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Items: 46


Cardiac microtubules in health and heart disease.

Caporizzo MA, Chen CY, Prosser BL.

Exp Biol Med (Maywood). 2019 Aug 9:1535370219868960. doi: 10.1177/1535370219868960. [Epub ahead of print] No abstract available.


Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.

Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE.

Dev Cell. 2019 Jun 17;49(6):920-935.e5. doi: 10.1016/j.devcel.2019.04.020. Epub 2019 May 16.


Microtubules Provide a Viscoelastic Resistance to Myocyte Motion.

Caporizzo MA, Chen CY, Salomon AK, Margulies KB, Prosser BL.

Biophys J. 2018 Nov 6;115(9):1796-1807. doi: 10.1016/j.bpj.2018.09.019. Epub 2018 Sep 28.


Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure.

Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL.

Nat Med. 2018 Aug;24(8):1225-1233. doi: 10.1038/s41591-018-0046-2. Epub 2018 Jun 11.


MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress.

Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves SL, Jaña F, Worth AM, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano MF, Seelam A, Manfred T, Itoh K, Meng S, Sesaki H, Craigen WJ, Rajan S, Shanmughapriya S, Caplan J, Prosser BL, Gill DL, Stathopulos PB, Gallo G, Chan DC, Mishra P, Madesh M.

Cell Rep. 2018 Apr 24;23(4):1005-1019. doi: 10.1016/j.celrep.2018.03.098.


Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.

Hu LR, Ackermann MA, Hecker PA, Prosser BL, King B, O'Connell KA, Grogan A, Meyer LC, Berndsen CE, Wright NT, Jonathan Lederer W, Kontrogianni-Konstantopoulos A.

Sci Adv. 2017 Jun 7;3(6):e1603081. doi: 10.1126/sciadv.1603081. eCollection 2017 Jun.


Microtubule mechanics in the working myocyte.

Robison P, Prosser BL.

J Physiol. 2017 Jun 15;595(12):3931-3937. doi: 10.1113/JP273046. Epub 2017 Mar 9. Review.


Mechanical signaling coordinates the embryonic heartbeat.

Chiou KK, Rocks JW, Chen CY, Cho S, Merkus KE, Rajaratnam A, Robison P, Tewari M, Vogel K, Majkut SF, Prosser BL, Discher DE, Liu AJ.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):8939-44. doi: 10.1073/pnas.1520428113. Epub 2016 Jul 25.


Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes.

Robison P, Caporizzo MA, Ahmadzadeh H, Bogush AI, Chen CY, Margulies KB, Shenoy VB, Prosser BL.

Science. 2016 Apr 22;352(6284):aaf0659. doi: 10.1126/science.aaf0659.


Modeling Local X-ROS and Calcium Signaling in the Heart.

Limbu S, Hoang-Trong TM, Prosser BL, Lederer WJ, Jafri MS.

Biophys J. 2015 Nov 17;109(10):2037-50. doi: 10.1016/j.bpj.2015.09.031.


Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle.

Kerr JP, Robison P, Shi G, Bogush AI, Kempema AM, Hexum JK, Becerra N, Harki DA, Martin SS, Raiteri R, Prosser BL, Ward CW.

Nat Commun. 2015 Oct 8;6:8526. doi: 10.1038/ncomms9526.


Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

Zhang M, Prosser BL, Bamboye MA, Gondim ANS, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM.

J Am Coll Cardiol. 2015 Jul 21;66(3):261-272. doi: 10.1016/j.jacc.2015.05.020.


Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling.

Previs MJ, Prosser BL, Mun JY, Previs SB, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM.

Sci Adv. 2015;1(1). pii: e1400205.


Mechano-chemo transduction tunes the heartstrings.

Prosser BL, Ward CW.

Sci Signal. 2014 Mar 18;7(317):pe7. doi: 10.1126/scisignal.2005214.


Mechanical stretch-induced activation of ROS/RNS signaling in striated muscle.

Ward CW, Prosser BL, Lederer WJ.

Antioxid Redox Signal. 2014 Feb 20;20(6):929-36. doi: 10.1089/ars.2013.5517. Epub 2014 Jan 3. Review.


X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch.

Prosser BL, Ward CW, Lederer WJ.

Cardiovasc Res. 2013 May 1;98(2):307-14. doi: 10.1093/cvr/cvt066. Epub 2013 Mar 21.


X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i.

Prosser BL, Khairallah RJ, Ziman AP, Ward CW, Lederer WJ.

J Mol Cell Cardiol. 2013 May;58:172-81. doi: 10.1016/j.yjmcc.2012.11.011. Epub 2012 Dec 6. Review.


Microtubules underlie dysfunction in duchenne muscular dystrophy.

Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen YW, Raiteri R, Lederer WJ, Dorsey SG, Ward CW.

Sci Signal. 2012 Aug 7;5(236):ra56. doi: 10.1126/scisignal.2002829.


X-ROS signaling: rapid mechano-chemo transduction in heart.

Prosser BL, Ward CW, Lederer WJ.

Science. 2011 Sep 9;333(6048):1440-5. doi: 10.1126/science.1202768.


S100A1 and calmodulin regulation of ryanodine receptor in striated muscle.

Prosser BL, Hernández-Ochoa EO, Schneider MF.

Cell Calcium. 2011 Oct;50(4):323-31. doi: 10.1016/j.ceca.2011.06.001. Epub 2011 Jul 23. Review.


Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1.

Yamaguchi N, Prosser BL, Ghassemi F, Xu L, Pasek DA, Eu JP, Hernández-Ochoa EO, Cannon BR, Wilder PT, Lovering RM, Weber D, Melzer W, Schneider MF, Meissner G.

Am J Physiol Cell Physiol. 2011 May;300(5):C998-C1012. doi: 10.1152/ajpcell.00370.2010. Epub 2011 Feb 2.


Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments.

Lovering RM, O'Neill A, Muriel JM, Prosser BL, Strong J, Bloch RJ.

Am J Physiol Cell Physiol. 2011 Apr;300(4):C803-13. doi: 10.1152/ajpcell.00394.2010. Epub 2011 Jan 5.


S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle.

Prosser BL, Hernández-Ochoa EO, Lovering RM, Andronache Z, Zimmer DB, Melzer W, Schneider MF.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C891-902. doi: 10.1152/ajpcell.00180.2010. Epub 2010 Aug 4.


Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity.

Prosser BL, Ward CW, Lederer WJ.

J Gen Physiol. 2010 Aug;136(2):135-42. doi: 10.1085/jgp.201010406. No abstract available.


Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons.

Hernández-Ochoa EO, Prosser BL, Wright NT, Contreras M, Weber DJ, Schneider MF.

Am J Physiol Cell Physiol. 2009 Oct;297(4):C955-70. doi: 10.1152/ajpcell.00140.2009. Epub 2009 Aug 5.


The Qgamma component of intra-membrane charge movement is present in mammalian muscle fibres, but suppressed in the absence of S100A1.

Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF.

J Physiol. 2009 Sep 15;587(Pt 18):4523-41. doi: 10.1113/jphysiol.2009.177238. Epub 2009 Aug 3.


Simultaneous recording of intramembrane charge movement components and calcium release in wild-type and S100A1-/- muscle fibres.

Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF.

J Physiol. 2009 Sep 15;587(Pt 18):4543-59. doi: 10.1113/jphysiol.2009.177246. Epub 2009 Aug 3.


S100A1 and calmodulin compete for the same binding site on ryanodine receptor.

Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ.

J Biol Chem. 2008 Sep 26;283(39):26676-83. doi: 10.1074/jbc.M804432200. Epub 2008 Jul 23.


S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling.

Prosser BL, Wright NT, Hernãndez-Ochoa EO, Varney KM, Liu Y, Olojo RO, Zimmer DB, Weber DJ, Schneider MF.

J Biol Chem. 2008 Feb 22;283(8):5046-57. Epub 2007 Dec 17.


Streptococcus pneumoniae in the USA: in vitro susceptibility and pharmacodynamic analysis.

Mason EO Jr, Lamberth LB, Kershaw NL, Prosser BL, Zoe A, Ambrose PG.

J Antimicrob Chemother. 2000 May;45(5):623-31.


Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography.

Fischman AJ, Livni E, Babich JW, Alpert NM, Bonab A, Chodosh S, McGovern F, Kamitsuka P, Liu YY, Cleeland R, Prosser BL, Correia JA, Rubin RH.

Antimicrob Agents Chemother. 1996 Mar;40(3):659-64.


Tissue pharmacokinetics of fleroxacin in humans as determined by positron emission tomography.

Rubin RH, Livni E, Babich J, Alpert NM, Liu YY, Cleeland R, Prosser BL, Thom E, Fischman AJ.

Int J Antimicrob Agents. 1994 Jul;4 Suppl 2:S15-20.


Pharmacokinetics of [18F]fleroxacin in healthy human subjects studied by using positron emission tomography.

Fischman AJ, Livni E, Babich J, Alpert NM, Liu YY, Thom E, Cleeland R, Prosser BL, Correia JA, Strauss HW, et al.

Antimicrob Agents Chemother. 1993 Oct;37(10):2144-52.


Synthesis and biodistribution of 18F-labeled fleroxacin.

Livni E, Babich J, Alpert NM, Liu YY, Thom E, Cleeland R, Prosser BL, Correia JA, Strauss HW, Rubin RH, et al.

Nucl Med Biol. 1993 Jan;20(1):81-7.


Pharmacokinetics of 18F-labeled fleroxacin in rabbits with Escherichia coli infections, studied with positron emission tomography.

Fischman AJ, Livni E, Babich J, Alpert NM, Liu YY, Thom E, Cleeland R, Prosser BL, Callahan RJ, Correia JA, et al.

Antimicrob Agents Chemother. 1992 Oct;36(10):2286-92.


In vitro activity of ceftriaxone and amikacin against Pseudomonas aeruginosa.

Prosser BL, Taylor DB, Cleeland R.

Chemotherapy. 1991;37(2):93-7.


Method of evaluating effects of antibiotics on bacterial biofilm.

Prosser BL, Taylor D, Dix BA, Cleeland R.

Antimicrob Agents Chemother. 1987 Oct;31(10):1502-6.


Novel polyether antibiotics X-14868A, B, C, and D produced by a Nocardia. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the producing culture.

Liu CM, Hermann TE, Downey A, Prosser BL, Schildknecht E, Palleroni NJ, Westley JW, Miller PA.

J Antibiot (Tokyo). 1983 Apr;36(4):343-50. No abstract available.


Microbial products. IV. X-14847, a new aminoglycoside from Micromonospora echinospora.

Maehr H, Liu CM, Hermann T, Prosser BL, Smallheer JM, Palleroni NJ.

J Antibiot (Tokyo). 1980 Dec;33(12):1431-6.


X-14547A, a new ionophorous antibiotic produced by Streptomyces antibioticus NRRL 8167. Discovery, fermentation, biological properties and taxonomy of the producing culture.

Liu CM, Hermann TE, Liu M, Bull DN, Palleroni NJ, Prosser BL, Westley JW, Miller PA.

J Antibiot (Tokyo). 1979 Feb;32(2):95-9.

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