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Items: 1 to 50 of 188

1.

The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome.

Arias-Pulido H, Cimino-Mathews A, Chaher N, Qualls C, Joste N, Colpaert C, Marotti JD, Foisey M, Prossnitz ER, Emens LA, Fiering S.

Breast Cancer Res Treat. 2018 Sep;171(2):273-282. doi: 10.1007/s10549-018-4834-7. Epub 2018 Jun 1.

2.

G-Protein-Coupled Estrogen Receptor (GPER) and Sex-Specific Metabolic Homeostasis.

Sharma G, Prossnitz ER.

Adv Exp Med Biol. 2017;1043:427-453. doi: 10.1007/978-3-319-70178-3_20. Review.

PMID:
29224106
3.

Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by α-Hemolysin.

Castleman MJ, Pokhrel S, Triplett KD, Kusewitt DF, Elmore BO, Joyner JA, Femling JK, Sharma G, Hathaway HJ, Prossnitz ER, Hall PR.

J Immunol. 2018 Jan 15;200(2):657-668. doi: 10.4049/jimmunol.1700810. Epub 2017 Dec 8.

PMID:
29222165
4.

The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.

Peretti AS, Dominguez D, Grimes MM, Hathaway HJ, Prossnitz ER, Rivera MR, Wandinger-Ness A, Kusewitt DF, Hudson LG.

Am J Pathol. 2018 Feb;188(2):515-524. doi: 10.1016/j.ajpath.2017.10.018. Epub 2017 Nov 21.

PMID:
29169987
5.

Rapid vasodilation to raloxifene: role of oestrogen receptors and off-target effects.

Barton M, Prossnitz ER.

Br J Pharmacol. 2017 Nov;174(22):4201-4202. doi: 10.1111/bph.14020. Epub 2017 Oct 6. No abstract available.

6.

New developments in the rapid actions of steroids and their receptors.

Prossnitz ER.

J Steroid Biochem Mol Biol. 2018 Feb;176:1-3. doi: 10.1016/j.jsbmb.2017.08.001. Epub 2017 Aug 5. No abstract available.

PMID:
28789973
7.

GPER Mediates Functional Endothelial Aging in Renal Arteries.

Meyer MR, Rosemann T, Barton M, Prossnitz ER.

Pharmacology. 2017;100(3-4):188-193. doi: 10.1159/000478732. Epub 2017 Jul 14.

8.

Role of GPER in estrogen-dependent nitric oxide formation and vasodilation.

Fredette NC, Meyer MR, Prossnitz ER.

J Steroid Biochem Mol Biol. 2018 Feb;176:65-72. doi: 10.1016/j.jsbmb.2017.05.006. Epub 2017 May 18.

PMID:
28529128
9.

Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives.

Barton M, Filardo EJ, Lolait SJ, Thomas P, Maggiolini M, Prossnitz ER.

J Steroid Biochem Mol Biol. 2018 Feb;176:4-15. doi: 10.1016/j.jsbmb.2017.03.021. Epub 2017 Mar 25. Review.

PMID:
28347854
10.

GPER modulators: Opportunity Nox on the heels of a class Akt.

Prossnitz ER.

J Steroid Biochem Mol Biol. 2018 Feb;176:73-81. doi: 10.1016/j.jsbmb.2017.03.005. Epub 2017 Mar 8. Review.

PMID:
28285016
11.

Roles of G protein-coupled estrogen receptor GPER in metabolic regulation.

Sharma G, Mauvais-Jarvis F, Prossnitz ER.

J Steroid Biochem Mol Biol. 2018 Feb;176:31-37. doi: 10.1016/j.jsbmb.2017.02.012. Epub 2017 Feb 20. Review.

PMID:
28223150
12.

Obligatory role for GPER in cardiovascular aging and disease.

Meyer MR, Fredette NC, Daniel C, Sharma G, Amann K, Arterburn JB, Barton M, Prossnitz ER.

Sci Signal. 2016 Nov 1;9(452):ra105. doi: 10.1126/scisignal.aag0240.

13.

Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.

Dobroff AS, D'Angelo S, Eckhardt BL, Ferrara F, Staquicini DI, Cardó-Vila M, Staquicini FI, Nunes DN, Kim K, Driessen WHP, Hajitou A, Lomo LC, Barry M, Krishnamurthy S, Sahin A, Woodward WA, Prossnitz ER, Anderson RL, Dias-Neto E, Brown-Glaberman UA, Royce ME, Ueno NT, Cristofanilli M, Hortobagyi GN, Marchiò S, Gelovani JG, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12780-12785. doi: 10.1073/pnas.1615288113. Epub 2016 Oct 24.

14.

GPER is required for the age-dependent upregulation of the myocardial endothelin system.

Meyer MR, Fredette NC, Sharma G, Barton M, Prossnitz ER.

Life Sci. 2016 Aug 15;159:61-65. doi: 10.1016/j.lfs.2016.02.041. Epub 2016 Feb 13.

15.

Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction.

Wagener BM, Marjon NA, Prossnitz ER.

PLoS One. 2016 Jan 20;11(1):e0147442. doi: 10.1371/journal.pone.0147442. eCollection 2016.

16.

GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism.

Sharma G, Prossnitz ER.

Methods Mol Biol. 2016;1366:489-502. doi: 10.1007/978-1-4939-3127-9_38.

17.

Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER.

Zekas E, Prossnitz ER.

BMC Cancer. 2015 Oct 15;15:702. doi: 10.1186/s12885-015-1699-6.

18.

Erratum: G Protein-coupled Estrogen Receptor Protects from Atherosclerosis.

Meyer MR, Fredette NC, Howard TA, Hu C, Ramesh C, Daniel C, Amann K, Arterburn JB, Barton M, Prossnitz ER.

Sci Rep. 2015 Sep 16;5:13510. doi: 10.1038/srep13510. No abstract available.

19.

G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity.

Meyer MR, Fredette NC, Barton M, Prossnitz ER.

J Endocrinol. 2015 Oct;227(1):61-9. doi: 10.1530/JOE-15-0257. Epub 2015 Aug 24.

20.

Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging.

Meyer MR, Fredette NC, Barton M, Prossnitz ER.

Age (Dordr). 2015 Aug;37(4):9806. doi: 10.1007/s11357-015-9806-9. Epub 2015 Aug 1.

21.

What have we learned about GPER function in physiology and disease from knockout mice?

Prossnitz ER, Hathaway HJ.

J Steroid Biochem Mol Biol. 2015 Sep;153:114-26. doi: 10.1016/j.jsbmb.2015.06.014. Epub 2015 Jul 16. Review.

22.

International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators.

Prossnitz ER, Arterburn JB.

Pharmacol Rev. 2015 Jul;67(3):505-40. doi: 10.1124/pr.114.009712. Review.

23.

Emerging roles of GPER in diabetes and atherosclerosis.

Barton M, Prossnitz ER.

Trends Endocrinol Metab. 2015 Apr;26(4):185-92. doi: 10.1016/j.tem.2015.02.003. Epub 2015 Mar 9. Review.

24.

Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts.

Albanito L, Lappano R, Madeo A, Chimento A, Prossnitz ER, Cappello AR, Dolce V, Abonante S, Pezzi V, Maggiolini M.

Environ Health Perspect. 2015 May;123(5):493-9. doi: 10.1289/ehp.1408586. Epub 2015 Jan 16.

25.

G protein-coupled estrogen receptor protects from atherosclerosis.

Meyer MR, Fredette NC, Howard TA, Hu C, Ramesh C, Daniel C, Amann K, Arterburn JB, Barton M, Prossnitz ER.

Sci Rep. 2014 Dec 23;4:7564. doi: 10.1038/srep07564. Erratum in: Sci Rep. 2015;5:13510.

26.

Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity.

Bielecka E, Scavenius C, Kantyka T, Jusko M, Mizgalska D, Szmigielski B, Potempa B, Enghild JJ, Prossnitz ER, Blom AM, Potempa J.

J Biol Chem. 2014 Nov 21;289(47):32481-7. doi: 10.1074/jbc.C114.617142. Epub 2014 Oct 16.

27.

GPER-targeted, 99mTc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding.

Nayak TK, Ramesh C, Hathaway HJ, Norenberg JP, Arterburn JB, Prossnitz ER.

Mol Cancer Res. 2014 Nov;12(11):1635-43. doi: 10.1158/1541-7786.MCR-14-0289. Epub 2014 Jul 16.

28.

G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis.

Marjon NA, Hu C, Hathaway HJ, Prossnitz ER.

Mol Cancer Res. 2014 Nov;12(11):1644-1654. doi: 10.1158/1541-7786.MCR-14-0128-T. Epub 2014 Jul 16.

29.

Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis.

Vaucher L, Funaro MG, Mehta A, Mielnik A, Bolyakov A, Prossnitz ER, Schlegel PN, Paduch DA.

PLoS One. 2014 Apr 15;9(4):e92425. doi: 10.1371/journal.pone.0092425. eCollection 2014.

30.

GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast.

Scaling AL, Prossnitz ER, Hathaway HJ.

Horm Cancer. 2014 Jun;5(3):146-160. doi: 10.1007/s12672-014-0174-1. Epub 2014 Apr 10.

31.

Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries.

Meyer MR, Fredette NC, Barton M, Prossnitz ER.

Life Sci. 2014 Nov 24;118(2):213-8. doi: 10.1016/j.lfs.2014.02.027. Epub 2014 Mar 5.

32.

Endometrial cancer: molecular and cellular basis of tumor development, novel biomarkers and therapeutic agents, and innovative research approaches.

Dai D, Bradford AP, Prossnitz ER.

Obstet Gynecol Int. 2014;2014:710405. doi: 10.1155/2014/710405. Epub 2014 Jan 16. No abstract available.

33.

Estrogen biology: new insights into GPER function and clinical opportunities.

Prossnitz ER, Barton M.

Mol Cell Endocrinol. 2014 May 25;389(1-2):71-83. doi: 10.1016/j.mce.2014.02.002. Epub 2014 Feb 12. Review.

34.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

35.

Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides.

Lu J, Hathaway HJ, Royce ME, Prossnitz ER, Miao Y.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):725-30. doi: 10.1016/j.bmcl.2013.12.120. Epub 2014 Jan 6.

36.

Functional heterogeneity of NADPH oxidase-mediated contractions to endothelin with vascular aging.

Meyer MR, Barton M, Prossnitz ER.

Life Sci. 2014 Nov 24;118(2):226-31. doi: 10.1016/j.lfs.2013.12.021. Epub 2013 Dec 29.

37.

G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth.

Petrie WK, Dennis MK, Hu C, Dai D, Arterburn JB, Smith HO, Hathaway HJ, Prossnitz ER.

Obstet Gynecol Int. 2013;2013:472720. doi: 10.1155/2013/472720. Epub 2013 Nov 27.

38.

Regulation of vascular smooth muscle tone by adipose-derived contracting factor.

Meyer MR, Fredette NC, Barton M, Prossnitz ER.

PLoS One. 2013 Nov 11;8(11):e79245. doi: 10.1371/journal.pone.0079245. eCollection 2013.

39.

Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides.

Guo H, Hathaway H, Royce ME, Prossnitz ER, Miao Y.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5484-7. doi: 10.1016/j.bmcl.2013.08.075. Epub 2013 Aug 23.

40.

GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state.

Sharma G, Hu C, Brigman JL, Zhu G, Hathaway HJ, Prossnitz ER.

Endocrinology. 2013 Nov;154(11):4136-45. doi: 10.1210/en.2013-1357. Epub 2013 Aug 22.

41.

Alike but not the same: anatomic heterogeneity of estrogen receptor-mediated vasodilation.

Barton M, Meyer MR, Prossnitz ER.

J Cardiovasc Pharmacol. 2013 Jul;62(1):22-5. doi: 10.1097/FJC.0b013e31829709d4. Review.

42.

The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions.

Brunsing RL, Owens KS, Prossnitz ER.

J Immunother. 2013 Apr;36(3):190-6. doi: 10.1097/CJI.0b013e31828d8e3b.

43.

G protein-coupled estrogen receptor: a new therapeutic target in stroke and traumatic brain/spinal cord injury?

Prossnitz ER.

Crit Care Med. 2012 Dec;40(12):3323-5. doi: 10.1097/CCM.0b013e31826be998. No abstract available.

44.

Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30.

Burai R, Ramesh C, Nayak TK, Dennis MK, Bryant BK, Prossnitz ER, Arterburn JB.

PLoS One. 2012;7(10):e46861. doi: 10.1371/journal.pone.0046861. Epub 2012 Oct 15.

45.

Testosterone and secondary hypertension: new pieces to the puzzle.

Barton M, Prossnitz ER, Meyer MR.

Hypertension. 2012 Jun;59(6):1101-3. doi: 10.1161/HYPERTENSIONAHA.112.195149. Epub 2012 May 7. No abstract available.

46.

GPER regulates endothelin-dependent vascular tone and intracellular calcium.

Meyer MR, Field AS, Kanagy NL, Barton M, Prossnitz ER.

Life Sci. 2012 Oct 15;91(13-14):623-7. doi: 10.1016/j.lfs.2012.01.007. Epub 2012 Feb 2.

47.

Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction.

Meyer MR, Amann K, Field AS, Hu C, Hathaway HJ, Kanagy NL, Walker MK, Barton M, Prossnitz ER.

Hypertension. 2012 Feb;59(2):507-12. doi: 10.1161/HYPERTENSIONAHA.111.184606. Epub 2011 Dec 27.

48.

The G-protein-coupled estrogen receptor GPER in health and disease.

Prossnitz ER, Barton M.

Nat Rev Endocrinol. 2011 Aug 16;7(12):715-26. doi: 10.1038/nrendo.2011.122. Review.

49.

Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle.

Yu X, Ma H, Barman SA, Liu AT, Sellers M, Stallone JN, Prossnitz ER, White RE, Han G.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E882-8. doi: 10.1152/ajpendo.00037.2011. Epub 2011 Jul 26. Erratum in: Am J Physiol Endocrinol Metab. 2012 Dec 15;303(12):E1502-3.

50.

Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.

Dennis MK, Field AS, Burai R, Ramesh C, Petrie WK, Bologa CG, Oprea TI, Yamaguchi Y, Hayashi S, Sklar LA, Hathaway HJ, Arterburn JB, Prossnitz ER.

J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):358-66. doi: 10.1016/j.jsbmb.2011.07.002. Epub 2011 Jul 14.

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