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STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation.

Nepal S, Tiruppathi C, Tsukasaki Y, Farahany J, Mittal M, Rehman J, Prockop DJ, Malik AB.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16513-16518. doi: 10.1073/pnas.1821601116. Epub 2019 Jul 30.


Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model.

Choi H, Phillips C, Oh JY, Potts L, Reger RL, Prockop DJ, Fulcher S.

Curr Eye Res. 2019 Aug;44(8):873-881. doi: 10.1080/02713683.2019.1597893. Epub 2019 Apr 2.


In Vitro Macrophage Assay Predicts the In Vivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells.

Pacienza N, Lee RH, Bae EH, Kim DK, Liu Q, Prockop DJ, Yannarelli G.

Mol Ther Methods Clin Dev. 2018 Dec 15;13:67-76. doi: 10.1016/j.omtm.2018.12.003. eCollection 2019 Jun 14.


Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.

Upadhya D, Hattiangady B, Castro OW, Shuai B, Kodali M, Attaluri S, Bates A, Dong Y, Zhang SC, Prockop DJ, Shetty AK.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):287-296. doi: 10.1073/pnas.1814185115. Epub 2018 Dec 17.


Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner.

Song HB, Park SY, Ko JH, Park JW, Yoon CH, Kim DH, Kim JH, Kim MK, Lee RH, Prockop DJ, Oh JY.

Mol Ther. 2018 Jan 3;26(1):162-172. doi: 10.1016/j.ymthe.2017.09.026. Epub 2017 Oct 5.


Erratum: iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

Ullah M, Kuroda Y, Bartosh TJ, Liu F, Zhao Q, Gregory C, Reger R, Xu J, Lee RH, Prockop DJ.

Cell Death Discov. 2017 Aug 21;3:17029. doi: 10.1038/cddiscovery.2017.29. eCollection 2017.


Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs.

Prockop DJ, Oh JY, Lee RH.

Mol Ther. 2017 Aug 2;25(8):1748-1756. doi: 10.1016/j.ymthe.2017.06.004. Epub 2017 Jun 22. Review.


MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Shigemoto-Kuroda T, Oh JY, Kim DK, Jeong HJ, Park SY, Lee HJ, Park JW, Kim TW, An SY, Prockop DJ, Lee RH.

Stem Cell Reports. 2017 May 9;8(5):1214-1225. doi: 10.1016/j.stemcr.2017.04.008.


Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus.

Long Q, Upadhya D, Hattiangady B, Kim DK, An SY, Shuai B, Prockop DJ, Shetty AK.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3536-E3545. doi: 10.1073/pnas.1703920114. Epub 2017 Apr 10.


iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

Ullah M, Kuroda Y, Bartosh TJ, Liu F, Zhao Q, Gregory C, Reger R, Xu J, Lee RH, Prockop DJ.

Cell Death Discov. 2017 Feb 6;3:16064. doi: 10.1038/cddiscovery.2016.64. eCollection 2017. Erratum in: Cell Death Discov. 2017 Aug 21;3:17029.


TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.

Mittal M, Tiruppathi C, Nepal S, Zhao YY, Grzych D, Soni D, Prockop DJ, Malik AB.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8151-E8158. Epub 2016 Nov 28.


Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury.

Yun YI, Park SY, Lee HJ, Ko JH, Kim MK, Wee WR, Reger RL, Gregory CA, Choi H, Fulcher SF, Prockop DJ, Oh JY.

Cytotherapy. 2017 Jan;19(1):28-35. doi: 10.1016/j.jcyt.2016.10.007. Epub 2016 Nov 10.


Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs).

Bartosh TJ, Ullah M, Zeitouni S, Beaver J, Prockop DJ.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6447-E6456. Epub 2016 Oct 3.


The exciting prospects of new therapies with mesenchymal stromal cells.

Prockop DJ.

Cytotherapy. 2017 Jan;19(1):1-8. doi: 10.1016/j.jcyt.2016.09.008. Epub 2016 Oct 18. Review.


Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli.

Mohammadipoor A, Lee RH, Prockop DJ, Bartosh TJ.

Transl Res. 2016 Nov;177:127-142. doi: 10.1016/j.trsl.2016.06.011. Epub 2016 Jul 9.


Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs.

Bazhanov N, Ylostalo JH, Bartosh TJ, Tiblow A, Mohammadipoor A, Foskett A, Prockop DJ.

Stem Cell Res Ther. 2016 Feb 10;7:27. doi: 10.1186/s13287-016-0284-5.


Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells.

Prockop DJ.

Matrix Biol. 2016 Apr;51:7-13. doi: 10.1016/j.matbio.2016.01.010. Epub 2016 Jan 22. Review.


Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It.

Kim DK, Choi H, Nishida H, Oh JY, Gregory C, Lee RH, Yu JM, Watanabe J, An SY, Bartosh TJ, Prockop DJ.

PLoS One. 2016 Jan 21;11(1):e0147553. doi: 10.1371/journal.pone.0147553. eCollection 2016.


Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI.

Kim DK, Nishida H, An SY, Shetty AK, Bartosh TJ, Prockop DJ.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):170-5. doi: 10.1073/pnas.1522297113. Epub 2015 Dec 22.


Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye.

Ko JH, Lee HJ, Jeong HJ, Kim MK, Wee WR, Yoon SO, Choi H, Prockop DJ, Oh JY.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):158-63. doi: 10.1073/pnas.1522905113. Epub 2015 Dec 22.


Hardly Tendentious--Repairing Like with Like.

Prockop DJ.

N Engl J Med. 2015 Oct;373(14):1371-2. doi: 10.1056/NEJMcibr1509841. No abstract available.


An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases.

Weiss DJ, Chambers D, Giangreco A, Keating A, Kotton D, Lelkes PI, Wagner DE, Prockop DJ; ATS Subcommittee on Stem Cells and Cell Therapies.

Ann Am Thorac Soc. 2015 Apr;12(4):S79-97. doi: 10.1513/AnnalsATS.201502-086ST.


MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs.

Zhao Q, Gregory CA, Lee RH, Reger RL, Qin L, Hai B, Park MS, Yoon N, Clough B, McNeill E, Prockop DJ, Liu F.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):530-5. doi: 10.1073/pnas.1423008112. Epub 2014 Dec 29.


TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo.

Lee RH, Yu JM, Foskett AM, Peltier G, Reneau JC, Bazhanov N, Oh JY, Prockop DJ.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16766-71. doi: 10.1073/pnas.1416121111. Epub 2014 Nov 10.


Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6.

Xie J, Broxmeyer HE, Feng D, Schweitzer KS, Yi R, Cook TG, Chitteti BR, Barwinska D, Traktuev DO, Van Demark MJ, Justice MJ, Ou X, Srour EF, Prockop DJ, Petrache I, March KL.

Stem Cells. 2015 Feb;33(2):468-78. doi: 10.1002/stem.1851.


Anti-inflammatory protein tumor necrosis factor-α-stimulated protein 6 (TSG-6) promotes early gingival wound healing: an in vivo study.

Beltran SR, Svoboda KK, Kerns DG, Sheth A, Prockop DJ.

J Periodontol. 2015 Jan;86(1):62-71. doi: 10.1902/jop.2014.140187.


Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions.

Ylostalo JH, Bartosh TJ, Tiblow A, Prockop DJ.

Cytotherapy. 2014 Nov;16(11):1486-1500. doi: 10.1016/j.jcyt.2014.07.010. Epub 2014 Sep 16.


Rapidly self-renewing human multipotent marrow stromal cells (hMSC) express sialyl Lewis X and actively adhere to arterial endothelium in a chick embryo model system.

McFerrin HE, Olson SD, Gutschow MV, Semon JA, Sullivan DE, Prockop DJ.

PLoS One. 2014 Aug 21;9(8):e105411. doi: 10.1371/journal.pone.0105411. eCollection 2014.


Are clinical trials with mesenchymal stem/progenitor cells too far ahead of the science? Lessons from experimental hematology.

Prockop DJ, Prockop SE, Bertoncello I.

Stem Cells. 2014 Dec;32(12):3055-61. doi: 10.1002/stem.1806. Review.


Should publications on mesenchymal stem/progenitor cells include in-process data on the preparation of the cells?

Reger RL, Prockop DJ.

Stem Cells Transl Med. 2014 May;3(5):632-5. doi: 10.5966/sctm.2013-0203. Epub 2014 Apr 1.


Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome.

Kim H, Darwish I, Monroy MF, Prockop DJ, Liles WC, Kain KC.

BMC Immunol. 2014 Jan 14;15:1. doi: 10.1186/1471-2172-15-1.


Mesenchymal stem/stromal cells inhibit the NLRP3 inflammasome by decreasing mitochondrial reactive oxygen species.

Oh JY, Ko JH, Lee HJ, Yu JM, Choi H, Kim MK, Wee WR, Prockop DJ.

Stem Cells. 2014 Jun;32(6):1553-63. doi: 10.1002/stem.1608.


Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs.

Foskett AM, Bazhanov N, Ti X, Tiblow A, Bartosh TJ, Prockop DJ.

Am J Physiol Lung Cell Mol Physiol. 2014 Jan;306(2):L120-31. doi: 10.1152/ajplung.00240.2013. Epub 2013 Nov 15.


Administration of TSG-6 improves memory after traumatic brain injury in mice.

Watanabe J, Shetty AK, Hattiangady B, Kim DK, Foraker JE, Nishida H, Prockop DJ.

Neurobiol Dis. 2013 Nov;59:86-99. doi: 10.1016/j.nbd.2013.06.017. Epub 2013 Jul 11.


Strategies for improving animal models for regenerative medicine.

Cibelli J, Emborg ME, Prockop DJ, Roberts M, Schatten G, Rao M, Harding J, Mirochnitchenko O.

Cell Stem Cell. 2013 Mar 7;12(3):271-4. doi: 10.1016/j.stem.2013.01.004.


New targets for osteoporosis.

Prockop DJ.

N Engl J Med. 2012 Dec 13;367(24):2353-4. doi: 10.1056/NEJMcibr1210178. No abstract available.


Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity.

Lee RH, Yoon N, Reneau JC, Prockop DJ.

Cell Stem Cell. 2012 Dec 7;11(6):825-35. doi: 10.1016/j.stem.2012.10.001. Epub 2012 Nov 8.


Stem cells in the face: tooth regeneration and beyond.

Mao JJ, Prockop DJ.

Cell Stem Cell. 2012 Sep 7;11(3):291-301. doi: 10.1016/j.stem.2012.08.010. Review. Erratum in: Cell Stem Cell. 2012 Oct 5;11(4):579. Robey, Pamela G [removed].


Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response.

Oh JY, Lee RH, Yu JM, Ko JH, Lee HJ, Ko AY, Roddy GW, Prockop DJ.

Mol Ther. 2012 Nov;20(11):2143-52. doi: 10.1038/mt.2012.165. Epub 2012 Aug 28.


A long-awaited discovery: hypoxia prevents mouse cells from undergoing spontaneous p53-dependent transformation.

Prockop DJ.

Cytotherapy. 2012 Oct;14(9):1029-31. doi: 10.3109/14653249.2012.718887. Epub 2012 Aug 22.


Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen.

Horie M, Choi H, Lee RH, Reger RL, Ylostalo J, Muneta T, Sekiya I, Prockop DJ.

Osteoarthritis Cartilage. 2012 Oct;20(10):1197-207. doi: 10.1016/j.joca.2012.06.002. Epub 2012 Jun 29.


Mitochondria to the rescue.

Prockop DJ.

Nat Med. 2012 May 4;18(5):653-4. doi: 10.1038/nm.2769.


Implantation of allogenic synovial stem cells promotes meniscal regeneration in a rabbit meniscal defect model.

Horie M, Driscoll MD, Sampson HW, Sekiya I, Caroom CT, Prockop DJ, Thomas DB.

J Bone Joint Surg Am. 2012 Apr 18;94(8):701-12. doi: 10.2106/JBJS.K.00176.


Relearning the lessons of genomic stability of human cells during expansion in culture: implications for clinical research.

Prockop DJ, Keating A.

Stem Cells. 2012 Jun;30(6):1051-2. doi: 10.1002/stem.1103. No abstract available.


Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model.

Tuo J, Cao X, Shen D, Wang Y, Zhang J, Oh JY, Prockop DJ, Chan CC.

J Neuroinflammation. 2012 Mar 27;9:59. doi: 10.1186/1742-2094-9-59.


Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea.

Oh JY, Choi H, Lee RH, Roddy GW, Ylöstalo JH, Wawrousek E, Prockop DJ.

EMBO Mol Med. 2012 May;4(5):435-48. doi: 10.1002/emmm.201200221. Epub 2012 Feb 22.

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