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Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.

Zhu Y, Gu L, Lin X, Liu C, Lu B, Cui K, Zhou F, Zhao Q, Prochownik EV, Fan C, Li Y.

Mol Cell. 2020 Jan 2;77(1):138-149.e5. doi: 10.1016/j.molcel.2019.10.015. Epub 2019 Nov 14.


β-Catenin mutations as determinants of hepatoblastoma phenotypes in mice.

Zhang W, Meyfeldt J, Wang H, Kulkarni S, Lu J, Mandel JA, Marburger B, Liu Y, Gorka JE, Ranganathan S, Prochownik EV.

J Biol Chem. 2019 Nov 15;294(46):17524-17542. doi: 10.1074/jbc.RA119.009979. Epub 2019 Oct 9.


Expression patterns of small numbers of transcripts from functionally-related pathways predict survival in multiple cancers.

Mandel J, Wang H, Normolle DP, Chen W, Yan Q, Lucas PC, Benos PV, Prochownik EV.

BMC Cancer. 2019 Jul 12;19(1):686. doi: 10.1186/s12885-019-5851-6.


Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet.

Rosselot C, Kumar A, Lakshmipathi J, Zhang P, Lu G, Katz LS, Prochownik EV, Stewart AF, Lambertini L, Scott DK, Garcia-Ocaña A.

Diabetes. 2019 Oct;68(10):1934-1949. doi: 10.2337/db18-1368. Epub 2019 Jul 10.


Inhibition of hepatocellular carcinoma by metabolic normalization.

Wang H, Lu J, Dolezal J, Kulkarni S, Zhang W, Chen A, Gorka J, Mandel JA, Prochownik EV.

PLoS One. 2019 Jun 26;14(6):e0218186. doi: 10.1371/journal.pone.0218186. eCollection 2019.


The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development.

Zhang Q, Li X, Cui K, Liu C, Wu M, Prochownik EV, Li Y.

Cell Death Differ. 2020 Feb;27(2):420-433. doi: 10.1038/s41418-019-0363-0. Epub 2019 Jun 11.


Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts.

Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES, Prochownik EV.

J Biol Chem. 2019 Apr 5;294(14):5466-5486. doi: 10.1074/jbc.RA118.005200. Epub 2019 Feb 12.


Erratum: Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5.

Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV.

Oncotarget. 2018 Oct 12;9(80):35196. doi: 10.18632/oncotarget.26241. eCollection 2018 Oct 12.


Amplification of Glyceronephosphate O-Acyltransferase and Recruitment of USP30 Stabilize DRP1 to Promote Hepatocarcinogenesis.

Gu L, Zhu Y, Lin X, Li Y, Cui K, Prochownik EV, Li Y.

Cancer Res. 2018 Oct 15;78(20):5808-5819. doi: 10.1158/0008-5472.CAN-18-0340. Epub 2018 Aug 24.


Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice.

Wang H, Dolezal JM, Kulkarni S, Lu J, Mandel J, Jackson LE, Alencastro F, Duncan AW, Prochownik EV.

J Biol Chem. 2018 Sep 21;293(38):14740-14757. doi: 10.1074/jbc.RA118.004099. Epub 2018 Aug 7.


The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues.

Goetzman ES, Prochownik EV.

Front Endocrinol (Lausanne). 2018 Apr 12;9:129. doi: 10.3389/fendo.2018.00129. eCollection 2018. Review.


The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth.

Li W, Cui K, Prochownik EV, Li Y.

Cell Death Dis. 2018 May 1;9(5):482. doi: 10.1038/s41419-018-0523-z.


Diagnostic and prognostic implications of ribosomal protein transcript expression patterns in human cancers.

Dolezal JM, Dash AP, Prochownik EV.

BMC Cancer. 2018 Mar 12;18(1):275. doi: 10.1186/s12885-018-4178-z.


Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation.

Jackson LE, Kulkarni S, Wang H, Lu J, Dolezal JM, Bharathi SS, Ranganathan S, Patel MS, Deshpande R, Alencastro F, Wendell SG, Goetzman ES, Duncan AW, Prochownik EV.

Cancer Res. 2017 Nov 1;77(21):5795-5807. doi: 10.1158/0008-5472.CAN-17-1325. Epub 2017 Sep 7.


Ribosomopathy-like properties of murine and human cancers.

Kulkarni S, Dolezal JM, Wang H, Jackson L, Lu J, Frodey BP, Dosunmu-Ogunbi A, Li Y, Fromherz M, Kang A, Santana-Santos L, Benos PV, Prochownik EV.

PLoS One. 2017 Aug 18;12(8):e0182705. doi: 10.1371/journal.pone.0182705. eCollection 2017.


OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.

Ivanov AA, Gonzalez-Pecchi V, Khuri LF, Niu Q, Wang Y, Xu Y, Bai Y, Mo X, Prochownik EV, Johns MA, Du Y, Khuri FR, Fu H.

Oncogene. 2017 Oct 19;36(42):5852-5860. doi: 10.1038/onc.2017.180. Epub 2017 Jun 19.


Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.

Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES.

J Biol Chem. 2017 Jun 16;292(24):10239-10249. doi: 10.1074/jbc.M117.785022. Epub 2017 Apr 30.


Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma.

Dolezal JM, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, Goetzman ES, Bharathi SS, Beezhold K, Byersdorfer CA, Prochownik EV.

J Biol Chem. 2017 Jun 16;292(24):10068-10086. doi: 10.1074/jbc.M117.782052. Epub 2017 Apr 21.


MicroRNA-based screens for synthetic lethal interactions with c-Myc.

Li Y, Zhu Y, Prochownik EV.

RNA Dis. 2016;3(3). pii: e1330. Epub 2016 May 30.


Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma.

Wang H, Lu J, Edmunds LR, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Beer-Stolz D, Uppala R, Bharathi S, Monga SP, Goetzman ES, Prochownik EV.

J Biol Chem. 2016 Dec 16;291(51):26241-26251. Epub 2016 Oct 13.


Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes.

Edmunds LR, Otero PA, Sharma L, D'Souza S, Dolezal JM, David S, Lu J, Lamm L, Basantani M, Zhang P, Sipula IJ, Li L, Zeng X, Ding Y, Ding F, Beck ME, Vockley J, Monga SP, Kershaw EE, O'Doherty RM, Kratz LE, Yates NA, Goetzman EP, Scott D, Duncan AW, Prochownik EV.

Oncotarget. 2016 May 24;7(21):30379-95. doi: 10.18632/oncotarget.8856.


microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13.

Han H, Chen Y, Cheng L, Prochownik EV, Li Y.

Oncotarget. 2016 Mar 29;7(13):16409-19. doi: 10.18632/oncotarget.7653.


Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.

Wang H, Teriete P, Hu A, Raveendra-Panickar D, Pendelton K, Lazo JS, Eiseman J, Holien T, Misund K, Oliynyk G, Arsenian-Henriksson M, Cosford ND, Sundan A, Prochownik EV.

Oncotarget. 2015 Oct 20;6(32):32380-95. doi: 10.18632/oncotarget.6116.


c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.

Edmunds LR, Sharma L, Kang A, Lu J, Vockley J, Basu S, Uppala R, Goetzman ES, Beck ME, Scott D, Prochownik EV.

J Biol Chem. 2015 Aug 14;290(33):20100. doi: 10.1074/jbc.A114.580662. No abstract available.


c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function.

Edmunds LR, Sharma L, Wang H, Kang A, d'Souza S, Lu J, McLaughlin M, Dolezal JM, Gao X, Weintraub ST, Ding Y, Zeng X, Yates N, Prochownik EV.

PLoS One. 2015 Jul 31;10(7):e0134049. doi: 10.1371/journal.pone.0134049. eCollection 2015.


Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion.

Wang H, Sharma L, Lu J, Finch P, Fletcher S, Prochownik EV.

Oncotarget. 2015 Jun 30;6(18):15857-70.


Small Molecule MYC Inhibitor Conjugated to Integrin-Targeted Nanoparticles Extends Survival in a Mouse Model of Disseminated Multiple Myeloma.

Soodgupta D, Pan D, Cui G, Senpan A, Yang X, Lu L, Weilbaecher KN, Prochownik EV, Lanza GM, Tomasson MH.

Mol Cancer Ther. 2015 Jun;14(6):1286-1294. doi: 10.1158/1535-7163.MCT-14-0774-T. Epub 2015 Mar 30.


Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.

Jung KY, Wang H, Teriete P, Yap JL, Chen L, Lanning ME, Hu A, Lambert LJ, Holien T, Sundan A, Cosford ND, Prochownik EV, Fletcher S.

J Med Chem. 2015 Apr 9;58(7):3002-24. doi: 10.1021/jm501440q. Epub 2015 Mar 30.


Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency.

Schiff M, Haberberger B, Xia C, Mohsen AW, Goetzman ES, Wang Y, Uppala R, Zhang Y, Karunanidhi A, Prabhu D, Alharbi H, Prochownik EV, Haack T, Häberle J, Munnich A, Rötig A, Taylor RW, Nicholls RD, Kim JJ, Prokisch H, Vockley J.

Hum Mol Genet. 2015 Jun 1;24(11):3238-47. doi: 10.1093/hmg/ddv074. Epub 2015 Feb 26.


c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.

Edmunds LR, Sharma L, Kang A, Lu J, Vockley J, Basu S, Uppala R, Goetzman ES, Beck ME, Scott D, Prochownik EV.

J Biol Chem. 2014 Sep 5;289(36):25382-92. doi: 10.1074/jbc.M114.580662. Epub 2014 Jul 22. Erratum in: J Biol Chem. 2015 Aug 14;290(33):20100.


Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization.

Chauhan J, Wang H, Yap JL, Sabato PE, Hu A, Prochownik EV, Fletcher S.

ChemMedChem. 2014 Oct;9(10):2274-2285. doi: 10.1002/cmdc.201402189. Epub 2014 Jun 27.


Targeting of the MYCN protein with small molecule c-MYC inhibitors.

Müller I, Larsson K, Frenzel A, Oliynyk G, Zirath H, Prochownik EV, Westwood NJ, Henriksson MA.

PLoS One. 2014 May 23;9(5):e97285. doi: 10.1371/journal.pone.0097285. eCollection 2014.


Small-molecule inhibitors of the Myc oncoprotein.

Fletcher S, Prochownik EV.

Biochim Biophys Acta. 2015 May;1849(5):525-43. doi: 10.1016/j.bbagrm.2014.03.005. Epub 2014 Mar 19. Review.


Rapid in vitro derivation of endothelium directly from human cancer cells.

Elster JD, McGuire TF, Lu J, Prochownik EV.

PLoS One. 2013 Oct 9;8(10):e77675. doi: 10.1371/journal.pone.0077675. eCollection 2013.


Disruption of Myc-Max heterodimerization with improved cell-penetrating analogs of the small molecule 10074-G5.

Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV.

Oncotarget. 2013 Jun;4(6):936-47. Erratum in: Oncotarget. 2018 Oct 12;9(80):35196.


Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.

Sarin M, Wang Y, Zhang F, Rothermund K, Zhang Y, Lu J, Sims-Lucas S, Beer-Stolz D, Van Houten BE, Vockley J, Goetzman ES, Graves JA, Prochownik EV.

Cell Death Dis. 2013 Jun 13;4:e670. doi: 10.1038/cddis.2013.201.


Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.

Kim SY, Rhee JG, Song X, Prochownik EV, Spitz DR, Lee YJ.

PLoS One. 2012;7(11):e50423. doi: 10.1371/journal.pone.0050423. Epub 2012 Nov 21.


Pharmacophore identification of c-Myc inhibitor 10074-G5.

Yap JL, Wang H, Hu A, Chauhan J, Jung KY, Gharavi RB, Prochownik EV, Fletcher S.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):370-4. doi: 10.1016/j.bmcl.2012.10.013. Epub 2012 Oct 17.


Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic target.

Zhang F, Rothermund K, Gangadharan SB, Pommier Y, Prochownik EV, Lazo JS.

Oncotarget. 2012 Sep;3(9):998-1010.


Mitochondrial structure, function and dynamics are temporally controlled by c-Myc.

Graves JA, Wang Y, Sims-Lucas S, Cherok E, Rothermund K, Branca MF, Elster J, Beer-Stolz D, Van Houten B, Vockley J, Prochownik EV.

PLoS One. 2012;7(5):e37699. doi: 10.1371/journal.pone.0037699. Epub 2012 May 21.


In vivo evolution of tumor-derived endothelial cells.

McGuire TF, Sajithlal GB, Lu J, Nicholls RD, Prochownik EV.

PLoS One. 2012;7(5):e37138. doi: 10.1371/journal.pone.0037138. Epub 2012 May 18.


Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.

Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F, Payne E, Mansour M, Dahlberg SE, Neuberg DS, den Hertog J, Prochownik EV, Testa JR, Harris M, Kanki JP, Look AT.

J Exp Med. 2011 Aug 1;208(8):1595-603. doi: 10.1084/jem.20101691. Epub 2011 Jul 4.


Therapeutic Targeting of Myc.

Prochownik EV, Vogt PK.

Genes Cancer. 2010 Jun;1(6):650-659.


Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts.

Graves JA, Rothermund K, Wang T, Qian W, Van Houten B, Prochownik EV.

PLoS One. 2010 Oct 28;5(10):e13717. doi: 10.1371/journal.pone.0013717.


In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.

Clausen DM, Guo J, Parise RA, Beumer JH, Egorin MJ, Lazo JS, Prochownik EV, Eiseman JL.

J Pharmacol Exp Ther. 2010 Dec;335(3):715-27. doi: 10.1124/jpet.110.170555. Epub 2010 Aug 26.


The c-Myc target glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cells.

Wu Q, Xu FL, Li Y, Prochownik EV, Saunders WS.

PLoS One. 2010 May 25;5(5):e10819. doi: 10.1371/journal.pone.0010819.


Permanently blocked stem cells derived from breast cancer cell lines.

Sajithlal GB, Rothermund K, Zhang F, Dabbs DJ, Latimer JJ, Grant SG, Prochownik EV.

Stem Cells. 2010 Jun;28(6):1008-18. doi: 10.1002/stem.424.


c-Myc is required for the CHREBP-dependent activation of glucose-responsive genes.

Zhang P, Metukuri MR, Bindom SM, Prochownik EV, O'Doherty RM, Scott DK.

Mol Endocrinol. 2010 Jun;24(6):1274-86. doi: 10.1210/me.2009-0437. Epub 2010 Apr 9.


Endothelial-like cells derived directly from human tumor xenografts.

Sajithlal GB, McGuire TF, Lu J, Beer-Stolz D, Prochownik EV.

Int J Cancer. 2010 Nov 15;127(10):2268-78. doi: 10.1002/ijc.25251.

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