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Items: 44

1.

Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria.

Żyła DS, Prota AE, Capitani G, Glockshuber R.

J Biol Chem. 2019 May 24. pii: jbc.RA119.008610. doi: 10.1074/jbc.RA119.008610. [Epub ahead of print]

2.

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF.

Int J Mol Sci. 2019 Mar 20;20(6). pii: E1392. doi: 10.3390/ijms20061392.

3.

Conformational Properties of the Chemotherapeutic Drug Analogue Epothilone A: How to Model a Flexible Protein Ligand Using Scarcely Available Experimental Data.

Dolenc J, van Gunsteren WF, Prota AE, Steinmetz MO, Missimer JH.

J Chem Inf Model. 2019 May 28;59(5):2218-2230. doi: 10.1021/acs.jcim.9b00171. Epub 2019 Mar 25.

PMID:
30855963
4.

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.

Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL.

ACS Omega. 2019 Jan 31;4(1):755-764. doi: 10.1021/acsomega.8b02879. Epub 2019 Jan 9.

5.

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, O'Sullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S.

Eur J Med Chem. 2019 Jan 15;162:290-320. doi: 10.1016/j.ejmech.2018.11.004. Epub 2018 Nov 3.

PMID:
30448418
6.

Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

Smedley CJ, Stanley PA, Qazzaz ME, Prota AE, Olieric N, Collins H, Eastman H, Barrow AS, Lim KH, Kam TS, Smith BJ, Duivenvoorden HM, Parker BS, Bradshaw TD, Steinmetz MO, Moses JE.

Sci Rep. 2018 Jul 13;8(1):10617. doi: 10.1038/s41598-018-28880-2.

7.

Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton.

Steinmetz MO, Prota AE.

Trends Cell Biol. 2018 Oct;28(10):776-792. doi: 10.1016/j.tcb.2018.05.001. Epub 2018 Jun 2. Review.

PMID:
29871823
8.

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

Menchon G, Prota AE, Lucena-Agell D, Bucher P, Jansen R, Irschik H, Müller R, Paterson I, Díaz JF, Altmann KH, Steinmetz MO.

Nat Commun. 2018 May 29;9(1):2106. doi: 10.1038/s41467-018-04535-8.

9.

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.

Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, Camarasa MJ, Barasoain I, Steinmetz MO, Díaz JF, Pérez-Pérez MJ, Liekens S, Priego EM.

Sci Rep. 2018 Mar 9;8(1):4242. doi: 10.1038/s41598-018-22382-x.

10.

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Jiang K, Faltova L, Hua S, Capitani G, Prota AE, Landgraf C, Volkmer R, Kammerer RA, Steinmetz MO, Akhmanova A.

Structure. 2018 Mar 6;26(3):375-382.e4. doi: 10.1016/j.str.2017.12.017. Epub 2018 Jan 26.

11.

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

Dohle W, Jourdan FL, Menchon G, Prota AE, Foster PA, Mannion P, Hamel E, Thomas MP, Kasprzyk PG, Ferrandis E, Steinmetz MO, Leese MP, Potter BVL.

J Med Chem. 2018 Feb 8;61(3):1031-1044. doi: 10.1021/acs.jmedchem.7b01474. Epub 2018 Jan 8.

PMID:
29227648
12.

Structural basis of katanin p60:p80 complex formation.

Rezabkova L, Jiang K, Capitani G, Prota AE, Akhmanova A, Steinmetz MO, Kammerer RA.

Sci Rep. 2017 Nov 2;7(1):14893. doi: 10.1038/s41598-017-14194-2.

13.

Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites.

Field JJ, Pera B, Gallego JE, Calvo E, Rodríguez-Salarichs J, Sáez-Calvo G, Zuwerra D, Jordi M, Andreu JM, Prota AE, Ménchon G, Miller JH, Altmann KH, Díaz JF.

J Nat Prod. 2018 Mar 23;81(3):494-505. doi: 10.1021/acs.jnatprod.7b00704. Epub 2017 Oct 12.

PMID:
29023132
14.

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS.

Mol Cell. 2017 Oct 5;68(1):210-223.e6. doi: 10.1016/j.molcel.2017.09.012.

15.

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.

Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Doré AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J.

Nat Commun. 2017 Sep 14;8(1):542. doi: 10.1038/s41467-017-00630-4.

16.

Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.

Sáez-Calvo G, Sharma A, Balaguer FA, Barasoain I, Rodríguez-Salarichs J, Olieric N, Muñoz-Hernández H, Berbís MÁ, Wendeborn S, Peñalva MA, Matesanz R, Canales Á, Prota AE, Jímenez-Barbero J, Andreu JM, Lamberth C, Steinmetz MO, Díaz JF.

Cell Chem Biol. 2017 Jun 22;24(6):737-750.e6. doi: 10.1016/j.chembiol.2017.05.016. Epub 2017 Jun 1.

17.

Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends.

Kumar A, Manatschal C, Rai A, Grigoriev I, Degen MS, Jaussi R, Kretzschmar I, Prota AE, Volkmer R, Kammerer RA, Akhmanova A, Steinmetz MO.

Structure. 2017 Jun 6;25(6):924-932.e4. doi: 10.1016/j.str.2017.04.010. Epub 2017 May 25.

18.

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.

Bohnacker T, Prota AE, Beaufils F, Burke JE, Melone A, Inglis AJ, Rageot D, Sele AM, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JF, Fabbro D, Zvelebil M, Williams RL, Steinmetz MO, Wymann MP.

Nat Commun. 2017 Mar 9;8:14683. doi: 10.1038/ncomms14683.

19.

Structural Basis of Microtubule Stabilization by Discodermolide.

Prota AE, Bargsten K, Redondo-Horcajo M, Smith AB 3rd, Yang CH, McDaid HM, Paterson I, Horwitz SB, Fernando Díaz J, Steinmetz MO.

Chembiochem. 2017 May 18;18(10):905-909. doi: 10.1002/cbic.201600696. Epub 2017 Mar 27.

20.

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.

Trigili C, Barasoain I, Sánchez-Murcia PA, Bargsten K, Redondo-Horcajo M, Nogales A, Gardner NM, Meyer A, Naylor GJ, Gómez-Rubio E, Gago F, Steinmetz MO, Paterson I, Prota AE, Díaz JF.

ACS Omega. 2016 Dec 31;1(6):1192-1204. doi: 10.1021/acsomega.6b00317. Epub 2016 Dec 13.

21.

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.

Wieczorek M, Tcherkezian J, Bernier C, Prota AE, Chaaban S, Rolland Y, Godbout C, Hancock MA, Arezzo JC, Ocal O, Rocha C, Olieric N, Hall A, Ding H, Bramoullé A, Annis MG, Zogopoulos G, Harran PG, Wilkie TM, Brekken RA, Siegel PM, Steinmetz MO, Shore GC, Brouhard GJ, Roulston A.

Sci Transl Med. 2016 Nov 16;8(365):365ra159. Erratum in: Sci Transl Med. 2017 Dec 20;9(421):.

22.

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.

Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE.

PLoS One. 2016 Aug 12;11(8):e0160890. doi: 10.1371/journal.pone.0160890. eCollection 2016.

23.

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation.

Prota AE, Setter J, Waight AB, Bargsten K, Murga J, Diaz JF, Steinmetz MO.

J Mol Biol. 2016 Jul 31;428(15):2981-8. doi: 10.1016/j.jmb.2016.06.023. Epub 2016 Jul 6.

24.

Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.

Doodhi H, Prota AE, Rodríguez-García R, Xiao H, Custar DW, Bargsten K, Katrukha EA, Hilbert M, Hua S, Jiang K, Grigoriev I, Yang CH, Cox D, Horwitz SB, Kapitein LC, Akhmanova A, Steinmetz MO.

Curr Biol. 2016 Jul 11;26(13):1713-1721. doi: 10.1016/j.cub.2016.04.053. Epub 2016 Jun 16.

25.

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.

Canela MD, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, Jimeno ML, Benkheil M, Ribatti D, Velázquez S, Camarasa MJ, Díaz JF, Steinmetz MO, Priego EM, Pérez-Pérez MJ, Liekens S.

Oncotarget. 2017 Feb 28;8(9):14325-14342. doi: 10.18632/oncotarget.9527.

26.

Fast native-SAD phasing for routine macromolecular structure determination.

Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota AE, Surana P, Kottur J, Nair DT, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang BC, Steinmetz MO, Caffrey M, Wang M.

Nat Methods. 2015 Feb;12(2):131-3. doi: 10.1038/nmeth.3211. Epub 2014 Dec 15. Erratum in: Nat Methods. 2015 Jul;12(7):692.

PMID:
25506719
27.

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.

Prota AE, Bargsten K, Diaz JF, Marsh M, Cuevas C, Liniger M, Neuhaus C, Andreu JM, Altmann KH, Steinmetz MO.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. doi: 10.1073/pnas.1408124111. Epub 2014 Aug 11.

28.

The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization.

Prota AE, Danel F, Bachmann F, Bargsten K, Buey RM, Pohlmann J, Reinelt S, Lane H, Steinmetz MO.

J Mol Biol. 2014 Apr 17;426(8):1848-60. doi: 10.1016/j.jmb.2014.02.005. Epub 2014 Feb 11.

PMID:
24530796
29.

Structural basis of microtubule stabilization by laulimalide and peloruside A.

Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Díaz JF, Steinmetz MO.

Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1621-5. doi: 10.1002/anie.201307749. Epub 2014 Jan 27.

PMID:
24470331
30.

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Leppänen VM, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, Markovic-Mueller S, Stuttfeld E, Goldie KN, Ballmer-Hofer K, Alitalo K.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12960-5. doi: 10.1073/pnas.1301415110. Epub 2013 Jul 22.

31.

Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin.

Furger E, Frei DC, Schibli R, Fischer E, Prota AE.

J Biol Chem. 2013 Aug 30;288(35):25466-76. doi: 10.1074/jbc.M113.483271. Epub 2013 Jul 11.

32.

Structural basis of tubulin tyrosination by tubulin tyrosine ligase.

Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO.

J Cell Biol. 2013 Feb 4;200(3):259-70. doi: 10.1083/jcb.201211017. Epub 2013 Jan 28.

33.

Molecular mechanism of action of microtubule-stabilizing anticancer agents.

Prota AE, Bargsten K, Zurwerra D, Field JJ, Díaz JF, Altmann KH, Steinmetz MO.

Science. 2013 Feb 1;339(6119):587-90. doi: 10.1126/science.1230582. Epub 2013 Jan 3.

34.

Structural determinants of growth factor binding and specificity by VEGF receptor 2.

Leppänen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2425-30. doi: 10.1073/pnas.0914318107.

35.

Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.

Grünewald FS, Prota AE, Giese A, Ballmer-Hofer K.

Biochim Biophys Acta. 2010 Mar;1804(3):567-80. doi: 10.1016/j.bbapap.2009.09.002. Epub 2009 Sep 15. Review.

PMID:
19761875
36.

Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.

Lingaraju GM, Prota AE, Winkler FK.

DNA Repair (Amst). 2009 Jul 4;8(7):857-64. doi: 10.1016/j.dnarep.2009.03.009. Epub 2009 May 1.

PMID:
19410520
37.

Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR.

Cébe-Suarez S, Grünewald FS, Jaussi R, Li X, Claesson-Welsh L, Spillmann D, Mercer AA, Prota AE, Ballmer-Hofer K.

FASEB J. 2008 Aug;22(8):3078-86. doi: 10.1096/fj.08-107219. Epub 2008 May 8.

PMID:
18467594
38.

Structure determination of VEGF-E by sulfur SAD.

Wagner A, Pieren M, Schulze-Briese C, Ballmer-Hofer K, Prota AE.

Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1430-4. Epub 2006 Oct 18.

PMID:
17057349
39.

Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity.

Pieren M, Prota AE, Ruch C, Kostrewa D, Wagner A, Biedermann K, Winkler FK, Ballmer-Hofer K.

J Biol Chem. 2006 Jul 14;281(28):19578-87. Epub 2006 May 3.

40.

A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure.

Lingaraju GM, Sartori AA, Kostrewa D, Prota AE, Jiricny J, Winkler FK.

Structure. 2005 Jan;13(1):87-98.

41.

A molecular dynamics study of reovirus attachment protein sigma1 reveals conformational changes in sigma1 structure.

Cavalli A, Prota AE, Stehle T, Dermody TS, Recanatini M, Folkers G, Scapozza L.

Biophys J. 2004 Jun;86(6):3423-31.

42.

Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding.

Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermody TS, Stehle T.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5366-71. Epub 2003 Apr 15.

43.

The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.

Prota AE, Sage DR, Stehle T, Fingeroth JD.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10641-6. Epub 2002 Jul 16.

44.

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