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A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing.

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A, Dhayade S, Athineos D, Caley M, Mannella V, Blyth K, Inman GJ, Leigh IM.

Int J Mol Sci. 2019 Jul 12;20(14). pii: E3428. doi: 10.3390/ijms20143428.


Azathioprine: friend or foe?

Leigh IM, Proby CM, Inman GJ, Harwood CA.

Br J Dermatol. 2019 May;180(5):961-963. doi: 10.1111/bjd.17345. No abstract available.


Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.

Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA, Dinkova-Kostova AT.

PLoS One. 2019 Mar 13;14(3):e0213095. doi: 10.1371/journal.pone.0213095. eCollection 2019.


Epidemiology of basal and cutaneous squamous cell carcinoma in the U.K. 2013-15: a cohort study.

Venables ZC, Nijsten T, Wong KF, Autier P, Broggio J, Deas A, Harwood CA, Hollestein LM, Langan SM, Morgan E, Proby CM, Rashbass J, Leigh IM.

Br J Dermatol. 2019 Sep;181(3):474-482. doi: 10.1111/bjd.17873. Epub 2019 May 6.


Keratinocyte Carcinomas: Current Concepts and Future Research Priorities.

Nagarajan P, Asgari MM, Green AC, Guhan SM, Arron ST, Proby CM, Rollison DE, Harwood CA, Toland AE.

Clin Cancer Res. 2019 Apr 15;25(8):2379-2391. doi: 10.1158/1078-0432.CCR-18-1122. Epub 2018 Dec 6. Review.


Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients.

Lanz J, Bouwes Bavinck JN, Westhuis M, Quint KD, Harwood CA, Nasir S, Van-de-Velde V, Proby CM, Ferrándiz C, Genders RE, Del Marmol V, Forchetti G, Hafner J, Vital DG, Hofbauer GFL.

JAMA Dermatol. 2019 Jan 1;155(1):66-71. doi: 10.1001/jamadermatol.2018.4406.


Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England.

Venables ZC, Autier P, Nijsten T, Wong KF, Langan SM, Rous B, Broggio J, Harwood C, Henson K, Proby CM, Rashbass J, Leigh IM.

JAMA Dermatol. 2019 Mar 1;155(3):298-306. doi: 10.1001/jamadermatol.2018.4219.


The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.

Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J, Hogan S, Spender LC, South AP, Stratton M, Chelala C, Harwood CA, Proby CM, Leigh IM.

Nat Commun. 2018 Sep 10;9(1):3667. doi: 10.1038/s41467-018-06027-1.


The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions.

Purdie KJ, Proby CM, Rizvi H, Griffin H, Doorbar J, Sommerlad M, Feltkamp MC, der Meijden EV, Inman GJ, South AP, Leigh IM, Harwood CA.

Front Microbiol. 2018 Aug 14;9:1806. doi: 10.3389/fmicb.2018.01806. eCollection 2018.


Completion lymphadenectomy should not necessarily be recommended after a positive sentinel lymph node biopsy.

Affleck AG, Proby CM.

Clin Exp Dermatol. 2019 Jan;44(1):79-80. doi: 10.1111/ced.13725. Epub 2018 Aug 20. No abstract available.


The new 8th edition of TNM staging and its implications for skin cancer: a review by the British Association of Dermatologists and the Royal College of Pathologists, U.K.

Keohane SG, Proby CM, Newlands C, Motley RJ, Nasr I, Mohd Mustapa MF; British Association of Dermatologists (Squamous and Basal Cell Carcinoma Guideline Development Groups), Slater DN; Royal College of Pathologists (Skin Cancer Lead).

Br J Dermatol. 2018 Oct;179(4):824-828. doi: 10.1111/bjd.16892. Epub 2018 Sep 5. Review.


Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity.

Hepburn LA, McHugh A, Fernandes K, Boag G, Proby CM, Leigh IM, Saville MK.

Oncotarget. 2018 May 1;9(33):23029-23046. doi: 10.18632/oncotarget.25196. eCollection 2018 May 1.


Patient preferences for topical treatment of actinic keratoses: a discrete-choice experiment.

Kopasker D, Kwiatkowski A, Matin RN, Harwood CA, Ismail F, Lear JT, Thomson J, Hasan Z, Wali GN, Milligan A, Crawford L, Ahmed I, Duffy H, Proby CM, Allanson PF.

Br J Dermatol. 2019 Apr;180(4):902-909. doi: 10.1111/bjd.16801. Epub 2018 Jul 26.


Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity.

McHugh A, Fernandes K, South AP, Mellerio JE, Salas-Alanís JC, Proby CM, Leigh IM, Saville MK.

Oncotarget. 2018 Apr 17;9(29):20265-20281. doi: 10.18632/oncotarget.24750. eCollection 2018 Apr 17.


The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis.

Harkins CP, McAleer MA, Bennett D, McHugh M, Fleury OM, Pettigrew KA, Oravcová K, Parkhill J, Proby CM, Dawe RS, Geoghegan JA, Irvine AD, Holden MTG.

Br J Dermatol. 2018 Oct;179(4):951-958. doi: 10.1111/bjd.16722. Epub 2018 Jul 24.


Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.

Rose AM, Spender LC, Stephen C, Mitchell A, Rickaby W, Bray S, Evans AT, Dayal J, Purdie KJ, Harwood CA, Proby CM, Leigh IM, Coates PJ, Inman GJ.

Oncotarget. 2018 Feb 22;9(18):14552-14566. doi: 10.18632/oncotarget.24545. eCollection 2018 Mar 6.


Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis.

Toutfaire M, Dumortier E, Fattaccioli A, Van Steenbrugge M, Proby CM, Debacq-Chainiaux F.

Int J Biochem Cell Biol. 2018 May;98:113-126. doi: 10.1016/j.biocel.2018.03.005. Epub 2018 Mar 14.


Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.

Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4.


Organ transplantation and cutaneous squamous cell carcinoma: progress, pitfalls and priorities in immunosuppression-associated keratinocyte carcinoma.

Harwood CA, Arron ST, Proby CM, Asgari MM, Bouwes Bavinck JN, Green AC, Toland AE; KeraCon Consortium.

Br J Dermatol. 2017 Nov;177(5):1150-1151. doi: 10.1111/bjd.15932. No abstract available.


Genomic analysis of atypical fibroxanthoma.

Lai K, Harwood CA, Purdie KJ, Proby CM, Leigh IM, Ravi N, Mully TW, Brooks L, Sandoval PM, Rosenblum MD, Arron ST.

PLoS One. 2017 Nov 15;12(11):e0188272. doi: 10.1371/journal.pone.0188272. eCollection 2017.


The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients.

Harwood CA, Toland AE, Proby CM, Euvrard S, Hofbauer GFL, Tommasino M, Bouwes Bavinck JN; KeraCon Consortium.

Br J Dermatol. 2017 Nov;177(5):1217-1224. doi: 10.1111/bjd.15956. Epub 2017 Oct 30. Review.


Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study.

Bouwes Bavinck JN, Feltkamp MCW, Green AC, Fiocco M, Euvrard S, Harwood CA, Nasir S, Thomson J, Proby CM, Naldi L, Diphoorn JCD, Venturuzzo A, Tessari G, Nindl I, Sampogna F, Abeni D, Neale RE, Goeman JJ, Quint KD, Halk AB, Sneek C, Genders RE, de Koning MNC, Quint WGV, Wieland U, Weissenborn S, Waterboer T, Pawlita M, Pfister H; EPI-HPV-UV-CA group.

Am J Transplant. 2018 May;18(5):1220-1230. doi: 10.1111/ajt.14537. Epub 2017 Nov 22.


The Microevolution and Epidemiology of Staphylococcus aureus Colonization during Atopic Eczema Disease Flare.

Harkins CP, Pettigrew KA, Oravcová K, Gardner J, Hearn RMR, Rice D, Mather AE, Parkhill J, Brown SJ, Proby CM, Holden MTG.

J Invest Dermatol. 2018 Feb;138(2):336-343. doi: 10.1016/j.jid.2017.09.023. Epub 2017 Sep 23.


Patients with low-risk cutaneous squamous cell carcinoma do not require extended out-patient follow-up.

Rose AM, Nicoll KJ, Moinie A, Jordan DJ, Evans AT, Proby CM, Naasan A.

J Plast Reconstr Aesthet Surg. 2017 Jun;70(6):852-855. doi: 10.1016/j.bjps.2017.03.006. Epub 2017 Apr 6. No abstract available.


Painful skin lesions and squamous cell carcinoma predict overall mortality risk in organ transplant recipients: a cohort study.

Oh CC, Hofbauer GFL, Serra AL, Harwood CA, Mitchell L, Proby CM, Olasz EB, Mosel DD, Piaserico S, Fortina AB, Geusau A, Jahn-Bassler K, Gerritsen MJP, Seçkin D, Güleç AT, Cetkovská P, Ricar J, Imko-Walczuk B, Dębska-Ślizień A, Bouwes Bavinck JN.

Br J Dermatol. 2017 May;176(5):1179-1186. doi: 10.1111/bjd.15269. Epub 2017 Apr 10.


Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.

Knatko EV, Praslicka B, Higgins M, Evans A, Purdie KJ, Harwood CA, Proby CM, Ooi A, Dinkova-Kostova AT.

Cancer Prev Res (Phila). 2017 Jan;10(1):67-75. doi: 10.1158/1940-6207.CAPR-16-0218. Epub 2016 Dec 6.


Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, Sapkota GP, Purdie KJ, Proby CM, Harwood CA, Leigh IM, Clevers H, Barker N, Karlsson S, Pritchard C, Marais R, Chelala C, South AP, Sansom OJ, Inman GJ.

Nat Commun. 2016 Aug 25;7:12493. doi: 10.1038/ncomms12493.


MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma.

Adelmann CH, Truong KA, Liang RJ, Bansal V, Gandee L, Saporito RC, Lee W, Du L, Nicholas C, Napoli M, Mino B, South AP, Proby CM, Leigh IM, Coarfa C, Flores ER, Tsai KY.

J Invest Dermatol. 2016 Sep;136(9):1920-1924. doi: 10.1016/j.jid.2016.05.110. Epub 2016 Jun 9. No abstract available.


CREBBP mutation in human cutaneous squamous cell carcinoma.

Watt SA, Purdie KJ, den Breems NY, Dimon M, Tucker S, Arron ST, McHugh A, Xue DJ, Dayal JH, Harwood CA, Leigh IM, Proby CM, South AP.

Exp Dermatol. 2016 Aug;25(8):650-1. doi: 10.1111/exd.13044. Epub 2016 Jun 30. No abstract available.


Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation.

Watt SA, Purdie KJ, den Breems NY, Dimon M, Arron ST, McHugh AT, Xue DJ, Dayal JH, Proby CM, Harwood CA, Leigh IM, South AP.

Am J Pathol. 2015 Sep;185(9):2354-63. doi: 10.1016/j.ajpath.2015.05.018. Epub 2015 Jul 26.


The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma.

Harwood CA, Proby CM, Inman GJ, Leigh IM.

Acta Derm Venereol. 2016 Jan;96(1):3-16. doi: 10.2340/00015555-2181. Review.


MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma.

Olasz EB, Seline LN, Schock AM, Duncan NE, Lopez A, Lazar J, Flister MJ, Lu Y, Liu P, Sokumbi O, Harwood CA, Proby CM, Neuburg M, Lazarova Z.

PLoS One. 2015 May 4;10(5):e0125412. doi: 10.1371/journal.pone.0125412. eCollection 2015.


Is an online skin cancer toolkit an effective way to educate primary care physicians about skin cancer diagnosis and referral?

Gulati A, Harwood CA, Rolph J, Pottinger E, Mcgregor JM, Goad N, Proby CM.

J Eur Acad Dermatol Venereol. 2015 Nov;29(11):2152-9. doi: 10.1111/jdv.13167. Epub 2015 Apr 27.


Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.

Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT.

Cancer Prev Res (Phila). 2015 Jun;8(6):475-86. doi: 10.1158/1940-6207.CAPR-14-0362. Epub 2015 Mar 24.


Actinic keratoses, actinic field change and associations with squamous cell carcinoma in renal transplant recipients in Manchester, UK.

Wallingford SC, Russell SA, Vail A, Proby CM, Lear JT, Green AC.

Acta Derm Venereol. 2015 Sep;95(7):830-4. doi: 10.2340/00015555-2098.


Pain identifies squamous cell carcinoma in organ transplant recipients: the SCOPE-ITSCC PAIN study.

Bouwes Bavinck JN, Harwood CA, Genders RE, Wisgerhof HC, Plasmeijer EI, Mitchell L, Olasz EB, Mosel DD, Pokorney MS, Serra AL, Feldmeyer L, Baumann Conzett K, Piaserico S, Belloni Fortina A, Jahn K, Geusau A, Gerritsen MJ, Seckin D, Gulec AT, Cetkovska P, Ricar J, Imko-Walczuk B, Proby CM, Hofbauer GF.

Am J Transplant. 2014 Mar;14(3):668-76.


NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.

South AP, Purdie KJ, Watt SA, Haldenby S, den Breems N, Dimon M, Arron ST, Kluk MJ, Aster JC, McHugh A, Xue DJ, Dayal JH, Robinson KS, Rizvi SH, Proby CM, Harwood CA, Leigh IM.

J Invest Dermatol. 2014 Oct;134(10):2630-2638. doi: 10.1038/jid.2014.154. Epub 2014 Mar 24.


Primary cutaneous posttransplant lymphoproliferative disorders in solid organ transplant recipients: a multicenter European case series.

Seçkin D, Barete S, Euvrard S, Francès C, Kanitakis J, Geusau A, Del Marmol V, Harwood CA, Proby CM, Ali I, Güleç AT, Durukan E, Lebbé C, Alaibac M, Laffitte E, Cooper S, Bouwes Bavinck JN, Murphy GM, Ferrándiz C, Mørk C, Cetkovská P, Kempf W, Hofbauer GF.

Am J Transplant. 2013 Aug;13(8):2146-53. doi: 10.1111/ajt.12281. Epub 2013 May 29.


p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.

Matin RN, Chikh A, Chong SL, Mesher D, Graf M, Sanza' P, Senatore V, Scatolini M, Moretti F, Leigh IM, Proby CM, Costanzo A, Chiorino G, Cerio R, Harwood CA, Bergamaschi D.

J Exp Med. 2013 Mar 11;210(3):581-603. doi: 10.1084/jem.20121439. Epub 2013 Feb 18.


Two-year randomized controlled prospective trial converting treatment of stable renal transplant recipients with cutaneous invasive squamous cell carcinomas to sirolimus.

Hoogendijk-van den Akker JM, Harden PN, Hoitsma AJ, Proby CM, Wolterbeek R, Bouwes Bavinck JN, de Fijter JW.

J Clin Oncol. 2013 Apr 1;31(10):1317-23. doi: 10.1200/JCO.2012.45.6376. Epub 2013 Jan 28.


Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients.

Antonsson A, Waterboer T, Bouwes Bavinck JN, Abeni D, de Koning M, Euvrard S, Feltkamp MC, Green AC, Harwood CA, Naldi L, Nindl I, Pfister HJ, Proby CM, Quint WG, Stockfleth E, Weissenborn SJ, Pawlita M, Neale RE; EPI-HPV-UV-CA group.

Virology. 2013 Feb 5;436(1):91-9. doi: 10.1016/j.virol.2012.10.037. Epub 2012 Nov 20.


Longitudinal study of seroprevalence and serostability of the human polyomaviruses JCV and BKV in organ transplant recipients.

Antonsson A, Pawlita M, Feltkamp MC, Bouwes Bavinck JN, Euvrard S, Harwood CA, Naldi L, Nindl I, Proby CM, Neale RE, Waterboer T.

J Med Virol. 2013 Feb;85(2):327-35. doi: 10.1002/jmv.23472. Epub 2012 Nov 21.


A surveillance model for skin cancer in organ transplant recipients: a 22-year prospective study in an ethnically diverse population.

Harwood CA, Mesher D, McGregor JM, Mitchell L, Leedham-Green M, Raftery M, Cerio R, Leigh IM, Sasieni P, Proby CM.

Am J Transplant. 2013 Jan;13(1):119-29. doi: 10.1111/j.1600-6143.2012.04292.x. Epub 2012 Oct 16.


Risk factors for actinic keratosis in eight European centres: a case-control study.

Traianou A, Ulrich M, Apalla Z, De Vries E, Bakirtzi K, Kalabalikis D, Ferrandiz L, Ruiz-de-Casas A, Moreno-Ramirez D, Sotiriadis D, Ioannides D, Aquilina S, Apap C, Micallef R, Scerri L, Pitkänen S, Saksela O, Altsitsiadis E, Hinrichs B, Magnoni C, Fiorentini C, Majewski S, Ranki A, Proby CM, Stockfleth E, Trakatelli M; EPIDERM Group.

Br J Dermatol. 2012 Aug;167 Suppl 2:36-42. doi: 10.1111/j.1365-2133.2012.11085.x.


Basal cell carcinomas without histological confirmation and their treatment: an audit in four European regions.

Flohil SC, Proby CM, Forrest AD, van Tiel S, Saksela O, Pitkänen S, Ahti T, Micallef R, de Vries E; EPIDERM Group.

Br J Dermatol. 2012 Aug;167 Suppl 2:22-8. doi: 10.1111/j.1365-2133.2012.11083.x.


Population-based estimates of the occurrence of multiple vs first primary basal cell carcinomas in 4 European regions.

de Vries E, Micallef R, Brewster DH, Gibbs JH, Flohil SC, Saksela O, Sankila R, Forrest AD, Trakatelli M, Coebergh JW, Proby CM; EPIDERM Group.

Arch Dermatol. 2012 Mar;148(3):347-54. doi: 10.1001/archdermatol.2011.2244.


Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene.

Lambert SR, Harwood CA, Purdie KJ, Gulati A, Matin RN, Romanowska M, Cerio R, Kelsell DP, Leigh IM, Proby CM.

Int J Cancer. 2012 Aug 1;131(3):E216-26. doi: 10.1002/ijc.27333. Epub 2011 Dec 21.


Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17761-6. doi: 10.1073/pnas.1114669108. Epub 2011 Oct 17.


Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients.

Sampogna F, Bavinck JN, Pawlita M, Abeni D, Harwood CA, Proby CM, Feltkamp MC, Euvrard S, Naldi L, Neale RE, Nindl I, Pfister H, Quint WG, Waterboer T; EPI-HPV-UV-CA Group.

J Gen Virol. 2012 Jan;93(Pt 1):165-74. doi: 10.1099/vir.0.035493-0. Epub 2011 Sep 7.


Beta-papillomavirus DNA loads in hair follicles of immunocompetent people and organ transplant recipients.

Weissenborn S, Neale RE, Waterboer T, Abeni D, Bavinck JN, Green AC, Harwood CA, Euvrard S, Feltkamp MC, de Koning MN, Naldi L, Quint WG, Tessari G, Proby CM, Wieland U, Pfister H; EPI-HPV-UV-CA group.

Med Microbiol Immunol. 2012 May;201(2):117-25. doi: 10.1007/s00430-011-0212-3. Epub 2011 Jul 27.


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