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Items: 1 to 50 of 81

1.

Mesenchymal Stem Cell Protection of Neurons against Glutamate Excitotoxicity Involves Reduction of NMDA-Triggered Calcium Responses and Surface GluR1, and Is Partly Mediated by TNF.

Papazian I, Kyrargyri V, Evangelidou M, Voulgari-Kokota A, Probert L.

Int J Mol Sci. 2018 Feb 25;19(3). pii: E651. doi: 10.3390/ijms19030651.

2.

A Cyclic Altered Peptide Analogue Based on Myelin Basic Protein 87-99 Provides Lasting Prophylactic and Therapeutic Protection Against Acute Experimental Autoimmune Encephalomyelitis.

Emmanouil M, Tseveleki V, Triantafyllakou I, Nteli A, Tselios T, Probert L.

Molecules. 2018 Jan 31;23(2). pii: E304. doi: 10.3390/molecules23020304.

3.

Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia.

Karamita M, Barnum C, Möbius W, Tansey MG, Szymkowski DE, Lassmann H, Probert L.

JCI Insight. 2017 Apr 20;2(8). pii: 87455. doi: 10.1172/jci.insight.87455. eCollection 2017 Apr 20.

4.

Inhibition of the neuronal NFκB pathway attenuates bortezomib-induced neuropathy in a mouse model.

Alé A, Bruna J, Calls A, Karamita M, Haralambous S, Probert L, Navarro X, Udina E.

Neurotoxicology. 2016 Jul;55:58-64. doi: 10.1016/j.neuro.2016.05.004. Epub 2016 May 19.

PMID:
27211850
5.

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects.

Probert L.

Neuroscience. 2015 Aug 27;302:2-22. doi: 10.1016/j.neuroscience.2015.06.038. Epub 2015 Jun 24. Review.

6.

Mannan-conjugated myelin peptides prime non-pathogenic Th1 and Th17 cells and ameliorate experimental autoimmune encephalomyelitis.

Tseveleki V, Tselios T, Kanistras I, Koutsoni O, Karamita M, Vamvakas SS, Apostolopoulos V, Dotsika E, Matsoukas J, Lassmann H, Probert L.

Exp Neurol. 2015 May;267:254-67. doi: 10.1016/j.expneurol.2014.10.019. Epub 2014 Oct 30.

PMID:
25447934
7.

Differential contributions of microglial and neuronal IKKβ to synaptic plasticity and associative learning in alert behaving mice.

Kyrargyri V, Vega-Flores G, Gruart A, Delgado-García JM, Probert L.

Glia. 2015 Apr;63(4):549-66. doi: 10.1002/glia.22756. Epub 2014 Oct 9.

PMID:
25297800
8.

Altered expression of oligodendrocyte and neuronal marker genes predicts the clinical onset of autoimmune encephalomyelitis and indicates the effectiveness of multiple sclerosis-directed therapeutics.

Evangelidou M, Karamita M, Vamvakas SS, Szymkowski DE, Probert L.

J Immunol. 2014 May 1;192(9):4122-33. doi: 10.4049/jimmunol.1300633. Epub 2014 Mar 28.

9.

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.

Schuh C, Wimmer I, Hametner S, Haider L, Van Dam AM, Liblau RS, Smith KJ, Probert L, Binder CJ, Bauer J, Bradl M, Mahad D, Lassmann H.

Acta Neuropathol. 2014 Aug;128(2):247-66. doi: 10.1007/s00401-014-1263-5. Epub 2014 Mar 13.

10.

Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function.

Voulgari-Kokota A, Fairless R, Karamita M, Kyrargyri V, Tseveleki V, Evangelidou M, Delorme B, Charbord P, Diem R, Probert L.

Exp Neurol. 2012 Jul;236(1):161-70. doi: 10.1016/j.expneurol.2012.04.011. Epub 2012 Apr 25.

PMID:
22561409
11.

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.

Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L.

Brain. 2011 Sep;134(Pt 9):2722-35. doi: 10.1093/brain/awr203.

PMID:
21908876
12.

A role for neuronal NF-κB in suppressing neuroinflammation and promoting neuroprotection in the CNS.

Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Probert L.

Adv Exp Med Biol. 2011;691:575-81. doi: 10.1007/978-1-4419-6612-4_60. No abstract available.

PMID:
21153363
13.

Erythropoietin: not just about erythropoiesis.

Ghezzi P, Bernaudin M, Bianchi R, Blomgren K, Brines M, Campana W, Cavaletti G, Cerami A, Chopp M, Coleman T, Digicaylioglu M, Ehrenreich H, Erbayraktar S, Erbayraktar Z, Gassmann M, Genc S, Gokmen N, Grasso G, Juul S, Lipton SA, Hand CC, Latini R, Lauria G, Leist M, Newton SS, Petit E, Probert L, Sfacteria A, Siren AL, Talan M, Thiemermann C, Westenbrink D, Yaqoob M, Zhu C.

Lancet. 2010 Jun 19;375(9732):2142. doi: 10.1016/S0140-6736(10)60992-0. No abstract available. Erratum in: Lancet. 2010 Aug 7;376(9739):418. Bernaudinb, Myriam [corrected to Bernaudin, Myrian]; Bianchic, Roberto [corrected to Bianchi, Roberto].

14.

Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes.

Tseveleki V, Rubio R, Vamvakas SS, White J, Taoufik E, Petit E, Quackenbush J, Probert L.

Genomics. 2010 Aug;96(2):82-91. doi: 10.1016/j.ygeno.2010.04.004. Epub 2010 May 7.

15.

TNFRI is a positive T-cell costimulatory molecule important for the timing of cytokine responses.

Evangelidou M, Tseveleki V, Vamvakas SS, Probert L.

Immunol Cell Biol. 2010 Jul;88(5):586-95. doi: 10.1038/icb.2010.12. Epub 2010 Mar 9.

PMID:
20212506
16.

Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system.

Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Tselios T, Karin M, Lassmann H, Probert L.

J Immunol. 2009 Dec 15;183(12):7877-89. doi: 10.4049/jimmunol.0900834.

17.

Gene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cells.

Moumtzi SS, Roberts ML, Joyce T, Evangelidou M, Probert L, Frillingos S, Fotsis T, Pintzas A.

Cancer Invest. 2010 Jul;28(6):563-87. doi: 10.3109/07357900903095623.

PMID:
19883200
18.
19.

Ischemic neuronal damage.

Taoufik E, Probert L.

Curr Pharm Des. 2008;14(33):3565-73. Review.

PMID:
19075733
20.

TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury.

Taoufik E, Petit E, Divoux D, Tseveleki V, Mengozzi M, Roberts ML, Valable S, Ghezzi P, Quackenbush J, Brines M, Cerami A, Probert L.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6185-90. doi: 10.1073/pnas.0801447105. Epub 2008 Apr 14.

21.

Positive and negative implications of tumor necrosis factor neutralization for the pathogenesis of multiple sclerosis.

Taoufik E, Tseveleki V, Euagelidou M, Emmanouil M, Voulgari-Kokota A, Haralambous S, Probert L.

Neurodegener Dis. 2008;5(1):32-7. Review.

PMID:
18075273
22.

Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt.

Quinones MP, Kalkonde Y, Estrada CA, Jimenez F, Ramirez R, Mahimainathan L, Mummidi S, Choudhury GG, Martinez H, Adams L, Mack M, Reddick RL, Maffi S, Haralambous S, Probert L, Ahuja SK, Ahuja SS.

Mol Cell Neurosci. 2008 Jan;37(1):96-109. Epub 2007 Sep 14.

23.

Cellular FLIP long isoform transgenic mice overcome inherent Th2-biased immune responses to efficiently resolve Leishmania major infection.

Tseveleki V, Tsagozis P, Koutsoni O, Dotsika E, Probert L.

Int Immunol. 2007 Oct;19(10):1183-9. Epub 2007 Sep 18.

PMID:
17878261
24.

FLIP(L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death.

Taoufik E, Valable S, Müller GJ, Roberts ML, Divoux D, Tinel A, Voulgari-Kokota A, Tseveleki V, Altruda F, Lassmann H, Petit E, Probert L.

J Neurosci. 2007 Jun 20;27(25):6633-46.

25.

Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.

Mastronardi FG, Wood DD, Mei J, Raijmakers R, Tseveleki V, Dosch HM, Probert L, Casaccia-Bonnefil P, Moscarello MA.

J Neurosci. 2006 Nov 1;26(44):11387-96.

26.

Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis.

Tseveleki V, Bauer J, Taoufik E, Ruan C, Leondiadis L, Haralambous S, Lassmann H, Probert L.

J Immunol. 2004 Dec 1;173(11):6619-26.

27.

Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis.

Akassoglou K, Adams RA, Bauer J, Mercado P, Tseveleki V, Lassmann H, Probert L, Strickland S.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6698-703. Epub 2004 Apr 19.

28.

Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice.

Akassoglou K, Douni E, Bauer J, Lassmann H, Kollias G, Probert L.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):709-14. Epub 2003 Jan 9.

29.

Antagonistic effects of human cyclic MBP(87-99) altered peptide ligands in experimental allergic encephalomyelitis and human T-cell proliferation.

Tselios T, Apostolopoulos V, Daliani I, Deraos S, Grdadolnik S, Mavromoustakos T, Melachrinou M, Thymianou S, Probert L, Mouzaki A, Matsoukas J.

J Med Chem. 2002 Jan 17;45(2):275-83.

PMID:
11784132
30.
31.

Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85.

Tselios T, Daliani I, Deraos S, Thymianou S, Matsoukas E, Troganis A, Gerothanassis I, Mouzaki A, Mavromoustakos T, Probert L, Matsoukas J.

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2713-7.

PMID:
11133075
32.

TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease.

Probert L, Eugster HP, Akassoglou K, Bauer J, Frei K, Lassmann H, Fontana A.

Brain. 2000 Oct;123 ( Pt 10):2005-19. Review.

PMID:
11004118
33.

Treatment of experimental allergic encephalomyelitis (EAE) induced by guinea pig myelin basic protein epitope 72-85 with a human MBP(87-99) analogue and effects of cyclic peptides.

Tselios T, Daliani I, Probert L, Deraos S, Matsoukas E, Roy S, Pires J, Moore G, Matsoukas J.

Bioorg Med Chem. 2000 Aug;8(8):1903-9.

PMID:
11003134
34.

Learning performances, brain NGF distribution and NPY levels in transgenic mice expressing TNF-alpha.

Fiore M, Angelucci F, Alleva E, Branchi I, Probert L, Aloe L.

Behav Brain Res. 2000 Jul;112(1-2):165-75.

PMID:
10862948
35.

Transgenic models of TNF induced demyelination.

Akassoglou K, Bauer J, Kassiotis G, Lassmann H, Kollias G, Probert L.

Adv Exp Med Biol. 1999;468:245-59. Review. No abstract available.

PMID:
10635034
36.

Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha transgenic mice, one characterized by neurological disorders, the other phenotypically normal.

Aloe L, Properzi F, Probert L, Akassoglou K, Kassiotis G, Micera A, Fiore M.

Brain Res. 1999 Sep 4;840(1-2):125-37.

PMID:
10517960
37.

Effects of hTNFalpha expression in T cells on haematopoiesis in transgenic mice.

Glosli H, Veiby OP, Fjerdingstad H, Mehlum A, Probert L, Kollias G, Gjernes E, Prydz H.

Eur J Haematol. 1999 Jul;63(1):50-60.

PMID:
10414455
38.

Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution?

Iqbal M, Probert LL, Alhumadi NH, Klandorf H.

J Gerontol A Biol Sci Med Sci. 1999 Apr;54(4):B171-6; discussion B177-8.

PMID:
10219005
39.

Design and synthesis of a potent cyclic analogue of the myelin basic protein epitope MBP72-85: importance of the Ala81 carboxyl group and of a cyclic conformation for induction of experimental allergic encephalomyelitis.

Tselios T, Probert L, Daliani I, Matsoukas E, Troganis A, Gerothanassis IP, Mavromoustakos T, Moore GJ, Matsoukas JM.

J Med Chem. 1999 Apr 8;42(7):1170-7.

PMID:
10197961
40.

A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice.

Kassiotis G, Bauer J, Akassoglou K, Lassmann H, Kollias G, Probert L.

Eur J Immunol. 1999 Mar;29(3):912-7.

41.
43.

Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on myelin basic protein (MBP).

Tselios T, Probert L, Kollias G, Matsoukas E, Roumelioti P, Alexopoulos K, Moore GJ, Matsoukas J.

Amino Acids. 1998;14(4):333-41.

PMID:
9871477
45.

Exploratory and displacement behavior in transgenic mice expressing high levels of brain TNF-alpha.

Fiore M, Alleva E, Probert L, Kollias G, Angelucci F, Aloe L.

Physiol Behav. 1998 Feb 15;63(4):571-6.

PMID:
9523900
46.

Interleukin 6 is required for the development of collagen-induced arthritis.

Alonzi T, Fattori E, Lazzaro D, Costa P, Probert L, Kollias G, De Benedetti F, Poli V, Ciliberto G.

J Exp Med. 1998 Feb 16;187(4):461-8.

47.
48.

Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling.

Cope AP, Liblau RS, Yang XD, Congia M, Laudanna C, Schreiber RD, Probert L, Kollias G, McDevitt HO.

J Exp Med. 1997 May 5;185(9):1573-84.

49.

TNF-alpha transgenic and knockout models of CNS inflammation and degeneration.

Probert L, Akassoglou K, Kassiotis G, Pasparakis M, Alexopoulou L, Kollias G.

J Neuroimmunol. 1997 Feb;72(2):137-41. Review.

PMID:
9042105
50.

TNF and related molecules: trends in neuroscience and clinical applications.

Probert L, Selmaj K.

J Neuroimmunol. 1997 Feb;72(2):113-7. Review.

PMID:
9042101

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