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Items: 1 to 50 of 77

1.

Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer.

Jarzabek MA, Proctor WR, Vogt J, Desai R, Dicker P, Cain G, Raja R, Brodbeck J, Stevens D, van der Stok EP, Martens JWM, Verhoef C, Hegde PS, Byrne AT, Tarrant JM.

PLoS One. 2018 Jun 7;13(6):e0198099. doi: 10.1371/journal.pone.0198099. eCollection 2018.

2.

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

Ewart L, Fabre K, Chakilam A, Dragan Y, Duignan DB, Eswaraka J, Gan J, Guzzie-Peck P, Otieno M, Jeong CG, Keller DA, de Morais SM, Phillips JA, Proctor W, Sura R, Van Vleet T, Watson D, Will Y, Tagle D, Berridge B.

Exp Biol Med (Maywood). 2017 Oct;242(16):1579-1585. doi: 10.1177/1535370217715441. Epub 2017 Jun 16.

3.

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.

Proctor WR, Foster AJ, Vogt J, Summers C, Middleton B, Pilling MA, Shienson D, Kijanska M, Ströbel S, Kelm JM, Morgan P, Messner S, Williams D.

Arch Toxicol. 2017 Aug;91(8):2849-2863. doi: 10.1007/s00204-017-2002-1. Epub 2017 Jun 13.

4.

Histone demethylases UTX and JMJD3 are required for NKT cell development in mice.

Northrup D, Yagi R, Cui K, Proctor WR, Wang C, Placek K, Pohl LR, Wang R, Ge K, Zhu J, Zhao K.

Cell Biosci. 2017 May 17;7:25. doi: 10.1186/s13578-017-0152-8. eCollection 2017.

5.

Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis.

Proctor WR, Ming X, Bourdet D, Han TK, Everett RS, Thakker DR.

J Pharm Sci. 2016 Feb;105(2):484-496. doi: 10.1016/j.xphs.2015.11.040. Review.

PMID:
26869413
6.

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.

Dambach DM, Misner D, Brock M, Fullerton A, Proctor W, Maher J, Lee D, Ford K, Diaz D.

Chem Res Toxicol. 2016 Apr 18;29(4):452-72. doi: 10.1021/acs.chemrestox.5b00396. Epub 2015 Dec 16. Review.

PMID:
26625186
7.

Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.

Chakraborty M, Fullerton AM, Semple K, Chea LS, Proctor WR, Bourdi M, Kleiner DE, Zeng X, Ryan PM, Dagur PK, Berkson JD, Reilly TP, Pohl LR.

Hepatology. 2015 Aug;62(2):546-57. doi: 10.1002/hep.27764. Epub 2015 Mar 25.

PMID:
25712247
8.

Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.

Han TK, Proctor WR, Costales CL, Cai H, Everett RS, Thakker DR.

J Pharmacol Exp Ther. 2015 Mar;352(3):519-28. doi: 10.1124/jpet.114.220350. Epub 2015 Jan 6.

9.

Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.

Proctor WR, Chakraborty M, Fullerton AM, Korrapati MC, Ryan PM, Semple K, Morrison JC, Berkson JD, Chea LS, Yang Q, Li AP, Spolski R, West EE, Rochman Y, Leonard WJ, Bourdi M, Pohl LR.

Hepatology. 2014 Nov;60(5):1741-52. doi: 10.1002/hep.27169. Epub 2014 May 20.

10.

Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.

Han TK, Everett RS, Proctor WR, Ng CM, Costales CL, Brouwer KL, Thakker DR.

Mol Pharmacol. 2013 Aug;84(2):182-9. doi: 10.1124/mol.112.084517. Epub 2013 May 16.

11.

Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites.

Swift B, Nebot N, Lee JK, Han T, Proctor WR, Thakker DR, Lang D, Radtke M, Gnoth MJ, Brouwer KL.

Drug Metab Dispos. 2013 Jun;41(6):1179-86. doi: 10.1124/dmd.112.048181. Epub 2013 Mar 12.

12.

Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice.

Proctor WR, Chakraborty M, Chea LS, Morrison JC, Berkson JD, Semple K, Bourdi M, Pohl LR.

Hepatology. 2013 May;57(5):2026-36. doi: 10.1002/hep.26196. Epub 2013 Mar 15.

13.

Cigarette smoke exposure greatly increases alcohol consumption in adolescent C57BL/6 mice.

Burns BE, Proctor WR.

Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E364-72. doi: 10.1111/j.1530-0277.2012.01911.x. Epub 2012 Jul 24.

14.

Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice.

Ryan PM, Bourdi M, Korrapati MC, Proctor WR, Vasquez RA, Yee SB, Quinn TD, Chakraborty M, Pohl LR.

Chem Res Toxicol. 2012 Jan 13;25(1):83-93. doi: 10.1021/tx2003992. Epub 2011 Dec 13.

15.
16.

Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase.

Hicklin TR, Wu PH, Radcliffe RA, Freund RK, Goebel-Goody SM, Correa PR, Proctor WR, Lombroso PJ, Browning MD.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6650-5. doi: 10.1073/pnas.1017856108. Epub 2011 Apr 4.

17.

Chronic nicotine treatment differentially modifies acute nicotine and alcohol actions on GABA(A) and glutamate receptors in hippocampal brain slices.

Proctor WR, Dobelis P, Moritz AT, Wu PH.

Br J Pharmacol. 2011 Mar;162(6):1351-63. doi: 10.1111/j.1476-5381.2010.01141.x.

18.

Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.

Wu PH, Coultrap S, Browning MD, Proctor WR.

J Neurochem. 2010 Dec;115(5):1112-22. doi: 10.1111/j.1471-4159.2010.06991.x. Epub 2010 Oct 12.

19.

Mucosal immunity and illness incidence in elite rugby union players across a season.

Cunniffe B, Griffiths H, Proctor W, Davies B, Baker JS, Jones KP.

Med Sci Sports Exerc. 2011 Mar;43(3):388-97. doi: 10.1249/MSS.0b013e3181ef9d6b.

PMID:
20631639
20.

Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia.

Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, Hunter SK, Freedman R, Adams CE.

J Child Psychol Psychiatry. 2010 May;51(5):535-49. doi: 10.1111/j.1469-7610.2009.02187.x. Epub 2009 Nov 18. Review.

21.

Illness monitoring in team sports using a Web-based training diary.

Cunniffe B, Griffiths H, Proctor W, Jones KP, Baker JS, Davies B.

Clin J Sport Med. 2009 Nov;19(6):476-81. doi: 10.1097/JSM.0b013e3181c125d3.

PMID:
19898075
22.

An evaluation of the physiological demands of elite rugby union using Global Positioning System tracking software.

Cunniffe B, Proctor W, Baker JS, Davies B.

J Strength Cond Res. 2009 Jul;23(4):1195-203. doi: 10.1519/JSC.0b013e3181a3928b.

PMID:
19528840
23.

Mechanisms underlying saturable intestinal absorption of metformin.

Proctor WR, Bourdet DL, Thakker DR.

Drug Metab Dispos. 2008 Aug;36(8):1650-8. doi: 10.1124/dmd.107.020180. Epub 2008 May 5.

24.

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.

Van Itallie CM, Holmes J, Bridges A, Gookin JL, Coccaro MR, Proctor W, Colegio OR, Anderson JM.

J Cell Sci. 2008 Feb 1;121(Pt 3):298-305. doi: 10.1242/jcs.021485. Epub 2008 Jan 15.

25.

Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons.

Proctor WR, Diao L, Freund RK, Browning MD, Wu PH.

J Physiol. 2006 Aug 15;575(Pt 1):145-59. Epub 2006 Jun 8.

26.

Differential GABAB Receptor Modulation of Ethanol Effects on GABA(A) synaptic activity in hippocampal CA1 neurons.

Wu PH, Poelchen W, Proctor WR.

J Pharmacol Exp Ther. 2005 Mar;312(3):1082-9. Epub 2004 Dec 22.

27.

Selective inhibition of human cytochrome P4502C8 by montelukast.

Walsky RL, Obach RS, Gaman EA, Gleeson JP, Proctor WR.

Drug Metab Dispos. 2005 Mar;33(3):413-8. Epub 2004 Dec 17.

28.
29.

Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice.

Proctor WR, Poelchen W, Bowers BJ, Wehner JM, Messing RO, Dunwiddie TV.

J Pharmacol Exp Ther. 2003 Apr;305(1):264-70.

30.

Pain and cognitive status among nursing home residents in Canada.

Proctor WR, Hirdes JP.

Pain Res Manag. 2001 Fall;6(3):119-25.

PMID:
11854774
31.

Electrophysiological analysis of G protein-coupled receptors in mammalian neurons.

Proctor WR, Dunwiddie TV.

Curr Protoc Pharmacol. 2001 May;Chapter 11:Unit11.2. doi: 10.1002/0471141755.ph1102s07.

PMID:
21965065
33.

Allosteric control of gating and kinetics at P2X(4) receptor channels.

Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA.

J Neurosci. 1999 Sep 1;19(17):7289-99.

34.
35.
36.

Antagonists of the receptor-G protein interface block Gi-coupled signal transduction.

Gilchrist A, Mazzoni MR, Dineen B, Dice A, Linden J, Proctor WR, Lupica CR, Dunwiddie TV, Hamm HE.

J Biol Chem. 1998 Jun 12;273(24):14912-9.

37.

The role of cyclic AMP as a precursor of extracellular adenosine in the rat hippocampus.

Brundege JM, Diao L, Proctor WR, Dunwiddie TV.

Neuropharmacology. 1997 Sep;36(9):1201-10.

PMID:
9364475
38.
39.
40.

Functional evaluation of gap vs. abutment repair of peripheral nerves in the rat.

Weber RA, Warner MR, Verheyden CN, Proctor WH.

J Reconstr Microsurg. 1996 Apr;12(3):159-63.

PMID:
8726335
41.

Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors.

Staley KJ, Soldo BL, Proctor WR.

Science. 1995 Aug 18;269(5226):977-81.

PMID:
7638623
42.

Ethanol increases GABAA responses in cells stably transfected with receptor subunits.

Harris RA, Proctor WR, McQuilkin SJ, Klein RL, Mascia MP, Whatley V, Whiting PJ, Dunwiddie TV.

Alcohol Clin Exp Res. 1995 Feb;19(1):226-32.

PMID:
7771653
44.

Autotomy and the sciatic functional index.

Weber RA, Proctor WH, Warner MR, Verheyden CN.

Microsurgery. 1993;14(5):323-7.

PMID:
8332052
45.

Ethanol enhances synaptically evoked GABAA receptor-mediated responses in cerebral cortical neurons in rat brain slices.

Proctor WR, Soldo BL, Allan AM, Dunwiddie TV.

Brain Res. 1992 Nov 13;595(2):220-7.

PMID:
1334772
46.
48.

Brain region-dependent sensitivity of GABAA receptor-mediated responses to modulation by ethanol.

Proctor WR, Allan AM, Dunwiddie TV.

Alcohol Clin Exp Res. 1992 Jun;16(3):480-9.

PMID:
1320806
49.
50.

In vitro electrophysiological analysis of mature rat hippocampal transplants in oculo.

Mynlieff M, Proctor WR, Seiger A, Dunwiddie TV.

Brain Res Dev Brain Res. 1989 Nov 1;50(1):113-22.

PMID:
2573439

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