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Items: 1 to 50 of 106

1.

Housing conditions modulate spontaneous physical activity, feeding behavior, aerobic running capacity and adiposity in C57BL/6J mice.

Scariot PPM, Manchado-Gobatto FB, Prolla TA, Masselli Dos Reis IG, Gobatto CA.

Horm Behav. 2019 Sep;115:104556. doi: 10.1016/j.yhbeh.2019.07.004. Epub 2019 Jul 20.

PMID:
31310763
2.

The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts.

Delic V, Noble K, Zivkovic S, Phan TA, Reynes C, Zhang Y, Phillips O, Claybaker C, Ta Y, Dinh VB, Cruz J, Prolla TA, Bradshaw PC.

Biol Open. 2018 Nov 16;7(11). pii: bio033852. doi: 10.1242/bio.033852.

3.

Accumulation of mitochondrial DNA mutations disrupts cardiac progenitor cell function and reduces survival.

Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB.

J Biol Chem. 2017 Jul 7;292(27):11348. doi: 10.1074/jbc.A115.649657. No abstract available.

4.

Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics.

Barger JL, Vann JM, Cray NL, Pugh TD, Mastaloudis A, Hester SN, Wood SM, Newton MA, Weindruch R, Prolla TA.

Aging Cell. 2017 Aug;16(4):750-760. doi: 10.1111/acel.12608. Epub 2017 May 26.

5.

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.

Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA.

PLoS One. 2017 Feb 3;12(2):e0171159. doi: 10.1371/journal.pone.0171159. eCollection 2017.

6.

Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.

Han C, Linser P, Park HJ, Kim MJ, White K, Vann JM, Ding D, Prolla TA, Someya S.

Neurobiol Aging. 2016 Jul;43:58-71. doi: 10.1016/j.neurobiolaging.2016.03.023. Epub 2016 Mar 30.

7.

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.

Safdar A, Khrapko K, Flynn JM, Saleem A, De Lisio M, Johnston AP, Kratysberg Y, Samjoo IA, Kitaoka Y, Ogborn DI, Little JP, Raha S, Parise G, Akhtar M, Hettinga BP, Rowe GC, Arany Z, Prolla TA, Tarnopolsky MA.

Skelet Muscle. 2016 Jan 31;6:7. doi: 10.1186/s13395-016-0075-9. eCollection 2016.

8.

Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival.

Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB.

J Biol Chem. 2015 Sep 4;290(36):22061-75. doi: 10.1074/jbc.M115.649657. Epub 2015 Jul 16. Erratum in: J Biol Chem. 2017 Jul 7;292(27):11348.

9.

SIRT3 mediates multi-tissue coupling for metabolic fuel switching.

Dittenhafer-Reed KE, Richards AL, Fan J, Smallegan MJ, Fotuhi Siahpirani A, Kemmerer ZA, Prolla TA, Roy S, Coon JJ, Denu JM.

Cell Metab. 2015 Apr 7;21(4):637-46. doi: 10.1016/j.cmet.2015.03.007.

10.

A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.

Barger JL, Anderson RM, Newton MA, da Silva C, Vann JA, Pugh TD, Someya S, Prolla TA, Weindruch R.

PLoS One. 2015 Apr 1;10(4):e0120738. doi: 10.1371/journal.pone.0120738. eCollection 2015.

11.

Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions.

Fuke S, Kametani M, Yamada K, Kasahara T, Kubota-Sakashita M, Kujoth GC, Prolla TA, Hitoshi S, Kato T.

Ann Clin Transl Neurol. 2014 Nov;1(11):909-20. doi: 10.1002/acn3.133. Epub 2014 Oct 22.

12.

Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice.

Dai Y, Clark J, Zheng K, Kujoth GC, Prolla TA, Simon DK.

Neurotoxicol Teratol. 2014 Nov-Dec;46:62-7.

13.

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M.

Blood. 2015 Jan 1;125(1):162-74. doi: 10.1182/blood-2014-07-586396. Epub 2014 Nov 19.

14.

Novel approaches in anaplastic thyroid cancer therapy.

Hsu KT, Yu XM, Audhya AW, Jaume JC, Lloyd RV, Miyamoto S, Prolla TA, Chen H.

Oncologist. 2014 Nov;19(11):1148-55. doi: 10.1634/theoncologist.2014-0182. Epub 2014 Sep 26. Review.

15.

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.

Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R.

Mol Neurodegener. 2014 May 2;9:16. doi: 10.1186/1750-1326-9-16.

16.

NAD+ deficiency in age-related mitochondrial dysfunction.

Prolla TA, Denu JM.

Cell Metab. 2014 Feb 4;19(2):178-80. doi: 10.1016/j.cmet.2014.01.005.

17.

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Joseph AM, Adhihetty PJ, Wawrzyniak NR, Wohlgemuth SE, Picca A, Kujoth GC, Prolla TA, Leeuwenburgh C.

PLoS One. 2013 Jul 23;8(7):e69327. doi: 10.1371/journal.pone.0069327. Print 2013.

18.

Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain.

Taylor SD, Ericson NG, Burton JN, Prolla TA, Silber JR, Shendure J, Bielas JH.

Aging Cell. 2014 Feb;13(1):29-38. doi: 10.1111/acel.12146. Epub 2013 Sep 11.

19.

Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice.

Dai Y, Kiselak T, Clark J, Clore E, Zheng K, Cheng A, Kujoth GC, Prolla TA, Maratos-Flier E, Simon DK.

Mitochondrion. 2013 Jul;13(4):282-91. doi: 10.1016/j.mito.2013.03.006. Epub 2013 Mar 27.

20.

Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains.

Collino S, Martin FP, Montoliu I, Barger JL, Da Silva L, Prolla TA, Weindruch R, Kochhar S.

Metabolites. 2013 Oct 11;3(4):881-911. doi: 10.3390/metabo3040881.

21.

Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.

Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.

Mol Cell. 2013 Jan 10;49(1):186-99. doi: 10.1016/j.molcel.2012.10.024. Epub 2012 Nov 29.

22.

Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse.

Dillon LM, Hida A, Garcia S, Prolla TA, Moraes CT.

PLoS One. 2012;7(9):e44335. doi: 10.1371/journal.pone.0044335. Epub 2012 Sep 4.

23.

Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse.

Dillon LM, Williams SL, Hida A, Peacock JD, Prolla TA, Lincoln J, Moraes CT.

Hum Mol Genet. 2012 May 15;21(10):2288-97. doi: 10.1093/hmg/dds049. Epub 2012 Feb 21.

24.

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption.

Fox RG, Magness S, Kujoth GC, Prolla TA, Maeda N.

Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G914-24. doi: 10.1152/ajpgi.00402.2011. Epub 2012 Feb 16.

25.

Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse.

Barger JL, Kayo T, Pugh TD, Vann JA, Power R, Dawson K, Weindruch R, Prolla TA.

Genes Nutr. 2012 Apr;7(2):155-65. doi: 10.1007/s12263-011-0243-9. Epub 2011 Aug 17.

26.

Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.

Fox R, Kim HS, Reddick RL, Kujoth GC, Prolla TA, Tsutsumi S, Wada Y, Smithies O, Maeda N.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8779-84. doi: 10.1073/pnas.1106344108. Epub 2011 May 9.

27.

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice.

Safdar A, Bourgeois JM, Ogborn DI, Little JP, Hettinga BP, Akhtar M, Thompson JE, Melov S, Mocellin NJ, Kujoth GC, Prolla TA, Tarnopolsky MA.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4135-40. doi: 10.1073/pnas.1019581108. Epub 2011 Feb 22.

28.

Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.

Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW 2nd, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS.

Circ Res. 2011 Apr 1;108(7):837-46. doi: 10.1161/CIRCRESAHA.110.232306. Epub 2011 Feb 10.

29.

The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.

Williams SL, Huang J, Edwards YJ, Ulloa RH, Dillon LM, Prolla TA, Vance JM, Moraes CT, Züchner S.

Cell Metab. 2010 Dec 1;12(6):675-82. doi: 10.1016/j.cmet.2010.11.012.

30.

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.

Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA.

Cell. 2010 Nov 24;143(5):802-12. doi: 10.1016/j.cell.2010.10.002.

31.

The Shc locus regulates insulin signaling and adiposity in mammals.

Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA.

Aging Cell. 2011 Feb;10(1):55-65. doi: 10.1111/j.1474-9726.2010.00641.x. Epub 2010 Nov 15.

32.

Mitochondria and aging.

Prolla TA, Bohr VA, de Souza-Pinto NC.

Mech Ageing Dev. 2010 Jul-Aug;131(7-8):449-50. doi: 10.1016/j.mad.2010.07.002. Epub 2010 Jul 17. No abstract available.

PMID:
20643157
33.

Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.

Hiona A, Sanz A, Kujoth GC, Pamplona R, Seo AY, Hofer T, Someya S, Miyakawa T, Nakayama C, Samhan-Arias AK, Servais S, Barger JL, Portero-Otín M, Tanokura M, Prolla TA, Leeuwenburgh C.

PLoS One. 2010 Jul 7;5(7):e11468. doi: 10.1371/journal.pone.0011468.

34.

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria.

Dai DF, Chen T, Wanagat J, Laflamme M, Marcinek DJ, Emond MJ, Ngo CP, Prolla TA, Rabinovitch PS.

Aging Cell. 2010 Aug;9(4):536-44. doi: 10.1111/j.1474-9726.2010.00581.x. Epub 2010 Apr 29.

35.

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging.

Xu J, Marzetti E, Seo AY, Kim JS, Prolla TA, Leeuwenburgh C.

Mech Ageing Dev. 2010 Jul-Aug;131(7-8):487-93. doi: 10.1016/j.mad.2010.04.007. Epub 2010 Apr 29. Review.

36.

Mitochondrial oxidative damage and apoptosis in age-related hearing loss.

Someya S, Prolla TA.

Mech Ageing Dev. 2010 Jul-Aug;131(7-8):480-6. doi: 10.1016/j.mad.2010.04.006. Epub 2010 Apr 29. Review.

37.

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.

Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC.

Cell. 2010 Apr 16;141(2):280-9. doi: 10.1016/j.cell.2010.02.026.

38.

Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys.

Someya S, Tanokura M, Weindruch R, Prolla TA, Yamasoba T.

Curr Aging Sci. 2010 Feb;3(1):20-5. Review.

39.

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19432-7. doi: 10.1073/pnas.0908786106. Epub 2009 Nov 9.

40.

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction.

Chen ML, Logan TD, Hochberg ML, Shelat SG, Yu X, Wilding GE, Tan W, Kujoth GC, Prolla TA, Selak MA, Kundu M, Carroll M, Thompson JE.

Blood. 2009 Nov 5;114(19):4045-53. doi: 10.1182/blood-2008-08-169474. Epub 2009 Sep 4.

41.

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants.

Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA.

Aging Cell. 2009 Aug;8(4):484-95. doi: 10.1111/j.1474-9726.2009.00496.x. Epub 2009 Jun 25.

42.

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA.

Bailey LJ, Cluett TJ, Reyes A, Prolla TA, Poulton J, Leeuwenburgh C, Holt IJ.

Nucleic Acids Res. 2009 Apr;37(7):2327-35. doi: 10.1093/nar/gkp091. Epub 2009 Feb 25.

43.

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.

Cell. 2008 Nov 28;135(5):907-18. doi: 10.1016/j.cell.2008.10.025.

44.

Evolution of the aging brain transcriptome and synaptic regulation.

Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA.

PLoS One. 2008 Oct 2;3(10):e3329. doi: 10.1371/journal.pone.0003329.

45.

Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart.

Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R.

Exp Gerontol. 2008 Sep;43(9):859-66. doi: 10.1016/j.exger.2008.06.013. Epub 2008 Jul 9.

PMID:
18657603
46.

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.

Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA.

PLoS One. 2008 Jun 4;3(6):e2264. doi: 10.1371/journal.pone.0002264. Erratum in: PLoS ONE. 2008;3(6). doi: 10.1371/annotation/7d56e94e-3582-413d-b987-fccd0da79081. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/8333176c-b08c-4dfb-a829-6331c0fc6064. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5.

47.

alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice.

Park SK, Page GP, Kim K, Allison DB, Meydani M, Weindruch R, Prolla TA.

J Nutr. 2008 Jun;138(6):1010-8.

48.

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.

Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA.

Nat Genet. 2008 Apr;40(4):392-4. doi: 10.1038/ng.95. Epub 2008 Mar 2.

PMID:
18311139
49.

Evolving insight into the role of mitochondrial DNA mutations in aging.

Kujoth GC, Prolla TA.

Exp Gerontol. 2008 Jan;43(1):20-3. Epub 2007 Oct 5. Review.

PMID:
18054193
50.

Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response.

Anderson RM, Barger JL, Edwards MG, Braun KH, O'Connor CE, Prolla TA, Weindruch R.

Aging Cell. 2008 Jan;7(1):101-11. Epub 2007 Nov 21.

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