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Identification of a Wheat Thaumatin-like Protein That Inhibits Saccharomyces cerevisiae.

Van der Maelen E, Rezaei MN, Struyf N, Proost P, Verstrepen KJ, Courtin CM.

J Agric Food Chem. 2019 Sep 18;67(37):10423-10431. doi: 10.1021/acs.jafc.9b03432. Epub 2019 Sep 5.


Chemical Mimics of Aspartate-Directed Proteases: Predictive and Strictly Specific Hydrolysis of a Globular Protein at Asp-X Sequence Promoted by Polyoxometalate Complexes Rationalized by a Combined Experimental and Theoretical Approach.

Ly HGT, Mihaylov TT, Proost P, Pierloot K, Harvey JN, Parac-Vogt TN.

Chemistry. 2019 Nov 13;25(63):14370-14381. doi: 10.1002/chem.201902675. Epub 2019 Oct 15.


Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity.

Rybakin V, Stas M, Ugarte-Berzal E, Noppen S, Vandooren J, Van Aelst I, Liekens S, Proost P, Opdenakker G.

Biochem J. 2019 Aug 9;476(15):2191-2208. doi: 10.1042/BCJ20180382.


MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus.

Ugarte-Berzal E, Boon L, Martens E, Rybakin V, Blockmans D, Vandooren J, Proost P, Opdenakker G.

Front Immunol. 2019 Mar 22;10:538. doi: 10.3389/fimmu.2019.00538. eCollection 2019.


Selective Hydrolysis of Ovalbumin Promoted by Hf(IV)-Substituted Wells-Dawson-Type Polyoxometalate.

Anyushin AV, Sap A, Quanten T, Proost P, Parac-Vogt TN.

Front Chem. 2018 Dec 13;6:614. doi: 10.3389/fchem.2018.00614. eCollection 2018.


Differential Effects of Posttranslational Modifications of CXCL8/Interleukin-8 on CXCR1 and CXCR2 Internalization and Signaling Properties.

Vacchini A, Mortier A, Proost P, Locati M, Metzemaekers M, Borroni EM.

Int J Mol Sci. 2018 Nov 27;19(12). pii: E3768. doi: 10.3390/ijms19123768.


Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.

Boon L, Ugarte-Berzal E, Martens E, Vandooren J, Rybakin V, Colau D, Gordon-Alonso M, van der Bruggen P, Stöcker W, Becker-Pauly C, Witters P, Morava E, Jaeken J, Proost P, Opdenakker G.

FEBS J. 2019 Mar;286(5):930-945. doi: 10.1111/febs.14698. Epub 2018 Nov 30.


Pathological roles of the homeostatic chemokine CXCL12.

Janssens R, Struyf S, Proost P.

Cytokine Growth Factor Rev. 2018 Dec;44:51-68. doi: 10.1016/j.cytogfr.2018.10.004. Epub 2018 Oct 23. Review.


EDTA/gelatin zymography method to identify C1s versus activated MMP-9 in plasma and immune complexes of patients with systemic lupus erythematosus.

Ugarte-Berzal E, Martens E, Boon L, Vandooren J, Blockmans D, Proost P, Opdenakker G.

J Cell Mol Med. 2019 Jan;23(1):576-585. doi: 10.1111/jcmm.13962. Epub 2018 Oct 24.


Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis.

Ugarte-Berzal E, Berghmans N, Boon L, Martens E, Vandooren J, Cauwe B, Thijs G, Proost P, Van Damme J, Opdenakker G.

PLoS One. 2018 Oct 1;13(10):e0197944. doi: 10.1371/journal.pone.0197944. eCollection 2018.


Chemokine-Induced Macrophage Polarization in Inflammatory Conditions.

Ruytinx P, Proost P, Van Damme J, Struyf S.

Front Immunol. 2018 Sep 7;9:1930. doi: 10.3389/fimmu.2018.01930. eCollection 2018. Review.


Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity.

Janssens R, Boff D, Ruytinx P, Mortier A, Vanheule V, Larsen O, Daugvilaite V, Rosenkilde MM, Noppen S, Liekens S, Schols D, De Meester I, Opdenakker G, Struyf S, Teixeira MM, Amaral FA, Proost P.

Front Immunol. 2018 Aug 28;9:1933. doi: 10.3389/fimmu.2018.01933. eCollection 2018.


Exaptation as a Mechanism for Functional Reinforcement of an Animal Pheromone System.

Maex M, Treer D, De Greve H, Proost P, Van Bocxlaer I, Bossuyt F.

Curr Biol. 2018 Sep 24;28(18):2955-2960.e5. doi: 10.1016/j.cub.2018.06.074. Epub 2018 Sep 6.


Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice.

Vanheule V, Crijns H, Poosti F, Ruytinx P, Berghmans N, Gerlza T, Ronsse I, Pörtner N, Matthys P, Kungl AJ, Opdenakker G, Struyf S, Proost P.

Clin Exp Allergy. 2018 Oct;48(10):1333-1344. doi: 10.1111/cea.13227. Epub 2018 Aug 14.


Matrix Metalloproteinase-9-Generated COOH-, but Not NH2-Terminal Fragments of Serum Amyloid A1 Retain Potentiating Activity in Neutrophil Migration to CXCL8, With Loss of Direct Chemotactic and Cytokine-Inducing Capacity.

Gouwy M, De Buck M, Abouelasrar Salama S, Vandooren J, Knoops S, Pörtner N, Vanbrabant L, Berghmans N, Opdenakker G, Proost P, Van Damme J, Struyf S.

Front Immunol. 2018 Jun 4;9:1081. doi: 10.3389/fimmu.2018.01081. eCollection 2018.


CXCL4 and CXCL4L1 in cancer.

Ruytinx P, Proost P, Struyf S.

Cytokine. 2018 Sep;109:65-71. doi: 10.1016/j.cyto.2018.02.022. Review.


How post-translational modifications influence the biological activity of chemokines.

Vanheule V, Metzemaekers M, Janssens R, Struyf S, Proost P.

Cytokine. 2018 Sep;109:29-51. doi: 10.1016/j.cyto.2018.02.026. Review.


Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase.

Vandooren J, Goeminne P, Boon L, Ugarte-Berzal E, Rybakin V, Proost P, Abu El-Asrar AM, Opdenakker G.

Front Immunol. 2018 May 28;9:1154. doi: 10.3389/fimmu.2018.01154. eCollection 2018.


Protein-Assisted Formation and Stabilization of Catalytically Active Polyoxometalate Species.

Vandebroek L, De Zitter E, Ly HGT, Conić D, Mihaylov T, Sap A, Proost P, Pierloot K, Van Meervelt L, Parac-Vogt TN.

Chemistry. 2018 May 25. doi: 10.1002/chem.201802052. [Epub ahead of print]


The chemokine fragment CXCL9(74-103) diminishes neutrophil recruitment and joint inflammation in antigen-induced arthritis.

Boff D, Crijns H, Janssens R, Vanheule V, Menezes GB, Macari S, Silva TA, Amaral FA, Proost P.

J Leukoc Biol. 2018 Aug;104(2):413-422. doi: 10.1002/JLB.3MA1217-502R. Epub 2018 May 7.


Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria.

Vågesjö E, Öhnstedt E, Mortier A, Lofton H, Huss F, Proost P, Roos S, Phillipson M.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1895-1900. doi: 10.1073/pnas.1716580115. Epub 2018 Feb 5.


Neutrophils: Beneficial and Harmful Cells in Septic Arthritis.

Boff D, Crijns H, Teixeira MM, Amaral FA, Proost P.

Int J Mol Sci. 2018 Feb 5;19(2). pii: E468. doi: 10.3390/ijms19020468. Review.


Dysbiotic Biofilms Deregulate the Periodontal Inflammatory Response.

Herrero ER, Fernandes S, Verspecht T, Ugarte-Berzal E, Boon N, Proost P, Bernaerts K, Quirynen M, Teughels W.

J Dent Res. 2018 May;97(5):547-555. doi: 10.1177/0022034517752675. Epub 2018 Feb 2.


Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands.

Metzemaekers M, Vanheule V, Janssens R, Struyf S, Proost P.

Front Immunol. 2018 Jan 15;8:1970. doi: 10.3389/fimmu.2017.01970. eCollection 2017. Review.


Intravital Microscopic Evaluation of the Effects of a CXCR2 Antagonist in a Model of Liver Ischemia Reperfusion Injury in Mice.

de Oliveira THC, Marques PE, Poosti F, Ruytinx P, Amaral FA, Brandolini L, Allegretti M, Proost P, Teixeira MM.

Front Immunol. 2018 Jan 5;8:1917. doi: 10.3389/fimmu.2017.01917. eCollection 2017.


COOH-terminal SAA1 peptides fail to induce chemokines but synergize with CXCL8 and CCL3 to recruit leukocytes via FPR2.

De Buck M, Gouwy M, Berghmans N, Opdenakker G, Proost P, Struyf S, Van Damme J.

Blood. 2018 Jan 25;131(4):439-449. doi: 10.1182/blood-2017-06-788554..


COOH-terminal SAA1 peptides fail to induce chemokines but synergize with CXCL8 and CCL3 to recruit leukocytes via FPR2.

De Buck M, Gouwy M, Berghmans N, Opdenakker G, Proost P, Struyf S, Van Damme J.

Blood. 2017 Dec 4. pii: blood-2017-06-788554. doi: 10.1182/blood-2017-06-788554. [Epub ahead of print]


CXCR2 is critical for bacterial control and development of joint damage and pain in Staphylococcus aureus-induced septic arthritis in mouse.

Boff D, Oliveira VLS, Queiroz Junior CM, Silva TA, Allegretti M, Verri WA Jr, Proost P, Teixeira MM, Amaral FA.

Eur J Immunol. 2018 Mar;48(3):454-463. doi: 10.1002/eji.201747198. Epub 2018 Jan 9.


Divergence of species-specific protein sex pheromone blends in two related, nonhybridizing newts (Salamandridae).

Treer D, Maex M, Van Bocxlaer I, Proost P, Bossuyt F.

Mol Ecol. 2018 Jan;27(2):508-519. doi: 10.1111/mec.14398. Epub 2017 Nov 18.


The unique structural and functional features of CXCL12.

Janssens R, Struyf S, Proost P.

Cell Mol Immunol. 2018 Apr;15(4):299-311. doi: 10.1038/cmi.2017.107. Epub 2017 Oct 30. Review.


Neutrophils: a cornerstone of liver ischemia and reperfusion injury.

Oliveira THC, Marques PE, Proost P, Teixeira MMM.

Lab Invest. 2018 Jan;98(1):51-62. doi: 10.1038/labinvest.2017.90. Epub 2017 Sep 18. Review.


Relative distribution and biological characterization of CXCL4L1 isoforms in platelets from healthy donors.

Ruytinx P, Janssens R, Berghmans N, Gouwy M, Ronsse I, Liekens S, Proost P, Van Damme J, Struyf S.

Biochem Pharmacol. 2017 Dec 1;145:123-131. doi: 10.1016/j.bcp.2017.08.020. Epub 2017 Aug 30.


Corrigendum to "Matrix metalloproteinase-9 (MMP-9) as an activator of nanosystems for targeted drug delivery in pancreatic cancer" [J. Control. Release 239 (2016) 39-48].

Grünwald B, Vandooren J, Locatelli E, Fiten P, Opdenakker G, Proost P, Krüger A, Lellouche JP, Israel LL, Shenkman L, Franchini MC.

J Control Release. 2017 Sep 10;261:367. doi: 10.1016/j.jconrel.2017.07.027. Epub 2017 Jul 27. No abstract available.


Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling.

Metzemaekers M, Mortier A, Janssens R, Boff D, Vanbrabant L, Lamoen N, Van Damme J, Teixeira MM, De Meester I, Amaral FA, Proost P.

Int J Mol Sci. 2017 Jul 13;18(7). pii: E1513. doi: 10.3390/ijms18071513.


Chemokine isoforms and processing in inflammation and immunity.

Proost P, Struyf S, Van Damme J, Fiten P, Ugarte-Berzal E, Opdenakker G.

J Autoimmun. 2017 Dec;85:45-57. doi: 10.1016/j.jaut.2017.06.009. Epub 2017 Jul 3. Review.


Highly Selective and Tunable Protein Hydrolysis by a Polyoxometalate Complex in Surfactant Solutions: A Step toward the Development of Artificial Metalloproteases for Membrane Proteins.

Sap A, Vandebroek L, Goovaerts V, Martens E, Proost P, Parac-Vogt TN.

ACS Omega. 2017 May 31;2(5):2026-2033. doi: 10.1021/acsomega.7b00168. Epub 2017 May 11.


CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions.

Vanheule V, Boff D, Mortier A, Janssens R, Petri B, Kolaczkowska E, Kubes P, Berghmans N, Struyf S, Kungl AJ, Teixeira MM, Amaral FA, Proost P.

Front Immunol. 2017 May 10;8:530. doi: 10.3389/fimmu.2017.00530. eCollection 2017.


Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes.

Janssens R, Mortier A, Boff D, Ruytinx P, Gouwy M, Vantilt B, Larsen O, Daugvilaite V, Rosenkilde MM, Parmentier M, Noppen S, Liekens S, Van Damme J, Struyf S, Teixeira MM, Amaral FA, Proost P.

Biochem Pharmacol. 2017 May 15;132:92-101. doi: 10.1016/j.bcp.2017.03.009. Epub 2017 Mar 18.


Regulation of Chemokine Activity - A Focus on the Role of Dipeptidyl Peptidase IV/CD26.

Metzemaekers M, Van Damme J, Mortier A, Proost P.

Front Immunol. 2016 Nov 11;7:483. eCollection 2016. Review.


Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo.

Janssens R, Mortier A, Boff D, Vanheule V, Gouwy M, Franck C, Larsen O, Rosenkilde MM, Van Damme J, Amaral FA, Teixeira MM, Struyf S, Proost P.

Oncotarget. 2016 Sep 20;7(38):62439-62459. doi: 10.18632/oncotarget.11516.


Matrix metalloproteinase-9 (MMP-9) as an activator of nanosystems for targeted drug delivery in pancreatic cancer.

Grünwald B, Vandooren J, Locatelli E, Fiten P, Opdenakker G, Proost P, Krüger A, Lellouche JP, Israel LL, Shenkman L, Comes Franchini M.

J Control Release. 2016 Oct 10;239:39-48. doi: 10.1016/j.jconrel.2016.08.016. Epub 2016 Aug 19. Erratum in: J Control Release. 2017 Sep 10;261:367.


Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases.

Opdenakker G, Proost P, Van Damme J.

Trends Mol Med. 2016 Sep;22(9):746-757. doi: 10.1016/j.molmed.2016.07.002. Epub 2016 Aug 2.


Beyond sodefrin: evidence for a multi-component pheromone system in the model newt Cynops pyrrhogaster (Salamandridae).

Van Bocxlaer I, Maex M, Treer D, Janssenswillen S, Janssens R, Vandebergh W, Proost P, Bossuyt F.

Sci Rep. 2016 Mar 3;6:21880. doi: 10.1038/srep21880.


IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.

Put K, Brisse E, Avau A, Imbrechts M, Mitera T, Janssens R, Proost P, Fallarino F, Wouters CH, Matthys P.

PLoS One. 2016 Feb 25;11(2):e0150075. doi: 10.1371/journal.pone.0150075. eCollection 2016.


Courtship Pheromone Use in a Model Urodele, the Mexican Axolotl (Ambystoma mexicanum).

Maex M, Van Bocxlaer I, Mortier A, Proost P, Bossuyt F.

Sci Rep. 2016 Feb 4;6:20184. doi: 10.1038/srep20184.


The cytokine-serum amyloid A-chemokine network.

De Buck M, Gouwy M, Wang JM, Van Snick J, Proost P, Struyf S, Van Damme J.

Cytokine Growth Factor Rev. 2016 Aug;30:55-69. doi: 10.1016/j.cytogfr.2015.12.010. Epub 2015 Dec 28. Review.


CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology.

Mortier A, Gouwy M, Van Damme J, Proost P, Struyf S.

J Leukoc Biol. 2016 Jun;99(6):955-69. doi: 10.1189/jlb.3MR0915-401R. Epub 2016 Jan 7. Review.


Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus.

Vanheule V, Vervaeke P, Mortier A, Noppen S, Gouwy M, Snoeck R, Andrei G, Van Damme J, Liekens S, Proost P.

Biochem Pharmacol. 2016 Jan 15;100:73-85. doi: 10.1016/j.bcp.2015.11.001. Epub 2015 Nov 10.


Different Ancestries of R Tailocins in Rhizospheric Pseudomonas Isolates.

Ghequire MG, Dillen Y, Lambrichts I, Proost P, Wattiez R, De Mot R.

Genome Biol Evol. 2015 Sep 26;7(10):2810-28. doi: 10.1093/gbe/evv184.


Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.

De Buck M, Berghmans N, Pörtner N, Vanbrabant L, Cockx M, Struyf S, Opdenakker G, Proost P, Van Damme J, Gouwy M.

J Leukoc Biol. 2015 Dec;98(6):1049-60. doi: 10.1189/jlb.3A0315-085R. Epub 2015 Aug 21.


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