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Items: 4


23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity.

Proia T, Jiang F, Bell A, Nicoletti R, Kong L, Kreuter K, Poling L, Winston WM, Flaherty M, Weiler S, Perino S, O'Hagan R, Lin J, Gyuris J, Okamura H.

Mol Cancer Ther. 2015 Aug;14(8):1858-67. doi: 10.1158/1535-7163.MCT-14-1104. Epub 2015 May 20.


Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation.

Phillips S, Prat A, Sedic M, Proia T, Wronski A, Mazumdar S, Skibinski A, Shirley SH, Perou CM, Gill G, Gupta PB, Kuperwasser C.

Stem Cell Reports. 2014 Apr 24;2(5):633-47. doi: 10.1016/j.stemcr.2014.03.008. eCollection 2014 May 6.


Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.

Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, Gupta PB.

Cancer Discov. 2014 Jun;4(6):702-15. doi: 10.1158/2159-8290.CD-13-0945. Epub 2014 Apr 4.


Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.

Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, Gilmore H, Tung N, Naber SP, Schnitt S, Lander ES, Kuperwasser C.

Cell Stem Cell. 2011 Feb 4;8(2):149-63. doi: 10.1016/j.stem.2010.12.007.

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