016/j.pharmthera.2017.02.041. Epub 2017 Feb 22. Review.


Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells.

Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M.

Cancer Biol Ther. 2016 Aug 2;17(8):849-58. doi: 10.1080/15384047.2015.1078028.


Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells.

Ciaglia E, Torelli G, Pisanti S, Picardi P, D'Alessandro A, Laezza C, Malfitano AM, Fiore D, Pagano Zottola AC, Proto MC, Catapano G, Gazzerro P, Bifulco M.

Oncotarget. 2015 Jun 20;6(17):15464-81.


Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration.

Pisanti S, Picardi P, Pallottini V, Martini C, Petrosino S, Proto MC, Vitale M, Laezza C, Gazzerro P, Di Marzo V, Bifulco M.

J Cell Physiol. 2015 Dec;230(12):2905-14. doi: 10.1002/jcp.24959.


Anandamide inhibits breast tumor-induced angiogenesis.

Picardi P, Ciaglia E, Proto M, Pisanti S.

Transl Med UniSa. 2014 Apr 8;10:8-12. eCollection 2014 Sep.


Statins in neurological disorders: an overview and update.

Malfitano AM, Marasco G, Proto MC, Laezza C, Gazzerro P, Bifulco M.

Pharmacol Res. 2014 Oct;88:74-83. doi: 10.1016/j.phrs.2014.06.007. Epub 2014 Jun 19. Review.


PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.

Gangemi G, Gazzerro P, Fiore D, Proto MC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Clive Williams D, Campiani G, Bifulco M.

Eur J Pharmacol. 2013 Aug 15;714(1-3):379-87. doi: 10.1016/j.ejphar.2013.07.011. Epub 2013 Jul 16. Retraction in: Eur J Pharmacol. 2014 Apr 5;728:190.


Pharmacological actions of statins: a critical appraisal in the management of cancer.

Gazzerro P, Proto MC, Gangemi G, Malfitano AM, Ciaglia E, Pisanti S, Santoro A, Laezza C, Bifulco M.

Pharmacol Rev. 2012 Jan;64(1):102-46. doi: 10.1124/pr.111.004994. Epub 2011 Nov 21. Review.


Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis.

Pisanti S, Picardi P, Prota L, Proto MC, Laezza C, McGuire PG, Morbidelli L, Gazzerro P, Ziche M, Das A, Bifulco M.

Blood. 2011 May 19;117(20):5541-50. doi: 10.1182/blood-2010-09-307355. Epub 2011 Apr 1.


Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth.

Proto MC, Gazzerro P, Di Croce L, Santoro A, Malfitano AM, Pisanti S, Laezza C, Bifulco M.

J Cell Physiol. 2012 Jan;227(1):250-8. doi: 10.1002/jcp.22727.


Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells.

Laezza C, Malfitano AM, Proto MC, Esposito I, Gazzerro P, Formisano P, Pisanti S, Santoro A, Caruso MG, Bifulco M.

Endocr Relat Cancer. 2010 May 18;17(2):495-503. doi: 10.1677/ERC-10-0009. Print 2010 Jun.


Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression.

Monteleone P, Bifulco M, Maina G, Tortorella A, Gazzerro P, Proto MC, Di Filippo C, Monteleone F, Canestrelli B, Buonerba G, Bogetto F, Maj M.

Pharmacol Res. 2010 May;61(5):400-4. doi: 10.1016/j.phrs.2010.01.002. Epub 2010 Jan 18.


Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin.

Gazzerro P, Malfitano AM, Proto MC, Santoro A, Pisanti S, Caruso MG, Notarnicola M, Messa C, Laezza C, Misso G, Caraglia M, Bifulco M.

Oncol Rep. 2010 Jan;23(1):171-5.


Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.

Monteleone P, Bifulco M, Di Filippo C, Gazzerro P, Canestrelli B, Monteleone F, Proto MC, Di Genio M, Grimaldi C, Maj M.

Genes Brain Behav. 2009 Oct;8(7):728-32. doi: 10.1111/j.1601-183X.2009.00518.x. Epub 2009 Jun 26.


Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon.

Santoro A, Pisanti S, Grimaldi C, Izzo AA, Borrelli F, Proto MC, Malfitano AM, Gazzerro P, Laezza C, Bifulco M.

Int J Cancer. 2009 Sep 1;125(5):996-1003. doi: 10.1002/ijc.24483.


Cannabinoids in the management of spasticity associated with multiple sclerosis.

Malfitano AM, Proto MC, Bifulco M.

Neuropsychiatr Dis Treat. 2008 Oct;4(5):847-53.


The cannabinoid CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase.

Esposito I, Proto MC, Gazzerro P, Laezza C, Miele C, Alberobello AT, D'Esposito V, Beguinot F, Formisano P, Bifulco M.

Mol Pharmacol. 2008 Dec;74(6):1678-86. doi: 10.1124/mol.108.049205. Epub 2008 Sep 18.


The first cosmetic treatise of history. A female point of view.

Cavallo P, Proto MC, Patruno C, Del Sorbo A, Bifulco M.

Int J Cosmet Sci. 2008 Apr;30(2):79-86. doi: 10.1111/j.1468-2494.2007.00414.x. Review.


Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug.

Bifulco M, Malfitano AM, Proto MC, Santoro A, Caruso MG, Laezza C.

Anticancer Agents Med Chem. 2008 Feb;8(2):200-4. Review.


Effects of angiotensin I of the American bullfrog Rana catesbeiana on amphibian tissues.

Coviello A, Soria MO, Proto MC, Peral de Bruno M, Berman DM, Khosla MC, Bumpus FM.

Comp Biochem Physiol Comp Physiol. 1993 Jan;104(1):113-6.


Effect of rat cardionatrin I (rat ANF 99-126) on the response of toad skin to angiotensin II.

Coviello A, Soria MO, Proto MC, Berman DM, Gamundi SS, Alonso CE, de Bold AJ.

Can J Physiol Pharmacol. 1989 Apr;67(4):362-5.


Effects of frog-skin angiotensin II in amphibians.

Proto MC, Coviello A, Khosla MC, Bumpus FM.

Hypertension. 1983 Nov-Dec;5(6 Pt 3):V101-4.


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